JP2016204383A5 - - Google Patents
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- Publication number
- JP2016204383A5 JP2016204383A5 JP2016160146A JP2016160146A JP2016204383A5 JP 2016204383 A5 JP2016204383 A5 JP 2016204383A5 JP 2016160146 A JP2016160146 A JP 2016160146A JP 2016160146 A JP2016160146 A JP 2016160146A JP 2016204383 A5 JP2016204383 A5 JP 2016204383A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- ammonium
- formula
- less
- bicarbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003863 ammonium salts Chemical class 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 102000008092 Norepinephrine Plasma Membrane Transport Proteins Human genes 0.000 claims 3
- 108010049586 Norepinephrine Plasma Membrane Transport Proteins Proteins 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 150000004820 halides Chemical class 0.000 claims 3
- 230000017531 blood circulation Effects 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- NLMDJJTUQPXZFG-UHFFFAOYSA-N 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane Chemical compound C1COCCOCCNCCOCCOCCN1 NLMDJJTUQPXZFG-UHFFFAOYSA-N 0.000 claims 1
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical group [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 claims 1
- UKFWSNCTAHXBQN-UHFFFAOYSA-N ammonium iodide Chemical compound [NH4+].[I-] UKFWSNCTAHXBQN-UHFFFAOYSA-N 0.000 claims 1
- RZOBLYBZQXQGFY-UHFFFAOYSA-N ammonium lactate Chemical compound [NH4+].CC(O)C([O-])=O RZOBLYBZQXQGFY-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- -1 ascorbate ion Chemical class 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- YCNIBOIOWCTRCL-UHFFFAOYSA-N azane;2,2,2-trifluoroacetic acid Chemical compound [NH4+].[O-]C(=O)C(F)(F)F YCNIBOIOWCTRCL-UHFFFAOYSA-N 0.000 claims 1
- GDCXBZMWKSBSJG-UHFFFAOYSA-N azane;4-methylbenzenesulfonic acid Chemical compound [NH4+].CC1=CC=C(S([O-])(=O)=O)C=C1 GDCXBZMWKSBSJG-UHFFFAOYSA-N 0.000 claims 1
- QHYIGPGWXQQZSA-UHFFFAOYSA-N azane;methanesulfonic acid Chemical compound [NH4+].CS([O-])(=O)=O QHYIGPGWXQQZSA-UHFFFAOYSA-N 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000002739 cryptand Substances 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 1
- ZYULQCDNUYJBRI-UHFFFAOYSA-N NC(NCc(cc1)cc(Br)c1OCCCF)=N Chemical compound NC(NCc(cc1)cc(Br)c1OCCCF)=N ZYULQCDNUYJBRI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33361810P | 2010-05-11 | 2010-05-11 | |
| US61/333,618 | 2010-05-11 | ||
| US40552410P | 2010-10-21 | 2010-10-21 | |
| US40557110P | 2010-10-21 | 2010-10-21 | |
| US61/405,571 | 2010-10-21 | ||
| US61/405,524 | 2010-10-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510284A Division JP5992399B2 (ja) | 2010-05-11 | 2011-05-11 | 造影剤の合成および使用のための組成物、方法およびシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016204383A JP2016204383A (ja) | 2016-12-08 |
| JP2016204383A5 true JP2016204383A5 (https=) | 2017-05-25 |
| JP6216421B2 JP6216421B2 (ja) | 2017-10-18 |
Family
ID=44914968
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510284A Active JP5992399B2 (ja) | 2010-05-11 | 2011-05-11 | 造影剤の合成および使用のための組成物、方法およびシステム |
| JP2016160146A Active JP6216421B2 (ja) | 2010-05-11 | 2016-08-17 | 造影剤の合成および使用のための組成物、方法およびシステム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510284A Active JP5992399B2 (ja) | 2010-05-11 | 2011-05-11 | 造影剤の合成および使用のための組成物、方法およびシステム |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US9388125B2 (https=) |
| EP (2) | EP2569019B1 (https=) |
| JP (2) | JP5992399B2 (https=) |
| KR (4) | KR20170042373A (https=) |
| CN (2) | CN106977429B (https=) |
| AU (1) | AU2011253052B2 (https=) |
| BR (4) | BR112012028806B1 (https=) |
| CA (2) | CA3041113C (https=) |
| DK (1) | DK2569019T3 (https=) |
| ES (1) | ES2763815T3 (https=) |
| IL (1) | IL222897A (https=) |
| MX (3) | MX367382B (https=) |
| NZ (1) | NZ604233A (https=) |
| RU (2) | RU2019142507A (https=) |
| SG (1) | SG185424A1 (https=) |
| TW (2) | TWI606842B (https=) |
| WO (1) | WO2011143360A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI618544B (zh) | 2006-12-26 | 2018-03-21 | 藍瑟斯醫學影像公司 | 使心臟神經分布顯像之配位體 |
| KR101602992B1 (ko) | 2009-04-15 | 2016-03-11 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| CN102858752B (zh) | 2010-02-08 | 2018-10-16 | 兰休斯医疗成像公司 | 用于合成显像剂和其中间体的方法和装置 |
| AU2011253052B2 (en) | 2010-05-11 | 2015-05-14 | Lantheus Medical Imaging, Inc. | Compositions, methods and systems for the synthesis and use of imaging agents |
| EP2753605B1 (en) * | 2011-09-09 | 2019-03-27 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| US20150023873A1 (en) | 2011-11-11 | 2015-01-22 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| WO2013173004A2 (en) | 2012-04-10 | 2013-11-21 | Lantheus Medical Imaging, Inc. | Radiopharmaceutical synthesis methods |
| AU2013203000B9 (en) * | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| US20150246142A1 (en) | 2012-09-25 | 2015-09-03 | The Regents Of The University Of Michigan | Imaging agents |
| WO2016065322A1 (en) | 2014-10-24 | 2016-04-28 | Molecular Insight Pharmaceuticals, Inc. | Preparations of meta-iodobenzylguanidine and precursors thereof |
| WO2016138448A1 (en) * | 2015-02-27 | 2016-09-01 | Schmitthenner Hans F | Transmetalation methods for the synthesis of pet and spect imaging agents |
| US10368774B2 (en) | 2015-07-30 | 2019-08-06 | Medtronic, Inc. | Absolute intrathoracic impedance based scheme to stratify patients for risk of a heart failure event |
| US10874752B2 (en) | 2015-09-25 | 2020-12-29 | Board Of Regents Of The University Of Nebraska | MIBG analogs and uses thereof |
| US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| FR3054445B1 (fr) * | 2016-07-26 | 2019-07-05 | Laboratoires Cyclopharma | Synthese d'une composition d'agent radioactif |
| US10924560B2 (en) * | 2018-07-30 | 2021-02-16 | Facebook, Inc. | Determining geographic locations of network devices |
| WO2020085238A1 (ja) * | 2018-10-24 | 2020-04-30 | 日本メジフィジックス株式会社 | 放射性フッ素標識前駆体化合物の塩 |
| CN111366643B (zh) * | 2018-12-25 | 2022-08-19 | 广东阿格蕾雅光电材料有限公司 | 一种oled材料中间体的检测方法 |
| RU196435U1 (ru) * | 2019-12-30 | 2020-02-28 | федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ) | Устройство для позитронно-эмиссионной томографии |
| NL2031332B1 (en) * | 2022-03-18 | 2023-09-29 | Plethora Therapeutics B V | Transmucosal delivery of psychoactive compounds |
| CN116351339B (zh) * | 2022-06-07 | 2026-01-23 | 北京先通国际医药科技股份有限公司 | 一种液体组合物的生产设备及其制备方法和用途 |
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| AU2011253052B2 (en) | 2010-05-11 | 2015-05-14 | Lantheus Medical Imaging, Inc. | Compositions, methods and systems for the synthesis and use of imaging agents |
| EP2753605B1 (en) | 2011-09-09 | 2019-03-27 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
-
2011
- 2011-05-11 AU AU2011253052A patent/AU2011253052B2/en active Active
- 2011-05-11 EP EP11781241.2A patent/EP2569019B1/en active Active
- 2011-05-11 TW TW100116554A patent/TWI606842B/zh not_active IP Right Cessation
- 2011-05-11 BR BR112012028806-7A patent/BR112012028806B1/pt not_active IP Right Cessation
- 2011-05-11 CN CN201611178266.0A patent/CN106977429B/zh not_active Expired - Fee Related
- 2011-05-11 SG SG2012081436A patent/SG185424A1/en unknown
- 2011-05-11 US US13/697,287 patent/US9388125B2/en active Active
- 2011-05-11 ES ES11781241T patent/ES2763815T3/es active Active
- 2011-05-11 CN CN2011800318199A patent/CN103002924A/zh active Pending
- 2011-05-11 KR KR1020177009313A patent/KR20170042373A/ko not_active Ceased
- 2011-05-11 BR BR122020018194-0A patent/BR122020018194B1/pt active IP Right Grant
- 2011-05-11 KR KR1020187015363A patent/KR102008635B1/ko not_active Expired - Fee Related
- 2011-05-11 CA CA3041113A patent/CA3041113C/en active Active
- 2011-05-11 EP EP19200889.4A patent/EP3653230B1/en active Active
- 2011-05-11 NZ NZ604233A patent/NZ604233A/en not_active IP Right Cessation
- 2011-05-11 RU RU2019142507A patent/RU2019142507A/ru unknown
- 2011-05-11 DK DK11781241.2T patent/DK2569019T3/da active
- 2011-05-11 TW TW105132631A patent/TWI592391B/zh not_active IP Right Cessation
- 2011-05-11 MX MX2016010906A patent/MX367382B/es unknown
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2012
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2016
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2017
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2021
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2025
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