JP2013528161A5 - - Google Patents

Download PDF

Info

Publication number
JP2013528161A5
JP2013528161A5 JP2013510284A JP2013510284A JP2013528161A5 JP 2013528161 A5 JP2013528161 A5 JP 2013528161A5 JP 2013510284 A JP2013510284 A JP 2013510284A JP 2013510284 A JP2013510284 A JP 2013510284A JP 2013528161 A5 JP2013528161 A5 JP 2013528161A5
Authority
JP
Japan
Prior art keywords
formula
subject
hydrogen
salt
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013510284A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013528161A (ja
JP5992399B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/036142 external-priority patent/WO2011143360A2/en
Publication of JP2013528161A publication Critical patent/JP2013528161A/ja
Publication of JP2013528161A5 publication Critical patent/JP2013528161A5/ja
Application granted granted Critical
Publication of JP5992399B2 publication Critical patent/JP5992399B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013510284A 2010-05-11 2011-05-11 造影剤の合成および使用のための組成物、方法およびシステム Active JP5992399B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33361810P 2010-05-11 2010-05-11
US61/333,618 2010-05-11
US40552410P 2010-10-21 2010-10-21
US40557110P 2010-10-21 2010-10-21
US61/405,571 2010-10-21
US61/405,524 2010-10-21
PCT/US2011/036142 WO2011143360A2 (en) 2010-05-11 2011-05-11 Compositions, methods and systems for the synthesis and use of imaging agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016160146A Division JP6216421B2 (ja) 2010-05-11 2016-08-17 造影剤の合成および使用のための組成物、方法およびシステム

Publications (3)

Publication Number Publication Date
JP2013528161A JP2013528161A (ja) 2013-07-08
JP2013528161A5 true JP2013528161A5 (https=) 2014-06-26
JP5992399B2 JP5992399B2 (ja) 2016-09-14

Family

ID=44914968

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013510284A Active JP5992399B2 (ja) 2010-05-11 2011-05-11 造影剤の合成および使用のための組成物、方法およびシステム
JP2016160146A Active JP6216421B2 (ja) 2010-05-11 2016-08-17 造影剤の合成および使用のための組成物、方法およびシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016160146A Active JP6216421B2 (ja) 2010-05-11 2016-08-17 造影剤の合成および使用のための組成物、方法およびシステム

Country Status (17)

Country Link
US (5) US9388125B2 (https=)
EP (2) EP2569019B1 (https=)
JP (2) JP5992399B2 (https=)
KR (4) KR20170042373A (https=)
CN (2) CN106977429B (https=)
AU (1) AU2011253052B2 (https=)
BR (4) BR112012028806B1 (https=)
CA (2) CA3041113C (https=)
DK (1) DK2569019T3 (https=)
ES (1) ES2763815T3 (https=)
IL (1) IL222897A (https=)
MX (3) MX367382B (https=)
NZ (1) NZ604233A (https=)
RU (2) RU2019142507A (https=)
SG (1) SG185424A1 (https=)
TW (2) TWI606842B (https=)
WO (1) WO2011143360A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
KR101602992B1 (ko) 2009-04-15 2016-03-11 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
EP2753605B1 (en) * 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US20150023873A1 (en) 2011-11-11 2015-01-22 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
WO2013173004A2 (en) 2012-04-10 2013-11-21 Lantheus Medical Imaging, Inc. Radiopharmaceutical synthesis methods
AU2013203000B9 (en) * 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US20150246142A1 (en) 2012-09-25 2015-09-03 The Regents Of The University Of Michigan Imaging agents
WO2016065322A1 (en) 2014-10-24 2016-04-28 Molecular Insight Pharmaceuticals, Inc. Preparations of meta-iodobenzylguanidine and precursors thereof
WO2016138448A1 (en) * 2015-02-27 2016-09-01 Schmitthenner Hans F Transmetalation methods for the synthesis of pet and spect imaging agents
US10368774B2 (en) 2015-07-30 2019-08-06 Medtronic, Inc. Absolute intrathoracic impedance based scheme to stratify patients for risk of a heart failure event
US10874752B2 (en) 2015-09-25 2020-12-29 Board Of Regents Of The University Of Nebraska MIBG analogs and uses thereof
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
FR3054445B1 (fr) * 2016-07-26 2019-07-05 Laboratoires Cyclopharma Synthese d'une composition d'agent radioactif
US10924560B2 (en) * 2018-07-30 2021-02-16 Facebook, Inc. Determining geographic locations of network devices
WO2020085238A1 (ja) * 2018-10-24 2020-04-30 日本メジフィジックス株式会社 放射性フッ素標識前駆体化合物の塩
CN111366643B (zh) * 2018-12-25 2022-08-19 广东阿格蕾雅光电材料有限公司 一种oled材料中间体的检测方法
RU196435U1 (ru) * 2019-12-30 2020-02-28 федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ) Устройство для позитронно-эмиссионной томографии
NL2031332B1 (en) * 2022-03-18 2023-09-29 Plethora Therapeutics B V Transmucosal delivery of psychoactive compounds
CN116351339B (zh) * 2022-06-07 2026-01-23 北京先通国际医药科技股份有限公司 一种液体组合物的生产设备及其制备方法和用途

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1010218A (fr) * 1949-02-10 1952-06-09 American Cyanamid Co Perfectionnements aux sels de guanidine
US3291829A (en) * 1961-03-02 1966-12-13 Ciba Geigy Corp Alkyl guanidines
GB1215255A (en) * 1968-03-13 1970-12-09 Pfizer & Co C Halophenylalkylguanidine compounds
US4094881A (en) 1976-03-10 1978-06-13 Smithkline Corporation Process for preparing triazolethiols
US4275074A (en) * 1979-03-09 1981-06-23 Graham J. Dobbie Catecholamine treatment of ocular hypertension
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4258188A (en) 1980-02-04 1981-03-24 American Home Products Corporation 2-(1-Piperazinyl)-cycloheptimidazole derivatives
US4622217A (en) 1984-04-27 1986-11-11 The Regents Of The University Of Michigan I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4886499A (en) 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
EP0288284A3 (en) 1987-04-24 1990-07-25 King Faisal Specialist Hospital And Research Centre Method of producing iodine 124 and meta-iodobenzylguanidine containing iodine 124
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
EP0955044B1 (en) 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
WO1999018053A1 (en) 1997-10-02 1999-04-15 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
WO1999052861A1 (de) 1998-04-09 1999-10-21 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik
AU5671699A (en) * 1998-08-14 2000-03-06 Smithkline Beecham Corporation Grp receptor ligands
CA2727746A1 (en) 1998-12-18 2000-06-22 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
DE10114561A1 (de) * 2001-03-24 2002-09-26 Wella Ag Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
EP1581533A2 (en) 2002-08-17 2005-10-05 ALTANA Pharma AG Novel benzonaphthyridines
AU2003298582A1 (en) * 2002-09-17 2004-05-13 Isis Pharmaceuticals, Inc. Therapeutic guanidines
EP1641493A4 (en) 2003-06-30 2007-10-31 Merck & Co Inc RADIOACTIVELY MARKED CANNABINOID-1 RECEPTOR MODULATORS
US20080228069A1 (en) * 2003-12-01 2008-09-18 Mediphysics, Inc. Novel Differential Imaging Method
US20060100225A1 (en) * 2004-03-23 2006-05-11 Xi Chen Heteroaryl guanidines; inhibitors of viral replication
WO2005115971A1 (ja) 2004-05-28 2005-12-08 Hamamatsu Photonics K.K. 放射性チロシン誘導体、その製造方法、放射性チロシン誘導体からなるポジトロンイメージング用標識剤及び腫瘍の悪性度評価薬剤並びに腫瘍の検出方法
JP2008513533A (ja) 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
US20060083681A1 (en) 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
US7534418B2 (en) * 2004-12-10 2009-05-19 The Regents Of The University Of Michigan Imaging agents
GB0512770D0 (en) 2005-06-23 2005-07-27 Hammersmith Imanet Ltd Imaging compounds
ES2364701T3 (es) 2006-12-13 2011-09-12 F. Hoffmann-La Roche Ag Nuevos 2-imidazoles como ligandos para receptores asociados a aminas trazas.
GB0625523D0 (en) * 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
TWI618544B (zh) * 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
WO2008082305A1 (en) 2006-12-28 2008-07-10 Raufoss Technology As Control arm
US8153100B2 (en) * 2007-01-11 2012-04-10 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
US7887784B2 (en) 2007-03-21 2011-02-15 University Of Montana 1-[(2′-substituted)-piperazin-1′ -yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents
US7807394B2 (en) 2007-04-05 2010-10-05 Siemens Medical Solutions Usa, Inc. Nitro-imidazole hypoxia imaging agents
CN101585816B (zh) 2008-05-20 2011-04-20 中国科学院上海应用物理研究所 一种苯磺酰胺类羟基衍生物及其中间体及制备方法和应用
WO2010015340A1 (en) * 2008-08-06 2010-02-11 Bayer Schering Pharma Aktiengesellschaft Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
KR101602992B1 (ko) 2009-04-15 2016-03-11 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
CN101555232B (zh) 2009-05-21 2011-01-05 北京师范大学 氟-18标记哒嗪酮类化合物及制备方法和应用
CA2803520C (en) 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
EP2753605B1 (en) 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents

Similar Documents

Publication Publication Date Title
JP2013528161A5 (https=)
RU2012153210A (ru) Композиции, способы и системы для синтеза и применение визуализирующих средств
KR101946089B1 (ko) 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
KR101709372B1 (ko) 조영제 및 이의 중간체를 합성하는 방법 및 장치
CN108472242A (zh) 治疗癌症的药物组合
JP2018076328A5 (https=)
JP2006524250A5 (https=)
JP2010529088A5 (https=)
JP2016204383A5 (https=)
JP2022508699A5 (https=)
US20130150440A1 (en) Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
JP2015508068A5 (https=)
WO2014169035A1 (en) Predictive and response biomarker for th-302 anti-cancer therapy
JP2016527202A5 (https=)
Yu et al. LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment
US20250090507A1 (en) Methods of Treating Cancer With a B-RAF Inhibitor
JP2007500730A5 (https=)
JP7679000B2 (ja) 新規化合物
RU2020109705A (ru) Соединения и их фармацевтические композиции для применения в лечении фиброзных заболеваний
JP2012504581A5 (https=)
JP2009538894A5 (https=)
JP2013507345A5 (https=)
JP7036543B2 (ja) 腫瘍イメージング剤、及びホウ素中性子捕捉療法用腫瘍治療剤
JP2012520855A5 (https=)
US9376432B2 (en) Use of VEGFR-3 inhibitors for treating hepatocellular carcinoma