RU2370535C2 - Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела - Google Patents

Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела Download PDF

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RU2370535C2
RU2370535C2 RU2005103627/13A RU2005103627A RU2370535C2 RU 2370535 C2 RU2370535 C2 RU 2370535C2 RU 2005103627/13 A RU2005103627/13 A RU 2005103627/13A RU 2005103627 A RU2005103627 A RU 2005103627A RU 2370535 C2 RU2370535 C2 RU 2370535C2
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cells
transplant
inducing
taic
cell
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RU2005103627/13A
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Russian (ru)
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RU2005103627A (ru
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Бернд Карл Фридрих КРЕМЕР (DE)
Бернд Карл Фридрих КРЕМЕР
Фред ФЕНДРИХ (DE)
Фред ФЕНДРИХ
Марен РУНКЕ (DE)
Марен РУНКЕ
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Бластикон Биотехнологише Форшунг Гмбх
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • General Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Wood Science & Technology (AREA)
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  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
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  • Cell Biology (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2005103627/13A 2002-07-12 2003-07-11 Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела RU2370535C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10231655A DE10231655A1 (de) 2002-07-12 2002-07-12 Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung
DE10231655.4 2002-07-12

Publications (2)

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RU2005103627A RU2005103627A (ru) 2005-08-27
RU2370535C2 true RU2370535C2 (ru) 2009-10-20

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RU2005103627/13A RU2370535C2 (ru) 2002-07-12 2003-07-11 Способ получения индуцирующих воспринимаемость трансплантата клеток моноцитарного происхождения, способ получения фармацевтической композиции для подавления реакций отторжения трансплантата, индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, клеточный препарат для индукции воспринимаемости трансплантата, фармацевтическая композиция для подавления реакций отторжения трансплантата, применение индуцирующих воспринимаемость трансплантата клеток (варианты), способ получения и/или размножения регуляторных т-лимфоцитов, гибридомная клеточная линия, антитело и применение антитела

Country Status (18)

Country Link
US (1) US20060286670A1 (https=)
EP (2) EP1492869B9 (https=)
JP (1) JP2005532803A (https=)
CN (1) CN100523176C (https=)
AT (2) ATE309331T1 (https=)
AU (1) AU2003250939B2 (https=)
BR (1) BR0312693A (https=)
CA (1) CA2492383A1 (https=)
DE (3) DE10231655A1 (https=)
DK (2) DK1492869T3 (https=)
ES (3) ES2304647T3 (https=)
IL (3) IL166021A0 (https=)
NO (1) NO20050719L (https=)
PT (2) PT1557462E (https=)
RU (1) RU2370535C2 (https=)
SI (3) SI1492869T1 (https=)
WO (1) WO2004007701A1 (https=)
ZA (2) ZA200501054B (https=)

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RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата

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DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
US20060188485A1 (en) * 2003-07-11 2006-08-24 Bernd Karl Friedrich Kremer Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical preparations
US8916147B2 (en) * 2005-08-24 2014-12-23 Yeda Research and Devolpment Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007043641A1 (ja) 2005-10-14 2007-04-19 Fukuoka University 膵島移植における移植膵島障害抑制剤
AR058135A1 (es) 2005-10-21 2008-01-23 Chugai Pharmaceutical Co Ltd Agentes para el tratamiento de cardiopatias
AR057582A1 (es) 2005-11-15 2007-12-05 Nat Hospital Organization Agentes para suprimir la induccion de linfocitos t citotoxicos
JP5754875B2 (ja) 2006-04-07 2015-07-29 国立大学法人大阪大学 筋再生促進剤
TWI438208B (zh) 2007-01-23 2014-05-21 中外製藥股份有限公司 抑制慢性排斥反應之藥劑
CA2728243C (en) 2008-06-05 2020-03-10 Chugai Seiyaku Kabushiki Kaisha Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer
US9738872B2 (en) * 2008-10-30 2017-08-22 Yeda Research And Development Co. Ltd. Anti third party central memory T cells, methods of producing same and use of same in transplantation and disease treatment
JP5436905B2 (ja) * 2009-03-26 2014-03-05 テルモ株式会社 シート状細胞培養物の製造方法
JP5667357B2 (ja) * 2009-11-30 2015-02-12 テルモ株式会社 シート状細胞培養物の製造方法
CN101812428A (zh) * 2010-04-26 2010-08-25 西北农林科技大学 一种乳腺上皮细胞的组织块种植方法
WO2011149051A1 (ja) 2010-05-28 2011-12-01 中外製薬株式会社 抗腫瘍t細胞応答増強剤
DE102011004335A1 (de) 2011-02-17 2012-08-23 Thomas Grammel Verfahren zur Herstellung eines Vakzins
JP5727665B2 (ja) * 2014-12-11 2015-06-03 テルモ株式会社 シート状細胞培養物の製造方法
JP5893786B2 (ja) * 2015-04-02 2016-03-23 テルモ株式会社 シート状細胞培養物の製造方法
US10724001B2 (en) * 2015-07-03 2020-07-28 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for obtaining regulatory T cells and uses thereof
JP6903866B2 (ja) * 2016-01-27 2021-07-14 国立大学法人 熊本大学 血液由来単球の増殖誘導方法
JP6140322B2 (ja) * 2016-02-24 2017-05-31 テルモ株式会社 シート状細胞培養物の製造方法
JP6490738B2 (ja) * 2017-04-28 2019-03-27 テルモ株式会社 シート状細胞培養物の製造方法
WO2018203545A1 (ja) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
JP7235249B2 (ja) 2017-10-20 2023-03-08 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
WO2019151418A1 (ja) 2018-01-31 2019-08-08 元一 加藤 Ｉｌ－６阻害剤を含有する喘息の治療剤
JP6657452B2 (ja) * 2019-02-27 2020-03-04 テルモ株式会社 シート状細胞培養物の製造方法
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JP7002497B2 (ja) * 2019-06-20 2022-01-20 テルモ株式会社 シート状細胞培養物の製造方法
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RU2508924C1 (ru) * 2013-02-21 2014-03-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ профилактики и лечения отторжения почечного трансплантата

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SI1557462T1 (sl) 2008-08-31
ATE309331T1 (de) 2005-11-15
ATE390480T1 (de) 2008-04-15
DE60320009D1 (de) 2008-05-08
EP1492869B1 (en) 2005-11-09
DE60302231T2 (de) 2006-07-20
AU2003250939A1 (en) 2004-02-02
US20060286670A1 (en) 2006-12-21
PT1644484E (pt) 2008-10-21
BR0312693A (pt) 2005-04-26
DE60302231D1 (de) 2005-12-15
ES2252696T3 (es) 2006-05-16
IL166021A (en) 2010-05-17
ZA200601074B (en) 2007-11-28
JP2005532803A (ja) 2005-11-04
WO2004007701A1 (en) 2004-01-22
IL172854A0 (en) 2006-06-11
EP1557462A3 (en) 2006-02-01
ES2304647T3 (es) 2008-10-16
SI1644484T1 (sl) 2009-02-28
CA2492383A1 (en) 2004-01-22
IL166021A0 (en) 2006-01-15
RU2005103627A (ru) 2005-08-27
ES2310711T3 (es) 2009-01-16
EP1492869B9 (en) 2006-05-24
DK1557462T3 (da) 2008-06-23
AU2003250939B2 (en) 2008-05-22
EP1492869A1 (en) 2005-01-05
CN1681918A (zh) 2005-10-12
CN100523176C (zh) 2009-08-05
PT1557462E (pt) 2008-06-18
ZA200501054B (en) 2005-08-30
NO20050719L (no) 2005-04-04
DE60320009T2 (de) 2009-05-20
HK1071586A1 (en) 2005-07-22
DE10231655A1 (de) 2004-02-26
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EP1557462A2 (en) 2005-07-27
DK1492869T3 (da) 2006-03-06

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