JP2005534627A5 - - Google Patents
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- Publication number
- JP2005534627A5 JP2005534627A5 JP2003587787A JP2003587787A JP2005534627A5 JP 2005534627 A5 JP2005534627 A5 JP 2005534627A5 JP 2003587787 A JP2003587787 A JP 2003587787A JP 2003587787 A JP2003587787 A JP 2003587787A JP 2005534627 A5 JP2005534627 A5 JP 2005534627A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- trifluoromethyl
- group
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- -1 cyano, difluoromethyl Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- PWUIGAMMOKVBTB-UHFFFAOYSA-N 1-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-phenyltriazol-4-yl]-3-(2-chlorophenyl)propan-1-one Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(CN2C(=C(C(=O)CCC=3C(=CC=CC=3)Cl)N=N2)C=2C=CC=CC=2)=C1 PWUIGAMMOKVBTB-UHFFFAOYSA-N 0.000 claims 1
- CBEQBMDMXIYMHX-UHFFFAOYSA-N 2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-imidazol-1-yltriazole-4-carbonyl]-3-(2-chlorophenyl)-3-oxopropanenitrile Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(CN2C(=C(C(=O)C(C#N)C(=O)C=3C(=CC=CC=3)Cl)N=N2)N2C=NC=C2)=C1 CBEQBMDMXIYMHX-UHFFFAOYSA-N 0.000 claims 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- LNIMUCHZHHHCSW-UHFFFAOYSA-N [1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-[2-(dimethylamino)ethyl-methylamino]triazol-4-yl]-[3-(2-chlorophenyl)-5-(hydroxymethyl)-1,2-oxazol-4-yl]methanone Chemical compound CN(C)CCN(C)C1=C(C(=O)C=2C(=NOC=2CO)C=2C(=CC=CC=2)Cl)N=NN1CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 LNIMUCHZHHHCSW-UHFFFAOYSA-N 0.000 claims 1
- ATKJWQDOFXFRJH-UHFFFAOYSA-N [1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-imidazol-1-yltriazol-4-yl]-[5-(2-chlorophenyl)-3-(hydroxymethyl)-1,2-oxazol-4-yl]methanone Chemical compound OCC1=NOC(C=2C(=CC=CC=2)Cl)=C1C(=O)C(=C1N2C=NC=C2)N=NN1CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 ATKJWQDOFXFRJH-UHFFFAOYSA-N 0.000 claims 1
- VQHAHRIHPDBMCN-UHFFFAOYSA-N [1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-phenyltriazol-4-yl]-[3-(2-chlorophenyl)-5-[(2-morpholin-4-ylethylamino)methyl]-1,2-oxazol-4-yl]methanone Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(CN2C(=C(C(=O)C=3C(=NOC=3CNCCN3CCOCC3)C=3C(=CC=CC=3)Cl)N=N2)C=2C=CC=CC=2)=C1 VQHAHRIHPDBMCN-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000002829 nitrogen Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000005554 pyridyloxy group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37612102P | 2002-04-26 | 2002-04-26 | |
| US60/376,121 | 2002-04-26 | ||
| US44086503P | 2003-01-16 | 2003-01-16 | |
| US60/440,865 | 2003-01-16 | ||
| PCT/US2003/010682 WO2003091227A1 (en) | 2002-04-26 | 2003-04-22 | Tachykinin receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534627A JP2005534627A (ja) | 2005-11-17 |
| JP2005534627A5 true JP2005534627A5 (https=) | 2006-06-15 |
| JP4895476B2 JP4895476B2 (ja) | 2012-03-14 |
Family
ID=29273048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587787A Expired - Fee Related JP4895476B2 (ja) | 2002-04-26 | 2003-04-22 | タキキニン受容体アンタゴニスト |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7179804B2 (https=) |
| EP (1) | EP1501808B1 (https=) |
| JP (1) | JP4895476B2 (https=) |
| CN (1) | CN1313450C (https=) |
| AT (1) | ATE399770T1 (https=) |
| BR (1) | BR0309486A (https=) |
| CA (1) | CA2484188C (https=) |
| CY (1) | CY1108539T1 (https=) |
| DE (1) | DE60321907D1 (https=) |
| DK (1) | DK1501808T3 (https=) |
| ES (1) | ES2307925T3 (https=) |
| IL (1) | IL164787A0 (https=) |
| MX (1) | MXPA04010625A (https=) |
| PT (1) | PT1501808E (https=) |
| SI (1) | SI1501808T1 (https=) |
| WO (1) | WO2003091227A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100755577B1 (ko) * | 2002-04-26 | 2007-09-12 | 일라이 릴리 앤드 캄파니 | 타키키닌 수용체 길항제로서의 트리아졸 유도체 |
| EP1638944A1 (en) * | 2003-06-12 | 2006-03-29 | Eli Lilly And Company | Tachykinin receptor antagonists |
| WO2005033079A1 (ja) * | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | ヘテロ環化合物を含有する新規な抗真菌剤 |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| US20090227799A1 (en) * | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
| JP4874958B2 (ja) | 2005-03-30 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジン誘導体を含有する抗真菌剤 |
| EP1894919B1 (en) * | 2005-06-07 | 2012-03-28 | Shionogi & Co., Ltd. | Heterocyclic compound having type i 11 beta hydroxysteroid dehydrogenase inhibitory activity |
| US20110060017A1 (en) * | 2008-03-11 | 2011-03-10 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| ES2353724T3 (es) * | 2005-07-25 | 2011-03-04 | F. Hoffmann-La Roche Ag | Derivados de triazol substitutidos y su uso como antagonistas del receptor neuroquinina 3. |
| TWI385169B (zh) * | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| WO2007052479A1 (ja) * | 2005-11-04 | 2007-05-10 | Ngk Insulators, Ltd. | ハニカム構造体及びハニカム触媒体 |
| EP2065377B1 (en) * | 2006-09-21 | 2011-11-23 | Eisai R&D Management Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| WO2008136279A1 (ja) * | 2007-04-27 | 2008-11-13 | Eisai R & D Management Co., Ltd. | ヘテロ環置換ピリジン誘導体の塩またはその結晶 |
| TW200841879A (en) * | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| BRPI0817897A2 (pt) * | 2007-11-02 | 2019-09-24 | Methylgene Inc | composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| AU2009263037B2 (en) * | 2008-06-26 | 2011-10-06 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| WO2010015583A1 (en) * | 2008-08-08 | 2010-02-11 | Neurosearch A/S | Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| WO2011115817A1 (en) | 2010-03-16 | 2011-09-22 | Isis Pharmaceuticals, Inc. | Methods of preparing 2'-o-substituted purine nucleosides |
| US9109005B2 (en) * | 2012-02-23 | 2015-08-18 | Boehringer Ingelheim International Gmbh | Method for manufacturing of ciclesonide |
| CN103073513B (zh) * | 2012-12-14 | 2015-12-02 | 雅本化学股份有限公司 | 1-取代-5-氯-2h-1,2,3-三氮唑-4-羧酸衍生物及其制备方法 |
| CA2978736C (en) | 2015-03-04 | 2023-11-07 | Vanda Pharmaceuticals Inc. | Dosing regimen of tradipitant |
| CA3073998A1 (en) | 2017-09-13 | 2019-03-21 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| CN108516942B (zh) * | 2018-03-12 | 2021-04-20 | 中国科学院成都有机化学有限公司 | 一种左旋盐酸米那普仑的制备方法 |
| WO2021195205A1 (en) | 2020-03-26 | 2021-09-30 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| US20240381760A1 (en) * | 2021-09-20 | 2024-11-14 | Novaled Gmbh | Compound, Semiconductor Layer Comprising Compound and Organic Electronic Device |
| WO2025114352A1 (en) * | 2023-12-01 | 2025-06-05 | Syngenta Crop Protection Ag | Herbicidal compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL50699A0 (en) | 1975-10-28 | 1976-12-31 | Ici America Inc | Triazole derivatives |
| AU7947594A (en) * | 1993-10-27 | 1995-05-22 | Merck Sharp & Dohme Limited | Substituted amides as tachykinin antagonists |
| US6175013B1 (en) * | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| US5998444A (en) * | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
| AU2633897A (en) | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles |
| US6060478A (en) | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| CN1272842A (zh) * | 1997-08-06 | 2000-11-08 | 伊莱利利公司 | 作为速激肽受体拮抗剂的2－酰氨基丙胺类化合物 |
| ES2258485T3 (es) * | 1999-12-17 | 2006-09-01 | Schering Corporation | Antagonistas selectivos de neuroquinina. |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| DE10036818A1 (de) * | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
| JP2002123925A (ja) | 2000-10-13 | 2002-04-26 | Fuji Photo Film Co Ltd | 磁気記録媒体 |
-
2003
- 2003-04-22 BR BR0309486-3A patent/BR0309486A/pt not_active IP Right Cessation
- 2003-04-22 SI SI200331308T patent/SI1501808T1/sl unknown
- 2003-04-22 MX MXPA04010625A patent/MXPA04010625A/es active IP Right Grant
- 2003-04-22 IL IL16478703A patent/IL164787A0/xx unknown
- 2003-04-22 PT PT03721561T patent/PT1501808E/pt unknown
- 2003-04-22 EP EP03721561A patent/EP1501808B1/en not_active Expired - Lifetime
- 2003-04-22 AT AT03721561T patent/ATE399770T1/de not_active IP Right Cessation
- 2003-04-22 US US10/512,248 patent/US7179804B2/en not_active Expired - Fee Related
- 2003-04-22 DK DK03721561T patent/DK1501808T3/da active
- 2003-04-22 ES ES03721561T patent/ES2307925T3/es not_active Expired - Lifetime
- 2003-04-22 CN CNB03809360XA patent/CN1313450C/zh not_active Expired - Fee Related
- 2003-04-22 JP JP2003587787A patent/JP4895476B2/ja not_active Expired - Fee Related
- 2003-04-22 DE DE60321907T patent/DE60321907D1/de not_active Expired - Lifetime
- 2003-04-22 WO PCT/US2003/010682 patent/WO2003091227A1/en not_active Ceased
- 2003-04-22 CA CA2484188A patent/CA2484188C/en not_active Expired - Fee Related
-
2008
- 2008-09-10 CY CY20081100968T patent/CY1108539T1/el unknown
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