JP2006328073A5 - - Google Patents

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Publication number
JP2006328073A5
JP2006328073A5 JP2006157094A JP2006157094A JP2006328073A5 JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5 JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5
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JP
Japan
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alkyl
substituted
het
halo
compound
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JP2006157094A
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English (en)
Japanese (ja)
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JP4815566B2 (ja
JP2006328073A (ja
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Publication of JP2006328073A5 publication Critical patent/JP2006328073A5/ja
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Publication of JP4815566B2 publication Critical patent/JP4815566B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2006157094A 1999-04-30 2006-06-06 グルココルチコイド受容体モジュレーター Expired - Fee Related JP4815566B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13213099P 1999-04-30 1999-04-30
US60/132,130 1999-04-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000615356A Division JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター

Publications (3)

Publication Number Publication Date
JP2006328073A JP2006328073A (ja) 2006-12-07
JP2006328073A5 true JP2006328073A5 (https=) 2007-05-10
JP4815566B2 JP4815566B2 (ja) 2011-11-16

Family

ID=22452621

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000615356A Expired - Fee Related JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター
JP2006157094A Expired - Fee Related JP4815566B2 (ja) 1999-04-30 2006-06-06 グルココルチコイド受容体モジュレーター

Family Applications Before (1)

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JP2000615356A Expired - Fee Related JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター

Country Status (45)

Country Link
US (3) US6380223B1 (https=)
EP (1) EP1175383B1 (https=)
JP (2) JP3901945B2 (https=)
KR (1) KR100511585B1 (https=)
CN (2) CN1275917C (https=)
AP (1) AP1542A (https=)
AR (1) AR032128A1 (https=)
AU (1) AU776608B2 (https=)
BG (3) BG65642B1 (https=)
BR (1) BR0010138B1 (https=)
CA (2) CA2372173A1 (https=)
CO (1) CO5280071A1 (https=)
CR (2) CR6478A (https=)
CU (1) CU23111A3 (https=)
CZ (1) CZ304203B6 (https=)
DZ (1) DZ3038A1 (https=)
EA (2) EA004886B1 (https=)
EE (1) EE05584B1 (https=)
EG (1) EG25606A (https=)
GE (1) GEP20053474B (https=)
GT (1) GT200000053A (https=)
HK (1) HK1042889B (https=)
HR (1) HRP20010804B1 (https=)
HU (1) HUP0201243A3 (https=)
IL (3) IL145450A0 (https=)
IS (1) IS2743B (https=)
MA (1) MA26729A1 (https=)
MX (1) MXPA01011018A (https=)
MY (1) MY133378A (https=)
NO (1) NO327612B1 (https=)
NZ (1) NZ514465A (https=)
OA (1) OA11877A (https=)
PA (1) PA8493801A1 (https=)
PE (1) PE20010112A1 (https=)
PL (1) PL207610B1 (https=)
RS (1) RS52134B (https=)
SK (1) SK287535B6 (https=)
SV (1) SV2004000061A (https=)
TN (1) TNSN00093A1 (https=)
TR (1) TR200103104T2 (https=)
TW (2) TWI272264B (https=)
UA (1) UA74145C2 (https=)
UY (1) UY26129A1 (https=)
WO (1) WO2000066522A1 (https=)
ZA (1) ZA200108846B (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01011018A (es) * 1999-04-30 2002-05-06 Pfizer Prod Inc Moduladores del receptor glucocorticoide.
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
SI1775305T1 (sl) 2000-08-05 2015-01-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
IL146057A (en) * 2000-10-27 2007-09-20 Pfizer Prod Inc A process for the preparation of modulators of a non-steroidal glucocorticoid receptor
ES2262612T3 (es) * 2000-10-28 2006-12-01 Pfizer Products Inc. Moduladpres del receptor de glucocorticoides.
ES2246292T3 (es) 2000-10-30 2006-02-16 Pfizer Products Inc. Moduladores de receptor glucocorticoide.
KR100831534B1 (ko) 2001-04-30 2008-05-22 글락소 그룹 리미티드 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
WO2003043640A2 (en) * 2001-11-23 2003-05-30 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists
US20060148725A1 (en) * 2001-12-21 2006-07-06 The Miriam Hospital Selective 11beta HSD inhibitors and methods of use thereof
AU2002361861A1 (en) * 2001-12-21 2003-07-30 Rhode Island Hospital SELECTIVE 11Beta-HSD INHIBITORS AND METHODS FOR USE THEREOF
AU2003202216A1 (en) 2002-01-14 2003-07-30 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
WO2003082787A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2478156C (en) * 2002-03-26 2011-02-15 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
JP4503436B2 (ja) * 2002-07-08 2010-07-14 ファイザー・プロダクツ・インク 糖質コルチコイド受容体のモジュレーター
JP2006504678A (ja) 2002-08-21 2006-02-09 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
WO2004019935A1 (en) * 2002-08-29 2004-03-11 Boehringer Ingelheim Pharmaceuticals, Inc. -3 (sulfonamidoethyl) -indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US20040077650A1 (en) * 2002-10-18 2004-04-22 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
JP2006508951A (ja) * 2002-11-05 2006-03-16 コーセプト セラピューティクス， インコーポレイテッド 片頭痛を処置するための方法
US20060052354A1 (en) * 2002-11-05 2006-03-09 Corcept Therapeutics, Inc. Methods for treating migraine
CA2512257A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004097002A2 (en) * 2003-04-29 2004-11-11 The Miriam Hospital SELECTIVE TESTICULAR 11β-HSD INHIBITORS AND METHODS OF USE THEREOF
NZ527142A (en) * 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7507843B2 (en) 2003-10-16 2009-03-24 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
CA2545020A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators
DE602004031356D1 (de) 2003-11-21 2011-03-24 Zalicus Inc Verfahren und reagenzien zur behandlung von entzündlichen erkrankungen
US7253283B2 (en) * 2004-01-16 2007-08-07 Bristol-Myers Squibb Company Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795272B2 (en) * 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US20050261292A1 (en) * 2004-05-19 2005-11-24 Solvay Pharmaceuticals Gmbh Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
US20090156565A1 (en) * 2004-12-03 2009-06-18 The Children's Hospital Of Philadelphia Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug
CA2592514A1 (en) 2004-12-27 2006-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
US7640389B2 (en) * 2006-02-28 2009-12-29 Freescale Semiconductor, Inc. Non-volatile memory having a multiple block erase mode and method therefor
US20080045475A1 (en) * 2006-08-20 2008-02-21 Phillip Edward Littmann Elemental cellular therapy is a genetic, cellular and disease-modifying therapy which enhances the systemic conduct of genetic and cellular transmethylation activity resulting in enhancement of concerted genetic and cellular metabolic, physiologic and homeostatic processes
AU2007329548A1 (en) * 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
HRP20110702T1 (hr) 2007-02-02 2011-10-31 Pfizer Products Inc. Triciklički spojevi i njihova uporaba kao modulatora glukokortikoidnih receptora
EP2114888B1 (en) * 2007-02-02 2010-11-10 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
EP2300472B1 (en) * 2008-06-06 2012-01-18 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ES2527137T3 (es) 2008-07-28 2015-01-21 Pfizer Inc. Compuestos de fenantrenona, composiciones y procedimientos
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101338200B (zh) * 2008-08-20 2011-08-17 石家庄国大工业有限公司 一种tn型液晶材料的混合物
US9216221B2 (en) * 2008-11-07 2015-12-22 University Of Sheffield Medicament and method of diagnosis for treating subclinical Cushing's syndrome
US20120220590A1 (en) 2009-07-31 2012-08-30 Thombare Pravin S Novel compounds as modulators of glucocorticoid receptors
EP2915812A1 (en) * 2009-08-31 2015-09-09 Merck Sharp & Dohme Corp. Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators
JP5845274B2 (ja) * 2010-10-27 2016-01-20 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 生物学的特性を賦与されたジテルペノイド誘導体
WO2012125797A1 (en) * 2011-03-15 2012-09-20 Abbott Laboratories Nuclear hormone receptor modulators
WO2013041599A1 (en) * 2011-09-21 2013-03-28 Givaudan Sa Pyridine derivates and their use as umami tastants
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
WO2014094357A1 (en) 2012-12-21 2014-06-26 Abbvie Inc. Heterocyclic nuclear hormone receptor modulators
KR20150127208A (ko) * 2013-03-14 2015-11-16 브리스톨-마이어스 스큅 컴퍼니 비시클로 [2.2.1] 산 gpr120 조절제
CZ2014575A3 (cs) * 2014-08-26 2016-02-24 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Amfifilní sloučeniny s neuroprotektivními účinky
SK592017A3 (sk) * 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
US12379266B2 (en) 2018-08-22 2025-08-05 University Of Utah Research Foundation Force and torque sensor for prosthetic and orthopedic devices
EP3823565A4 (en) 2018-08-28 2022-04-27 University of Utah Research Foundation VARIABLE GEAR FOR ASSISTIVE PROSTHESES
CA3123490A1 (en) 2019-01-22 2020-07-30 Akribes Biomedical Gmbh Selective glucocorticoid receptor modifiers for treating impaired skin wound healing
AU2020239920A1 (en) * 2019-03-18 2021-11-04 Arnold L. Newman Method of improving insulin sensitivity
EP4103133A4 (en) 2020-03-20 2024-03-06 University of Utah Research Foundation SELF-ALIGNING MECHANISMS IN PASSIVE AND POWERED EXOSKELETONS
WO2022232025A1 (en) * 2021-04-26 2022-11-03 Alkermes, Inc. Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4514056Y1 (https=) 1965-09-09 1970-06-15
US3516993A (en) * 1967-03-15 1970-06-23 Sandoz Ag Benzylidene-substituted nitrogenous heterocyclic compounds
US3683091A (en) 1967-11-13 1972-08-08 Wataru Nagata Certain phenanthrene compounds for treatment of acne
JPS50111098A (https=) * 1974-02-18 1975-09-01
JPS6183138A (ja) 1984-09-28 1986-04-26 Harima Kasei Kogyo Kk ３−デオキシアフィディコリンの製造方法
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
JPS61271216A (ja) 1985-05-27 1986-12-01 Mitsubishi Chem Ind Ltd 抗腫瘍剤
JPS6256422A (ja) 1985-09-04 1987-03-12 Mitsubishi Chem Ind Ltd 抗菌剤
JPH07100357B2 (ja) 1986-03-11 1995-11-01 三菱化学株式会社 繊維補強セメントモルタル成形体
US5039706A (en) * 1987-11-30 1991-08-13 Du Pont Merck Pharmaceutical Company Antiinflammatory PLA2 inhibitors
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins
JPH06263688A (ja) 1991-09-04 1994-09-20 Otsuka Pharmaceut Factory Inc フェナンスレン誘導体
KR950703941A (ko) 1993-10-13 1995-11-17 오오쓰까 아끼히꼬 일산화질소 합성 억제제(nitrogen monoxide synthesis inhibitor)
DE69500542T2 (de) 1994-05-19 1998-01-02 Akzo Nobel Nv 11,21-Bisphenyl-19-nor-pregnan Derivate
JPH0952899A (ja) 1994-09-30 1997-02-25 Tsumura & Co ロイコトリエン拮抗剤
US5696130A (en) 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Tricyclic steroid receptor modulator compounds and methods
US5767113A (en) 1995-05-10 1998-06-16 The Salk Institute For Biological Studies Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance
US5725694A (en) * 1996-11-25 1998-03-10 Reynolds Metals Company Free-machining aluminum alloy and method of use
FR2757400B1 (fr) 1996-12-19 1999-12-17 Hoechst Marion Roussel Inc Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs
WO1998027986A1 (en) 1996-12-24 1998-07-02 Zymogenetics, Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
IL122740A (en) * 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
EP0903146A1 (en) 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
MXPA01011018A (es) * 1999-04-30 2002-05-06 Pfizer Prod Inc Moduladores del receptor glucocorticoide.

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