DE602004015970D1 - Verfahren zur überwachung des blutflusses und der metabolischen aufnahme in gewebe mit radioaktiv markierter alkansäure - Google Patents
Verfahren zur überwachung des blutflusses und der metabolischen aufnahme in gewebe mit radioaktiv markierter alkansäureInfo
- Publication number
- DE602004015970D1 DE602004015970D1 DE602004015970T DE602004015970T DE602004015970D1 DE 602004015970 D1 DE602004015970 D1 DE 602004015970D1 DE 602004015970 T DE602004015970 T DE 602004015970T DE 602004015970 T DE602004015970 T DE 602004015970T DE 602004015970 D1 DE602004015970 D1 DE 602004015970D1
- Authority
- DE
- Germany
- Prior art keywords
- fatty acid
- metabolic
- inclusion
- tissue
- blood flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title 1
- 230000017531 blood circulation Effects 0.000 title 1
- 230000002503 metabolic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 abstract 5
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 3
- 229930195729 fatty acid Natural products 0.000 abstract 3
- 239000000194 fatty acid Substances 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 230000006652 catabolic pathway Effects 0.000 abstract 1
- 150000004668 long chain fatty acids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46357403P | 2003-04-17 | 2003-04-17 | |
PCT/US2004/012084 WO2004093650A2 (en) | 2003-04-17 | 2004-04-19 | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004015970D1 true DE602004015970D1 (de) | 2008-10-02 |
Family
ID=33310796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004015970T Expired - Lifetime DE602004015970D1 (de) | 2003-04-17 | 2004-04-19 | Verfahren zur überwachung des blutflusses und der metabolischen aufnahme in gewebe mit radioaktiv markierter alkansäure |
Country Status (10)
Country | Link |
---|---|
US (9) | US7494642B2 (de) |
EP (1) | EP1622602B1 (de) |
JP (1) | JP4633052B2 (de) |
AT (1) | ATE405258T1 (de) |
AU (1) | AU2004232297B2 (de) |
CA (1) | CA2522737C (de) |
DE (1) | DE602004015970D1 (de) |
HK (1) | HK1083414A1 (de) |
MX (1) | MXPA05011189A (de) |
WO (1) | WO2004093650A2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69636881T2 (de) * | 1995-12-01 | 2007-09-20 | Molecular Insight Pharmaceuticals, Inc., Cambridge | Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung |
US8489176B1 (en) | 2000-08-21 | 2013-07-16 | Spectrum Dynamics Llc | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
US8565860B2 (en) | 2000-08-21 | 2013-10-22 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system |
US8909325B2 (en) | 2000-08-21 | 2014-12-09 | Biosensors International Group, Ltd. | Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures |
AU2004232297B2 (en) * | 2003-04-17 | 2010-11-04 | The General Hospital Corporation | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid |
WO2008010227A2 (en) | 2006-07-19 | 2008-01-24 | Spectrum Dynamics Llc | Imaging protocols |
WO2006051531A2 (en) | 2004-11-09 | 2006-05-18 | Spectrum Dynamics Llc | Radioimaging |
US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
CN1981210A (zh) | 2004-01-13 | 2007-06-13 | 光谱动力学有限责任公司 | 多维图像重构 |
US8571881B2 (en) | 2004-11-09 | 2013-10-29 | Spectrum Dynamics, Llc | Radiopharmaceutical dispensing, administration, and imaging |
US8586932B2 (en) | 2004-11-09 | 2013-11-19 | Spectrum Dynamics Llc | System and method for radioactive emission measurement |
US9470801B2 (en) | 2004-01-13 | 2016-10-18 | Spectrum Dynamics Llc | Gating with anatomically varying durations |
EP1778957A4 (de) | 2004-06-01 | 2015-12-23 | Biosensors Int Group Ltd | Optimierung der messung radioaktiver strahlung an besonderen körperstrukturen |
US9943274B2 (en) | 2004-11-09 | 2018-04-17 | Spectrum Dynamics Medical Limited | Radioimaging using low dose isotope |
US9316743B2 (en) | 2004-11-09 | 2016-04-19 | Biosensors International Group, Ltd. | System and method for radioactive emission measurement |
US8615405B2 (en) | 2004-11-09 | 2013-12-24 | Biosensors International Group, Ltd. | Imaging system customization using data from radiopharmaceutical-associated data carrier |
US8423125B2 (en) | 2004-11-09 | 2013-04-16 | Spectrum Dynamics Llc | Radioimaging |
WO2008059489A2 (en) | 2006-11-13 | 2008-05-22 | Spectrum Dynamics Llc | Radioimaging applications of and novel formulations of teboroxime |
EP1909853B1 (de) | 2005-07-19 | 2015-03-18 | Biosensors International Group, Ltd. | Bildgebungsprotokolle |
US8837793B2 (en) | 2005-07-19 | 2014-09-16 | Biosensors International Group, Ltd. | Reconstruction stabilizer and active vision |
GB0525949D0 (en) | 2005-12-21 | 2006-02-01 | Hammersmith Imanet Ltd | Pet radiotracers |
US20090177098A1 (en) * | 2006-01-16 | 2009-07-09 | Kousuke Yakubo | Examination System and Examination Method |
US8894974B2 (en) | 2006-05-11 | 2014-11-25 | Spectrum Dynamics Llc | Radiopharmaceuticals for diagnosis and therapy |
WO2008075362A2 (en) | 2006-12-20 | 2008-06-26 | Spectrum Dynamics Llc | A method, a system, and an apparatus for using and processing multidimensional data |
US8521253B2 (en) | 2007-10-29 | 2013-08-27 | Spectrum Dynamics Llc | Prostate imaging |
CA2760334A1 (en) * | 2009-05-04 | 2010-11-11 | Washington University | Pet radiotracers for imaging fatty acid metabolism and storage |
US20120237937A1 (en) * | 2009-06-12 | 2012-09-20 | University Of Louisville Research Foundation, Inc. | Methods to detect cancer in animals |
US8338788B2 (en) | 2009-07-29 | 2012-12-25 | Spectrum Dynamics Llc | Method and system of optimized volumetric imaging |
US20110110570A1 (en) * | 2009-11-10 | 2011-05-12 | Avi Bar-Shalev | Apparatus and methods for generating a planar image |
DE102010010666A1 (de) * | 2010-03-01 | 2011-09-01 | Sven Reske | Diagnose und Therapie von Krebserkrankungen mittels Fettsäuren |
EP3041414B1 (de) * | 2013-09-06 | 2018-10-10 | Koninklijke Philips N.V. | Verarbeitungsvorrichtung zur verarbeitung von herzdaten |
WO2018089491A1 (en) * | 2016-11-08 | 2018-05-17 | The Regents Of The University Of California | Methods for multi-dose synthesis of [f-18]fddnp for clinical settings |
CN108727229B (zh) * | 2017-04-17 | 2021-07-02 | 北京先通国际医药科技股份有限公司 | 一种修饰脂肪酸型pet试剂前体的新工艺路线 |
CN112638868B (zh) * | 2018-07-20 | 2023-06-20 | 安斯泰来制药株式会社 | 由正电子放射性核素标记的脂肪酸衍生物 |
CN116351339A (zh) * | 2022-06-07 | 2023-06-30 | 北京先通国际医药科技股份有限公司 | 一种液体组合物的生产设备及其制备方法和用途 |
CN114732918B (zh) * | 2022-06-10 | 2022-09-13 | 北京先通国际医药科技股份有限公司 | 一种液体组合物的生产设备及其制备方法和用途 |
CN114736112A (zh) * | 2022-06-14 | 2022-07-12 | 北京先通国际医药科技股份有限公司 | 一种心肌代谢pet显像剂的制备方法及用途 |
CN114773179B (zh) * | 2022-06-23 | 2022-09-16 | 北京先通国际医药科技股份有限公司 | 一种化合物ⅰ液体组合物的制备方法、及其在心肌代谢pet显像上的用途 |
CN114796534B (zh) * | 2022-06-23 | 2022-09-16 | 北京先通国际医药科技股份有限公司 | 包含化合物ⅰ的液体组合物、制备方法及用途 |
CN115181013B (zh) * | 2022-07-22 | 2023-08-08 | 北京先通国际医药科技股份有限公司 | 修饰脂肪酸型pet试剂前体关键中间体的制备方法及其用途 |
CN116199658A (zh) * | 2022-07-22 | 2023-06-02 | 北京先通国际医药科技股份有限公司 | 一种修饰长链脂肪酸型pet试剂前体的合成方法及其用途 |
CN116217356A (zh) * | 2022-09-06 | 2023-06-06 | 北京先通国际医药科技股份有限公司 | Pet前体关键中间体的异构体的合成方法及其用途 |
CN115970012A (zh) * | 2023-03-16 | 2023-04-18 | 北京先通国际医药科技股份有限公司 | 正电子心肌脂肪酸代谢显像剂与正电子18f-fdg心肌葡萄糖显像剂用于pet联合显像的用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4119640A (en) * | 1975-07-10 | 1978-10-10 | Union Carbide Corporation | Polymerizable epoxide-modified compositions |
DE2828623C2 (de) * | 1978-06-29 | 1983-11-17 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung |
US4202902A (en) * | 1979-03-05 | 1980-05-13 | Shell Oil Company | Lipogenesis control by cyclopropane-carboxylic acids, esters and amides |
US4524059A (en) * | 1983-01-28 | 1985-06-18 | The General Hospital Corporation | Fatty acid analogs |
US4933365A (en) * | 1989-01-25 | 1990-06-12 | American Home Products Corporation | Phospholipase A2 inhibitors |
DE4012405C1 (en) * | 1990-04-19 | 1991-08-14 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | Radioisotope labelled oxiranyl carboxylic acid derivs. prodn. - by nucleophilic replacement of corresp. bromo or iodo substits. with radioactive alkali halide(s) in polar medium |
DE69636881T2 (de) | 1995-12-01 | 2007-09-20 | Molecular Insight Pharmaceuticals, Inc., Cambridge | Stereoisomere von fettsäureanalogen zur diagnostischen bildgebung |
IT1295658B1 (it) * | 1997-09-29 | 1999-05-24 | Menarini Ricerche Spa | Composizioni farmaceutiche contenenti acido ricinoleico e loro uso per la terapia antifiammatoria ed analgesica |
EP1173226B1 (de) * | 1999-04-14 | 2006-08-23 | Molecular Insight Pharmaceuticals, Inc. | Fettsaure analoge zur diagnose von kranzarterie erkrankungen |
WO2004092184A1 (de) | 2003-04-12 | 2004-10-28 | Forschungszentrum Rossendorf E.V. | Technetiummarkierte fettsäuren und deren verwendung für die myokarddiagnostik sowie verfahren zur herstellung der technetiummarkierten fettsäuren |
AU2004232297B2 (en) * | 2003-04-17 | 2010-11-04 | The General Hospital Corporation | Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid |
JP5520286B2 (ja) * | 2008-04-04 | 2014-06-11 | アドバンスト・マイクロ・ディバイシズ・インコーポレイテッド | アンチエイリアシングのためのフィルタ処理方法及び装置 |
-
2004
- 2004-04-19 AU AU2004232297A patent/AU2004232297B2/en not_active Ceased
- 2004-04-19 MX MXPA05011189A patent/MXPA05011189A/es active IP Right Grant
- 2004-04-19 CA CA2522737A patent/CA2522737C/en not_active Expired - Fee Related
- 2004-04-19 DE DE602004015970T patent/DE602004015970D1/de not_active Expired - Lifetime
- 2004-04-19 JP JP2006513138A patent/JP4633052B2/ja not_active Expired - Fee Related
- 2004-04-19 EP EP04760019A patent/EP1622602B1/de not_active Expired - Fee Related
- 2004-04-19 AT AT04760019T patent/ATE405258T1/de not_active IP Right Cessation
- 2004-04-19 WO PCT/US2004/012084 patent/WO2004093650A2/en active Application Filing
- 2004-04-19 US US10/827,054 patent/US7494642B2/en not_active Expired - Fee Related
-
2006
- 2006-05-11 HK HK06105481.9A patent/HK1083414A1/xx not_active IP Right Cessation
-
2007
- 2007-10-10 US US11/973,810 patent/US20080214853A1/en not_active Abandoned
- 2007-10-11 US US11/973,925 patent/US20080213178A1/en not_active Abandoned
- 2007-10-11 US US11/973,921 patent/US20080095702A1/en not_active Abandoned
- 2007-10-11 US US11/973,926 patent/US20080214851A1/en not_active Abandoned
- 2007-10-11 US US11/974,139 patent/US7790142B2/en active Active
- 2007-10-11 US US11/973,922 patent/US8309053B2/en active Active
-
2009
- 2009-02-23 US US12/391,250 patent/US8268291B2/en active Active
-
2012
- 2012-08-27 US US13/595,546 patent/US8871179B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2006524250A (ja) | 2006-10-26 |
US20040253177A1 (en) | 2004-12-16 |
CA2522737C (en) | 2017-06-06 |
WO2004093650A2 (en) | 2004-11-04 |
US20130052129A1 (en) | 2013-02-28 |
EP1622602B1 (de) | 2008-08-20 |
US8871179B2 (en) | 2014-10-28 |
US20080095702A1 (en) | 2008-04-24 |
US20080213173A1 (en) | 2008-09-04 |
US7790142B2 (en) | 2010-09-07 |
US20080214851A1 (en) | 2008-09-04 |
JP4633052B2 (ja) | 2011-02-16 |
CA2522737A1 (en) | 2004-11-04 |
MXPA05011189A (es) | 2006-05-25 |
EP1622602A2 (de) | 2006-02-08 |
US20080206135A1 (en) | 2008-08-28 |
US20090156848A1 (en) | 2009-06-18 |
AU2004232297A1 (en) | 2004-11-04 |
US20080214853A1 (en) | 2008-09-04 |
US7494642B2 (en) | 2009-02-24 |
AU2004232297B2 (en) | 2010-11-04 |
US8309053B2 (en) | 2012-11-13 |
ATE405258T1 (de) | 2008-09-15 |
EP1622602A4 (de) | 2006-06-21 |
US8268291B2 (en) | 2012-09-18 |
HK1083414A1 (en) | 2006-06-30 |
WO2004093650A3 (en) | 2005-04-14 |
US20080213178A1 (en) | 2008-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |