JP2005525371A - 糖尿病および他の疾患を治療するための二環式複素環 - Google Patents

糖尿病および他の疾患を治療するための二環式複素環 Download PDF

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JP2005525371A
JP2005525371A JP2003574134A JP2003574134A JP2005525371A JP 2005525371 A JP2005525371 A JP 2005525371A JP 2003574134 A JP2003574134 A JP 2003574134A JP 2003574134 A JP2003574134 A JP 2003574134A JP 2005525371 A JP2005525371 A JP 2005525371A
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alkyl
compound
amino
substituted
aryl
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JP2005525371A5 (https=
Inventor
マグナス ファール，
キャサリン タッジアン，
フセイン エー． アル−シャマ，
アンドリア ファンジュル ギアチーノ，
カリン ジャキュボウィック−ジェラルドン，
ジャンフ グオ，
リチャード エム． ファイン，
ライル ダブリュー． スプルース，
ジェイムス ダブリュー． ザッフ，
Original Assignee
インサイト サン ディエゴ インコーポレイテッド
オーソ−マクネイル ファーマシューティカル インコーポレイテッド
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Publication of JP2005525371A publication Critical patent/JP2005525371A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2003574134A 2002-03-08 2003-03-07 糖尿病および他の疾患を治療するための二環式複素環 Pending JP2005525371A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36273202P 2002-03-08 2002-03-08
PCT/US2003/007240 WO2003075858A2 (en) 2002-03-08 2003-03-07 Bicyclic heterocycles for the treatment of diabetes and other diseases

Publications (2)

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JP2005525371A true JP2005525371A (ja) 2005-08-25
JP2005525371A5 JP2005525371A5 (https=) 2006-03-23

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JP2003574134A Pending JP2005525371A (ja) 2002-03-08 2003-03-07 糖尿病および他の疾患を治療するための二環式複素環

Country Status (9)

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US (1) US7196108B2 (https=)
EP (1) EP1487446A4 (https=)
JP (1) JP2005525371A (https=)
AU (1) AU2003223233A1 (https=)
BR (1) BR0308278A (https=)
CA (1) CA2478765A1 (https=)
IL (1) IL163953A0 (https=)
TW (1) TWI277415B (https=)
WO (1) WO2003075858A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013536693A (ja) * 2010-09-01 2013-09-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脂肪生成および筋線維芽細胞分化を制御する薬剤についての細胞培養スクリーニング
US10494402B2 (en) 2012-11-25 2019-12-03 The Regents Of The University Of California Peptides that stimulate subcutaneous adipogenesis
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis

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US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013536693A (ja) * 2010-09-01 2013-09-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脂肪生成および筋線維芽細胞分化を制御する薬剤についての細胞培養スクリーニング
US10494402B2 (en) 2012-11-25 2019-12-03 The Regents Of The University Of California Peptides that stimulate subcutaneous adipogenesis
US10766927B2 (en) 2012-11-25 2020-09-08 The Regents Of The University Of California Peptides that stimulate subcutaneous adipogenesis
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis

Also Published As

Publication number Publication date
US7196108B2 (en) 2007-03-27
TW200304814A (en) 2003-10-16
WO2003075858A3 (en) 2004-03-18
TWI277415B (en) 2007-04-01
US20040034004A1 (en) 2004-02-19
BR0308278A (pt) 2005-02-09
CA2478765A1 (en) 2003-09-18
AU2003223233A2 (en) 2003-09-22
EP1487446A4 (en) 2006-04-19
IL163953A0 (en) 2005-12-18
WO2003075858A2 (en) 2003-09-18
EP1487446A2 (en) 2004-12-22
AU2003223233A1 (en) 2003-09-22

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