JP2005522514A5 - - Google Patents
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- JP2005522514A5 JP2005522514A5 JP2003584086A JP2003584086A JP2005522514A5 JP 2005522514 A5 JP2005522514 A5 JP 2005522514A5 JP 2003584086 A JP2003584086 A JP 2003584086A JP 2003584086 A JP2003584086 A JP 2003584086A JP 2005522514 A5 JP2005522514 A5 JP 2005522514A5
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- 235000001014 amino acid Nutrition 0.000 claims 34
- 238000006467 substitution reaction Methods 0.000 claims 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 8
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 6
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- -1 wherein D28 (V L ) Chemical compound 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37160902P | 2002-04-10 | 2002-04-10 | |
| PCT/US2003/011031 WO2003087131A2 (en) | 2002-04-10 | 2003-04-09 | Anti-her2 antibody variants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009023157A Division JP2009149661A (ja) | 2002-04-10 | 2009-02-03 | 抗ｈｅｒ２抗体改変体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005522514A JP2005522514A (ja) | 2005-07-28 |
| JP2005522514A5 true JP2005522514A5 (ru) | 2006-04-27 |
Family
ID=29250707
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584086A Withdrawn JP2005522514A (ja) | 2002-04-10 | 2003-04-09 | 抗ｈｅｒ２抗体改変体 |
| JP2009023157A Withdrawn JP2009149661A (ja) | 2002-04-10 | 2009-02-03 | 抗ｈｅｒ２抗体改変体 |
| JP2012212026A Expired - Fee Related JP5782419B2 (ja) | 2002-04-10 | 2012-09-26 | 抗ｈｅｒ２抗体改変体 |
| JP2014141059A Withdrawn JP2014218505A (ja) | 2002-04-10 | 2014-07-09 | 抗ｈｅｒ２抗体改変体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009023157A Withdrawn JP2009149661A (ja) | 2002-04-10 | 2009-02-03 | 抗ｈｅｒ２抗体改変体 |
| JP2012212026A Expired - Fee Related JP5782419B2 (ja) | 2002-04-10 | 2012-09-26 | 抗ｈｅｒ２抗体改変体 |
| JP2014141059A Withdrawn JP2014218505A (ja) | 2002-04-10 | 2014-07-09 | 抗ｈｅｒ２抗体改変体 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US7435797B2 (ru) |
| EP (2) | EP2289942B1 (ru) |
| JP (4) | JP2005522514A (ru) |
| AU (2) | AU2003224916B2 (ru) |
| CA (1) | CA2481515C (ru) |
| DK (1) | DK1501856T3 (ru) |
| ES (2) | ES2429112T3 (ru) |
| HK (2) | HK1069586A1 (ru) |
| IL (2) | IL164417A (ru) |
| SI (2) | SI2289942T1 (ru) |
| WO (1) | WO2003087131A2 (ru) |
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-
2003
- 2003-04-09 CA CA2481515A patent/CA2481515C/en not_active Expired - Lifetime
- 2003-04-09 EP EP10178444.5A patent/EP2289942B1/en not_active Expired - Lifetime
- 2003-04-09 US US10/410,894 patent/US7435797B2/en active Active
- 2003-04-09 ES ES10178444T patent/ES2429112T3/es not_active Expired - Lifetime
- 2003-04-09 EP EP03721610A patent/EP1501856B1/en not_active Expired - Lifetime
- 2003-04-09 SI SI200332309T patent/SI2289942T1/sl unknown
- 2003-04-09 SI SI200332246T patent/SI1501856T1/sl unknown
- 2003-04-09 DK DK03721610.8T patent/DK1501856T3/da active
- 2003-04-09 ES ES03721610T patent/ES2401428T3/es not_active Expired - Lifetime
- 2003-04-09 AU AU2003224916A patent/AU2003224916B2/en not_active Expired
- 2003-04-09 WO PCT/US2003/011031 patent/WO2003087131A2/en active Search and Examination
- 2003-04-09 JP JP2003584086A patent/JP2005522514A/ja not_active Withdrawn
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2004
- 2004-10-05 IL IL164417A patent/IL164417A/en active IP Right Grant
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2005
- 2005-03-24 HK HK05102579.0A patent/HK1069586A1/xx not_active IP Right Cessation
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2008
- 2008-09-24 US US12/237,009 patent/US7850966B2/en not_active Expired - Lifetime
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2009
- 2009-02-03 JP JP2009023157A patent/JP2009149661A/ja not_active Withdrawn
- 2009-04-07 AU AU2009201370A patent/AU2009201370B2/en not_active Expired
- 2009-11-26 IL IL202348A patent/IL202348A/en active IP Right Grant
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2010
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- 2011-08-06 HK HK11108218.6A patent/HK1153763A1/xx not_active IP Right Cessation
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2012
- 2012-09-26 JP JP2012212026A patent/JP5782419B2/ja not_active Expired - Fee Related
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- 2014-09-18 US US14/489,810 patent/US20160060353A1/en not_active Abandoned
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