JP2006505550A5 - - Google Patents
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- Publication number
- JP2006505550A5 JP2006505550A5 JP2004542629A JP2004542629A JP2006505550A5 JP 2006505550 A5 JP2006505550 A5 JP 2006505550A5 JP 2004542629 A JP2004542629 A JP 2004542629A JP 2004542629 A JP2004542629 A JP 2004542629A JP 2006505550 A5 JP2006505550 A5 JP 2006505550A5
- Authority
- JP
- Japan
- Prior art keywords
- radioactive
- group
- contrast agent
- barbituric acid
- matrix metalloproteinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002285 radioactive effect Effects 0.000 claims 14
- 239000002872 contrast media Substances 0.000 claims 11
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 claims 10
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 8
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 8
- 229910021645 metal ion Inorganic materials 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 4
- 239000012217 radiopharmaceutical Substances 0.000 claims 4
- 229940121896 radiopharmaceutical Drugs 0.000 claims 4
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229910052755 nonmetal Inorganic materials 0.000 claims 3
- 230000005298 paramagnetic effect Effects 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002993 cycloalkylene group Chemical group 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000006294 amino alkylene group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 150000002843 nonmetals Chemical class 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223249.4A GB0223249D0 (en) | 2002-10-08 | 2002-10-08 | Improved imaging agents |
| PCT/GB2003/004351 WO2004032936A1 (en) | 2002-10-08 | 2003-10-08 | Improved imaging agents comprising barbituric acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006505550A JP2006505550A (ja) | 2006-02-16 |
| JP2006505550A5 true JP2006505550A5 (https=) | 2006-11-30 |
Family
ID=9945439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542629A Pending JP2006505550A (ja) | 2002-10-08 | 2003-10-08 | バルビツール酸誘導体を含む進歩した造影剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060120956A1 (https=) |
| EP (1) | EP1549317A1 (https=) |
| JP (1) | JP2006505550A (https=) |
| CN (1) | CN1720050A (https=) |
| AU (1) | AU2003273505B2 (https=) |
| CA (1) | CA2501136A1 (https=) |
| GB (1) | GB0223249D0 (https=) |
| NO (1) | NO20051641L (https=) |
| RU (1) | RU2005109272A (https=) |
| WO (1) | WO2004032936A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006021495A1 (de) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit |
| PL2029178T3 (pl) | 2006-06-21 | 2012-08-31 | Ge Healthcare Ltd | Produkty radiofarmaceutyczne |
| GB0612333D0 (en) * | 2006-06-21 | 2006-08-02 | Ge Healthcare Ltd | Radiopharmaceutical products |
| KR101578225B1 (ko) * | 2007-05-16 | 2015-12-17 | 지이 헬스케어 에이에스 | 영상화를 위한 표지된 ｈｇｆ 결합성 펩티드 |
| GB0718386D0 (en) * | 2007-09-21 | 2007-10-31 | Ge Healthcare As | Improved radiopharmaceutical formulation |
| GB201115937D0 (en) | 2011-09-14 | 2011-10-26 | Univ Aberdeen | 18F-labelled compounds for use as positron emission imaging agents |
| JP2021534215A (ja) * | 2018-08-24 | 2021-12-09 | ゼニオプロ ゲーエムベーハー | 病的症状の治療における使用のための芳香族分子 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3952971A (en) * | 1971-11-09 | 1976-04-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Airfoil shape for flight at subsonic speeds |
| US3952091A (en) * | 1974-10-23 | 1976-04-20 | Hoffmann-La Roche Inc. | Simultaneous multiple radioimmunoassay |
| GB1527416A (en) * | 1976-07-20 | 1978-10-04 | Ciba Geigy Ag | Photopolymerisible diepoxides |
| US6472227B1 (en) * | 1986-06-04 | 2002-10-29 | Abbott Laboratories | Barbiturate assay, tracers, immunogens, antibodies and kit |
| US5102786A (en) * | 1987-05-21 | 1992-04-07 | Pb Diagnostic Systems, Inc. | Biological diagnostic assay system |
| IL139385A (en) * | 1998-05-15 | 2005-09-25 | Amersham Plc | Labelled glutamine and lysine analogues, metal complexes thereof, and uses thereof for diagnosis |
| US6656448B1 (en) * | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| DE60114022T2 (de) * | 2000-05-30 | 2006-07-13 | Board Of Governors Of Wayne State University, Detroit | Matrix metalloproteinase-inhibitoren |
| CN1501937A (zh) * | 2000-10-26 | 2004-06-02 | �Ʒ� | 螺-嘧啶-2,4,6-三酮金属蛋白酶抑制剂 |
| HUP0302337A3 (en) * | 2000-10-26 | 2004-01-28 | Pfizer Prod Inc | Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use |
| CN100336521C (zh) * | 2000-12-12 | 2007-09-12 | 血管实验室公司 | 蜜蜂花叶提取物制备抑制血管生成相关疾病药物的用途 |
| GB0115929D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase electrophilic fluorination |
-
2002
- 2002-10-08 GB GBGB0223249.4A patent/GB0223249D0/en not_active Ceased
-
2003
- 2003-10-08 CA CA002501136A patent/CA2501136A1/en not_active Abandoned
- 2003-10-08 US US10/530,836 patent/US20060120956A1/en not_active Abandoned
- 2003-10-08 WO PCT/GB2003/004351 patent/WO2004032936A1/en not_active Ceased
- 2003-10-08 AU AU2003273505A patent/AU2003273505B2/en not_active Expired - Fee Related
- 2003-10-08 RU RU2005109272/15A patent/RU2005109272A/ru not_active Application Discontinuation
- 2003-10-08 JP JP2004542629A patent/JP2006505550A/ja active Pending
- 2003-10-08 EP EP03755663A patent/EP1549317A1/en not_active Withdrawn
- 2003-10-08 CN CN200380105207.5A patent/CN1720050A/zh active Pending
-
2005
- 2005-04-04 NO NO20051641A patent/NO20051641L/no not_active Application Discontinuation
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