HUP0104942A2 - Policiklusos tiazolidin-2-ilidén-aminok, eljárás a vegyületek előállítására és gyógyszerként történő alkalmazásuk - Google Patents
Policiklusos tiazolidin-2-ilidén-aminok, eljárás a vegyületek előállítására és gyógyszerként történő alkalmazásukInfo
- Publication number
- HUP0104942A2 HUP0104942A2 HU0104942A HUP0104942A HUP0104942A2 HU P0104942 A2 HUP0104942 A2 HU P0104942A2 HU 0104942 A HU0104942 A HU 0104942A HU P0104942 A HUP0104942 A HU P0104942A HU P0104942 A2 HUP0104942 A2 HU P0104942A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- carbon atom
- phenyl
- group
- thienyl
- Prior art date
Links
- -1 Polycyclic thiazolidin-2-ylidene amines Chemical class 0.000 title abstract 13
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229910052731 fluorine Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011737 fluorine Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A tal lm ny policiklusos tiazolidin-2-ilidén-aminokra, valamint ezekfiziológiailag elfogadható sóira és fiziológiailag reakcióképes szrmazékaira vonatkozik. A tal lm ny policiklusos tiazolidin-2-ilidén-aminok (I) ltal nos képletében a szubsztituensek jelentése az albbiakban megadott. A tal lm ny kiterjed a fiziológiailag elfogadhatósókra és az azok elő llít s ra szolg ló elj r sra és a vegyületekettartalmazó gyógyszerkészítmények is. A tal lm ny szerinti vegyületekétv gycs"kkentőként alkalmazhatók. Y jelentése vegyértékvonal, -CH2-vagy -CH2-CH2- csoport; X jelentése -CH2, CH(CH3), CH(C2H5), CH(C3H7);R1 jelentése ciano-, karboxil-, COO-(1-6 szénatomos alkil)-,karboxamido-, CONH-(1-6 szénatomos alkil)-, CON(1-6 szénatomosalkil)2, 2-6 szénatomos alkil-, 2-6 szénatomos alkenil-, 2-6szénatomos alkinil-, O-CH2-CF3, O-CH2-CF2-CF3 vagy O-(4-6 szénatomosalkil)-csoport, ahol az alkilcsoportokban egy vagy t"bb vagyvalamennyi hidrogénatomot fluoratom helyettesíthet, vagy egyhidrogénatom hidroxil-, OC(O)CH3, O-CH2-fenil, amin vagy N(COOCH2Ph)2csoporttal lehet helyettesítve, S-(1-6 szénatomos alkil)-, S-(CH2)n-fenil-, SO2-(1-6 szénatomos alkil)-, SO2- (CH2)n-fenil-, SO2-(1-6szénatomos alkil)-, SO2-(CH2)n-fenilcsoport, ahol n 0-6 k"z"tti egészsz m; R1' jelentése hidrogén-, fluor-, klór-, bróm- vagy jódatom, vagymetil-, trifluor-metil-, O-(1-3 szénatomos alkil)-, nitro-, SO2-NH2-,SO2NH(1-6 szénatomos alkil)-, SO2N-(1-6 szénatomos alkil)2- vagy R1,R2 jelentése hidrogénatom, 1-6 szénatomos alkil-, 3-6 szénatomoscikloalkil-, (CH2)n-fenil-, (CH2)n-tienil-, (CH2)n-piridil-, (CH2)n-furil-, C(O)-(CH2)n-fenil-, C(O)-(CH2)n-tienil-, C(O)-(CH2)n-piridil-,C(O)-(CH2)n-furilcsoport, ahol n értéke 0-5 k"z"tti egész sz m lehet,és ahol a fenil-, tienil-, piridil- vagy furilcsoport legfeljebb kettőklór-, fluoratommal, ciano-, trifluor-metil-, 1-3 szénatomos alkil-,hidroxil-, O-(1-6 szénatomos alkil)-csoporttal lehet szubsztitu lva,C(O)-(1-6 szénatomos alkil)-, C(O)-(3-6 szénatomos cikloalkil)-csoport; R3 jelentése hidrogénatom, 1-6 szénatomos alkil-, fluoratom,ciano- vagy azidocsoport, O-(1-6 szénatomos alkil)-, CH2-COO(1-6szénatomos alkil)-, CH2-COO(3-8 szénatomos cikloalkil)-, CH2- COOH,CH2-CONH2, CH2-CONHCH3, CH2-CON(CH3)2, (CH2)n-fenil-, (CH2)n-tienil-,(CH2)n-piridil-, (CH2)n-furilcsoport, ahol n 0-5 k"z"tti egész sz mlehet, és ahol a fenil-, tienil-, piridil- vagy furilcsoportlegfeljebb két klór-, fluoratommal, ciano-, trifluor-metil-, 1-3szénatomos alkil-, hidroxil-, O-(1-6 szénatomos alkil)-csoporttallehet szubsztitu lva, 2-6 szénatomos alkinil-, 2-6 szénatomosalkenil-, C(O)OCH3, C(O)OCH2CH3, C(O)OH, C(O)NH2, C(O)NHCH3,C(O)N(CH3)2 vagy OC(O)CH3 csoport; R4 jelentése 1-6 szénatomos alkil-,3-6 szénatomos cikloalkil-, (CH2)n-fenil=, (CH2)n-tienil-; (CH2)n-piridil-, (CH2)n-furilcsoport, ahol n értéke 0-5 k"z"tti e
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19831878A DE19831878C2 (de) | 1998-07-17 | 1998-07-17 | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/004644 WO2000004006A1 (de) | 1998-07-17 | 1999-07-03 | Polycyclische thiazolidin-2-yliden amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104942A2 true HUP0104942A2 (hu) | 2002-04-29 |
| HUP0104942A3 HUP0104942A3 (en) | 2003-12-29 |
Family
ID=7874197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104942A HUP0104942A3 (en) | 1998-07-17 | 1999-07-03 | Polycyclic thiazolidin-2-ylidene amines, method for the production and use thereof as medicaments |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6159996A (hu) |
| EP (1) | EP1098891B1 (hu) |
| JP (1) | JP3541808B2 (hu) |
| KR (1) | KR20010083118A (hu) |
| CN (1) | CN1144797C (hu) |
| AR (1) | AR019925A1 (hu) |
| AT (1) | ATE301645T1 (hu) |
| AU (1) | AU767151B2 (hu) |
| BR (1) | BR9912151A (hu) |
| CA (1) | CA2337838A1 (hu) |
| CL (1) | CL2004000219A1 (hu) |
| DE (2) | DE19831878C2 (hu) |
| DK (1) | DK1098891T3 (hu) |
| ES (1) | ES2246089T3 (hu) |
| HK (1) | HK1038560A1 (hu) |
| HU (1) | HUP0104942A3 (hu) |
| ID (1) | ID26985A (hu) |
| IL (1) | IL140767A (hu) |
| NO (1) | NO318790B1 (hu) |
| NZ (1) | NZ509395A (hu) |
| PL (1) | PL345619A1 (hu) |
| PT (1) | PT1098891E (hu) |
| RU (1) | RU2236405C2 (hu) |
| TR (1) | TR200100125T2 (hu) |
| WO (1) | WO2000004006A1 (hu) |
| ZA (1) | ZA200100279B (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19908537A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908538A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908533A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| BR0015322A (pt) * | 1999-11-05 | 2002-07-09 | Aventis Pharma Gmbh | Derivados de indeno-, nafto- e benzociclohepta-dihidrotiazol, sua preparação e seu emprego como medicamentos anoréticos |
| DK1261593T3 (da) * | 2000-02-26 | 2003-12-01 | Aventis Pharma Gmbh | 8,8a-Dihydro-indeno[1,2-d]thiazol-derivater med en sulfonamido- eller sulfonosubstituent i 2-stillingen, en fremgangsmåde til fremstilling deraf og anvendelse deraf som lægemiddel |
| DE10142722A1 (de) | 2001-08-31 | 2003-03-27 | Aventis Pharma Gmbh | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10142665B4 (de) * | 2001-08-31 | 2004-05-06 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-one und ihre Derivate |
| US7977532B2 (en) * | 2002-09-05 | 2011-07-12 | The Procter & Gamble Company | Tampon with clean appearance post use |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| EP1767565B1 (en) * | 2004-07-09 | 2015-04-01 | Nissan Chemical Industries, Ltd. | Process for purification of oligoanilines and oligoanilines |
| EP2202222A3 (en) * | 2005-11-08 | 2010-09-15 | Laboratorios Del Dr. Esteve, S.A. | Indene derivatives, their preparation and use as medicaments |
| EP2276767B1 (en) * | 2008-03-31 | 2014-05-07 | Genentech, Inc. | Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use |
| CN103443080B (zh) | 2011-03-16 | 2016-10-12 | 田边三菱制药株式会社 | 具有trpm8拮抗活性的磺酰胺化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507868A (en) * | 1968-10-21 | 1970-04-21 | Sandoz Ag | Imidazo(2,1-b)thiazoles and thiazolo(3,2-a)pyrimidines |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
-
1998
- 1998-07-17 DE DE19831878A patent/DE19831878C2/de not_active Expired - Fee Related
-
1999
- 1999-07-03 KR KR1020017000694A patent/KR20010083118A/ko not_active Application Discontinuation
- 1999-07-03 DE DE59912402T patent/DE59912402D1/de not_active Expired - Lifetime
- 1999-07-03 CN CNB998087165A patent/CN1144797C/zh not_active Expired - Fee Related
- 1999-07-03 CA CA002337838A patent/CA2337838A1/en not_active Abandoned
- 1999-07-03 BR BR9912151-4A patent/BR9912151A/pt not_active Application Discontinuation
- 1999-07-03 JP JP2000560113A patent/JP3541808B2/ja not_active Expired - Fee Related
- 1999-07-03 NZ NZ509395A patent/NZ509395A/en unknown
- 1999-07-03 TR TR2001/00125T patent/TR200100125T2/xx unknown
- 1999-07-03 WO PCT/EP1999/004644 patent/WO2000004006A1/de not_active Application Discontinuation
- 1999-07-03 AT AT99934568T patent/ATE301645T1/de not_active IP Right Cessation
- 1999-07-03 PT PT99934568T patent/PT1098891E/pt unknown
- 1999-07-03 HU HU0104942A patent/HUP0104942A3/hu unknown
- 1999-07-03 ES ES99934568T patent/ES2246089T3/es not_active Expired - Lifetime
- 1999-07-03 IL IL14076799A patent/IL140767A/xx not_active IP Right Cessation
- 1999-07-03 EP EP99934568A patent/EP1098891B1/de not_active Expired - Lifetime
- 1999-07-03 ID IDW20010125A patent/ID26985A/id unknown
- 1999-07-03 RU RU2001104480/04A patent/RU2236405C2/ru not_active IP Right Cessation
- 1999-07-03 DK DK99934568T patent/DK1098891T3/da active
- 1999-07-03 PL PL99345619A patent/PL345619A1/xx not_active Application Discontinuation
- 1999-07-03 AU AU50308/99A patent/AU767151B2/en not_active Ceased
- 1999-07-12 US US09/351,621 patent/US6159996A/en not_active Expired - Lifetime
- 1999-07-15 AR ARP990103487A patent/AR019925A1/es unknown
-
2001
- 2001-01-10 ZA ZA200100279A patent/ZA200100279B/en unknown
- 2001-01-12 NO NO20010219A patent/NO318790B1/no unknown
- 2001-12-28 HK HK01109163A patent/HK1038560A1/xx not_active IP Right Cessation
-
2004
- 2004-02-06 CL CL200400219A patent/CL2004000219A1/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |