JP2006507321A5 - - Google Patents
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- Publication number
- JP2006507321A5 JP2006507321A5 JP2004551017A JP2004551017A JP2006507321A5 JP 2006507321 A5 JP2006507321 A5 JP 2006507321A5 JP 2004551017 A JP2004551017 A JP 2004551017A JP 2004551017 A JP2004551017 A JP 2004551017A JP 2006507321 A5 JP2006507321 A5 JP 2006507321A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- trifluoromethyl
- nmr
- alkylcarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 10
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- IQBNYYCGZHTSAZ-UHFFFAOYSA-N 2-[2-[[3,5-bis(trifluoromethyl)phenyl]sulfonylamino]-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridin-5-yl]-4-(trifluoromethyl)benzamide Chemical compound NC(=O)C1=CC=C(C(F)(F)F)C=C1N1CC(SC(NS(=O)(=O)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)=N2)=C2CC1 IQBNYYCGZHTSAZ-UHFFFAOYSA-N 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- -1 hydrochloride Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
- BQNZIRSNAKWERJ-UHFFFAOYSA-N 2-fluoro-4-(trifluoromethyl)benzamide Chemical compound NC(=O)C1=CC=C(C(F)(F)F)C=C1F BQNZIRSNAKWERJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- OGZKCTDWGFRJGD-UHFFFAOYSA-N N-(4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridin-2-yl)-3,5-bis(trifluoromethyl)benzenesulfonamide hydrochloride Chemical compound Cl.FC(F)(F)C1=CC(C(F)(F)F)=CC(S(=O)(=O)NC=2SC=3CNCCC=3N=2)=C1 OGZKCTDWGFRJGD-UHFFFAOYSA-N 0.000 description 1
- 108010087999 Steryl-Sulfatase Proteins 0.000 description 1
- 102100038021 Steryl-sulfatase Human genes 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0226602A GB0226602D0 (en) | 2002-11-14 | 2002-11-14 | Organic compounds |
| GB0226616A GB0226616D0 (en) | 2002-11-14 | 2002-11-14 | Organic compounds |
| PCT/EP2003/012707 WO2004043968A1 (en) | 2002-11-14 | 2003-11-13 | N-sulfonylaminothiazole |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507321A JP2006507321A (ja) | 2006-03-02 |
| JP2006507321A5 true JP2006507321A5 (https=) | 2006-12-28 |
| JP4551767B2 JP4551767B2 (ja) | 2010-09-29 |
Family
ID=32313994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551017A Expired - Fee Related JP4551767B2 (ja) | 2002-11-14 | 2003-11-13 | Ｎ−スルホニルアミノチアゾール |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7291734B2 (https=) |
| EP (1) | EP1562958B1 (https=) |
| JP (1) | JP4551767B2 (https=) |
| AR (1) | AR041952A1 (https=) |
| AT (1) | ATE396192T1 (https=) |
| AU (1) | AU2003288056A1 (https=) |
| BR (1) | BR0316205A (https=) |
| CA (1) | CA2505249A1 (https=) |
| DE (1) | DE60321209D1 (https=) |
| ES (1) | ES2305542T3 (https=) |
| MY (1) | MY135750A (https=) |
| PE (1) | PE20040693A1 (https=) |
| PT (1) | PT1562958E (https=) |
| TW (1) | TWI318212B (https=) |
| WO (1) | WO2004043968A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1976944A (zh) * | 2004-06-30 | 2007-06-06 | 默克公司 | 雌激素受体调节剂 |
| GB0505541D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
| GB0505539D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
| US20100204146A1 (en) | 2007-09-17 | 2010-08-12 | Preglem S.A. | Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1620508A1 (de) | 1965-07-23 | 1969-09-18 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine |
| DE2429195A1 (de) | 1974-06-18 | 1976-02-05 | Basf Ag | 2-amino-pyrazolo eckige klammer auf 3,4-d eckige klammer zu thiazole |
| GB8333514D0 (en) * | 1983-12-16 | 1984-01-25 | Erba Farmitalia | Tetrahydrothiazolo(5 4-c)pyridine derivatives |
| DE3533331A1 (de) * | 1985-09-18 | 1987-03-26 | Heumann Ludwig & Co Gmbh | Pyridothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CO5261573A1 (es) * | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
| JP2001294572A (ja) * | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| AU2002213467A8 (en) | 2000-10-11 | 2009-07-30 | Chemocentryx Inc | Modulation of ccr4 function |
| JP4266092B2 (ja) | 2001-10-09 | 2009-05-20 | 第一三共株式会社 | ジアミン誘導体 |
-
2003
- 2003-11-12 PE PE2003001143A patent/PE20040693A1/es not_active Application Discontinuation
- 2003-11-12 AR ARP030104165A patent/AR041952A1/es not_active Application Discontinuation
- 2003-11-13 WO PCT/EP2003/012707 patent/WO2004043968A1/en not_active Ceased
- 2003-11-13 EP EP03779918A patent/EP1562958B1/en not_active Expired - Lifetime
- 2003-11-13 AU AU2003288056A patent/AU2003288056A1/en not_active Abandoned
- 2003-11-13 AT AT03779918T patent/ATE396192T1/de not_active IP Right Cessation
- 2003-11-13 TW TW092131800A patent/TWI318212B/zh not_active IP Right Cessation
- 2003-11-13 US US10/533,335 patent/US7291734B2/en not_active Expired - Fee Related
- 2003-11-13 MY MYPI20034348A patent/MY135750A/en unknown
- 2003-11-13 PT PT03779918T patent/PT1562958E/pt unknown
- 2003-11-13 JP JP2004551017A patent/JP4551767B2/ja not_active Expired - Fee Related
- 2003-11-13 BR BR0316205-2A patent/BR0316205A/pt not_active IP Right Cessation
- 2003-11-13 CA CA002505249A patent/CA2505249A1/en not_active Abandoned
- 2003-11-13 DE DE60321209T patent/DE60321209D1/de not_active Expired - Lifetime
- 2003-11-13 ES ES03779918T patent/ES2305542T3/es not_active Expired - Lifetime
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