JP2005529082A - ９−デオキソ−９ａ−アザ−９ａ−メチル−９ａ−ホモエリスロマイシンＡ等構造擬似多形 - Google Patents

９−デオキソ−９ａ−アザ−９ａ−メチル−９ａ−ホモエリスロマイシンＡ等構造擬似多形 Download PDF

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Publication number
JP2005529082A
JP2005529082A JP2003575884A JP2003575884A JP2005529082A JP 2005529082 A JP2005529082 A JP 2005529082A JP 2003575884 A JP2003575884 A JP 2003575884A JP 2003575884 A JP2003575884 A JP 2003575884A JP 2005529082 A JP2005529082 A JP 2005529082A
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JP
Japan
Prior art keywords
deoxo
aza
homoerythromycin
methyl
pseudopolymorph
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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JP2003575884A
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English (en)
Japanese (ja)
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JP2005529082A5 (https=
Inventor
デュミック，ミリエンコ
ヴィンコヴィッチ，ムラデン
オレシック，マリナ
メストロヴィッチ，エルネスト
ダニロフスキー，アレクサンダー
ダムボヴィッチ，アロイズ
クネツェヴィッチ，ズドラフカ
ラザレフスキー，ゴリアナ
シンシック，ドミニク
フィリック，ダルコ
ラザリック，カティカ
ブカール，デヤン−クレシミール
Original Assignee
プリバ−イストラジヴァッキ・インスティテュート・ディーオーオー
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Application filed by プリバ−イストラジヴァッキ・インスティテュート・ディーオーオー filed Critical プリバ−イストラジヴァッキ・インスティテュート・ディーオーオー
Publication of JP2005529082A publication Critical patent/JP2005529082A/ja
Publication of JP2005529082A5 publication Critical patent/JP2005529082A5/ja
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Instructional Devices (AREA)
  • Finger-Pressure Massage (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2003575884A 2002-03-18 2003-03-18 ９−デオキソ−９ａ−アザ−９ａ−メチル−９ａ−ホモエリスロマイシンＡ等構造擬似多形 Abandoned JP2005529082A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
JP2005529082A true JP2005529082A (ja) 2005-09-29
JP2005529082A5 JP2005529082A5 (https=) 2006-04-06

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003575884A Abandoned JP2005529082A (ja) 2002-03-18 2003-03-18 ９−デオキソ−９ａ−アザ−９ａ−メチル−９ａ−ホモエリスロマイシンＡ等構造擬似多形

Country Status (23)

Country Link
US (1) US7569549B2 (https=)
EP (2) EP1627883A1 (https=)
JP (1) JP2005529082A (https=)
KR (1) KR20050002872A (https=)
CN (1) CN1642966A (https=)
AT (1) ATE440104T1 (https=)
AU (1) AU2003215779A1 (https=)
BG (1) BG108874A (https=)
BR (1) BR0308644A (https=)
CA (1) CA2479211A1 (https=)
DE (1) DE60328872D1 (https=)
EA (1) EA200401217A1 (https=)
ES (1) ES2331733T3 (https=)
HR (2) HRP20020231A2 (https=)
IL (1) IL163836A0 (https=)
IS (1) IS7449A (https=)
MX (1) MXPA04009009A (https=)
NO (1) NO20044341L (https=)
NZ (1) NZ535477A (https=)
PL (1) PL372468A1 (https=)
RS (1) RS82504A (https=)
TN (1) TNSN04166A1 (https=)
WO (1) WO2003077830A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1648473B1 (en) 2003-07-24 2009-01-28 PLIVA HRVATSKA d.o.o. Single dose fast dissolving azithromycin
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CA2549225A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
ATE399536T1 (de) * 2003-12-04 2008-07-15 Pfizer Prod Inc Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
BRPI0416534A (pt) 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
EP1694304A2 (en) * 2003-12-04 2006-08-30 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
EP0699207B1 (en) 1993-05-19 1997-06-25 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
AU768219B2 (en) * 1998-11-30 2003-12-04 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
ES2267549T3 (es) * 1999-06-29 2007-03-16 Sandoz Ag Procedimiento para la produccion de azitromicina.
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
CA2396426A1 (en) * 2000-01-04 2001-07-12 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
WO2002015842A2 (en) * 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
EE05200B1 (et) * 2000-11-27 2009-08-17 Biochemie S.A. Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
DK1390377T3 (da) 2001-05-22 2006-06-19 Pfizer Prod Inc Ny krystalform af azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
PL371259A1 (pl) 2001-12-21 2005-06-13 Pfizer Products Inc. Bezpośrednio sprasowywalne preparaty azytromycyny
AU2002353316A1 (en) 2001-12-21 2003-07-09 Pfizer Products Inc. Methods for wet granulating azithromycin
BR0307331A (pt) 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
TNSN04166A1 (en) 2007-03-12
PL372468A1 (en) 2005-07-25
IS7449A (is) 2004-09-16
CN1642966A (zh) 2005-07-20
EP1485393B1 (en) 2009-08-19
ES2331733T3 (es) 2010-01-14
HRP20020231A2 (en) 2003-12-31
BR0308644A (pt) 2005-01-25
EP1627883A1 (en) 2006-02-22
US7569549B2 (en) 2009-08-04
KR20050002872A (ko) 2005-01-10
MXPA04009009A (es) 2005-06-17
NO20044341L (no) 2004-11-23
ATE440104T1 (de) 2009-09-15
CA2479211A1 (en) 2003-09-25
RS82504A (sr) 2006-12-15
AU2003215779A1 (en) 2003-09-29
IL163836A0 (en) 2005-12-18
US20040014951A1 (en) 2004-01-22
EP1485393A2 (en) 2004-12-15
HRP20040858A2 (en) 2005-06-30
WO2003077830A3 (en) 2004-05-13
NZ535477A (en) 2006-11-30
EA200401217A1 (ru) 2005-02-24
BG108874A (en) 2005-12-30
DE60328872D1 (en) 2009-10-01
WO2003077830A2 (en) 2003-09-25

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