JP2008517976A5 - - Google Patents
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- Publication number
- JP2008517976A5 JP2008517976A5 JP2007538405A JP2007538405A JP2008517976A5 JP 2008517976 A5 JP2008517976 A5 JP 2008517976A5 JP 2007538405 A JP2007538405 A JP 2007538405A JP 2007538405 A JP2007538405 A JP 2007538405A JP 2008517976 A5 JP2008517976 A5 JP 2008517976A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorophenyl
- carboxamide
- dichlorophenyl
- phenyl
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62107704P | 2004-10-25 | 2004-10-25 | |
| EP04105265 | 2004-10-25 | ||
| US65162505P | 2005-02-11 | 2005-02-11 | |
| PCT/EP2005/055534 WO2006045799A2 (en) | 2004-10-25 | 2005-10-25 | Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517976A JP2008517976A (ja) | 2008-05-29 |
| JP2008517976A5 true JP2008517976A5 (https=) | 2008-09-11 |
Family
ID=34929757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538405A Pending JP2008517976A (ja) | 2004-10-25 | 2005-10-25 | Cb1カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病1型、肥満及び関連症状の治療用の医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8058264B2 (https=) |
| EP (1) | EP1807063A2 (https=) |
| JP (1) | JP2008517976A (https=) |
| AU (1) | AU2005298692A1 (https=) |
| BR (1) | BRPI0517434A (https=) |
| CA (1) | CA2585175A1 (https=) |
| MX (1) | MX2007004889A (https=) |
| RU (1) | RU2007119315A (https=) |
| WO (1) | WO2006045799A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7271189B2 (en) * | 2003-10-20 | 2007-09-18 | Solvay Pharmaceuticals, Inc. | 1H-imidazole derivatives as cannabinoid receptor modulators |
| US7745476B2 (en) * | 2004-01-30 | 2010-06-29 | Solvay Pharmaceuticals B.V. | 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2342090T3 (es) | 2004-08-25 | 2010-07-01 | Essentialis, Inc. | Formulaciones farmaceuticas de agentes de apertura de canales de potasio dependientes de atp y usos de los mismos. |
| WO2006060192A2 (en) * | 2004-11-30 | 2006-06-08 | Bayer Pharmaceuticals Corporation | Pyrazole derivatives |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1757587A1 (en) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743892A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| KR20080039996A (ko) * | 2005-08-17 | 2008-05-07 | 솔베이 파머슈티컬스 게엠베하 | 칼륨 채널 억제 화합물의 사용 방법 |
| CN101868239B (zh) | 2006-01-05 | 2015-06-10 | 伊森舍丽斯有限公司 | 钾atp通道开放剂的盐及其用途 |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| EP2026798A1 (en) * | 2006-04-27 | 2009-02-25 | Solvay Pharmaceuticals GmbH | Pharmaceutical compositions comprising cbx cannabinoid receptor modulators and potassium channel modulators |
| US7923026B2 (en) | 2006-10-20 | 2011-04-12 | Solvay Pharmaceuticals B.V. | Embedded micellar nanoparticles |
| EP2083799A1 (en) * | 2006-10-20 | 2009-08-05 | Solvay Pharmaceuticals B.V. | Micellar nanoparticles of chemical substances |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2231615A1 (en) * | 2007-12-10 | 2010-09-29 | 7TM Pharma A/S | Cannabinoid receptor modulators |
| WO2009099820A2 (en) * | 2008-02-01 | 2009-08-13 | Mayo Foundation For Medical Education And Research | Modulating body weight |
| EP2151234A1 (en) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion |
| US20120053172A1 (en) | 2009-02-12 | 2012-03-01 | Cooperatieve Mirzorg U.A. | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| CN102771060B (zh) | 2009-11-24 | 2016-05-18 | 韩国电子通信研究院 | 用于在基于多用户多输入多输出的无线通信系统中恢复传送失败的帧的方法 |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| KR20150113762A (ko) * | 2014-03-31 | 2015-10-08 | 한미약품 주식회사 | 황 작용기를 포함하는 4,5-다이하이드로-1h-피라졸-3-카복스이미드아마이드 유도체, 이의 제조방법 및 이를 포함하는 약학 조성물 |
| PL3217963T3 (pl) * | 2014-11-14 | 2020-10-19 | Essentialis, Inc. | Sposoby leczenia osobników z zespołem pradera-williego lub smith-magenis |
| WO2020130836A1 (en) * | 2018-12-21 | 2020-06-25 | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) | Compound for use in treatment and prevention of type i diabetes |
| NL2022291B1 (en) * | 2018-12-21 | 2020-07-21 | Academisch Ziekenhuis Leiden | Compound for Use in Treatment and Prevention of Type I Diabetes |
| WO2021178271A1 (en) * | 2020-03-02 | 2021-09-10 | Goldfinch Bio, Inc. | 1,2,4-triazolinoe cb1 inhibitors |
| WO2022190107A1 (en) * | 2021-03-12 | 2022-09-15 | Bionanosim (Bns) Ltd | Peripherally restricted cb1 receptor blockers and uses thereof |
| US12521159B2 (en) * | 2021-10-29 | 2026-01-13 | Joint Development, Inc. | Dual-purpose orthopedic surgery instrument |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL158178B (nl) | 1974-07-12 | 1978-10-16 | Philips Nv | Werkwijze ter bereiding van insekticide preparaten die een pyrazolinederivaat bevatten, aldus verkregen gevormde preparaten, en werkwijze ter bereiding van pyrazolinederivaten met insekticide werking. |
| US4156007A (en) | 1974-07-12 | 1979-05-22 | U.S. Philips Corporation | Pyrazoline compounds |
| US4174393A (en) | 1975-07-09 | 1979-11-13 | Duphar International Research B.V. | 1,3,4-Substituted pyrazoline derivatives |
| DE3064749D1 (en) | 1979-07-03 | 1983-10-13 | Duphar Int Res | New pyrazoline derivatives, method of preparing the new compounds, as well as insecticidal composition on the basis of these new compounds |
| JPS56128774A (en) | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1247547A (en) | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| AU577802B2 (en) | 1983-10-17 | 1988-10-06 | Duphar International Research B.V. | Blood-pressure lowering piperazine derivatives |
| JP3003148B2 (ja) | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
| AU3201095A (en) | 1994-07-27 | 1996-02-22 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| US5616601A (en) | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| FR2758723B1 (fr) | 1997-01-28 | 1999-04-23 | Sanofi Sa | Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| AR022204A1 (es) | 1999-01-08 | 2002-09-04 | Norgine Bv | Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende. |
| US6492516B1 (en) | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| US6197765B1 (en) * | 1999-06-08 | 2001-03-06 | Pnina Vardi | Use of diazoxide for the treatment of metabolic syndrome and diabetes complications |
| US6352949B1 (en) | 1999-06-15 | 2002-03-05 | Peter Willems | Fluoro glass ceramic showing photostimulable properties |
| GB9914744D0 (en) | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| CA2387892A1 (en) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| DZ3335A1 (fr) * | 2000-03-23 | 2001-09-27 | Solvay Pharm Bv | Derives de 4,5-dihydro-1h-pyrazole ayant une activite antagoniste de cb1 |
| FR2814678B1 (fr) | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| US20020091114A1 (en) | 2000-10-04 | 2002-07-11 | Odile Piot-Grosjean | Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity |
| PL363751A1 (en) | 2001-03-22 | 2004-11-29 | Solvay Pharmaceuticals B.V. | 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity |
| AU2002319627A1 (en) | 2001-07-20 | 2003-03-03 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| TWI231757B (en) | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
| US7109216B2 (en) | 2001-09-21 | 2006-09-19 | Solvay Pharmaceuticals B.V. | 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
| IL157704A0 (en) | 2001-09-21 | 2004-03-28 | Solvay Pharm Bv | 4,5-dihydro-1h-pyrazole derivatives having potent cbi-antagonistic activity |
| KR100903760B1 (ko) | 2001-09-21 | 2009-06-19 | 솔베이 파마슈티칼스 비. 브이 | Cb1-길항 작용을 가지는 신규한4,5-디하이드로-1h-피라졸 유도체 |
| UY27450A1 (es) | 2001-09-24 | 2003-04-30 | Bayer Corp | Preparación y uso de derivados de imidazol para el tratamiento de la obesidad |
| JP2005510508A (ja) | 2001-11-08 | 2005-04-21 | 藤沢薬品工業株式会社 | アデノシンアンタゴニストとしてのチアゾールピリダジノン類 |
| TW200407110A (en) | 2001-11-23 | 2004-05-16 | Astrazeneca Ab | New use for the treatment of gastroesophageal reflux disease |
| SE0104330D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| AU2003209388A1 (en) | 2002-01-29 | 2003-09-02 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| DE10208986A1 (de) | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
| US20030236288A1 (en) | 2002-02-28 | 2003-12-25 | Karl Schoenafinger | Use of substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadizol-2-ones for inhibiting pancreatic lipase |
| DE10208987A1 (de) | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| AR038966A1 (es) * | 2002-03-18 | 2005-02-02 | Solvay Pharm Bv | Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1 |
| TW200412942A (en) | 2002-08-06 | 2004-08-01 | Abbott Lab | Appetite control method |
| HRP20050053A2 (en) | 2002-09-19 | 2005-04-30 | Solvay Pharmaceuticals B.V. | 1 h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands |
| GB0230087D0 (en) * | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
-
2005
- 2005-10-25 JP JP2007538405A patent/JP2008517976A/ja active Pending
- 2005-10-25 WO PCT/EP2005/055534 patent/WO2006045799A2/en not_active Ceased
- 2005-10-25 BR BRPI0517434-1A patent/BRPI0517434A/pt not_active IP Right Cessation
- 2005-10-25 AU AU2005298692A patent/AU2005298692A1/en not_active Abandoned
- 2005-10-25 RU RU2007119315/15A patent/RU2007119315A/ru unknown
- 2005-10-25 EP EP05801545A patent/EP1807063A2/en not_active Withdrawn
- 2005-10-25 CA CA002585175A patent/CA2585175A1/en not_active Abandoned
- 2005-10-25 MX MX2007004889A patent/MX2007004889A/es unknown
- 2005-10-25 US US11/257,056 patent/US8058264B2/en not_active Expired - Fee Related
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