JP2005532803A - 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 - Google Patents

単球由来の移植片受容誘導細胞ならびにその調製およびその使用 Download PDF

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JP2005532803A
JP2005532803A JP2004520603A JP2004520603A JP2005532803A JP 2005532803 A JP2005532803 A JP 2005532803A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2005532803 A JP2005532803 A JP 2005532803A
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cells
taic
cell
lymphocytes
monocytes
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ベルント カール フリードリヒ クレーマー，
フレッド フェンドリヒ，
マーレン ルーンケ，
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ブラスティコン ビオテクノロギッシュ フォーシュング ゲーエムベーハー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2004520603A 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 Pending JP2005532803A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
PCT/EP2003/007551 WO2004007701A1 (en) 2002-07-12 2003-07-11 Transplant acceptance inducing cells of monocytic origin and their preparation and use

Publications (2)

Publication Number Publication Date
JP2005532803A true JP2005532803A (ja) 2005-11-04
JP2005532803A5 JP2005532803A5 (https=) 2006-09-21

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JP2004520603A Pending JP2005532803A (ja) 2002-07-12 2003-07-11 単球由来の移植片受容誘導細胞ならびにその調製およびその使用

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US (1) US20060286670A1 (https=)
EP (2) EP1492869B9 (https=)
JP (1) JP2005532803A (https=)
CN (1) CN100523176C (https=)
AT (2) ATE309331T1 (https=)
AU (1) AU2003250939B2 (https=)
BR (1) BR0312693A (https=)
CA (1) CA2492383A1 (https=)
DE (3) DE10231655A1 (https=)
DK (2) DK1492869T3 (https=)
ES (3) ES2304647T3 (https=)
IL (3) IL166021A0 (https=)
NO (1) NO20050719L (https=)
PT (2) PT1557462E (https=)
RU (1) RU2370535C2 (https=)
SI (3) SI1492869T1 (https=)
WO (1) WO2004007701A1 (https=)
ZA (2) ZA200501054B (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010226991A (ja) * 2009-03-26 2010-10-14 Terumo Corp シート状細胞培養物の製造方法
JP2011110368A (ja) * 2009-11-30 2011-06-09 Terumo Corp シート状細胞培養物の製造方法
JP2015057071A (ja) * 2014-12-11 2015-03-26 テルモ株式会社 シート状細胞培養物の製造方法
JP2015133981A (ja) * 2015-04-02 2015-07-27 テルモ株式会社 シート状細胞培養物の製造方法
JP2016136960A (ja) * 2016-02-24 2016-08-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2017131136A (ja) * 2016-01-27 2017-08-03 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP2017136089A (ja) * 2017-04-28 2017-08-10 テルモ株式会社 シート状細胞培養物の製造方法
JP2019107013A (ja) * 2019-02-27 2019-07-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2019193645A (ja) * 2019-06-20 2019-11-07 テルモ株式会社 シート状細胞培養物の製造方法
JP2020078320A (ja) * 2020-02-05 2020-05-28 テルモ株式会社 シート状細胞培養物の製造方法

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DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
US20060188485A1 (en) * 2003-07-11 2006-08-24 Bernd Karl Friedrich Kremer Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
US8916147B2 (en) * 2005-08-24 2014-12-23 Yeda Research and Devolpment Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007043641A1 (ja) 2005-10-14 2007-04-19 Fukuoka University 膵島移植における移植膵島障害抑制剤
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
TWI438208B (zh) 2007-01-23 2014-05-21 中外製藥股份有限公司 抑制慢性排斥反應之藥劑
CA2728243C (en) 2008-06-05 2020-03-10 Chugai Seiyaku Kabushiki Kaisha Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
US9738872B2 (en) * 2008-10-30 2017-08-22 Yeda Research And Development Co. Ltd. Anti third party central memory T cells, methods of producing same and use of same in transplantation and disease treatment
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
WO2011149051A1 (ja) 2010-05-28 2011-12-01 中外製薬株式会社 抗腫瘍t細胞応答増強剤
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата
US10724001B2 (en) * 2015-07-03 2020-07-28 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for obtaining regulatory T cells and uses thereof
WO2018203545A1 (ja) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
JP7235249B2 (ja) 2017-10-20 2023-03-08 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
EP3957324A4 (en) 2019-04-17 2023-02-08 Hiroshima University THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR

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US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US5683693A (en) * 1994-04-25 1997-11-04 Trustees Of Dartmouth College Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40
US9068164B1 (en) * 1995-02-02 2015-06-30 Tristem Trading (Cyprus) Limited Method of preparing an undifferentiated cell
GB9502022D0 (en) * 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US7410773B2 (en) * 1995-02-02 2008-08-12 Ghazi Jaswinder Dhoot Method of preparing an undifferentiated cell
US7112440B2 (en) * 1995-02-02 2006-09-26 Ghazi Jaswinder Dhoot Method of increasing the relative number of CD45 low cells in a cell population
CA2214649C (en) * 1995-03-08 2007-06-12 Zeling Cai Antigen presenting system and methods for activation of t-cells
EP0983345A1 (en) * 1997-05-21 2000-03-08 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
NL1017973C2 (nl) * 2000-05-10 2002-11-08 Tristem Trading Cyprus Ltd Inrichting.
US7405076B2 (en) * 2000-11-14 2008-07-29 Universite Libre De Bruxelles Generation and use of dendritic cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010226991A (ja) * 2009-03-26 2010-10-14 Terumo Corp シート状細胞培養物の製造方法
JP2011110368A (ja) * 2009-11-30 2011-06-09 Terumo Corp シート状細胞培養物の製造方法
JP2015057071A (ja) * 2014-12-11 2015-03-26 テルモ株式会社 シート状細胞培養物の製造方法
JP2015133981A (ja) * 2015-04-02 2015-07-27 テルモ株式会社 シート状細胞培養物の製造方法
JP2017131136A (ja) * 2016-01-27 2017-08-03 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP2016136960A (ja) * 2016-02-24 2016-08-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2017136089A (ja) * 2017-04-28 2017-08-10 テルモ株式会社 シート状細胞培養物の製造方法
JP2019107013A (ja) * 2019-02-27 2019-07-04 テルモ株式会社 シート状細胞培養物の製造方法
JP2019193645A (ja) * 2019-06-20 2019-11-07 テルモ株式会社 シート状細胞培養物の製造方法
JP7002497B2 (ja) 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
JP2020078320A (ja) * 2020-02-05 2020-05-28 テルモ株式会社 シート状細胞培養物の製造方法
JP2021106609A (ja) * 2020-02-05 2021-07-29 テルモ株式会社 シート状細胞培養物の製造方法
JP7074908B2 (ja) 2020-02-05 2022-05-24 テルモ株式会社 シート状細胞培養物の製造方法
JP2022106986A (ja) * 2020-02-05 2022-07-20 テルモ株式会社 シート状細胞培養物の製造方法
JP7486544B2 (ja) 2020-02-05 2024-05-17 テルモ株式会社 シート状細胞培養物の製造方法

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SI1492869T1 (sl) 2006-04-30
SI1557462T1 (sl) 2008-08-31
ATE309331T1 (de) 2005-11-15
ATE390480T1 (de) 2008-04-15
DE60320009D1 (de) 2008-05-08
RU2370535C2 (ru) 2009-10-20
EP1492869B1 (en) 2005-11-09
DE60302231T2 (de) 2006-07-20
AU2003250939A1 (en) 2004-02-02
US20060286670A1 (en) 2006-12-21
PT1644484E (pt) 2008-10-21
BR0312693A (pt) 2005-04-26
DE60302231D1 (de) 2005-12-15
ES2252696T3 (es) 2006-05-16
IL166021A (en) 2010-05-17
ZA200601074B (en) 2007-11-28
WO2004007701A1 (en) 2004-01-22
IL172854A0 (en) 2006-06-11
EP1557462A3 (en) 2006-02-01
ES2304647T3 (es) 2008-10-16
SI1644484T1 (sl) 2009-02-28
CA2492383A1 (en) 2004-01-22
IL166021A0 (en) 2006-01-15
RU2005103627A (ru) 2005-08-27
ES2310711T3 (es) 2009-01-16
EP1492869B9 (en) 2006-05-24
DK1557462T3 (da) 2008-06-23
AU2003250939B2 (en) 2008-05-22
EP1492869A1 (en) 2005-01-05
CN1681918A (zh) 2005-10-12
CN100523176C (zh) 2009-08-05
PT1557462E (pt) 2008-06-18
ZA200501054B (en) 2005-08-30
NO20050719L (no) 2005-04-04
DE60320009T2 (de) 2009-05-20
HK1071586A1 (en) 2005-07-22
DE10231655A1 (de) 2004-02-26
EP1557462B1 (en) 2008-03-26
EP1557462A2 (en) 2005-07-27
DK1492869T3 (da) 2006-03-06

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