JP2007531744A5 - - Google Patents
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- JP2007531744A5 JP2007531744A5 JP2007506366A JP2007506366A JP2007531744A5 JP 2007531744 A5 JP2007531744 A5 JP 2007531744A5 JP 2007506366 A JP2007506366 A JP 2007506366A JP 2007506366 A JP2007506366 A JP 2007506366A JP 2007531744 A5 JP2007531744 A5 JP 2007531744A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- formula
- optionally substituted
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 55
- 150000001875 compounds Chemical class 0.000 claims description 26
- 125000000623 heterocyclic group Chemical group 0.000 claims description 23
- 239000000651 prodrug Substances 0.000 claims description 19
- 229940002612 prodrug Drugs 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 9
- 125000002252 acyl group Chemical group 0.000 claims description 7
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 229940124597 therapeutic agent Drugs 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000000069 prophylactic effect Effects 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 239000003458 I kappa b kinase inhibitor Substances 0.000 claims description 4
- 125000005476 oxopyrrolidinyl group Chemical group 0.000 claims description 3
- TUWFVEZGIMLNNG-UHFFFAOYSA-N (5-methoxy-1h-pyrrolo[2,3-c]pyridin-2-yl)methanol Chemical compound C1=NC(OC)=CC2=C1NC(CO)=C2 TUWFVEZGIMLNNG-UHFFFAOYSA-N 0.000 claims description 2
- LMUBRGXCKFURFF-UHFFFAOYSA-N (5-phenylmethoxy-1h-pyrrolo[2,3-c]pyridin-2-yl)methanol Chemical compound N=1C=C2NC(CO)=CC2=CC=1OCC1=CC=CC=C1 LMUBRGXCKFURFF-UHFFFAOYSA-N 0.000 claims description 2
- GCDUCIUOANUNHX-UHFFFAOYSA-N (5-phenylmethoxy-1h-pyrrolo[2,3-c]pyridin-3-yl)methanol Chemical compound C1=C2C(CO)=CNC2=CN=C1OCC1=CC=CC=C1 GCDUCIUOANUNHX-UHFFFAOYSA-N 0.000 claims description 2
- GRFOOXWCQURPKR-UHFFFAOYSA-N 2-[2-[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5-methoxypyrrolo[2,3-c]pyridin-1-yl]acetic acid Chemical compound OC(=O)CN1C=2C=NC(OC)=CC=2C=C1C(=O)NC(S1)=NC(C=2C(=CC(Cl)=C(OC)C=2)OC)=C1CCC1CCCCC1 GRFOOXWCQURPKR-UHFFFAOYSA-N 0.000 claims description 2
- ZFQNWDOJNLGVLV-UHFFFAOYSA-N 5-methoxy-1h-pyrrolo[2,3-c]pyridine-2-carbaldehyde Chemical compound C1=NC(OC)=CC2=C1NC(C=O)=C2 ZFQNWDOJNLGVLV-UHFFFAOYSA-N 0.000 claims description 2
- ZOZREFCQGIXKDZ-UHFFFAOYSA-N 5-phenylmethoxy-1h-pyrrolo[2,3-c]pyridine-2-carbaldehyde Chemical compound N=1C=C2NC(C=O)=CC2=CC=1OCC1=CC=CC=C1 ZOZREFCQGIXKDZ-UHFFFAOYSA-N 0.000 claims description 2
- QMULSMMKMCFGGW-UHFFFAOYSA-N N-(1H-pyrrolo[2,3-c]pyridin-3-ylmethylidene)hydroxylamine Chemical compound N1=CC=C2C(C=NO)=CNC2=C1 QMULSMMKMCFGGW-UHFFFAOYSA-N 0.000 claims description 2
- NEVYAJIGZRCDOX-UHFFFAOYSA-N ethyl 2,4-dimethyl-5-(5-phenylmethoxy-1h-pyrrolo[2,3-c]pyridine-2-carbonyl)-1h-pyrrole-3-carboxylate Chemical compound CCOC(=O)C1=C(C)NC(C(=O)C=2NC3=CN=C(OCC=4C=CC=CC=4)C=C3C=2)=C1C NEVYAJIGZRCDOX-UHFFFAOYSA-N 0.000 claims description 2
- QHFCJCSJSXWHQM-UHFFFAOYSA-N ethyl 3-(hydroxymethyl)-1h-pyrrolo[2,3-c]pyridine-5-carboxylate Chemical compound C1=NC(C(=O)OCC)=CC2=C1NC=C2CO QHFCJCSJSXWHQM-UHFFFAOYSA-N 0.000 claims description 2
- ZZCLQDDYJKTVIL-UHFFFAOYSA-N tert-butyl 3-(3-ethoxy-2-fluoro-1-hydroxy-3-oxopropyl)-5-phenylmethoxypyrrolo[2,3-c]pyridine-1-carboxylate Chemical compound C1=C2C(C(O)C(F)C(=O)OCC)=CN(C(=O)OC(C)(C)C)C2=CN=C1OCC1=CC=CC=C1 ZZCLQDDYJKTVIL-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 6
- 238000000034 method Methods 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- 102000001284 I-kappa-B kinase Human genes 0.000 description 1
- 108060006678 I-kappa-B kinase Proteins 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55898104P | 2004-04-05 | 2004-04-05 | |
| PCT/US2005/011531 WO2005097129A2 (en) | 2004-04-05 | 2005-04-04 | 6-azaindole compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007531744A JP2007531744A (ja) | 2007-11-08 |
| JP2007531744A5 true JP2007531744A5 (https=) | 2008-04-03 |
Family
ID=35125607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506366A Abandoned JP2007531744A (ja) | 2004-04-05 | 2005-04-04 | ６−アザインドール化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7608627B2 (https=) |
| EP (1) | EP1732566A4 (https=) |
| JP (1) | JP2007531744A (https=) |
| WO (1) | WO2005097129A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE527258T1 (de) | 2004-07-28 | 2011-10-15 | Takeda Pharmaceutical | Pyrroloä2,3-cüpyridinverbindung, verfahren zu deren herstellung und anwendung |
| ATE449776T1 (de) * | 2005-12-15 | 2009-12-15 | Hoffmann La Roche | Pyrroloä2,3-cüpyridinderivate |
| GB2435830A (en) * | 2006-03-09 | 2007-09-12 | Del Dr Esteve S A Spain Lab | Oxime ether compounds for the treatment of conditions associated with food uptake |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| ES2422603T3 (es) | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009125434A2 (en) * | 2008-04-07 | 2009-10-15 | Cadila Healthcare Limited | Oxime derivatives |
| US8518934B2 (en) | 2008-06-11 | 2013-08-27 | Shonogi & Co., Ltd. | Oxycarbamoyl compounds and the use thereof |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| EA201200046A1 (ru) * | 2009-06-24 | 2012-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения, фармацевтическая композиция и связанные с ними способы |
| MX2012001729A (es) | 2009-08-26 | 2012-06-13 | Sanofi Sa | Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo. |
| WO2011109593A1 (en) * | 2010-03-03 | 2011-09-09 | OSI Pharmaceuticals, LLC | Substituted-5-aminopyrrolo/pyrazolopyridines |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2714688B1 (en) | 2011-05-26 | 2016-02-24 | Daiichi Sankyo Company, Limited | Heterocyclic compounds as protein kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014091465A2 (en) * | 2012-12-16 | 2014-06-19 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome and lipid disorders |
| CN103524435B (zh) * | 2013-10-22 | 2015-11-04 | 华南农业大学 | 一种乙酰甲喹残留标示物脱二氧乙酰甲喹的半抗原和完全抗原及其制备方法 |
| EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| US11008340B2 (en) | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| EP3515912B1 (fr) | 2016-09-26 | 2020-10-14 | Centre National De La Recherche Scientifique | Composes pour leur utilisation en imagerie et notamment pour le diagnostic de maladies neuro-degeneratives |
| JP2020528904A (ja) | 2017-07-24 | 2020-10-01 | ヴァイティー ファーマシューティカルズ，エルエルシー | ＲＯＲγの阻害剤 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| WO2019106087A1 (en) * | 2017-11-29 | 2019-06-06 | Syddansk Universitet | Ampk inhibitors |
| KR102919209B1 (ko) | 2018-08-10 | 2026-01-28 | 다이아핀 테라퓨틱스, 엘엘씨 | 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 |
| US12453716B2 (en) | 2019-02-13 | 2025-10-28 | University Of Vermont And State Agricultural College | Small molecule antagonist to PACAP receptor and uses thereof |
| WO2021062316A1 (en) * | 2019-09-26 | 2021-04-01 | The Global Alliance For Tb Drug Development, Inc. | Azaindole carboxamide compounds for the treatment of mycobacterial infections |
| EP4370207B1 (en) * | 2021-07-12 | 2025-12-17 | Nido Biosciences, Inc. | Bicyclic compounds as androgen receptor modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3465827B2 (ja) * | 1993-02-24 | 2003-11-10 | 株式会社日清製粉グループ本社 | アザインドール誘導体およびこれを有効成分とする抗潰瘍薬 |
| GB9415575D0 (en) * | 1994-08-02 | 1994-09-21 | Merck Sharp & Dohme | Therapeutic agents |
| IL152771A0 (en) * | 2000-06-26 | 2003-06-24 | Pfizer Prod Inc | PYRROLO(2,3-d) PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
| GB0127547D0 (en) * | 2001-11-16 | 2002-01-09 | Astrazeneca Ab | Chemical compounds |
| JPWO2003091213A1 (ja) * | 2002-04-25 | 2005-09-02 | アステラス製薬株式会社 | 新規なアミド誘導体又はその塩 |
| MXPA05012547A (es) * | 2003-05-21 | 2006-05-25 | Prosidion Ltd | Inhibidores de amida de acido pirrolopiridina-2-carboxilico de fosforilasa de glucogeno. |
-
2005
- 2005-04-04 EP EP05732504A patent/EP1732566A4/en not_active Withdrawn
- 2005-04-04 WO PCT/US2005/011531 patent/WO2005097129A2/en not_active Ceased
- 2005-04-04 US US11/547,308 patent/US7608627B2/en not_active Expired - Fee Related
- 2005-04-04 JP JP2007506366A patent/JP2007531744A/ja not_active Abandoned
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