JP2005532803A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005532803A5 JP2005532803A5 JP2004520603A JP2004520603A JP2005532803A5 JP 2005532803 A5 JP2005532803 A5 JP 2005532803A5 JP 2004520603 A JP2004520603 A JP 2004520603A JP 2004520603 A JP2004520603 A JP 2004520603A JP 2005532803 A5 JP2005532803 A5 JP 2005532803A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- inducing
- medium
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 40
- 238000000034 method Methods 0.000 claims 23
- 230000001939 inductive effect Effects 0.000 claims 12
- 210000001616 monocyte Anatomy 0.000 claims 10
- 239000002609 medium Substances 0.000 claims 9
- 210000003289 regulatory T cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012894 fetal calf serum Substances 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10231655A DE10231655A1 (de) | 2002-07-12 | 2002-07-12 | Transplantat-Akzeptanz induzierende Zellen monozytären Ursprungs, sowie deren Herstellung und Verwendung |
| PCT/EP2003/007551 WO2004007701A1 (en) | 2002-07-12 | 2003-07-11 | Transplant acceptance inducing cells of monocytic origin and their preparation and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532803A JP2005532803A (ja) | 2005-11-04 |
| JP2005532803A5 true JP2005532803A5 (https=) | 2006-09-21 |
Family
ID=30009939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004520603A Pending JP2005532803A (ja) | 2002-07-12 | 2003-07-11 | 単球由来の移植片受容誘導細胞ならびにその調製およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060286670A1 (https=) |
| EP (2) | EP1492869B9 (https=) |
| JP (1) | JP2005532803A (https=) |
| CN (1) | CN100523176C (https=) |
| AT (2) | ATE309331T1 (https=) |
| AU (1) | AU2003250939B2 (https=) |
| BR (1) | BR0312693A (https=) |
| CA (1) | CA2492383A1 (https=) |
| DE (3) | DE10231655A1 (https=) |
| DK (2) | DK1557462T3 (https=) |
| ES (3) | ES2304647T3 (https=) |
| IL (3) | IL166021A0 (https=) |
| NO (1) | NO20050719L (https=) |
| PT (2) | PT1557462E (https=) |
| RU (1) | RU2370535C2 (https=) |
| SI (3) | SI1557462T1 (https=) |
| WO (1) | WO2004007701A1 (https=) |
| ZA (2) | ZA200501054B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10362002B4 (de) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adulte pluripotente Stammzellen |
| KR20060040671A (ko) * | 2003-07-11 | 2006-05-10 | 블라스티콘 바이오테크놀로지셰 포르슝 게엠베하 | 단구성 기원의 자기 유래 자가 관용성 유도 세포 및약제학적 제제에 있어서의 이의 용도 |
| EP1928479B1 (en) * | 2005-08-24 | 2016-06-08 | Yeda Research And Development Co., Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
| RU2446826C2 (ru) | 2005-10-14 | 2012-04-10 | Фукуока Юниверсити | Агенты для подавления повреждения трансплантированных островков после трансплантации островков |
| AR058135A1 (es) | 2005-10-21 | 2008-01-23 | Chugai Pharmaceutical Co Ltd | Agentes para el tratamiento de cardiopatias |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| EP2025346B1 (en) | 2006-04-07 | 2016-08-10 | Osaka University | Muscle regeneration promoter |
| WO2008090901A1 (ja) * | 2007-01-23 | 2008-07-31 | Shinshu University | 慢性拒絶反応抑制剤 |
| TWI528973B (zh) | 2008-06-05 | 2016-04-11 | Chugai Pharmaceutical Co Ltd | Nerve infiltration inhibitor |
| EP2365823B1 (en) * | 2008-10-30 | 2016-11-30 | Yeda Research And Development Company Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| JP5436905B2 (ja) * | 2009-03-26 | 2014-03-05 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP5667357B2 (ja) * | 2009-11-30 | 2015-02-12 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| CN101812428A (zh) * | 2010-04-26 | 2010-08-25 | 西北农林科技大学 | 一种乳腺上皮细胞的组织块种植方法 |
| JP6051049B2 (ja) | 2010-05-28 | 2016-12-21 | 中外製薬株式会社 | 抗腫瘍ｔ細胞応答増強剤 |
| DE102011004335A1 (de) | 2011-02-17 | 2012-08-23 | Thomas Grammel | Verfahren zur Herstellung eines Vakzins |
| RU2508924C1 (ru) * | 2013-02-21 | 2014-03-10 | Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" | Способ профилактики и лечения отторжения почечного трансплантата |
| JP5727665B2 (ja) * | 2014-12-11 | 2015-06-03 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP5893786B2 (ja) * | 2015-04-02 | 2016-03-23 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| KR102769850B1 (ko) * | 2015-07-03 | 2025-02-20 | 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 | 조절 t 세포를 수득하는 방법 및 이의 용도 |
| JP6903866B2 (ja) * | 2016-01-27 | 2021-07-14 | 国立大学法人 熊本大学 | 血液由来単球の増殖誘導方法 |
| JP6140322B2 (ja) * | 2016-02-24 | 2017-05-31 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP6490738B2 (ja) * | 2017-04-28 | 2019-03-27 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| EP3698808B1 (en) | 2017-10-20 | 2025-01-01 | Hyogo College Of Medicine | Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Ｉｌ－６阻害剤を含有する喘息の治療剤 |
| JP6657452B2 (ja) * | 2019-02-27 | 2020-03-04 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| IL287220B2 (en) | 2019-04-17 | 2026-03-01 | Univ Hiroshima | A therapeutic agent for urological cancer characterized by administering an IL-6 inhibitor in combination with a CCR2 inhibitor |
| JP7002497B2 (ja) * | 2019-06-20 | 2022-01-20 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| JP6872051B2 (ja) * | 2020-02-05 | 2021-05-19 | テルモ株式会社 | シート状細胞培養物の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766920A (en) * | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US9068164B1 (en) * | 1995-02-02 | 2015-06-30 | Tristem Trading (Cyprus) Limited | Method of preparing an undifferentiated cell |
| US7410773B2 (en) * | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| US7112440B2 (en) * | 1995-02-02 | 2006-09-26 | Ghazi Jaswinder Dhoot | Method of increasing the relative number of CD45 low cells in a cell population |
| GB9502022D0 (en) * | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
| JP3926842B2 (ja) * | 1995-03-08 | 2007-06-06 | ザ・スクリプス・リサーチ・インステイチユート | 抗原提示系およびｔ−細胞の活性化方法 |
| WO1998053048A1 (en) * | 1997-05-21 | 1998-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells |
| NL1017973C2 (nl) * | 2000-05-10 | 2002-11-08 | Tristem Trading Cyprus Ltd | Inrichting. |
| DE60108661T2 (de) * | 2000-11-14 | 2006-01-05 | Université Libre de Bruxelles | Herstellung und verwendung von dendritischen zellen |
| TWI288779B (en) * | 2002-03-28 | 2007-10-21 | Blasticon Biotech Forschung | Dedifferentiated, programmable stem cells of monocytic origin, and their production and use |
-
2002
- 2002-07-12 DE DE10231655A patent/DE10231655A1/de not_active Ceased
-
2003
- 2003-07-11 IL IL16602103A patent/IL166021A0/xx unknown
- 2003-07-11 WO PCT/EP2003/007551 patent/WO2004007701A1/en not_active Ceased
- 2003-07-11 JP JP2004520603A patent/JP2005532803A/ja active Pending
- 2003-07-11 AT AT03763823T patent/ATE309331T1/de not_active IP Right Cessation
- 2003-07-11 SI SI200331240T patent/SI1557462T1/sl unknown
- 2003-07-11 DK DK05009317T patent/DK1557462T3/da active
- 2003-07-11 ES ES05009317T patent/ES2304647T3/es not_active Expired - Lifetime
- 2003-07-11 SI SI200330146T patent/SI1492869T1/sl unknown
- 2003-07-11 BR BR0312693-5A patent/BR0312693A/pt not_active IP Right Cessation
- 2003-07-11 CA CA002492383A patent/CA2492383A1/en not_active Abandoned
- 2003-07-11 AU AU2003250939A patent/AU2003250939B2/en not_active Ceased
- 2003-07-11 RU RU2005103627/13A patent/RU2370535C2/ru not_active IP Right Cessation
- 2003-07-11 EP EP03763823A patent/EP1492869B9/en not_active Expired - Lifetime
- 2003-07-11 ES ES03763823T patent/ES2252696T3/es not_active Expired - Lifetime
- 2003-07-11 CN CNB038215748A patent/CN100523176C/zh not_active Expired - Fee Related
- 2003-07-11 DE DE60320009T patent/DE60320009T2/de not_active Expired - Fee Related
- 2003-07-11 DE DE60302231T patent/DE60302231T2/de not_active Expired - Fee Related
- 2003-07-11 PT PT05009317T patent/PT1557462E/pt unknown
- 2003-07-11 DK DK03763823T patent/DK1492869T3/da active
- 2003-07-11 EP EP05009317A patent/EP1557462B1/en not_active Expired - Lifetime
- 2003-07-11 AT AT05009317T patent/ATE390480T1/de not_active IP Right Cessation
- 2003-07-11 US US10/520,931 patent/US20060286670A1/en not_active Abandoned
-
2004
- 2004-01-09 PT PT04701001T patent/PT1644484E/pt unknown
- 2004-01-09 SI SI200430965T patent/SI1644484T1/sl unknown
- 2004-01-09 ES ES04701001T patent/ES2310711T3/es not_active Expired - Lifetime
- 2004-12-28 IL IL166021A patent/IL166021A/en not_active IP Right Cessation
-
2005
- 2005-02-04 ZA ZA200501054A patent/ZA200501054B/xx unknown
- 2005-02-10 NO NO20050719A patent/NO20050719L/no not_active Application Discontinuation
- 2005-12-27 IL IL172854A patent/IL172854A0/en unknown
-
2006
- 2006-02-07 ZA ZA200601074A patent/ZA200601074B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005532803A5 (https=) | ||
| RU2005103627A (ru) | Индуцирующие воспринимаемость трансплантата клетки моноцитарного происхождения, их получение и применение | |
| US20230399615A1 (en) | Icos critically regulates the expansion and function of inflammatory human th17 cells | |
| Lombardi et al. | CD8α+ β− and CD8α+ β+ plasmacytoid dendritic cells induce Foxp3+ regulatory T cells and prevent the induction of airway hyper-reactivity | |
| JP2023052777A5 (https=) | ||
| CN107109364A (zh) | 缺氧与常氧交替条件下的骨髓浸润淋巴细胞的激活 | |
| CA2448599A1 (en) | Maturation of antigen-presenting cells using activated t cells | |
| Velardi et al. | Lymphokine production by T-cell clones after human bone marrow transplantation | |
| CN113943704B (zh) | 一种肿瘤新生抗原特异性t细胞的制备方法 | |
| Vandekerckhove et al. | Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse | |
| US20040197903A1 (en) | Method for induction of proliferation of natural killer cells by dendritic cells cultured with GM-CSF and IL-15 | |
| US20210087530A1 (en) | Compositions and methods for culturing and expanding cells | |
| JP2003511064A (ja) | ヒト末梢血単核細胞由来の樹状細胞の産生および特徴付け | |
| Pancholi et al. | Dendritic cells efficiently immunoselect mycobacterial-reactive T cells in human blood, including clonable antigen-reactive precursors | |
| Kalinski et al. | Generation of stable Th1/CTL-, Th2-, and Th17-inducing human dendritic cells | |
| JP2648318B2 (ja) | ヒトモノクローナル抗体製造法、およびそのキット | |
| JPH11506902A (ja) | イン・ビトロｔリンパ球生成系 | |
| EP1644484B1 (en) | Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations | |
| ES2472452B1 (es) | Procedimiento para la selección de linfocitos T antígeno-específicos mediante la identificación de dobletes. | |
| Mingari et al. | Lymphokine production by T-cell clones after human bone marrow | |
| CN118222483A (zh) | 免疫类器官的培养方法及应用 | |
| Baum | The Role of Interleukin-21 in the Chronic Rejection of Transplant Allografts and the Development of Type 1 Diabetes | |
| CZ20160U1 (cs) | Individuální imunoterapeutická protinádorová vakcína | |
| Carter et al. | Sam Schatten, Jeffrey A. Drebin, Muneo Takaoki | |
| Ajduk et al. | Detection of regulatory T cells in human blood |