JP2005533246A5 - - Google Patents
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- JP2005533246A5 JP2005533246A5 JP2004520851A JP2004520851A JP2005533246A5 JP 2005533246 A5 JP2005533246 A5 JP 2005533246A5 JP 2004520851 A JP2004520851 A JP 2004520851A JP 2004520851 A JP2004520851 A JP 2004520851A JP 2005533246 A5 JP2005533246 A5 JP 2005533246A5
- Authority
- JP
- Japan
- Prior art keywords
- serrs
- beads
- bead
- active
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011324 bead Substances 0.000 claims 66
- 229910052751 metal Inorganic materials 0.000 claims 17
- 239000002184 metal Substances 0.000 claims 17
- 229920000642 polymer Polymers 0.000 claims 16
- 239000000084 colloidal system Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- -1 4-vinylamine Chemical compound 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 238000002372 labelling Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 3
- FUGYGGDSWSUORM-UHFFFAOYSA-N 4-hydroxystyrene Chemical compound OC1=CC=C(C=C)C=C1 FUGYGGDSWSUORM-UHFFFAOYSA-N 0.000 claims 2
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000003926 acrylamides Chemical class 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000000379 polymerizing effect Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- QWMJEUJXWVZSAG-UHFFFAOYSA-N (4-ethenylphenyl)boronic acid Chemical compound OB(O)C1=CC=C(C=C)C=C1 QWMJEUJXWVZSAG-UHFFFAOYSA-N 0.000 claims 1
- FQTLCLSUCSAZDY-SDNWHVSQSA-N (6E)-nerolidol Chemical compound CC(C)=CCC\C(C)=C\CCC(C)(O)C=C FQTLCLSUCSAZDY-SDNWHVSQSA-N 0.000 claims 1
- SYZVQXIUVGKCBJ-UHFFFAOYSA-N 1-ethenyl-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(C=C)=C1 SYZVQXIUVGKCBJ-UHFFFAOYSA-N 0.000 claims 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 claims 1
- DGPVNNMFVYYVDF-UHFFFAOYSA-N 1-prop-2-enoylpyrrolidin-2-one Chemical compound C=CC(=O)N1CCCC1=O DGPVNNMFVYYVDF-UHFFFAOYSA-N 0.000 claims 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims 1
- VLSRKCIBHNJFHA-UHFFFAOYSA-N 2-(trifluoromethyl)prop-2-enoic acid Chemical compound OC(=O)C(=C)C(F)(F)F VLSRKCIBHNJFHA-UHFFFAOYSA-N 0.000 claims 1
- ULIKDJVNUXNQHS-UHFFFAOYSA-N 2-Propene-1-thiol Chemical compound SCC=C ULIKDJVNUXNQHS-UHFFFAOYSA-N 0.000 claims 1
- HMENQNSSJFLQOP-UHFFFAOYSA-N 2-bromoprop-2-enoic acid Chemical compound OC(=O)C(Br)=C HMENQNSSJFLQOP-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical class C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 claims 1
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 claims 1
- IOJFHZXQSLNAQJ-UHFFFAOYSA-N 4-azido-2,3,5,6-tetrafluorobenzoic acid Chemical compound OC(=O)C1=C(F)C(F)=C(N=[N+]=[N-])C(F)=C1F IOJFHZXQSLNAQJ-UHFFFAOYSA-N 0.000 claims 1
- QBFNGLBSVFKILI-UHFFFAOYSA-N 4-ethenylbenzaldehyde Chemical compound C=CC1=CC=C(C=O)C=C1 QBFNGLBSVFKILI-UHFFFAOYSA-N 0.000 claims 1
- MAGFQRLKWCCTQJ-UHFFFAOYSA-N 4-ethenylbenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(C=C)C=C1 MAGFQRLKWCCTQJ-UHFFFAOYSA-N 0.000 claims 1
- IRQWEODKXLDORP-UHFFFAOYSA-N 4-ethenylbenzoic acid Chemical compound OC(=O)C1=CC=C(C=C)C=C1 IRQWEODKXLDORP-UHFFFAOYSA-N 0.000 claims 1
- 229910001316 Ag alloy Inorganic materials 0.000 claims 1
- 229910001020 Au alloy Inorganic materials 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 239000004971 Cross linker Substances 0.000 claims 1
- 229910000881 Cu alloy Inorganic materials 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- IWTYTFSSTWXZFU-QPJJXVBHSA-N [(e)-3-chloroprop-1-enyl]benzene Chemical compound ClC\C=C\C1=CC=CC=C1 IWTYTFSSTWXZFU-QPJJXVBHSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- PYGXUPRQBBNETH-UHFFFAOYSA-N acetic acid;2-hydroxypropyl prop-2-enoate Chemical compound CC(O)=O.CC(O)COC(=O)C=C PYGXUPRQBBNETH-UHFFFAOYSA-N 0.000 claims 1
- 125000005396 acrylic acid ester group Chemical group 0.000 claims 1
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000005620 boronic acid group Chemical class 0.000 claims 1
- ITMIAZBRRZANGB-UHFFFAOYSA-N but-3-ene-1,2-diol Chemical compound OCC(O)C=C ITMIAZBRRZANGB-UHFFFAOYSA-N 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 125000003700 epoxy group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- PQLFROTZSIMBKR-UHFFFAOYSA-N ethenyl carbonochloridate Chemical compound ClC(=O)OC=C PQLFROTZSIMBKR-UHFFFAOYSA-N 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000006249 magnetic particle Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 229910001092 metal group alloy Inorganic materials 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical class CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 claims 1
- 125000005395 methacrylic acid group Chemical group 0.000 claims 1
- DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 claims 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 1
- GUAQVFRUPZBRJQ-UHFFFAOYSA-N n-(3-aminopropyl)-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCCN GUAQVFRUPZBRJQ-UHFFFAOYSA-N 0.000 claims 1
- YPHQUSNPXDGUHL-UHFFFAOYSA-N n-methylprop-2-enamide Chemical compound CNC(=O)C=C YPHQUSNPXDGUHL-UHFFFAOYSA-N 0.000 claims 1
- HVAMZGADVCBITI-UHFFFAOYSA-N pent-4-enoic acid Chemical compound OC(=O)CCC=C HVAMZGADVCBITI-UHFFFAOYSA-N 0.000 claims 1
- 150000004291 polyenes Chemical class 0.000 claims 1
- 229920000647 polyepoxide Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 1
- 235000013824 polyphenols Nutrition 0.000 claims 1
- QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical group C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- QGRSLAYMCFPMHW-UHFFFAOYSA-M sodium;3-(2-methylprop-2-enoyloxy)propane-1-sulfonate Chemical compound [Na+].CC(=C)C(=O)OCCCS([O-])(=O)=O QGRSLAYMCFPMHW-UHFFFAOYSA-M 0.000 claims 1
- 150000003440 styrenes Chemical class 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims 1
- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 150000003673 urethanes Chemical class 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0216197.4 | 2002-07-12 | ||
| GBGB0216197.4A GB0216197D0 (en) | 2002-07-12 | 2002-07-12 | Serrs active particles |
| PCT/GB2003/003009 WO2004007767A2 (en) | 2002-07-12 | 2003-07-11 | Serrs reactive particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533246A JP2005533246A (ja) | 2005-11-04 |
| JP2005533246A5 true JP2005533246A5 (enExample) | 2007-02-15 |
| JP4754213B2 JP4754213B2 (ja) | 2011-08-24 |
Family
ID=9940323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520851A Expired - Fee Related JP4754213B2 (ja) | 2002-07-12 | 2003-07-11 | Ｓｅｒｒｓ活性粒子群 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050130163A1 (enExample) |
| EP (1) | EP1521846B1 (enExample) |
| JP (1) | JP4754213B2 (enExample) |
| CN (2) | CN101241078A (enExample) |
| AU (1) | AU2003281070B2 (enExample) |
| CA (1) | CA2492213C (enExample) |
| GB (1) | GB0216197D0 (enExample) |
| WO (1) | WO2004007767A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19936059A1 (de) * | 1999-07-30 | 2001-02-01 | J Peter Guggenbichler | Verfahren zur Herstellung von antimikrobiellen Kunststoffkörpern |
| US7588827B2 (en) * | 2003-08-18 | 2009-09-15 | Emory University | Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof |
| US20050191665A1 (en) * | 2003-12-29 | 2005-09-01 | Xing Su | Composite organic-inorganic nanoclusters |
| US20050147963A1 (en) * | 2003-12-29 | 2005-07-07 | Intel Corporation | Composite organic-inorganic nanoparticles and methods for use thereof |
| US7361410B2 (en) * | 2003-12-29 | 2008-04-22 | Intel Corporation | External modification of composite organic inorganic nanoclusters comprising raman active organic compound |
| US20080076119A9 (en) * | 2003-12-29 | 2008-03-27 | Lei Sun | Composite organic inorganic nanoclusters |
| JP4665161B2 (ja) * | 2004-02-06 | 2011-04-06 | 国立大学法人高知大学 | ラマンスペクトルの測定方法、該方法に使用する貴金属粒子および該貴金属粒子の製造方法 |
| US20070048797A1 (en) * | 2004-08-11 | 2007-03-01 | Xing Su | Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules |
| US9494581B2 (en) | 2004-08-24 | 2016-11-15 | University Of Wyoming | System and method for Raman spectroscopy assay using paramagnetic particles |
| US7776547B2 (en) * | 2004-08-26 | 2010-08-17 | Intel Corporation | Cellular analysis using Raman surface scanning |
| US7285427B2 (en) | 2004-10-06 | 2007-10-23 | General Electric Company | Raman-active particles and methods of making and using them |
| US7485471B1 (en) * | 2004-12-17 | 2009-02-03 | Intel Corporation | Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy |
| US20060147941A1 (en) * | 2004-12-30 | 2006-07-06 | Intel Corporation | Methods and apparatus for SERS assay of biological analytes |
| US20060216697A1 (en) * | 2005-03-24 | 2006-09-28 | General Electric Company | Method of separating unattached Raman-active tag from bioassay or other reaction mixture |
| US20060216835A1 (en) * | 2005-03-24 | 2006-09-28 | General Electric Company | Method of separating unattached Raman-active tag from bioassay or other reaction mixture |
| US7410763B2 (en) * | 2005-09-01 | 2008-08-12 | Intel Corporation | Multiplex data collection and analysis in bioanalyte detection |
| US7355703B2 (en) | 2005-09-09 | 2008-04-08 | Ge Homeland Protection, Inc. | Raman-active lateral flow device and methods of detection and making |
| US7518721B2 (en) | 2005-09-09 | 2009-04-14 | Ge Homeland Protection, Inc. | Raman-active lateral flow device and methods of detection |
| CA2628968C (en) | 2005-10-17 | 2016-10-11 | Sword Diagnostics, Inc. | Method and apparatus for detection of biological organisms using raman scattering |
| US20100041016A1 (en) | 2005-10-17 | 2010-02-18 | Sword Diagnostics, Inc. | Methods for detecting organisms and enzymatic reactions using raman spectroscopy and aromatic compounds comprising phosphate |
| US7947437B2 (en) | 2005-10-17 | 2011-05-24 | Sword Diagnostics, Inc. | Methods for detecting organisms and enzymatic reactions using raman spectroscopy |
| US20070155022A1 (en) * | 2005-12-30 | 2007-07-05 | Mineo Yamakawa | Degenerate binding detection and protein identification using Raman spectroscopy nanoparticle labels |
| EP2644615B1 (en) * | 2006-02-08 | 2017-04-05 | Becton Dickinson and Company | SERS nanotag assays |
| JP2009537816A (ja) * | 2006-05-16 | 2009-10-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 分析的検出方法におけるサンプルマトリクス効果の補正のためのサンプル制御 |
| WO2007135593A1 (en) * | 2006-05-16 | 2007-11-29 | Koninklijke Philips Electronics N.V. | Se(r)rs displacement assay |
| US8889347B2 (en) * | 2006-06-02 | 2014-11-18 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
| WO2008007242A2 (en) | 2006-06-15 | 2008-01-17 | Koninklijke Philips Electronics N.V. | Increased specificity of analyte detection by measurement of bound and unbound labels |
| DE102006043107A1 (de) * | 2006-09-07 | 2008-03-20 | Bundesdruckerei Gmbh | Sicherheits- und/oder Wertdokument mit SERS-aktiven Partikeln |
| GB0621050D0 (en) * | 2006-10-23 | 2006-11-29 | Univ Strathclyde | Functionalised polymers for labelling metal surfaces |
| US7833960B2 (en) * | 2006-12-15 | 2010-11-16 | International Flavors & Fragrances Inc. | Encapsulated active material containing nanoscaled material |
| CA2681523C (en) * | 2007-03-20 | 2017-11-28 | Kristin Weidemaier | Assays using surface-enhanced raman spectroscopy (sers)-active particles |
| EP2040075A1 (en) | 2007-09-24 | 2009-03-25 | Julius-Maximilians-Universität Würzburg | Compounds and markers for surface-enhanced raman scattering |
| EP2078757A1 (en) | 2007-12-10 | 2009-07-15 | Koninklijke Philips Electronics N.V. | New labels for surface-enhanced resonant Raman spectroscopy |
| EP2141246A1 (en) * | 2008-07-01 | 2010-01-06 | Koninklijke Philips Electronics N.V. | Separation-free methods of PCR detection using SERRS |
| US8877511B2 (en) | 2008-11-10 | 2014-11-04 | Luminex Corporation | Method and system for manufacture and use of macroporous beads in a multiplex assay |
| US7879625B1 (en) | 2008-12-03 | 2011-02-01 | The United States Of America As Represented By The Secretary Of The Navy | Preparation of SERS substrates on silica-coated magnetic microspheres |
| EP2386061A4 (en) * | 2009-01-12 | 2012-07-18 | Univ California | WOVEN POLYMERNANOPARTICLES |
| PL2433131T3 (pl) * | 2009-05-18 | 2017-01-31 | Sicpa Holding Sa | Cząstki dla długofalowej SERS, sposób wytwarzania i sposób oznaczania materiału |
| RU2542386C2 (ru) * | 2009-12-11 | 2015-02-20 | Корея Рисерч Инститьют Оф Кемикал Текнолоджи | Димерная окклюдантная наноструктура, меченная молекулой, активной в отношении рамановского рассеяния, локализованной в межчастичном соединении, ее использование и способ ее получения |
| FR2954338B1 (fr) * | 2009-12-22 | 2013-01-18 | Commissariat Energie Atomique | Procede d'elaboration de ballons ou billes polymeriques comprenant des elements metalliques |
| WO2011099925A1 (en) * | 2010-02-09 | 2011-08-18 | Phase Holographic Imaging Phi Ab | Method for and use of digital holographic microscopy and imaging on labelled cell samples |
| KR101207695B1 (ko) * | 2010-08-11 | 2012-12-03 | 서울대학교산학협력단 | 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치 |
| US9833145B2 (en) | 2010-08-11 | 2017-12-05 | Snu R&Db Foundation | Method for simultaneously detecting fluorescence and raman signals for multiple fluorescence and raman signal targets, and medical imaging device for simultaneously detecting multiple targets using the method |
| AU2011340796A1 (en) * | 2010-12-07 | 2013-07-18 | Clemson University | Multifunctional nanoparticles |
| JP5822239B2 (ja) | 2010-12-08 | 2015-11-24 | 公立大学法人大阪府立大学 | 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法 |
| CA2731892A1 (fr) | 2011-02-18 | 2012-08-18 | Universite De Montreal | Sondes a diffusion raman a capsule nanometrique, methode de fabrication et utilisation |
| GB201207821D0 (en) * | 2012-04-05 | 2012-06-13 | Renishaw Diagnostics Ltd | Dye sets for surface enhanced resonant raman spectroscopy |
| CN102323412B (zh) * | 2011-08-09 | 2014-01-01 | 中国科学院合肥物质科学研究院 | 一种拉曼编码微球的用途及利用拉曼编码微球检测肿瘤标志物的方法 |
| CN104937391A (zh) | 2013-01-25 | 2015-09-23 | 惠普发展公司，有限责任合伙企业 | 化学传感装置 |
| JP6099108B2 (ja) | 2013-05-30 | 2017-03-29 | 公立大学法人大阪府立大学 | 被検出物質の検出装置および方法 |
| CN104975279B (zh) * | 2015-07-22 | 2018-04-20 | 中国工程物理研究院材料研究所 | 一种制备表面增强拉曼基底的溶胶及方法 |
| CN106947018B (zh) * | 2017-03-09 | 2019-02-05 | 江苏大学 | 一种高性能和高度可控的核壳型印迹传感器及制备方法和用途 |
| EP3593137A1 (en) | 2017-03-10 | 2020-01-15 | Universität Duisburg-Essen | Efficient ligand exchange of a detergent bilayer on the surface of metal nanoparticles for molecular functionalization and assembly, corresponding functionalized nanoparticles and nanoparticle assemblies, and their use in plasmonic applications including surface-enhanced raman spectroscopy |
| CN110161243B (zh) * | 2018-02-13 | 2021-05-04 | 北京化工大学 | 一种用于活细胞内肿瘤标志物实时成像的纳米人工抗体抑制剂及其制备方法 |
| CN109342387B (zh) * | 2018-10-19 | 2021-08-24 | 福建省林业科学研究院 | 一种基于纳米银胶表面拉曼增强检测酮康唑的方法 |
| CN109307697B (zh) * | 2018-11-05 | 2021-02-23 | 济南大学 | 一种检测吡喹酮的电致化学发光传感电极的制备方法及应用 |
| CN109342392B (zh) * | 2018-11-09 | 2021-09-17 | 中国科学院烟台海岸带研究所 | 一种以聚苯乙烯为包裹壳层材料的表面增强拉曼散射纳米探针及其制备方法 |
| CN109540867B (zh) * | 2018-11-30 | 2021-07-27 | 东南大学 | 一种基于分子印迹纳米纤维膜的塑化剂拉曼光谱检测方法 |
| CN110376179B (zh) * | 2019-07-25 | 2022-03-29 | 东南大学 | 一种分子印迹纳米纤维增强基底膜的制备方法、应用及检测方法 |
| WO2021193589A1 (ja) * | 2020-03-23 | 2021-09-30 | 積水化学工業株式会社 | 検査方法、検査キット及び検査システム |
| CN114295601B (zh) * | 2021-12-31 | 2024-01-30 | 厦门大学 | 一种基于连续体束缚态的表面拉曼增强传感结构 |
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- 2003-07-11 US US10/507,717 patent/US20050130163A1/en not_active Abandoned
- 2003-07-11 CA CA2492213A patent/CA2492213C/en not_active Expired - Fee Related
- 2003-07-11 CN CNA2008100823662A patent/CN101241078A/zh active Pending
- 2003-07-11 CN CNB038166070A patent/CN100413977C/zh not_active Expired - Fee Related
- 2003-07-11 WO PCT/GB2003/003009 patent/WO2004007767A2/en not_active Ceased
- 2003-07-11 JP JP2004520851A patent/JP4754213B2/ja not_active Expired - Fee Related
- 2003-07-11 AU AU2003281070A patent/AU2003281070B2/en not_active Ceased
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