JP2005531563A5 - - Google Patents

Info

Publication number

JP2005531563A5

JP2005531563A5 JP2004505374A JP2004505374A JP2005531563A5 JP 2005531563 A5 JP2005531563 A5 JP 2005531563A5 JP 2004505374 A JP2004505374 A JP 2004505374A JP 2004505374 A JP2004505374 A JP 2004505374A JP 2005531563 A5 JP2005531563 A5 JP 2005531563A5

Authority

JP

Japan

Prior art keywords

formula

compound

optionally substituted

group

iii

Prior art date

2003-05-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 28
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 125000000623 heterocyclic group Chemical group 0.000 claims 7
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 229910052799 carbon Inorganic materials 0.000 claims 6
• 229910052757 nitrogen Inorganic materials 0.000 claims 6
• 229910052760 oxygen Inorganic materials 0.000 claims 6
• 230000002062 proliferating effect Effects 0.000 claims 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 239000002246 antineoplastic agent Substances 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 5
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 4
• 229920006395 saturated elastomer Polymers 0.000 claims 4
• 150000001408 amides Chemical class 0.000 claims 3
• 125000004093 cyano group Chemical group *C#N 0.000 claims 3
• 125000001475 halogen functional group Chemical group 0.000 claims 3
• 125000005647 linker group Chemical group 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• 229940002612 prodrug Drugs 0.000 claims 3
• 239000000651 prodrug Substances 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• 150000001204 N-oxides Chemical class 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 125000002947 alkylene group Chemical group 0.000 claims 2
• 150000001412 amines Chemical class 0.000 claims 2
• 125000002431 aminoalkoxy group Chemical group 0.000 claims 2
• 125000004103 aminoalkyl group Chemical group 0.000 claims 2
• 229940034982 antineoplastic agent Drugs 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 210000000481 breast Anatomy 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 125000002837 carbocyclic group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 230000004568 DNA-binding Effects 0.000 claims 1
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
• 239000005977 Ethylene Substances 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 241000277331 Salmonidae Species 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 125000004450 alkenylene group Chemical group 0.000 claims 1
• 125000004419 alkynylene group Chemical group 0.000 claims 1
• 230000000118 anti-neoplastic effect Effects 0.000 claims 1
• 230000000259 anti-tumor effect Effects 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 208000035269 cancer or benign tumor Diseases 0.000 claims 1
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 230000001413 cellular effect Effects 0.000 claims 1
• 239000003638 chemical reducing agent Substances 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002124 endocrine Effects 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 150000004820 halides Chemical class 0.000 claims 1
• 210000000777 hematopoietic system Anatomy 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 230000001926 lymphatic effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• -1 methoxy-substituted phenyl Chemical group 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• CSMRPIFORJZYCJ-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxobenzo[b][1,6]naphthyridine-4-carboxamide Chemical compound C1=CC(C)=C2N=C3C(C(=O)NCCN(C)C)=CN(C)C(=O)C3=CC2=C1 CSMRPIFORJZYCJ-UHFFFAOYSA-N 0.000 claims 1
• 230000001537 neural effect Effects 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 230000002611 ovarian Effects 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
• 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
• 210000002307 prostate Anatomy 0.000 claims 1
• 210000003491 skin Anatomy 0.000 claims 1
• 210000001550 testis Anatomy 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 210000004291 uterus Anatomy 0.000 claims 1