JP2005524069A - 励起光源として発光ダイオードを有する蛍光検出装置及び方法 - Google Patents

励起光源として発光ダイオードを有する蛍光検出装置及び方法 Download PDF

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Publication number
JP2005524069A
JP2005524069A JP2004500051A JP2004500051A JP2005524069A JP 2005524069 A JP2005524069 A JP 2005524069A JP 2004500051 A JP2004500051 A JP 2004500051A JP 2004500051 A JP2004500051 A JP 2004500051A JP 2005524069 A JP2005524069 A JP 2005524069A
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Prior art keywords
light
sample
filter
fluorescence
excitation
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JP2004500051A
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Japanese (ja)
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JP2005524069A5 (https=
Inventor
バッカレッセ−ハミルトン，チトー
クリサンティ，アンドレア
フリードランダー，ウリ
カナス，トニー
アトリッジ，ジョン
ベッセイ，フィリップ
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インペリアル カレッジ イノベーションズ リミテッド
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Publication of JP2005524069A publication Critical patent/JP2005524069A/ja
Publication of JP2005524069A5 publication Critical patent/JP2005524069A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2004500051A 2002-04-24 2003-04-24 励起光源として発光ダイオードを有する蛍光検出装置及び方法 Pending JP2005524069A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0209329.2A GB0209329D0 (en) 2002-04-24 2002-04-24 A device
PCT/GB2003/001756 WO2003091712A1 (en) 2002-04-24 2003-04-24 Device and method for detecting fluorescence comprising a lightr emitting diode as excitation source

Publications (2)

Publication Number Publication Date
JP2005524069A true JP2005524069A (ja) 2005-08-11
JP2005524069A5 JP2005524069A5 (https=) 2006-01-26

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JP2004500051A Pending JP2005524069A (ja) 2002-04-24 2003-04-24 励起光源として発光ダイオードを有する蛍光検出装置及び方法

Country Status (6)

Country Link
US (1) US20050225764A1 (https=)
EP (1) EP1499876A1 (https=)
JP (1) JP2005524069A (https=)
AU (1) AU2003224303A1 (https=)
GB (1) GB0209329D0 (https=)
WO (1) WO2003091712A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008039655A (ja) * 2006-08-09 2008-02-21 National Institute Of Advanced Industrial & Technology 微小対象物放出光検出装置
JP5569761B1 (ja) * 2013-03-29 2014-08-13 シャープ株式会社 分析方法
JP2017156310A (ja) * 2016-03-04 2017-09-07 パナソニックヘルスケアホールディングス株式会社 蛍光測定装置
CN113686542A (zh) * 2020-05-19 2021-11-23 蔚海光学仪器（上海）有限公司 光斑检测装置和方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006115863A2 (en) * 2005-04-12 2006-11-02 Caliper Life Sciences, Inc. Compact optical detection system for microfluidic devices
BRPI0715823A2 (pt) * 2006-08-24 2013-07-16 Agency Science Tech & Res sistema de detecÇço àtica compacto
JP5337676B2 (ja) * 2009-06-25 2013-11-06 株式会社日立ハイテクノロジーズ 蛍光分析装置および蛍光検出装置
GB201002601D0 (en) 2010-02-16 2010-03-31 Microtest Matrices Ltd Allergen microarray

Citations (9)

* Cited by examiner, † Cited by third party
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JPH11304707A (ja) * 1998-04-20 1999-11-05 Bunshi Bio Photonics Kenkyusho:Kk 蛍光測定装置
WO1999060380A1 (en) * 1998-05-19 1999-11-25 Cepheid Multi-channel optical detection system
JP2000131237A (ja) * 1998-10-22 2000-05-12 Fuji Photo Film Co Ltd マイクロアレイチップの読取方法および読取装置
JP2000151916A (ja) * 1998-11-12 2000-05-30 Fuji Photo Film Co Ltd 画像情報読取装置
JP2001108684A (ja) * 1999-10-05 2001-04-20 Hitachi Ltd Ｄｎａ検査方法及びｄｎａ検査装置
JP2001228088A (ja) * 2000-02-18 2001-08-24 Nippon Laser & Electronics Lab 生体試料光学的走査装置
JP2001242082A (ja) * 2000-02-29 2001-09-07 Nippon Laser & Electronics Lab 生体試料光学的走査装置
JP2002508837A (ja) * 1997-05-23 2002-03-19 モレキュラー・ダイナミックス・インコーポレイテッド 蛍光の検出性を強化するための光学的基板
JP2002098639A (ja) * 2000-09-21 2002-04-05 Olympus Optical Co Ltd 画像データ取得方法

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JPS5567718A (en) * 1978-11-16 1980-05-22 Mitsubishi Chem Ind Ltd Optical system of multipurpose photometric microscope
EP0067921B1 (en) * 1981-06-22 1987-11-11 Prutec Limited A method for determining bioactive substances
JPS6238346A (ja) * 1985-08-14 1987-02-19 Hitachi Ltd 蛍光偏光測定装置
US5578818A (en) * 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
DE29700253U1 (de) * 1997-01-09 1997-02-27 Lehner Optoelectronic GmbH, 79312 Emmendingen Überwachungseinrichtung
WO2001004608A1 (en) * 1999-07-07 2001-01-18 Ljl Biosystems, Inc. Light detection device
US6327037B1 (en) * 1997-11-12 2001-12-04 Chien Chou Optical rotation angle polarimeter
US6369893B1 (en) * 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6587197B1 (en) * 1999-12-06 2003-07-01 Royce Technologies Llc Multiple microchannels chip for biomolecule imaging, and method of use thereof
US6721471B2 (en) * 2000-03-10 2004-04-13 Tidal Photonics, Inc. Apparatus and methods relating to fluorescent optical switches
JP2004500572A (ja) * 2000-03-13 2004-01-08 ジェノスペクトラ，インコーポレイティド 光ファイバ走査装置
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US6888635B2 (en) * 2000-12-05 2005-05-03 Ambalux Corporation Detection method and apparatus
US6754414B2 (en) * 2001-09-27 2004-06-22 Bio-Rad Laboratories, Inc. Imaging of microarrays using fiber optic exciter

Patent Citations (9)

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Publication number Priority date Publication date Assignee Title
JP2002508837A (ja) * 1997-05-23 2002-03-19 モレキュラー・ダイナミックス・インコーポレイテッド 蛍光の検出性を強化するための光学的基板
JPH11304707A (ja) * 1998-04-20 1999-11-05 Bunshi Bio Photonics Kenkyusho:Kk 蛍光測定装置
WO1999060380A1 (en) * 1998-05-19 1999-11-25 Cepheid Multi-channel optical detection system
JP2000131237A (ja) * 1998-10-22 2000-05-12 Fuji Photo Film Co Ltd マイクロアレイチップの読取方法および読取装置
JP2000151916A (ja) * 1998-11-12 2000-05-30 Fuji Photo Film Co Ltd 画像情報読取装置
JP2001108684A (ja) * 1999-10-05 2001-04-20 Hitachi Ltd Ｄｎａ検査方法及びｄｎａ検査装置
JP2001228088A (ja) * 2000-02-18 2001-08-24 Nippon Laser & Electronics Lab 生体試料光学的走査装置
JP2001242082A (ja) * 2000-02-29 2001-09-07 Nippon Laser & Electronics Lab 生体試料光学的走査装置
JP2002098639A (ja) * 2000-09-21 2002-04-05 Olympus Optical Co Ltd 画像データ取得方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008039655A (ja) * 2006-08-09 2008-02-21 National Institute Of Advanced Industrial & Technology 微小対象物放出光検出装置
JP5569761B1 (ja) * 2013-03-29 2014-08-13 シャープ株式会社 分析方法
JP2017156310A (ja) * 2016-03-04 2017-09-07 パナソニックヘルスケアホールディングス株式会社 蛍光測定装置
CN113686542A (zh) * 2020-05-19 2021-11-23 蔚海光学仪器（上海）有限公司 光斑检测装置和方法

Also Published As

Publication number Publication date
AU2003224303A1 (en) 2003-11-10
EP1499876A1 (en) 2005-01-26
GB0209329D0 (en) 2002-06-05
US20050225764A1 (en) 2005-10-13
WO2003091712A1 (en) 2003-11-06

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