BR0308644A - Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos - Google Patents

Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos

Info

Publication number
BR0308644A
BR0308644A BR0308644-5A BR0308644A BR0308644A BR 0308644 A BR0308644 A BR 0308644A BR 0308644 A BR0308644 A BR 0308644A BR 0308644 A BR0308644 A BR 0308644A
Authority
BR
Brazil
Prior art keywords
deoxo
aza
methylhomoerythromromine
pseudopolymorph
isostructural pseudopolymorphs
Prior art date
Application number
BR0308644-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominik Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Original Assignee
Pliva Istrazivacki Inst D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Inst D O O filed Critical Pliva Istrazivacki Inst D O O
Publication of BR0308644A publication Critical patent/BR0308644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)
BR0308644-5A 2002-03-18 2003-03-18 Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos BR0308644A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
BR0308644A true BR0308644A (pt) 2005-01-25

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308644-5A BR0308644A (pt) 2002-03-18 2003-03-18 Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos

Country Status (23)

Country Link
US (1) US7569549B2 (https=)
EP (2) EP1485393B1 (https=)
JP (1) JP2005529082A (https=)
KR (1) KR20050002872A (https=)
CN (1) CN1642966A (https=)
AT (1) ATE440104T1 (https=)
AU (1) AU2003215779A1 (https=)
BG (1) BG108874A (https=)
BR (1) BR0308644A (https=)
CA (1) CA2479211A1 (https=)
DE (1) DE60328872D1 (https=)
EA (1) EA200401217A1 (https=)
ES (1) ES2331733T3 (https=)
HR (2) HRP20020231A2 (https=)
IL (1) IL163836A0 (https=)
IS (1) IS7449A (https=)
MX (1) MXPA04009009A (https=)
NO (1) NO20044341L (https=)
NZ (1) NZ535477A (https=)
PL (1) PL372468A1 (https=)
RS (1) RS82504A (https=)
TN (1) TNSN04166A1 (https=)
WO (1) WO2003077830A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
ATE421882T1 (de) * 2003-07-24 2009-02-15 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
ES2600577T3 (es) * 2003-12-04 2017-02-09 Bend Research, Inc. Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
KR100844628B1 (ko) * 2003-12-04 2008-07-07 화이자 프로덕츠 인크. 제약상 다입자의 제조 방법
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5686587A (en) 1993-05-19 1997-11-11 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
SI20639A (sl) * 1998-11-30 2002-02-28 Teva Pharmaceutical Industries Ltd. Etanolat azitromicina, postopek za njegovo pripravo in njegovi farmacevtski sestavki
AU5820400A (en) * 1999-06-29 2001-01-31 Biochemie S.A. Macrolides
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de) * 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
JP2004506664A (ja) * 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
HRP20030430B1 (hr) 2000-11-27 2011-11-30 Biochemie S.A. Makrolidni solvati
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
ES2258142T3 (es) * 2001-05-22 2006-08-16 Pfizer Products Inc. Nueva forma cristalina.
PL371259A1 (pl) * 2001-12-21 2005-06-13 Pfizer Products Inc. Bezpośrednio sprasowywalne preparaty azytromycyny
NZ532063A (en) * 2001-12-21 2006-03-31 Pfizer Prod Inc Methods for wet granulating azithromycin
RU2283092C2 (ru) 2002-02-01 2006-09-10 Пфайзер Продактс Инк. Сухие гранулированные композиции азитромицина
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
TNSN04166A1 (en) 2007-03-12
BG108874A (en) 2005-12-30
EP1485393A2 (en) 2004-12-15
IS7449A (is) 2004-09-16
WO2003077830A2 (en) 2003-09-25
ATE440104T1 (de) 2009-09-15
HRP20040858A2 (en) 2005-06-30
CA2479211A1 (en) 2003-09-25
US20040014951A1 (en) 2004-01-22
KR20050002872A (ko) 2005-01-10
WO2003077830A3 (en) 2004-05-13
NZ535477A (en) 2006-11-30
JP2005529082A (ja) 2005-09-29
EP1627883A1 (en) 2006-02-22
EA200401217A1 (ru) 2005-02-24
NO20044341L (no) 2004-11-23
DE60328872D1 (en) 2009-10-01
AU2003215779A1 (en) 2003-09-29
HRP20020231A2 (en) 2003-12-31
RS82504A (sr) 2006-12-15
PL372468A1 (en) 2005-07-25
US7569549B2 (en) 2009-08-04
CN1642966A (zh) 2005-07-20
IL163836A0 (en) 2005-12-18
ES2331733T3 (es) 2010-01-14
EP1485393B1 (en) 2009-08-19
MXPA04009009A (es) 2005-06-17

Similar Documents

Publication Publication Date Title
BR0308644A (pt) Pseudopolimorfos isoestruturais de 9-deoxo-9a -aza-9a-metil-homoeritrotromicina a e seus usos
BR0210205A (pt) Antiinfecciosos
IT1313610B1 (it) Processo per la preparazione di formulazioni acquose per uso oftalmico
NO2012012I2 (no) Pasireotide (som diaspartat salt). Det kjemiske navnet er cyclo[(4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-)
BR0113643A (pt) Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos
WO2002100455A3 (en) Use of ozone for the prevention of infection caused by medical devices
NO20042112L (no) Anvendelse av glycosider av mono- og diacylglycerol som anti-inflammatoriske midler.
EP3738591A3 (en) Novel antibacterial agents
CU23210A3 (es) NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS
EP1163910A4 (en) PREVENTIVE / MEDICINE AGAINST INTERSTITIAL PNEUMONIA AND PULMONAL FIBROSIS
EA200300948A1 (ru) Водная композиция амфотерицина b
MXPA03002911A (es) Compuestos quimicos.
AR022791A1 (es) Composiciones y metodos para el tratamiento de la infeccion por estafilococo mientras que suprimen la formacion de cepas resistentes al antibiotico
BR0111780A (pt) Agente herbicida
WO2003053971A8 (en) Pyridoquinoxaline antivirals
SE9904765D0 (sv) Pharmaceutically-useful compounds
DK0866791T3 (da) Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
BR0208131A (pt) Derivados biguanida
TW200609228A (en) Substituted n-acyl-2-aminothiazoles
NO20081103L (no) 9-Aminoklarbonylsubstituerte derivater av glycylcykliner
TW200503675A (en) Combination of phenylcarboxamides with blockers of the Ikr channel and their use for the treatment of atrial arrhythmias
DE60318033D1 (de) Biguanid-derivate und deren verwendung als antidiabetika
TR200103659T2 (tr) Kardiyak aritmaların tedavisinde faydalı yeni bispidin bileşikleri.
WO2002057286A3 (en) 9-amino erythromycin derivatives with antibacterial activity
AU2003282256A1 (en) Substituted 9a-n-{n'-(4-(sulfonyl)phenyl)carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin a and 5-0-desosaminyl--9-deoxo-9-di-hydro-9a-aza-9a-homoerithronolide a

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]