JP2006524250A5 - - Google Patents

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Publication number
JP2006524250A5
JP2006524250A5 JP2006513138A JP2006513138A JP2006524250A5 JP 2006524250 A5 JP2006524250 A5 JP 2006524250A5 JP 2006513138 A JP2006513138 A JP 2006513138A JP 2006513138 A JP2006513138 A JP 2006513138A JP 2006524250 A5 JP2006524250 A5 JP 2006524250A5
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JP
Japan
Prior art keywords
fatty acid
acid analog
tissue
radiolabeled fatty
radiolabeled
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JP2006513138A
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English (en)
Japanese (ja)
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JP2006524250A (ja
JP4633052B2 (ja
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Priority claimed from PCT/US2004/012084 external-priority patent/WO2004093650A2/en
Publication of JP2006524250A publication Critical patent/JP2006524250A/ja
Publication of JP2006524250A5 publication Critical patent/JP2006524250A5/ja
Application granted granted Critical
Publication of JP4633052B2 publication Critical patent/JP4633052B2/ja
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Expired - Fee Related legal-status Critical Current

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JP2006513138A 2003-04-17 2004-04-19 放射性同位元素で標識したアルカン酸を使用することによる血流および組織への代謝的取込みのモニター法 Expired - Fee Related JP4633052B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46357403P 2003-04-17 2003-04-17
PCT/US2004/012084 WO2004093650A2 (en) 2003-04-17 2004-04-19 Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid

Publications (3)

Publication Number Publication Date
JP2006524250A JP2006524250A (ja) 2006-10-26
JP2006524250A5 true JP2006524250A5 (https=) 2007-04-19
JP4633052B2 JP4633052B2 (ja) 2011-02-16

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JP2006513138A Expired - Fee Related JP4633052B2 (ja) 2003-04-17 2004-04-19 放射性同位元素で標識したアルカン酸を使用することによる血流および組織への代謝的取込みのモニター法

Country Status (9)

Country Link
US (9) US7494642B2 (https=)
EP (1) EP1622602B1 (https=)
JP (1) JP4633052B2 (https=)
AT (1) ATE405258T1 (https=)
AU (1) AU2004232297B2 (https=)
CA (1) CA2522737C (https=)
DE (1) DE602004015970D1 (https=)
MX (1) MXPA05011189A (https=)
WO (1) WO2004093650A2 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE526995T1 (de) * 1995-12-01 2011-10-15 Molecular Insight Pharm Inc Stereoisomers von fettsäureanalogen für diagnostische bildgebung
US8565860B2 (en) 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
US8909325B2 (en) 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
WO2005119025A2 (en) 2004-06-01 2005-12-15 Spectrum Dynamics Llc Radioactive-emission-measurement optimization to specific body structures
CA2522737C (en) * 2003-04-17 2017-06-06 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
US9470801B2 (en) 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
WO2005067383A2 (en) 2004-01-13 2005-07-28 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US9040016B2 (en) 2004-01-13 2015-05-26 Biosensors International Group, Ltd. Diagnostic kit and methods for radioimaging myocardial perfusion
EP1827505A4 (en) 2004-11-09 2017-07-12 Biosensors International Group, Ltd. Radioimaging
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
US8423125B2 (en) 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
EP1909853B1 (en) 2005-07-19 2015-03-18 Biosensors International Group, Ltd. Imaging protocols
GB0525949D0 (en) 2005-12-21 2006-02-01 Hammersmith Imanet Ltd Pet radiotracers
WO2007080743A1 (ja) * 2006-01-16 2007-07-19 National University Corporation Hokkaido University 検査システムおよび検査方法
US8894974B2 (en) 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
US9275451B2 (en) 2006-12-20 2016-03-01 Biosensors International Group, Ltd. Method, a system, and an apparatus for using and processing multidimensional data
US8521253B2 (en) 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
CA2760334A1 (en) * 2009-05-04 2010-11-11 Washington University Pet radiotracers for imaging fatty acid metabolism and storage
US20120237937A1 (en) * 2009-06-12 2012-09-20 University Of Louisville Research Foundation, Inc. Methods to detect cancer in animals
US8338788B2 (en) 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
US20110110570A1 (en) * 2009-11-10 2011-05-12 Avi Bar-Shalev Apparatus and methods for generating a planar image
DE102010010666A1 (de) * 2010-03-01 2011-09-01 Sven Reske Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren
CN105517492B (zh) * 2013-09-06 2019-10-18 皇家飞利浦有限公司 用于处理心脏数据的处理设备
ES2929277T3 (es) * 2016-11-08 2022-11-28 Univ California Métodos para la síntesis multidosis de [F-18]FDDNP para contextos clínicos
CN108727229B (zh) * 2017-04-17 2021-07-02 北京先通国际医药科技股份有限公司 一种修饰脂肪酸型pet试剂前体的新工艺路线
ES3009015T3 (en) 2018-07-20 2025-03-25 Astellas Pharma Inc Fatty acid derivative labeled with positron-emitting radionuclide
US20230065079A1 (en) * 2020-01-17 2023-03-02 Astellas Pharma Inc. Fatty acid derivative labeled with positron-emitting radionuclide
CN116351339B (zh) * 2022-06-07 2026-01-23 北京先通国际医药科技股份有限公司 一种液体组合物的生产设备及其制备方法和用途
CN114732918B (zh) * 2022-06-10 2022-09-13 北京先通国际医药科技股份有限公司 一种液体组合物的生产设备及其制备方法和用途
CN114736112A (zh) * 2022-06-14 2022-07-12 北京先通国际医药科技股份有限公司 一种心肌代谢pet显像剂的制备方法及用途
CN114773179B (zh) * 2022-06-23 2022-09-16 北京先通国际医药科技股份有限公司 一种化合物ⅰ液体组合物的制备方法、及其在心肌代谢pet显像上的用途
CN114796534B (zh) * 2022-06-23 2022-09-16 北京先通国际医药科技股份有限公司 包含化合物ⅰ的液体组合物、制备方法及用途
CN115181013B (zh) * 2022-07-22 2023-08-08 北京先通国际医药科技股份有限公司 修饰脂肪酸型pet试剂前体关键中间体的制备方法及其用途
CN116199658B (zh) * 2022-07-22 2025-07-22 北京先通国际医药科技股份有限公司 一种修饰长链脂肪酸型pet试剂前体的合成方法及其用途
CN115141087B (zh) * 2022-09-06 2023-03-24 北京先通国际医药科技股份有限公司 Pet前体关键中间体的异构体的合成方法及其用途
CN115970012A (zh) * 2023-03-16 2023-04-18 北京先通国际医药科技股份有限公司 正电子心肌脂肪酸代谢显像剂与正电子18f-fdg心肌葡萄糖显像剂用于pet联合显像的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119640A (en) * 1975-07-10 1978-10-10 Union Carbide Corporation Polymerizable epoxide-modified compositions
DE2828623C2 (de) * 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
US4202902A (en) * 1979-03-05 1980-05-13 Shell Oil Company Lipogenesis control by cyclopropane-carboxylic acids, esters and amides
US4524059A (en) * 1983-01-28 1985-06-18 The General Hospital Corporation Fatty acid analogs
US4933365A (en) * 1989-01-25 1990-06-12 American Home Products Corporation Phospholipase A2 inhibitors
DE4012405C1 (en) * 1990-04-19 1991-08-14 Forschungszentrum Juelich Gmbh, 5170 Juelich, De Radioisotope labelled oxiranyl carboxylic acid derivs. prodn. - by nucleophilic replacement of corresp. bromo or iodo substits. with radioactive alkali halide(s) in polar medium
ATE526995T1 (de) * 1995-12-01 2011-10-15 Molecular Insight Pharm Inc Stereoisomers von fettsäureanalogen für diagnostische bildgebung
IT1295658B1 (it) * 1997-09-29 1999-05-24 Menarini Ricerche Spa Composizioni farmaceutiche contenenti acido ricinoleico e loro uso per la terapia antifiammatoria ed analgesica
CA2366789C (en) 1999-04-14 2010-09-28 Biostream, Inc. Fatty acid analogs for diagnosis of coronary artery disease
WO2004092184A1 (de) 2003-04-12 2004-10-28 Forschungszentrum Rossendorf E.V. Technetiummarkierte fettsäuren und deren verwendung für die myokarddiagnostik sowie verfahren zur herstellung der technetiummarkierten fettsäuren
CA2522737C (en) 2003-04-17 2017-06-06 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
KR101574279B1 (ko) * 2008-04-04 2015-12-04 어드밴스드 마이크로 디바이시즈, 인코포레이티드 앤티 엘리어싱을 위한 필터링 방법 및 장치

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