JP2005526043A5 - - Google Patents
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- Publication number
- JP2005526043A5 JP2005526043A5 JP2003570772A JP2003570772A JP2005526043A5 JP 2005526043 A5 JP2005526043 A5 JP 2005526043A5 JP 2003570772 A JP2003570772 A JP 2003570772A JP 2003570772 A JP2003570772 A JP 2003570772A JP 2005526043 A5 JP2005526043 A5 JP 2005526043A5
- Authority
- JP
- Japan
- Prior art keywords
- tramadol
- pharmaceutical composition
- improved release
- release
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 71
- 229960004380 tramadol Drugs 0.000 claims 71
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 71
- 239000008194 pharmaceutical composition Substances 0.000 claims 52
- 239000000203 mixture Substances 0.000 claims 19
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims 12
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 229960003107 tramadol hydrochloride Drugs 0.000 claims 12
- 230000036470 plasma concentration Effects 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 230000003111 delayed effect Effects 0.000 claims 6
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 238000004090 dissolution Methods 0.000 claims 5
- 239000011230 binding agent Substances 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 239000004014 plasticizer Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical group CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 3
- HIKIGWCXRDSDRC-UHFFFAOYSA-L disodium (E)-4-octadecoxy-4-oxobut-2-enoate Chemical group [Na+].C(C=CC(=O)[O-])(=O)OCCCCCCCCCCCCCCCCCC.[Na+].C(CCCCCCCCCCCCCCCCC)OC(C=CC(=O)[O-])=O HIKIGWCXRDSDRC-UHFFFAOYSA-L 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 3
- 229920003169 water-soluble polymer Polymers 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 1
- 239000002547 new drug Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35785102P | 2002-02-21 | 2002-02-21 | |
| US60/357,851 | 2002-02-21 | ||
| PCT/US2003/004866 WO2003072025A2 (en) | 2002-02-21 | 2003-02-21 | Modified release formulations of at least one form of tramadol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010086646A Division JP2010155864A (ja) | 2002-02-21 | 2010-04-05 | トラマドールの少なくとも１つの形の放出が改良された医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526043A JP2005526043A (ja) | 2005-09-02 |
| JP2005526043A5 true JP2005526043A5 (https=) | 2006-01-05 |
| JP5069395B2 JP5069395B2 (ja) | 2012-11-07 |
Family
ID=27765948
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003570772A Expired - Fee Related JP5069395B2 (ja) | 2002-02-21 | 2003-02-21 | トラマドールの少なくとも１つの形の放出が改良された医薬組成物 |
| JP2003570835A Expired - Lifetime JP4704685B2 (ja) | 2002-02-21 | 2003-02-21 | 徐放性製剤 |
| JP2010086646A Pending JP2010155864A (ja) | 2002-02-21 | 2010-04-05 | トラマドールの少なくとも１つの形の放出が改良された医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003570835A Expired - Lifetime JP4704685B2 (ja) | 2002-02-21 | 2003-02-21 | 徐放性製剤 |
| JP2010086646A Pending JP2010155864A (ja) | 2002-02-21 | 2010-04-05 | トラマドールの少なくとも１つの形の放出が改良された医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7780987B2 (https=) |
| EP (2) | EP1476139B1 (https=) |
| JP (3) | JP5069395B2 (https=) |
| AT (1) | ATE536173T1 (https=) |
| AU (2) | AU2003211145B2 (https=) |
| CA (2) | CA2476201C (https=) |
| CY (1) | CY1112517T1 (https=) |
| DK (1) | DK1476138T3 (https=) |
| ES (2) | ES2627842T3 (https=) |
| MX (2) | MXPA04008100A (https=) |
| NO (1) | NO20043913L (https=) |
| NZ (2) | NZ535456A (https=) |
| PT (1) | PT1476138E (https=) |
| SI (1) | SI1476138T1 (https=) |
| WO (2) | WO2003072025A2 (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ260408A (en) | 1993-05-10 | 1996-05-28 | Euro Celtique Sa | Controlled release preparation comprising tramadol |
| MXPA04008100A (es) | 2002-02-21 | 2005-06-17 | Biovail Lab Int Srl | Formulaciones de liberacion modificada de al menos una forma de tramadol. |
| US8128957B1 (en) * | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
| US8323692B2 (en) * | 2002-02-21 | 2012-12-04 | Valeant International Bermuda | Controlled release dosage forms |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7413749B2 (en) | 2003-03-11 | 2008-08-19 | Purdue Pharma L.P. | Titration dosing regimen for controlled release tramadol |
| EP1905435A3 (en) * | 2003-03-11 | 2008-05-14 | Euro-Celtique S.A. | Titration dosing regimen for controlled release tramadol |
| WO2005016318A1 (en) * | 2003-08-08 | 2005-02-24 | Biovail Laboratories Inc. | Modified-release tablet of bupropion hydrochloride |
| US7206632B2 (en) * | 2003-10-02 | 2007-04-17 | Medtronic, Inc. | Patient sensory response evaluation for neuromodulation efficacy rating |
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| EP2540725A1 (de) | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
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| JP5685550B2 (ja) | 2009-02-13 | 2015-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用 |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
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-
2003
- 2003-02-21 MX MXPA04008100A patent/MXPA04008100A/es active IP Right Grant
- 2003-02-21 NZ NZ535456A patent/NZ535456A/en not_active IP Right Cessation
- 2003-02-21 ES ES03743148.3T patent/ES2627842T3/es not_active Expired - Lifetime
- 2003-02-21 WO PCT/US2003/004866 patent/WO2003072025A2/en not_active Ceased
- 2003-02-21 CA CA002476201A patent/CA2476201C/en not_active Expired - Fee Related
- 2003-02-21 EP EP03743148.3A patent/EP1476139B1/en not_active Expired - Lifetime
- 2003-02-21 CA CA002476496A patent/CA2476496C/en not_active Expired - Fee Related
- 2003-02-21 US US10/370,109 patent/US7780987B2/en not_active Expired - Lifetime
- 2003-02-21 AT AT03743147T patent/ATE536173T1/de active
- 2003-02-21 EP EP03743147A patent/EP1476138B8/en not_active Expired - Lifetime
- 2003-02-21 PT PT03743147T patent/PT1476138E/pt unknown
- 2003-02-21 NZ NZ535455A patent/NZ535455A/en not_active IP Right Cessation
- 2003-02-21 JP JP2003570772A patent/JP5069395B2/ja not_active Expired - Fee Related
- 2003-02-21 SI SI200332108T patent/SI1476138T1/sl unknown
- 2003-02-21 AU AU2003211145A patent/AU2003211145B2/en not_active Ceased
- 2003-02-21 WO PCT/US2003/004867 patent/WO2003072089A1/en not_active Ceased
- 2003-02-21 JP JP2003570835A patent/JP4704685B2/ja not_active Expired - Lifetime
- 2003-02-21 DK DK03743147.5T patent/DK1476138T3/da active
- 2003-02-21 AU AU2003211146A patent/AU2003211146B2/en not_active Expired
- 2003-02-21 MX MXPA04008164A patent/MXPA04008164A/es active IP Right Grant
- 2003-02-21 ES ES03743147T patent/ES2377729T3/es not_active Expired - Lifetime
-
2004
- 2004-09-20 NO NO20043913A patent/NO20043913L/no not_active Application Discontinuation
-
2008
- 2008-07-09 US US12/169,852 patent/US20080274177A1/en not_active Abandoned
-
2010
- 2010-04-05 JP JP2010086646A patent/JP2010155864A/ja active Pending
-
2012
- 2012-02-13 CY CY20121100144T patent/CY1112517T1/el unknown
-
2013
- 2013-05-13 US US13/892,657 patent/US20130245154A1/en not_active Abandoned
-
2014
- 2014-04-25 US US14/262,622 patent/US20150030675A1/en not_active Abandoned
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