JP2006501133A - 眼科学および鼻科学における適用のための薬学的組成物 - Google Patents
眼科学および鼻科学における適用のための薬学的組成物 Download PDFInfo
- Publication number
- JP2006501133A JP2006501133A JP2003550796A JP2003550796A JP2006501133A JP 2006501133 A JP2006501133 A JP 2006501133A JP 2003550796 A JP2003550796 A JP 2003550796A JP 2003550796 A JP2003550796 A JP 2003550796A JP 2006501133 A JP2006501133 A JP 2006501133A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- hyaluronic acid
- eye
- composition according
- hyaluronate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Spektrum Augenheilkunde(1998)3/4:174〜176 Spektrum Augenheilkunde(1995)9/5:215〜217 Jpn.J.Ophthalmol.(1996)40:62〜65 Klinische Monatsblatter fur Augenheilkunde(1996)209;84〜88
50mg/mlのデクスパンテノール
1.55mg/mlのヒアルロン酸、分子量:1.5×106〜3.5×106ダルトン
2mg/mlのクエン酸ナトリウム
pH7.0〜pH7.4が到達されるまで1%クエン酸水溶液の添加
1mlへの注射の目的のための水の添加。
Claims (13)
- 少なくともパンテノールおよび/またはパントテン酸、ならびにヒアルロン酸および/またはヒアルロン酸塩、ならびに必要に応じてさらなる薬学的な助剤を含む、薬学的組成物。
- 請求項1に記載の薬学的組成物であって、各場合において薬学的組成物の総重量に関して、ヒアルロン酸の量および/またはヒアルロン酸塩の量が約0.005重量%〜約5重量%、好ましくは約0.01重量%〜約1重量%であることを特徴とする、薬学的組成物。
- 請求項1または請求項2に記載の薬学的組成物であって、ヒアルロン酸および/またはヒアルロン酸塩が、約50,000〜約10,000,000ダルトン、好ましくは約250,000〜約5,000,000ダルトンの範囲にある分子量を有することを特徴とする、薬学的組成物。
- 請求項1〜3のいずれかに記載の薬学的組成物であって、ヒアルロン酸塩がヒアルロン酸ナトリウムであることを特徴とする、薬学的組成物。
- 請求項1〜4のいずれかに記載の薬学的組成物であって、薬学的組成物の総重量に関して、パンテノールおよび/またはパントテン酸の量が約0.5重量%〜10重量%、好ましくは約2重量%〜5重量%であることを特徴とする、薬学的組成物。
- 請求項1〜5のいずれかに記載の薬学的組成物であって、パンテノールがデクスパンテノールの形態にあることを特徴とする、薬学的組成物。
- 請求項1〜5のいずれかに記載の薬学的組成物であって、パントテン酸が水溶性の塩、好ましくはパントテン酸ナトリウムまたはパントテン酸カルシウムの形態にあることを特徴とする、薬学的組成物。
- 請求項1〜7のいずれかに記載の薬学的組成物であって、薬学的組成物が、溶液、懸濁液、乳濁液、ゲル、軟膏、ペースト、粉末、粒子、顆粒、または錠剤の形態にあることを特徴とする、薬学的組成物。
- 眼科学的なおよび/または鼻科学的な機能障害の処置のための、請求項1〜8のいずれかに記載の薬学的組成物の使用。
- 請求項9に記載の使用であって、眼科学的な機能障害が、眼の角膜および結膜の湿潤に対する障害に関連されることを特徴とする、使用。
- 請求項9または請求項10に記載の使用であって、眼科学的な機能障害が、アレルギー性鼻結膜炎、アトピー性角結膜炎、アレルギー性角結膜炎、巨大乳頭結膜炎、春季カタル、上強膜炎、強膜炎、テノン嚢炎、シェーグレン症候群、およびそれらの複合型の形態からなる群より選択されることを特徴とする、使用。
- 請求項9に記載の使用であって、鼻科学的な機能障害が、鼻粘膜の乾きの現象に関連されることを特徴とする、使用。
- 請求項9または請求項12に記載の使用であって、鼻科学的な機能障害が、慢性鼻炎、乾燥性鼻炎、およびそれらの複合型の形態からなる群より選択されることを特徴とする、使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10161110A DE10161110A1 (de) | 2001-12-12 | 2001-12-12 | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
PCT/DE2002/004527 WO2003049747A1 (de) | 2001-12-12 | 2002-12-11 | Pharmazeutische zusammensetzung zur ophtalmologischen und rhinologischen anwendung |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2006501133A true JP2006501133A (ja) | 2006-01-12 |
JP2006501133A5 JP2006501133A5 (ja) | 2006-02-23 |
JP3994089B2 JP3994089B2 (ja) | 2007-10-17 |
Family
ID=7708986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003550796A Expired - Lifetime JP3994089B2 (ja) | 2001-12-12 | 2002-12-11 | 眼科学および鼻科学における適用のための薬学的組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20050164979A1 (ja) |
EP (1) | EP1455803B2 (ja) |
JP (1) | JP3994089B2 (ja) |
CN (1) | CN1310651C (ja) |
AT (1) | ATE300306T1 (ja) |
AU (1) | AU2002360895A1 (ja) |
CA (1) | CA2468771C (ja) |
DE (2) | DE10161110A1 (ja) |
ES (1) | ES2244831T5 (ja) |
MX (1) | MXPA04005387A (ja) |
WO (1) | WO2003049747A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068866A1 (en) * | 2006-11-30 | 2008-06-12 | Menicon Co., Ltd. | Ophthalmic composition |
JP2013534527A (ja) * | 2010-07-02 | 2013-09-05 | ブライエン ホールデン ビジョン インスティテュート | コンタクトレンズ乳頭結膜炎及びアレルギー性眼疾患の予防及び処置のための組成物 |
JP2018115119A (ja) * | 2017-01-16 | 2018-07-26 | ロート製薬株式会社 | 眼科組成物 |
JP2019511494A (ja) * | 2016-03-07 | 2019-04-25 | ウルサファルム アルツナイミッテル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 眼科用組成物 |
JP2021522189A (ja) * | 2018-04-18 | 2021-08-30 | アイ.コム メディカル ゲーエムベーハー | 上皮の生存と体表面の再構成を高めるための高分子量ヒアルロン酸 |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10356248A1 (de) | 2003-11-13 | 2005-06-23 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Pharmazeutische Zusammensetzung zur Behandlung von Rhinitiden |
DE102004002001A1 (de) | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
CN1285382C (zh) * | 2004-12-20 | 2006-11-22 | 凌沛学 | 含海藻糖和玻璃酸的鼻腔用药传递系统及其制备方法 |
DE102005055275A1 (de) | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
CA2658646A1 (en) | 2006-07-25 | 2008-01-31 | Osmotica Corp. | Ophthalmic solutions |
KR100927579B1 (ko) * | 2006-12-13 | 2009-11-23 | 주식회사 엘지생명과학 | 히아루론산 및/또는 그것의 염을 함유하는 아토피성피부염의 개선 및 치료를 위한 조성물 |
FR2919185B1 (fr) | 2007-07-23 | 2010-09-10 | Ard Sa | Utilisation d'acide hyaluronique pour la preparation de compositions destinees a l'amelioration notamment de l'etat des muqueuses |
DE202008016517U1 (de) * | 2008-12-12 | 2009-03-05 | Ratiopharm Gmbh | Wässrige Zusammensetzung enthaltend Dexpanthenol und Natriumchlorid |
US9473792B2 (en) | 2009-11-06 | 2016-10-18 | Texas Instruments Incorporated | Method and system to improve the performance of a video encoder |
FR2962044B1 (fr) * | 2010-04-21 | 2013-02-22 | Horus Pharma | Emulsion lacrymimetique |
DE202010012255U1 (de) * | 2010-09-07 | 2010-11-18 | Krewel Meuselbach Gmbh | Nasenspray |
WO2012119261A1 (en) * | 2011-03-10 | 2012-09-13 | Biocia Inc. | Enhanced artificial mucus composition comprising hyaluronan for the treatment of rhinitis |
CN102579478A (zh) * | 2012-03-30 | 2012-07-18 | 济南康众医药科技开发有限公司 | 玻璃酸钠在制备药物中的应用 |
DE202012005650U1 (de) | 2012-05-14 | 2013-05-15 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Kombinationstherapeutikum für die Behandlung von Rhinitis |
EP2664330A1 (de) * | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Zusammensetzung und Arzneimittel enthaltend Omega-3-Fettsäuren sowie einen Glucosaminoglucan |
CN102989045B (zh) * | 2012-11-12 | 2015-02-25 | 广州共禾医药科技有限公司 | 生物相容的水性组合物及其用途 |
WO2016019627A1 (en) * | 2014-08-08 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Liquid formulation compositions, medicament delivery devices, and methods of preparation and use thereof |
EP2985019B1 (en) | 2014-08-16 | 2021-10-20 | Church & Dwight Co., Inc. | Nasal composition having anti-viral properties |
EP2985027B1 (en) | 2014-08-16 | 2021-03-31 | Church & Dwight Co., Inc. | Nasal composition comprising mixture of hyaluronic acids and saline solution |
EP3072503B1 (en) | 2015-03-26 | 2020-09-23 | D.M.G. Italia Srl | Ophthalmic composition for the corneal protection |
DE102016204472A1 (de) * | 2016-03-17 | 2017-09-21 | Ursapharm Arzneimittel Gmbh | Kit zur kosmetischen Behandlung des Auges und der Haut und Kosmetikum zur Anwendung am Auge und auf der Haut |
TWI609957B (zh) * | 2016-06-27 | 2018-01-01 | 晶碩光學股份有限公司 | 用以處理隱形眼鏡之溶液及隱形眼鏡的包裝系統 |
DE102017117987A1 (de) * | 2017-07-31 | 2019-01-31 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Neue Zusammensetzung für die nasale Applikation |
CN107260657B (zh) * | 2017-08-03 | 2019-02-05 | 广东莱恩医药研究院有限公司 | 一种缓释型连翘苷滴眼液及其制备方法 |
EP3664818B1 (en) * | 2017-08-10 | 2023-11-29 | Elixir Ilaç Arastirma Ve Gelistirme A.S. | Nasal decongestant compositions comprising menthol, dexpanthenol and sodium hyaluronate |
WO2019202017A1 (en) * | 2018-04-18 | 2019-10-24 | i.com medical GmbH | High molecular weight hyaluronic acid for treatment and prevention of severe ocular surface disease |
US11576926B2 (en) * | 2018-09-12 | 2023-02-14 | Neilos S.r.l. | Composition for use in the prevention and/or treatment of epistaxis |
EP3827818A1 (en) * | 2019-11-26 | 2021-06-02 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
CN112870216A (zh) * | 2021-01-29 | 2021-06-01 | 张宽才 | 一种药物组合物及制剂和用途 |
EP4039248A1 (en) * | 2021-02-04 | 2022-08-10 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
Family Cites Families (12)
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US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
JPS6479103A (en) * | 1987-06-09 | 1989-03-24 | Lion Corp | External preparation |
DE3832401A1 (de) † | 1988-09-23 | 1990-03-29 | Cassella Ag | Pharmazeutische zubereitung zur behandlung entzuendeter nasenschleimhaeute |
US5141741A (en) * | 1988-12-09 | 1992-08-25 | Lion Corporation | Anti-sunburn skin-care preparation |
IL101056A (en) † | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
IT1273011B (it) * | 1994-07-25 | 1997-07-01 | Trhecnopharma S A | Preparato oftalmico per l'uso come lacrima artificiale |
DE19517251A1 (de) * | 1995-05-11 | 1996-11-14 | Klosterfrau Mcm Vetrieb Gmbh | Verwendung von Dexpanthenol zur Behandlung trockener Nasenschleimhäute |
DE19549421C2 (de) † | 1995-11-10 | 1999-11-18 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
DE19541919C2 (de) † | 1995-11-10 | 1997-11-20 | Klosterfrau Mcm Vetrieb Gmbh | Pharmazeutische Zubereitung zur Behandlung akuter Rhinitiden |
EP0948965B1 (en) * | 1997-07-11 | 2004-06-02 | Toray Industries, Inc. | Stable medicinal compositions containing 4,5-epoxymorphinane derivatives |
DE19923829A1 (de) * | 1999-05-17 | 2000-11-23 | Ulrich Kluegel | Hyaluronat-Wirkstoff-Wasser-Komplex, dessen Herstellung und Verwendung |
DE60203691T3 (de) * | 2001-01-09 | 2011-08-18 | Louis Johan Wagenaar | Verwendung von Dexpanthenol in Kontaktlinsenpflegezusammensetzungen |
-
2001
- 2001-12-12 DE DE10161110A patent/DE10161110A1/de not_active Ceased
-
2002
- 2002-12-11 EP EP02794984.1A patent/EP1455803B2/de not_active Expired - Lifetime
- 2002-12-11 AT AT02794984T patent/ATE300306T1/de active
- 2002-12-11 WO PCT/DE2002/004527 patent/WO2003049747A1/de active IP Right Grant
- 2002-12-11 CA CA002468771A patent/CA2468771C/en not_active Expired - Lifetime
- 2002-12-11 AU AU2002360895A patent/AU2002360895A1/en not_active Abandoned
- 2002-12-11 ES ES02794984.1T patent/ES2244831T5/es not_active Expired - Lifetime
- 2002-12-11 DE DE50203788T patent/DE50203788D1/de not_active Expired - Lifetime
- 2002-12-11 JP JP2003550796A patent/JP3994089B2/ja not_active Expired - Lifetime
- 2002-12-11 CN CNB028248309A patent/CN1310651C/zh not_active Expired - Lifetime
- 2002-12-11 MX MXPA04005387A patent/MXPA04005387A/es active IP Right Grant
- 2002-12-11 US US10/496,456 patent/US20050164979A1/en not_active Abandoned
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068866A1 (en) * | 2006-11-30 | 2008-06-12 | Menicon Co., Ltd. | Ophthalmic composition |
JP2010510961A (ja) * | 2006-11-30 | 2010-04-08 | 株式会社メニコン | 眼科用組成物 |
JP2013534527A (ja) * | 2010-07-02 | 2013-09-05 | ブライエン ホールデン ビジョン インスティテュート | コンタクトレンズ乳頭結膜炎及びアレルギー性眼疾患の予防及び処置のための組成物 |
JP2019511494A (ja) * | 2016-03-07 | 2019-04-25 | ウルサファルム アルツナイミッテル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 眼科用組成物 |
JP2018115119A (ja) * | 2017-01-16 | 2018-07-26 | ロート製薬株式会社 | 眼科組成物 |
JP7044467B2 (ja) | 2017-01-16 | 2022-03-30 | ロート製薬株式会社 | 眼科組成物 |
JP2021522189A (ja) * | 2018-04-18 | 2021-08-30 | アイ.コム メディカル ゲーエムベーハー | 上皮の生存と体表面の再構成を高めるための高分子量ヒアルロン酸 |
Also Published As
Publication number | Publication date |
---|---|
CN1310651C (zh) | 2007-04-18 |
ATE300306T1 (de) | 2005-08-15 |
CA2468771C (en) | 2007-01-30 |
ES2244831T5 (es) | 2016-05-10 |
ES2244831T3 (es) | 2005-12-16 |
DE50203788D1 (de) | 2005-09-01 |
WO2003049747A1 (de) | 2003-06-19 |
CA2468771A1 (en) | 2003-06-19 |
EP1455803B2 (de) | 2016-03-23 |
WO2003049747A8 (de) | 2003-10-02 |
AU2002360895A1 (en) | 2003-06-23 |
DE10161110A1 (de) | 2003-06-26 |
MXPA04005387A (es) | 2005-03-23 |
EP1455803B1 (de) | 2005-07-27 |
CN1602198A (zh) | 2005-03-30 |
US20050164979A1 (en) | 2005-07-28 |
EP1455803A1 (de) | 2004-09-15 |
JP3994089B2 (ja) | 2007-10-17 |
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