JP2025160318A5 - - Google Patents
Info
- Publication number
- JP2025160318A5 JP2025160318A5 JP2025123923A JP2025123923A JP2025160318A5 JP 2025160318 A5 JP2025160318 A5 JP 2025160318A5 JP 2025123923 A JP2025123923 A JP 2025123923A JP 2025123923 A JP2025123923 A JP 2025123923A JP 2025160318 A5 JP2025160318 A5 JP 2025160318A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutically acceptable
- polymorph
- stereoisomer
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110159956.6 | 2021-02-05 | ||
| CN202110159956 | 2021-02-05 | ||
| CN202110533304.4 | 2021-05-17 | ||
| CN202110533304 | 2021-05-17 | ||
| CN202110718245 | 2021-06-28 | ||
| CN202110718245.8 | 2021-06-28 | ||
| CN202110936768.X | 2021-08-16 | ||
| CN202110936768 | 2021-08-16 | ||
| CN202111355330.9 | 2021-11-16 | ||
| CN202111355330 | 2021-11-16 | ||
| JP2023544762A JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
| PCT/CN2022/074328 WO2022166762A1 (zh) | 2021-02-05 | 2022-01-27 | 喜树碱类化合物及其制备方法和应用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Division JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025160318A JP2025160318A (ja) | 2025-10-22 |
| JP2025160318A5 true JP2025160318A5 (enExample) | 2026-02-24 |
Family
ID=82741966
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Active JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
| JP2025123923A Pending JP2025160318A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
| JP2025123921A Pending JP2025160317A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023544762A Active JP7821188B2 (ja) | 2021-02-05 | 2022-01-27 | カンプトテシン化合物、その調製方法、及びその適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025123921A Pending JP2025160317A (ja) | 2021-02-05 | 2025-07-24 | カンプトテシン化合物、その調製方法、及びその適用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20240158410A1 (enExample) |
| EP (3) | EP4628165A3 (enExample) |
| JP (3) | JP7821188B2 (enExample) |
| KR (3) | KR20230142710A (enExample) |
| CN (3) | CN116829561A (enExample) |
| AU (1) | AU2022216696A1 (enExample) |
| CA (1) | CA3209426A1 (enExample) |
| MX (1) | MX2023008716A (enExample) |
| WO (1) | WO2022166762A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL301793A (en) | 2020-09-30 | 2023-05-01 | Duality Biologics Suzhou Co Ltd | Anticancer compound and method for its preparation and use |
| EP4227310A4 (en) * | 2020-10-12 | 2024-11-06 | Sichuan Baili Pharmaceutical Co. Ltd. | CAMPTOTHECIN DERIVATIVE AND LIGAND-DRUG CONJUGATE THEREOF |
| KR20230142710A (ko) * | 2021-02-05 | 2023-10-11 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| AU2022315277A1 (en) | 2021-07-19 | 2024-01-18 | Immunome, Inc. | Immunoconjugates and methods |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| WO2023020605A1 (zh) * | 2021-08-19 | 2023-02-23 | 江苏先声药业有限公司 | 喜树碱衍生物、其药物组合物及其应用 |
| US20250059143A1 (en) * | 2021-10-26 | 2025-02-20 | Shanghai Best-Link Bioscience, Llc | Camptothecin derivative intermediate, and preparation method therefor and use thereof |
| KR20240101682A9 (ko) | 2021-11-15 | 2025-12-10 | 시스트이뮨, 인코포레이티드 | 이중특이 항체-캄프토테신 약물 접합체 및 이의 약학적 용도 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| CN118696048A (zh) * | 2022-05-09 | 2024-09-24 | 同宜医药（苏州）有限公司 | 一种喜树碱衍生物，基于其的抗体-药物偶联物和药物组合物，及其应用 |
| WO2023216956A1 (zh) | 2022-05-13 | 2023-11-16 | 四川科伦博泰生物医药股份有限公司 | 喜树碱类化合物及其制备方法和应用 |
| IL318296A (en) | 2022-07-15 | 2025-03-01 | Genequantum Healthcare Suzhou Co Ltd | Anti-TROP2 antibody and its conjugate |
| JP2025524985A (ja) * | 2022-07-26 | 2025-08-01 | イムノーム，インク． | イムノコンジュゲート及び方法 |
| GEAP202516720A (en) * | 2022-09-02 | 2025-07-10 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
| CN121064210A (zh) * | 2022-09-09 | 2025-12-05 | 杭州爱科瑞思生物医药有限公司 | 喜树碱-7-乙基胺衍生物及其制备方法和应用 |
| CN119948031A (zh) * | 2022-09-30 | 2025-05-06 | 广州百济神州生物制药有限公司 | 依沙替康类似物的配体-药物缀合物以及其医疗用途 |
| AU2023359114A1 (en) | 2022-10-09 | 2025-04-24 | LaNova Medicines Limited | Compounds, compositions and methods |
| IL320396A (en) * | 2022-10-25 | 2025-06-01 | Merck Sharp & Dohme Llc | Charge-linkers of anti-drug conjugates derived from extacan, pharmaceutical compositions, and uses thereof |
| KR20250112249A (ko) * | 2022-11-22 | 2025-07-23 | 키메드 바이오사이언시스 (청두) 컴퍼니 리미티드 | 융합된 고리 화합물, 이의 접합체 및 이의 용도 |
| WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| CN116870187A (zh) * | 2022-12-29 | 2023-10-13 | 杭州爱科瑞思生物医药有限公司 | N-氧杂环烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116712563A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | N-卤代烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116712562A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | N-叠氮烷基取代的喜树碱衍生物的抗体偶联药物 |
| WO2024158996A2 (en) * | 2023-01-25 | 2024-08-02 | Zeno Management, Inc. | Immunoconjugates and methods |
| WO2024175069A1 (zh) * | 2023-02-23 | 2024-08-29 | 一线医药（杭州）有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| TW202502774A (zh) * | 2023-03-01 | 2025-01-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種茚并［１，２－ｂ］喹啉－１０，１３－二酮衍生物的製備方法 |
| AU2024243250A1 (en) * | 2023-04-07 | 2025-10-16 | Changchun Genescience Pharmaceutical Co., Ltd. | Camptothecin derivative, and pharmaceutical composition, preparation method therefor and use thereof |
| CN116478051B (zh) * | 2023-04-13 | 2024-06-21 | 戊言医药科技（上海）有限公司 | 一种贝洛替康盐酸盐及其关键中间体的制备方法 |
| WO2024227432A1 (zh) * | 2023-04-30 | 2024-11-07 | 泰诚思(上海)生物医药有限公司 | 喜树碱衍生物、其制备方法及用途、抗体药物偶联物及其应用 |
| WO2024227439A1 (zh) * | 2023-05-04 | 2024-11-07 | 四川科伦博泰生物医药股份有限公司 | 具有靶向作用的偶联物及其制备方法和用途 |
| CN117417346B (zh) * | 2023-09-11 | 2025-07-25 | 常州合全药业有限公司 | 喜树碱类衍生物的制备方法 |
| KR20250059577A (ko) | 2023-10-24 | 2025-05-07 | 삼성디스플레이 주식회사 | 표시 장치 |
| CN120000805A (zh) * | 2023-11-15 | 2025-05-16 | 四川科伦博泰生物医药股份有限公司 | 靶向EGFR/c-MET的抗体-药物缀合物及其制备方法和用途 |
| CN120058720A (zh) * | 2024-01-08 | 2025-05-30 | 杭州爱科瑞思生物医药有限公司 | 7-含羟胺结构取代的烷基喜树碱衍生物的制备及其应用 |
| CN120058721A (zh) * | 2024-01-08 | 2025-05-30 | 杭州爱科瑞思生物医药有限公司 | 7-氟烷基取代的喜树碱衍生物的制备及其应用 |
| WO2025162049A1 (zh) * | 2024-02-02 | 2025-08-07 | 长春金赛药业有限责任公司 | 卤代烯烃类喜树碱衍生物、药物组合物及其制备方法和应用 |
| WO2025242090A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技（成都）有限公司 | 喜树碱衍生物及其中间体的制备方法 |
| WO2026046398A1 (en) * | 2024-08-30 | 2026-03-05 | Hansoh Bio Llc | Novel camptothecin derivative and conjugate thereof, preparation method therefor and application thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| ES2184882T3 (es) * | 1995-06-21 | 2003-04-16 | Sod Conseils Rech Applic | Nuevos analogos de la camptotecina, procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. |
| CA2192725C (en) * | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| CN100408582C (zh) * | 2004-02-12 | 2008-08-06 | 中国人民解放军第二军医大学 | 高喜树碱类化合物及其制备方法和用途 |
| WO2017176648A1 (en) * | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| WO2019011170A1 (zh) * | 2017-07-14 | 2019-01-17 | 四川科伦博泰生物医药股份有限公司 | 噁二唑类衍生物、其制备方法及其在医药上的应用 |
| EP4667495A3 (en) * | 2017-12-15 | 2026-03-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive molecule conjugate, preparation method and use thereof |
| IL277748B2 (en) * | 2018-04-06 | 2024-07-01 | Seagen Inc | Camptothecin peptide conjugates |
| TW202519270A (zh) | 2018-06-07 | 2025-05-16 | 美商思進公司 | 喜樹鹼結合物 |
| AU2019349207B2 (en) * | 2018-09-26 | 2026-01-08 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof |
| JP7408646B2 (ja) * | 2018-09-30 | 2024-01-05 | ジエンス ハンソー ファーマスーティカル グループ カンパニー リミテッド | 抗－ｂ７ｈ３抗体－エキサテカンアナログコンジュゲート及びその医薬用途 |
| CN118221763A (zh) * | 2019-03-29 | 2024-06-21 | 免疫医疗有限公司 | 化合物及其缀合物 |
| EP3958977B1 (en) | 2019-04-26 | 2023-09-13 | ImmunoGen, Inc. | Camptothecin derivatives |
| CN111689980A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种喜树碱药物及其抗体偶联物 |
| CN110357897A (zh) * | 2019-07-26 | 2019-10-22 | 上海健康医学院 | 一种具有抗肿瘤活性的喜树碱衍生物及其制备方法和应用 |
| JP7467610B2 (ja) * | 2019-09-18 | 2024-04-15 | バイリ－バイオ（チェンドゥ）ファーマスーティカル シーオー．，エルティーディー． | カンプトテシン誘導体及びその複合体 |
| US20230101735A1 (en) * | 2020-01-22 | 2023-03-30 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-trop-2 antidody-exatecan analog conjugate and medical use thereof |
| KR20230022211A (ko) * | 2020-06-08 | 2023-02-14 | 바이리-바이오 (청두) 파마슈티칼 컴퍼니, 리미티드 | 고안정성 친수성 연결 단위를 갖는 캄프토테신 약물 및 이의 접합체 |
| CN113943310A (zh) * | 2020-10-12 | 2022-01-18 | 四川百利药业有限责任公司 | 一种氘代的喜树碱衍生物及其抗体药物偶联物 |
| KR20230142710A (ko) * | 2021-02-05 | 2023-10-11 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| KR20240016249A (ko) * | 2021-06-02 | 2024-02-06 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 항체 약물 접합체, 이의 제조 방법, 및 이의 용도 |
| WO2022253033A1 (zh) * | 2021-06-02 | 2022-12-08 | 四川科伦博泰生物医药股份有限公司 | 一类化学偶联连接子及其用途 |
| US11814394B2 (en) * | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| CN117567487A (zh) * | 2023-11-27 | 2024-02-20 | 金宏气体股份有限公司 | 双核Ag(I)配合物晶体、制备方法、负载物、装置及应用 |
-
2022
- 2022-01-27 KR KR1020237025527A patent/KR20230142710A/ko active Pending
- 2022-01-27 US US18/262,821 patent/US20240158410A1/en active Pending
- 2022-01-27 WO PCT/CN2022/074328 patent/WO2022166762A1/zh not_active Ceased
- 2022-01-27 EP EP25191607.8A patent/EP4628165A3/en active Pending
- 2022-01-27 JP JP2023544762A patent/JP7821188B2/ja active Active
- 2022-01-27 CN CN202280008418.XA patent/CN116829561A/zh active Pending
- 2022-01-27 CA CA3209426A patent/CA3209426A1/en active Pending
- 2022-01-27 CN CN202510232225.8A patent/CN120058723A/zh active Pending
- 2022-01-27 CN CN202311518671.2A patent/CN117567478B/zh active Active
- 2022-01-27 KR KR1020257024905A patent/KR20250120438A/ko active Pending
- 2022-01-27 MX MX2023008716A patent/MX2023008716A/es unknown
- 2022-01-27 KR KR1020257024904A patent/KR20250119655A/ko active Pending
- 2022-01-27 EP EP25191605.2A patent/EP4613335A3/en active Pending
- 2022-01-27 AU AU2022216696A patent/AU2022216696A1/en active Pending
- 2022-01-27 EP EP22749041.4A patent/EP4289851A4/en active Pending
-
2025
- 2025-07-24 JP JP2025123923A patent/JP2025160318A/ja active Pending
- 2025-07-24 JP JP2025123921A patent/JP2025160317A/ja active Pending
- 2025-07-24 US US19/279,242 patent/US20250346606A1/en active Pending
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