JP2006328073A5 - - Google Patents

Download PDF

Info

Publication number
JP2006328073A5
JP2006328073A5 JP2006157094A JP2006157094A JP2006328073A5 JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5 JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006157094 A JP2006157094 A JP 2006157094A JP 2006328073 A5 JP2006328073 A5 JP 2006328073A5
Authority
JP
Japan
Prior art keywords
alkyl
substituted
het
halo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006157094A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006328073A (ja
JP4815566B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2006328073A publication Critical patent/JP2006328073A/ja
Publication of JP2006328073A5 publication Critical patent/JP2006328073A5/ja
Application granted granted Critical
Publication of JP4815566B2 publication Critical patent/JP4815566B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006157094A 1999-04-30 2006-06-06 グルココルチコイド受容体モジュレーター Expired - Fee Related JP4815566B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13213099P 1999-04-30 1999-04-30
US60/132,130 1999-04-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000615356A Division JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター

Publications (3)

Publication Number Publication Date
JP2006328073A JP2006328073A (ja) 2006-12-07
JP2006328073A5 true JP2006328073A5 (https=) 2007-05-10
JP4815566B2 JP4815566B2 (ja) 2011-11-16

Family

ID=22452621

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000615356A Expired - Fee Related JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター
JP2006157094A Expired - Fee Related JP4815566B2 (ja) 1999-04-30 2006-06-06 グルココルチコイド受容体モジュレーター

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000615356A Expired - Fee Related JP3901945B2 (ja) 1999-04-30 2000-03-27 グルココルチコイド受容体モジュレーター

Country Status (45)

Country Link
US (3) US6380223B1 (https=)
EP (1) EP1175383B1 (https=)
JP (2) JP3901945B2 (https=)
KR (1) KR100511585B1 (https=)
CN (2) CN1275917C (https=)
AP (1) AP1542A (https=)
AR (1) AR032128A1 (https=)
AU (1) AU776608B2 (https=)
BG (3) BG110227A (https=)
BR (1) BR0010138B1 (https=)
CA (2) CA2635196C (https=)
CO (1) CO5280071A1 (https=)
CR (2) CR6478A (https=)
CU (1) CU23111A3 (https=)
CZ (1) CZ304203B6 (https=)
DZ (1) DZ3038A1 (https=)
EA (2) EA007483B1 (https=)
EE (1) EE05584B1 (https=)
EG (1) EG25606A (https=)
GE (1) GEP20053474B (https=)
GT (1) GT200000053A (https=)
HK (1) HK1042889B (https=)
HR (1) HRP20010804B1 (https=)
HU (1) HUP0201243A3 (https=)
IL (3) IL145450A0 (https=)
IS (1) IS2743B (https=)
MA (1) MA26729A1 (https=)
MX (1) MXPA01011018A (https=)
MY (1) MY133378A (https=)
NO (1) NO327612B1 (https=)
NZ (1) NZ514465A (https=)
OA (1) OA11877A (https=)
PA (1) PA8493801A1 (https=)
PE (1) PE20010112A1 (https=)
PL (1) PL207610B1 (https=)
RS (1) RS52134B (https=)
SK (1) SK287535B6 (https=)
SV (1) SV2004000061A (https=)
TN (1) TNSN00093A1 (https=)
TR (1) TR200103104T2 (https=)
TW (2) TWI309566B (https=)
UA (1) UA74145C2 (https=)
UY (1) UY26129A1 (https=)
WO (1) WO2000066522A1 (https=)
ZA (1) ZA200108846B (https=)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1542A (en) * 1999-04-30 2006-01-31 Pfizer Prod Inc Glucocorticoid receptor modulators.
WO2002012266A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
IL180679A0 (en) * 2000-10-27 2009-02-11 Pfizer Prod Inc Process for the preparation of non-steroidal glucocorticoid receptor modulators
ES2262612T3 (es) * 2000-10-28 2006-12-01 Pfizer Products Inc. Moduladpres del receptor de glucocorticoides.
DE60113032T2 (de) 2000-10-30 2006-07-06 Pfizer Products Inc., Groton Glukokortikoidrezeptor-Modulatoren
PT1383786E (pt) 2001-04-30 2008-12-30 Glaxo Group Ltd Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
AU2002366217A1 (en) 2001-11-23 2003-06-10 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists
WO2003059267A2 (en) * 2001-12-21 2003-07-24 Rhode Island Hospital SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF
US20060148725A1 (en) * 2001-12-21 2006-07-06 The Miriam Hospital Selective 11beta HSD inhibitors and methods of use thereof
CA2472746A1 (en) 2002-01-14 2003-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
CA2477764A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
UA80120C2 (en) * 2002-03-26 2007-08-27 Boehringer Ingelheim Pharma Glucocorticoid mimetics, pharmaceutical composition based thereon
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) * 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
SI1521733T1 (sl) * 2002-07-08 2014-10-30 Pfizer Products Inc. Modulatorji glukokortikoidnega receptorja
CA2496175A1 (en) 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EA011095B1 (ru) * 2002-08-29 2008-12-30 Бёрингер Ингельхайм Фармасьютиклз, Инк. Производные 3-(сульфонамидоэтил)индола, предназначенные для использования в качестве миметиков глюкокортикоидов при лечении воспалительных, аллергических и пролиферативных заболеваний
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
AU2003267728A1 (en) * 2002-10-18 2004-05-04 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
CA2504751C (en) * 2002-11-05 2013-02-05 Corcept Therapeutics, Inc. Methods for treating gastroesophageal reflux disease
US20060052354A1 (en) * 2002-11-05 2006-03-09 Corcept Therapeutics, Inc. Methods for treating migraine
CA2512257A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004097002A2 (en) * 2003-04-29 2004-11-11 The Miriam Hospital SELECTIVE TESTICULAR 11β-HSD INHIBITORS AND METHODS OF USE THEREOF
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
NZ527142A (en) * 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
ES2290769T3 (es) 2003-10-16 2008-02-16 Boehringer Ingelheim Pharmaceuticals Inc. Sintesis estereoselectiva de ciertos alcoholes substituidos con trifluormetilo.
WO2005047254A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators
SG148198A1 (en) 2003-11-21 2008-12-31 Combinatorx Inc Methods and reagents for the treatment of inflammatory disorders
US7253283B2 (en) 2004-01-16 2007-08-07 Bristol-Myers Squibb Company Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7795272B2 (en) * 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US20050261292A1 (en) * 2004-05-19 2005-11-24 Solvay Pharmaceuticals Gmbh Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
US20090156565A1 (en) * 2004-12-03 2009-06-18 The Children's Hospital Of Philadelphia Composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug
PE20060776A1 (es) 2004-12-27 2006-09-26 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
US7640389B2 (en) * 2006-02-28 2009-12-29 Freescale Semiconductor, Inc. Non-volatile memory having a multiple block erase mode and method therefor
US20080045475A1 (en) * 2006-08-20 2008-02-21 Phillip Edward Littmann Elemental cellular therapy is a genetic, cellular and disease-modifying therapy which enhances the systemic conduct of genetic and cellular transmethylation activity resulting in enhancement of concerted genetic and cellular metabolic, physiologic and homeostatic processes
EP2102170A2 (en) * 2006-12-06 2009-09-23 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2008211613B2 (en) 2007-02-02 2013-05-23 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
AU2008211622B2 (en) * 2007-02-02 2012-04-19 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
CA2726449A1 (en) * 2008-06-06 2009-12-10 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP2307375B1 (en) 2008-07-28 2014-11-19 Pfizer Inc. Phenanthrenone compounds, compositions and methods
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101338200B (zh) * 2008-08-20 2011-08-17 石家庄国大工业有限公司 一种tn型液晶材料的混合物
EP3607942B1 (en) 2008-11-07 2025-10-01 University of Sheffield Medicament and method of diagnosis
SG178174A1 (en) 2009-07-31 2012-03-29 Cadila Healthcare Ltd Novel compounds as modulators of glucocorticoid receptors
AU2010286683B9 (en) * 2009-08-31 2014-09-04 Merck Sharp & Dohme Llc Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators
NZ609769A (en) * 2010-10-27 2015-02-27 Sigma Tau Ind Farmaceuti Diterpenoid derivatives endowed of biological properties
PE20141211A1 (es) * 2011-03-15 2014-10-15 Abbvie Inc Moduladores receptores de hormonas nucleares
EP2758374B1 (en) * 2011-09-21 2016-08-31 Givaudan SA Pyridine derivatives and their use as umami tastants
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
WO2014094357A1 (en) 2012-12-21 2014-06-26 Abbvie Inc. Heterocyclic nuclear hormone receptor modulators
CN105189439B (zh) * 2013-03-14 2017-12-29 百时美施贵宝公司 二环[2.2.1]酸gpr120调节剂
CZ2014575A3 (cs) * 2014-08-26 2016-02-24 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Amfifilní sloučeniny s neuroprotektivními účinky
SK592017A3 (sk) * 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
US12379266B2 (en) 2018-08-22 2025-08-05 University Of Utah Research Foundation Force and torque sensor for prosthetic and orthopedic devices
EP3823565A4 (en) 2018-08-28 2022-04-27 University of Utah Research Foundation VARIABLE TRANSMISSION FOR ASSISTANT PROSTHESIS DEVICE
ES2980934T3 (es) 2019-01-22 2024-10-03 Akribes Biomedical Gmbh Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel
EP4653047A3 (en) * 2019-03-18 2026-02-18 Nieman, Lynnette K. Mifepristone for use in improving insulin sensitivity
WO2021188947A1 (en) 2020-03-20 2021-09-23 University Of Utah Research Foundation Self-aligning mechanisms in passive and powered exoskeletons
CN117440955A (zh) * 2021-04-26 2024-01-23 阿尔克姆斯有限公司 具有食欲素-2受体激动剂活性的取代的酰胺大环化合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4514056Y1 (https=) 1965-09-09 1970-06-15
US3516993A (en) * 1967-03-15 1970-06-23 Sandoz Ag Benzylidene-substituted nitrogenous heterocyclic compounds
US3683091A (en) 1967-11-13 1972-08-08 Wataru Nagata Certain phenanthrene compounds for treatment of acne
JPS50111098A (https=) * 1974-02-18 1975-09-01
JPS6183138A (ja) 1984-09-28 1986-04-26 Harima Kasei Kogyo Kk 3−デオキシアフィディコリンの製造方法
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
JPS61271216A (ja) 1985-05-27 1986-12-01 Mitsubishi Chem Ind Ltd 抗腫瘍剤
JPS6256422A (ja) 1985-09-04 1987-03-12 Mitsubishi Chem Ind Ltd 抗菌剤
JPH07100357B2 (ja) 1986-03-11 1995-11-01 三菱化学株式会社 繊維補強セメントモルタル成形体
US5039706A (en) 1987-11-30 1991-08-13 Du Pont Merck Pharmaceutical Company Antiinflammatory PLA2 inhibitors
US5116865A (en) * 1990-09-05 1992-05-26 Peters Richard H 15,16-seco-19-nor progestins
JPH06263688A (ja) 1991-09-04 1994-09-20 Otsuka Pharmaceut Factory Inc フェナンスレン誘導体
WO1995010266A1 (fr) 1993-10-13 1995-04-20 Otsuka Pharmaceutical Co., Ltd. Inhibiteur de synthese de monoxyde d'azote
EP0683172B1 (en) 1994-05-19 1997-08-13 Akzo Nobel N.V. 11,21-Bisphenyl-19-norpregnane derivatives
JPH0952899A (ja) 1994-09-30 1997-02-25 Tsumura & Co ロイコトリエン拮抗剤
US5696127A (en) 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US5767113A (en) 1995-05-10 1998-06-16 The Salk Institute For Biological Studies Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance
US5725694A (en) * 1996-11-25 1998-03-10 Reynolds Metals Company Free-machining aluminum alloy and method of use
FR2757400B1 (fr) 1996-12-19 1999-12-17 Hoechst Marion Roussel Inc Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs
AU5729098A (en) 1996-12-24 1998-07-17 Zymogenetics Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
IL122740A (en) * 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
EP0903146A1 (en) 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
AP1542A (en) * 1999-04-30 2006-01-31 Pfizer Prod Inc Glucocorticoid receptor modulators.

Similar Documents

Publication Publication Date Title
JP2006328073A5 (https=)
JP5588040B2 (ja) S1p1/edg1受容体アゴニストとしてのアミノ−ピリジン誘導体
US12145924B2 (en) Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
US8106078B2 (en) Human protein tyrosine phosphatase inhibitors and methods of use
ES2597453T3 (es) Compuestos heterocíclicos adecuados para el tratamiento de enfermedades relacionadas con un elevado nivel de lípidos
JP2008511683A5 (https=)
US8772502B2 (en) Alkylsulfinyl-substituted thiazolide compounds
JP2010504913A5 (https=)
JP2002529532A5 (https=)
JP2009519965A5 (https=)
JP2007535551A5 (https=)
US20110015240A1 (en) Thiazole derivative and use thereof as vap-1 inhibitor
JP2013532726A5 (https=)
HRP20110335T1 (hr) Supstituirani biciklolaktamski spojevi
JP2007531744A5 (https=)
JP2009531280A5 (https=)
JP2006517939A5 (https=)
JP2013527847A5 (https=)
NZ592297A (en) 2-Aryl-5-heteroaryl pyridine and pyrimidine derivatives as pharmaceutical active agents
JP2010513438A5 (https=)
JP2005500286A5 (https=)
CN103102348B (zh) 噁二唑类化合物及其制备方法、药物组合物及其用途
JP2012524110A5 (https=)
JP2007502817A5 (https=)
JP2011517674A (ja) 嚢胞性線維症膜コンダクタンス制御因子の水溶性小分子阻害剤