JP2005525371A5 - - Google Patents
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- JP2005525371A5 JP2005525371A5 JP2003574134A JP2003574134A JP2005525371A5 JP 2005525371 A5 JP2005525371 A5 JP 2005525371A5 JP 2003574134 A JP2003574134 A JP 2003574134A JP 2003574134 A JP2003574134 A JP 2003574134A JP 2005525371 A5 JP2005525371 A5 JP 2005525371A5
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- Prior art keywords
- alkyl
- substituted
- compound
- amino
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 nitro, hydroxyl Chemical group 0.000 claims 111
- 150000001875 compounds Chemical class 0.000 claims 69
- 229910052739 hydrogen Inorganic materials 0.000 claims 34
- 239000001257 hydrogen Substances 0.000 claims 34
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 30
- 125000004432 carbon atom Chemical group C* 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 26
- 150000002367 halogens Chemical class 0.000 claims 26
- 125000002252 acyl group Chemical group 0.000 claims 23
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims 23
- 125000005432 dialkylcarboxamide group Chemical group 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 125000004422 alkyl sulphonamide group Chemical group 0.000 claims 21
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 20
- 125000001188 haloalkyl group Chemical group 0.000 claims 18
- 125000004423 acyloxy group Chemical group 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 125000004421 aryl sulphonamide group Chemical group 0.000 claims 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 125000004438 haloalkoxy group Chemical group 0.000 claims 15
- 125000004001 thioalkyl group Chemical group 0.000 claims 15
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 13
- 125000000547 substituted alkyl group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 8
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 8
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 125000000962 organic group Chemical group 0.000 claims 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 241000699670 Mus sp. Species 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 4
- 230000023852 carbohydrate metabolic process Effects 0.000 claims 3
- 235000021256 carbohydrate metabolism Nutrition 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 230000037356 lipid metabolism Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 210000000229 preadipocyte Anatomy 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 1
- GXJFKJQSRGQZGR-UHFFFAOYSA-N 2-[[7-[5-ethenyl-2-(trifluoromethoxy)phenyl]-3,3-dimethyl-2h-1-benzofuran-5-yl]methoxy]ethanol Chemical compound CC1(C)COC2=C1C=C(COCCO)C=C2C1=CC(C=C)=CC=C1OC(F)(F)F GXJFKJQSRGQZGR-UHFFFAOYSA-N 0.000 claims 1
- UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical group O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 claims 1
- WYPANKNORPQJBO-UHFFFAOYSA-N 5-[[3-(3,3-dimethyl-5-methylsulfonyl-2h-1-benzofuran-7-yl)-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound CC1(C)COC2=C1C=C(S(C)(=O)=O)C=C2C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O WYPANKNORPQJBO-UHFFFAOYSA-N 0.000 claims 1
- GOYKDWCTWAKXSY-UHFFFAOYSA-N 5-[[3-(5-acetyl-3,3-dimethyl-2h-1-benzofuran-7-yl)-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C=1C(C(=O)C)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O GOYKDWCTWAKXSY-UHFFFAOYSA-N 0.000 claims 1
- ZJCNMAXBWOCKCH-UHFFFAOYSA-N 5-[[3-[3,3-dimethyl-5-(1,2-oxazol-5-yl)-2h-1-benzofuran-7-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound CC1(C)COC2=C1C=C(C=1ON=CC=1)C=C2C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O ZJCNMAXBWOCKCH-UHFFFAOYSA-N 0.000 claims 1
- IIABODSWSJVMPL-UHFFFAOYSA-N 5-[[3-[3,3-dimethyl-5-(1,3-oxazol-2-yl)-2h-1-benzofuran-7-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound CC1(C)COC2=C1C=C(C=1OC=CN=1)C=C2C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O IIABODSWSJVMPL-UHFFFAOYSA-N 0.000 claims 1
- RHAXOVIBEIBLCS-UHFFFAOYSA-N 5-[[3-[3,3-dimethyl-5-(2-methylpropyl)-2h-1-benzofuran-7-yl]-2,5-difluoro-4-methoxyphenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound FC1=C(C=2C3=C(C(CO3)(C)C)C=C(CC(C)C)C=2)C(OC)=C(F)C=C1C=C1SC(=O)NC1=O RHAXOVIBEIBLCS-UHFFFAOYSA-N 0.000 claims 1
- HPZMJNWGVDLITO-UHFFFAOYSA-N 5-[[3-[3,3-dimethyl-5-(2-methylpropyl)-2h-1-benzofuran-7-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C=1C(CC(C)C)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O HPZMJNWGVDLITO-UHFFFAOYSA-N 0.000 claims 1
- JDCHZNVEEADSFN-UHFFFAOYSA-N 5-[[3-[5-(furan-3-yl)-3,3-dimethyl-2h-1-benzofuran-7-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound CC1(C)COC2=C1C=C(C1=COC=C1)C=C2C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O JDCHZNVEEADSFN-UHFFFAOYSA-N 0.000 claims 1
- BUCSWOOTHTYFNE-UHFFFAOYSA-N 5-[[3-[5-(methoxymethyl)-3,3-dimethyl-2h-1-benzofuran-7-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C=1C(COC)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O BUCSWOOTHTYFNE-UHFFFAOYSA-N 0.000 claims 1
- KMVZOYWRGKZLGB-UHFFFAOYSA-N 5-[[3-[6-(2-methylpropyl)-1,3-benzodioxol-4-yl]-4-(trifluoromethoxy)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C=1C(CC(C)C)=CC=2OCOC=2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O KMVZOYWRGKZLGB-UHFFFAOYSA-N 0.000 claims 1
- GZGJZTKREUNCGV-UHFFFAOYSA-N 7-[5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(trifluoromethoxy)phenyl]-3,3-dimethyl-2h-1-benzofuran-5-carboxylic acid Chemical compound CC1(C)COC2=C1C=C(C(O)=O)C=C2C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O GZGJZTKREUNCGV-UHFFFAOYSA-N 0.000 claims 1
- UTAGEPVUNHXEAG-UHFFFAOYSA-N 7-[5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(trifluoromethoxy)phenyl]-n,3,3-trimethyl-2h-1-benzofuran-5-carboxamide Chemical compound C=1C(C(=O)NC)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O UTAGEPVUNHXEAG-UHFFFAOYSA-N 0.000 claims 1
- BEMFENZSTXJOCT-UHFFFAOYSA-N 7-[5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(trifluoromethoxy)phenyl]-n,3,3-trimethyl-2h-1-benzofuran-5-sulfonamide Chemical compound C=1C(S(=O)(=O)NC)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O BEMFENZSTXJOCT-UHFFFAOYSA-N 0.000 claims 1
- BOLNQUPXEJLMMP-UHFFFAOYSA-N 7-[5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(trifluoromethoxy)phenyl]-n,n,3,3-tetramethyl-2h-1-benzofuran-5-carboxamide Chemical compound C=1C(C(=O)N(C)C)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O BOLNQUPXEJLMMP-UHFFFAOYSA-N 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 125000005332 alkyl sulfoxy group Chemical group 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- UCFNUNDTGDWNKC-UHFFFAOYSA-N methyl 7-[5-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(trifluoromethoxy)phenyl]-3,3-dimethyl-2h-1-benzofuran-5-carboxylate Chemical compound C=1C(C(=O)OC)=CC(C(CO2)(C)C)=C2C=1C(C(=CC=1)OC(F)(F)F)=CC=1C=C1SC(=O)NC1=O UCFNUNDTGDWNKC-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical compound O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 claims 1
- 0 C**c1c2OC(*C)(*3(C)*=C3)C(C)(*C)c2cc(*)c1 Chemical compound C**c1c2OC(*C)(*3(C)*=C3)C(C)(*C)c2cc(*)c1 0.000 description 5
- GXITUSCERRRNDI-UHFFFAOYSA-N C=C(C(N1)=O)SC1=O Chemical compound C=C(C(N1)=O)SC1=O GXITUSCERRRNDI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36273202P | 2002-03-08 | 2002-03-08 | |
| PCT/US2003/007240 WO2003075858A2 (en) | 2002-03-08 | 2003-03-07 | Bicyclic heterocycles for the treatment of diabetes and other diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005525371A JP2005525371A (ja) | 2005-08-25 |
| JP2005525371A5 true JP2005525371A5 (https=) | 2006-03-23 |
Family
ID=27805219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574134A Pending JP2005525371A (ja) | 2002-03-08 | 2003-03-07 | 糖尿病および他の疾患を治療するための二環式複素環 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7196108B2 (https=) |
| EP (1) | EP1487446A4 (https=) |
| JP (1) | JP2005525371A (https=) |
| AU (1) | AU2003223233A1 (https=) |
| BR (1) | BR0308278A (https=) |
| CA (1) | CA2478765A1 (https=) |
| IL (1) | IL163953A0 (https=) |
| TW (1) | TWI277415B (https=) |
| WO (1) | WO2003075858A2 (https=) |
Families Citing this family (27)
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| IL157740A0 (en) * | 2001-03-07 | 2004-03-28 | Incyte San Diego Inc | Heterocyclic derivatives and pharmaceutical compositions containing the same |
| US7265139B2 (en) * | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
| WO2003016267A1 (en) * | 2001-08-17 | 2003-02-27 | Incyte San Diego Incorporated | Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia |
| US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| ATE540047T1 (de) * | 2002-06-25 | 2012-01-15 | Helicon Therapeutics Inc | Gedächtnisveränderung durch beeinflussung der funktion von staufen |
| EP2133340B1 (en) | 2002-12-20 | 2013-01-16 | Glaxo Group Limited | Novel benzazepine derivatives |
| CN1774246A (zh) * | 2003-04-18 | 2006-05-17 | 因齐特圣迭戈公司 | 用于治疗代谢失调、癌症和其它疾病的取代异色满化合物 |
| US7122700B2 (en) | 2004-07-30 | 2006-10-17 | Xerox Corporation | Arylamine processes |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| CN101203505A (zh) * | 2005-04-22 | 2008-06-18 | 惠氏公司 | 苯并二氢吡喃和苯并吡喃衍生物及其用途 |
| US7638533B2 (en) * | 2005-09-30 | 2009-12-29 | Janssen Pharmaceutica N.V. | Dihydro-1[1H]-quinolin-2-one derivatives as RXR agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes |
| BRPI1010974A2 (pt) | 2009-05-22 | 2019-09-24 | Exelixis Inc | benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas |
| CN102459248A (zh) | 2009-05-26 | 2012-05-16 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧杂环庚三烯以及它们使用与制造方法 |
| US8952034B2 (en) | 2009-07-27 | 2015-02-10 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| BR112012033402A2 (pt) | 2010-07-02 | 2017-01-24 | Gilead Sciences Inc | moduladores de canais de íons conforme os compostos heterocíclicos fundidos |
| WO2012031015A1 (en) * | 2010-09-01 | 2012-03-08 | The Regents Of The University Of California | Cell culture screen for agents that control adipogenesis and myofibroblast differentiation |
| CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
| JP6014816B2 (ja) | 2011-05-10 | 2016-10-26 | 国立大学法人神戸大学 | Ｒａｓ機能阻害作用を有するチオキソチアゾリジン誘導体 |
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (https=) | 2011-07-01 | 2018-04-28 | ||
| WO2014082042A2 (en) | 2012-11-25 | 2014-05-30 | The Regents Of The University Of California | Peptides that stimulate subcutaneous adipogenesis |
| US10844102B2 (en) | 2014-05-28 | 2020-11-24 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
| CR20200553A (es) | 2018-04-18 | 2021-04-08 | Constellation Pharmaceuticals Inc | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| WO2021016414A1 (en) | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
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-
2003
- 2003-03-06 US US10/384,391 patent/US7196108B2/en not_active Expired - Fee Related
- 2003-03-07 CA CA002478765A patent/CA2478765A1/en not_active Abandoned
- 2003-03-07 BR BR0308278-4A patent/BR0308278A/pt not_active IP Right Cessation
- 2003-03-07 IL IL16395303A patent/IL163953A0/xx unknown
- 2003-03-07 EP EP03719363A patent/EP1487446A4/en not_active Withdrawn
- 2003-03-07 AU AU2003223233A patent/AU2003223233A1/en not_active Abandoned
- 2003-03-07 TW TW092105026A patent/TWI277415B/zh not_active IP Right Cessation
- 2003-03-07 WO PCT/US2003/007240 patent/WO2003075858A2/en not_active Ceased
- 2003-03-07 JP JP2003574134A patent/JP2005525371A/ja active Pending
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