JP2005538191A5 - - Google Patents
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- JP2005538191A5 JP2005538191A5 JP2005505627A JP2005505627A JP2005538191A5 JP 2005538191 A5 JP2005538191 A5 JP 2005538191A5 JP 2005505627 A JP2005505627 A JP 2005505627A JP 2005505627 A JP2005505627 A JP 2005505627A JP 2005538191 A5 JP2005538191 A5 JP 2005538191A5
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- JP
- Japan
- Prior art keywords
- formulation
- volume
- weight
- amount
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000009472 formulation Methods 0.000 claims 122
- 239000000203 mixture Substances 0.000 claims 122
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 54
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims 43
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 32
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 32
- 229960004134 propofol Drugs 0.000 claims 23
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 17
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 15
- 229920001993 poloxamer 188 Polymers 0.000 claims 14
- 229940044519 poloxamer 188 Drugs 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 235000019445 benzyl alcohol Nutrition 0.000 claims 5
- 229920001400 block copolymer Polymers 0.000 claims 5
- 206010002091 Anaesthesia Diseases 0.000 claims 4
- 230000037005 anaesthesia Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 229920001983 poloxamer Polymers 0.000 claims 3
- 229960000502 poloxamer Drugs 0.000 claims 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 235000002639 sodium chloride Nutrition 0.000 claims 2
- 239000008181 tonicity modifier Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920002511 Poloxamer 237 Polymers 0.000 claims 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 claims 1
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims 1
- 229940089206 anhydrous dextrose Drugs 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- -1 metabisulfate Chemical compound 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39949002P | 2002-07-29 | 2002-07-29 | |
| US42219502P | 2002-10-29 | 2002-10-29 | |
| US43697902P | 2002-12-30 | 2002-12-30 | |
| US46245003P | 2003-04-11 | 2003-04-11 | |
| US46431403P | 2003-04-21 | 2003-04-21 | |
| US47040303P | 2003-05-14 | 2003-05-14 | |
| US48535403P | 2003-07-07 | 2003-07-07 | |
| PCT/US2003/023512 WO2004010941A2 (en) | 2002-07-29 | 2003-07-29 | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265559A Division JP2011144161A (ja) | 2002-07-29 | 2010-11-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538191A JP2005538191A (ja) | 2005-12-15 |
| JP2005538191A5 true JP2005538191A5 (https=) | 2006-03-02 |
Family
ID=31192580
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005505627A Withdrawn JP2005538191A (ja) | 2002-07-29 | 2003-07-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
| JP2010265559A Pending JP2011144161A (ja) | 2002-07-29 | 2010-11-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
| JP2013248238A Pending JP2014058553A (ja) | 2002-07-29 | 2013-11-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010265559A Pending JP2011144161A (ja) | 2002-07-29 | 2010-11-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
| JP2013248238A Pending JP2014058553A (ja) | 2002-07-29 | 2013-11-29 | 水性２，６―ジイソプロピルフェノール医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7915317B2 (https=) |
| EP (1) | EP1539122B1 (https=) |
| JP (3) | JP2005538191A (https=) |
| KR (1) | KR101145692B1 (https=) |
| CN (1) | CN100438861C (https=) |
| AU (1) | AU2003261274C1 (https=) |
| BR (1) | BR0313060A (https=) |
| CA (1) | CA2494297C (https=) |
| HR (1) | HRP20050182A2 (https=) |
| MX (1) | MXPA05001061A (https=) |
| NZ (1) | NZ538255A (https=) |
| PL (1) | PL375874A1 (https=) |
| RS (1) | RS54275B1 (https=) |
| WO (1) | WO2004010941A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040220283A1 (en) * | 2002-07-29 | 2004-11-04 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| BR0313060A (pt) | 2002-07-29 | 2005-06-28 | Transform Pharmaceuticals Inc | Composições farmacêuticas aquosas de 2,6-diisopropilfenol |
| AU2003286725B2 (en) * | 2002-10-29 | 2007-07-12 | Transform Pharmaceuticals, Inc. | Propofol with cysteine |
| US20040225022A1 (en) * | 2003-05-09 | 2004-11-11 | Desai Neil P. | Propofol formulation containing reduced oil and surfactants |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| MXPA06013437A (es) | 2004-05-19 | 2007-03-23 | Los Angeles Biomed Res Inst | Uso de un detergente para la eliminacion no quirurgica de grasa. |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| DE102004045622A1 (de) * | 2004-09-17 | 2006-03-30 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Konservierungsmittel-Zusammensetzungen |
| WO2007128866A2 (en) * | 2006-05-09 | 2007-11-15 | Novobion Oy | Novel chemical compositions |
| US8197499B2 (en) * | 2006-06-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| US8608760B2 (en) * | 2006-06-21 | 2013-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| CA2656179A1 (en) * | 2006-06-21 | 2007-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| WO2008092084A2 (en) * | 2007-01-26 | 2008-07-31 | Centocor, Inc. | Injectable non-aqueous suspension with high concentration of therapeutic agent |
| WO2009086206A2 (en) * | 2007-12-20 | 2009-07-09 | Synvascular, Inc. | Compositions and methods for joining non-conjoined lumens |
| CN101977619B (zh) | 2008-02-15 | 2013-06-05 | 诺沃百欧公司 | 姜黄素的可溶性复合物 |
| US8563037B2 (en) * | 2009-02-06 | 2013-10-22 | Tautona Group, L.P. | Compositions and methods for joining non-conjoined lumens |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| AU2011234492B2 (en) | 2010-04-01 | 2014-02-27 | Palette Life Sciences AB | Thermogelling anaesthetic compositions |
| WO2012047870A2 (en) * | 2010-10-05 | 2012-04-12 | The Medicines Company | Antimicrobial preservation of propofol emulsions |
| PL2627173T5 (pl) * | 2010-10-12 | 2019-11-29 | Chiesi Farm Spa | Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| MX363465B (es) | 2011-02-18 | 2019-03-25 | Kythera Biopharmaceuticals Inc | Tratamiento de la grasa submental. |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| GB201106031D0 (en) | 2011-04-08 | 2011-05-25 | Highway Resource Solutions Ltd | Adaptions to a lantern |
| US20180022698A1 (en) | 2014-10-16 | 2018-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Novel methods, compounds, and compositions for anesthesia |
| MX383940B (es) | 2015-12-09 | 2025-03-14 | Phosphagenics Ltd | Formulación farmacéutica que contiene tocol fosfato. |
| IL267006B2 (en) | 2016-12-21 | 2024-11-01 | Phosphagenics Ltd | Process for phosphorylation of a complex alcohol with p4o10 at high temperatures, and products thereof |
| CN106581737B (zh) * | 2017-01-06 | 2019-09-06 | 哈尔滨鼓润生物技术有限公司 | 一种止血组合物及其制备方法 |
| WO2018225229A1 (en) * | 2017-06-08 | 2018-12-13 | Terumo Kabushiki Kaisha | Parenteral aqueous pharmaceutical composition |
| JP2022526976A (ja) * | 2019-04-05 | 2022-05-27 | ソレント・セラピューティクス・インコーポレイテッド | カンナビジオール医薬組成物 |
| CN114601800B (zh) * | 2021-09-28 | 2023-07-28 | 天津瑞普生物技术股份有限公司 | 一种甲磷丙泊酚钠无菌粉针剂及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4798846A (en) * | 1974-03-28 | 1989-01-17 | Imperial Chemical Industries Plc | Pharmaceutical compositions |
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| US5296161A (en) * | 1986-06-09 | 1994-03-22 | The Clorox Company | Enzymatic perhydrolysis system and method of use for bleaching |
| ES2140408T3 (es) * | 1991-03-19 | 2000-03-01 | Cytrx Corp | Copolimeros de polioxipropileno/polioxietileno con actividad biologica mejorada. |
| US6277410B1 (en) * | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
| GB9405593D0 (en) | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5731356A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| US5635540A (en) * | 1994-12-09 | 1997-06-03 | The University Of Virginia Patent Foundation | Stabilized topical pharmaceutical preparations |
| AU6708096A (en) | 1995-09-18 | 1997-04-09 | Vesifact Ag | Propofol nanodispersions |
| US6077545A (en) * | 1995-10-30 | 2000-06-20 | Matrix Pharmaceuticals, Inc. | Process and composition for therapeutic cisplatin (CDDP) |
| US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
| US20020107291A1 (en) * | 1997-05-26 | 2002-08-08 | Vincenzo De Tommaso | Clear, injectable formulation of an anesthetic compound |
| US5962536A (en) * | 1998-07-31 | 1999-10-05 | Komer; Gene | Injectable propofol formulations |
| DE69912441T2 (de) * | 1998-08-19 | 2004-08-19 | Skyepharma Canada Inc., Verdun | Injizierbare wässerige propofoldispersionen |
| US6150423A (en) | 1998-10-15 | 2000-11-21 | Phoenix Scientific, Inc. | Propofol-based anesthetic and method of making same |
| US6140373A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| US6100302A (en) * | 1999-04-05 | 2000-08-08 | Baxter International Inc. | Propofol formulation with enhanced microbial characteristics |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| AU5574200A (en) * | 1999-06-21 | 2001-01-09 | Kuhnil Pharm. Co., Ltd. | Anesthetic composition for intravenous injection comprising propofol |
| GB2359747B (en) * | 2000-02-29 | 2002-04-24 | Maelor Pharmaceuticals Ltd | Anaesthetic formulations |
| EP1289518A2 (en) | 2000-05-25 | 2003-03-12 | AstraZeneca AB | Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent |
| EP1292282A2 (en) | 2000-06-16 | 2003-03-19 | RTP Pharma Inc. | Improved injectable dispersions of propofol |
| IN187686B (https=) | 2000-06-21 | 2002-06-08 | Bharat Serums & Vaccines Ltd | |
| US6623765B1 (en) * | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| IN188917B (https=) | 2000-12-07 | 2002-11-23 | Bharat Surums & Vaccines Ltd | |
| EP1383445A4 (en) | 2001-03-20 | 2005-04-13 | Cydex Inc | FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| GB0120702D0 (en) | 2001-08-24 | 2001-10-17 | Maelor Pharmaceuticals Ltd | Anaesthetic formulations |
| GB0124071D0 (en) * | 2001-10-08 | 2001-11-28 | Kbig Ltd | Improvement in the administration of high boiling point aneasthetics |
| US20040220283A1 (en) * | 2002-07-29 | 2004-11-04 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| BR0313060A (pt) * | 2002-07-29 | 2005-06-28 | Transform Pharmaceuticals Inc | Composições farmacêuticas aquosas de 2,6-diisopropilfenol |
| KR100482269B1 (ko) | 2002-10-08 | 2005-04-14 | 센츄론(주) | 2,6-디이소프로필페놀을 활성성분으로 하는 수용액상의마취용 주사제 및 그 제조방법 |
| US8476010B2 (en) * | 2003-07-10 | 2013-07-02 | App Pharmaceuticals Llc | Propofol formulations with non-reactive container closures |
-
2003
- 2003-07-29 BR BR0313060-6A patent/BR0313060A/pt not_active Application Discontinuation
- 2003-07-29 US US10/629,308 patent/US7915317B2/en not_active Expired - Fee Related
- 2003-07-29 NZ NZ538255A patent/NZ538255A/en not_active IP Right Cessation
- 2003-07-29 RS YU20050066A patent/RS54275B1/sr unknown
- 2003-07-29 WO PCT/US2003/023512 patent/WO2004010941A2/en not_active Ceased
- 2003-07-29 EP EP03771951.5A patent/EP1539122B1/en not_active Expired - Lifetime
- 2003-07-29 CA CA2494297A patent/CA2494297C/en not_active Expired - Fee Related
- 2003-07-29 JP JP2005505627A patent/JP2005538191A/ja not_active Withdrawn
- 2003-07-29 CN CNB038180758A patent/CN100438861C/zh not_active Expired - Fee Related
- 2003-07-29 KR KR1020057001649A patent/KR101145692B1/ko not_active Expired - Fee Related
- 2003-07-29 PL PL03375874A patent/PL375874A1/xx unknown
- 2003-07-29 HR HR20050182A patent/HRP20050182A2/xx not_active Application Discontinuation
- 2003-07-29 AU AU2003261274A patent/AU2003261274C1/en not_active Ceased
- 2003-07-29 MX MXPA05001061A patent/MXPA05001061A/es active IP Right Grant
-
2010
- 2010-11-29 JP JP2010265559A patent/JP2011144161A/ja active Pending
-
2013
- 2013-11-29 JP JP2013248238A patent/JP2014058553A/ja active Pending
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