JP2005518363A5 - - Google Patents
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- Publication number
- JP2005518363A5 JP2005518363A5 JP2003546888A JP2003546888A JP2005518363A5 JP 2005518363 A5 JP2005518363 A5 JP 2005518363A5 JP 2003546888 A JP2003546888 A JP 2003546888A JP 2003546888 A JP2003546888 A JP 2003546888A JP 2005518363 A5 JP2005518363 A5 JP 2005518363A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- methoxy
- benzothiazol
- morpholin
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- -1 methoxyacetyl Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UNXGAEHOTFBPJG-UHFFFAOYSA-N 4-(acetamidomethyl)-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CNC(C)=O)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 UNXGAEHOTFBPJG-UHFFFAOYSA-N 0.000 claims 1
- PNWOFJJGUXAKNP-UHFFFAOYSA-N 4-[(cyclobutanecarbonylamino)methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CNC(=O)C4CCC4)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 PNWOFJJGUXAKNP-UHFFFAOYSA-N 0.000 claims 1
- SZFSIZPBUFZDQQ-UHFFFAOYSA-N 4-[(cyclopropanecarbonylamino)methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CNC(=O)C4CC4)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 SZFSIZPBUFZDQQ-UHFFFAOYSA-N 0.000 claims 1
- ARHLNOHEPHJERX-UHFFFAOYSA-N 4-[[(2-methoxyacetyl)amino]methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=CC(CNC(=O)COC)=CC=C1C(=O)NC1=NC2=C(OC)C=CC(N3CCOCC3)=C2S1 ARHLNOHEPHJERX-UHFFFAOYSA-N 0.000 claims 1
- KKVQONQFDHWHNB-UHFFFAOYSA-N 4-[[[2-(dimethylamino)acetyl]-methylamino]methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CN(C)C(=O)CN(C)C)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 KKVQONQFDHWHNB-UHFFFAOYSA-N 0.000 claims 1
- PBFPZLHHNNGHPB-UHFFFAOYSA-N 4-[[acetyl(methyl)amino]methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CN(C)C(C)=O)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 PBFPZLHHNNGHPB-UHFFFAOYSA-N 0.000 claims 1
- USPGKLDBUNNKDY-UHFFFAOYSA-N 4-[[cyclopropanecarbonyl(methyl)amino]methyl]-n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)benzamide Chemical compound C1=2SC(NC(=O)C=3C=CC(CN(C)C(=O)C4CC4)=CC=3)=NC=2C(OC)=CC=C1N1CCOCC1 USPGKLDBUNNKDY-UHFFFAOYSA-N 0.000 claims 1
- 102000009346 Adenosine receptors Human genes 0.000 claims 1
- 108050000203 Adenosine receptors Proteins 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YBDMUDKMZWQLSU-UHFFFAOYSA-N n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-[(propanoylamino)methyl]benzamide Chemical compound C1=CC(CNC(=O)CC)=CC=C1C(=O)NC1=NC2=C(OC)C=CC(N3CCOCC3)=C2S1 YBDMUDKMZWQLSU-UHFFFAOYSA-N 0.000 claims 1
- KBXOACYWKNPWMR-UHFFFAOYSA-N n-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-[[methyl(propanoyl)amino]methyl]benzamide Chemical compound C1=CC(CN(C)C(=O)CC)=CC=C1C(=O)NC1=NC2=C(OC)C=CC(N3CCOCC3)=C2S1 KBXOACYWKNPWMR-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01128338 | 2001-11-29 | ||
| PCT/EP2002/013046 WO2003045386A1 (en) | 2001-11-29 | 2002-11-21 | Benzothiazole derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518363A JP2005518363A (ja) | 2005-06-23 |
| JP2005518363A5 true JP2005518363A5 (enExample) | 2005-12-22 |
| JP4146799B2 JP4146799B2 (ja) | 2008-09-10 |
Family
ID=8179392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003546888A Expired - Fee Related JP4146799B2 (ja) | 2001-11-29 | 2002-11-21 | ベンゾチアゾール誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6624163B2 (enExample) |
| EP (1) | EP1450797B1 (enExample) |
| JP (1) | JP4146799B2 (enExample) |
| KR (1) | KR100581704B1 (enExample) |
| CN (1) | CN1304383C (enExample) |
| AR (1) | AR037457A1 (enExample) |
| AT (1) | ATE330603T1 (enExample) |
| AU (1) | AU2002365506B2 (enExample) |
| BR (1) | BR0214488A (enExample) |
| CA (1) | CA2468311C (enExample) |
| DE (1) | DE60212694T2 (enExample) |
| ES (1) | ES2266608T3 (enExample) |
| MX (1) | MXPA04005077A (enExample) |
| PA (1) | PA8558701A1 (enExample) |
| PE (1) | PE20030821A1 (enExample) |
| PL (1) | PL373947A1 (enExample) |
| RU (1) | RU2301232C2 (enExample) |
| TW (1) | TW200408395A (enExample) |
| UY (1) | UY27559A1 (enExample) |
| WO (1) | WO2003045386A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005000301A1 (en) * | 2003-06-20 | 2005-01-06 | F. Hoffmann-La Roche Ag | 2-aminobenzothiazoles as cb1 receptor inverse agonists |
| MXPA06002943A (es) | 2003-09-19 | 2006-05-31 | Hoffmann La Roche | Derivados de tiazolopiridina como ligandos del receptor de adenosina. |
| TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
| US7714009B2 (en) | 2003-10-31 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing fused heterocyclic compounds |
| DK1701951T3 (da) * | 2003-12-23 | 2010-06-07 | Serodus As | Modulatorer af perifere 5-HT receptorer |
| CN1989117B (zh) * | 2004-07-22 | 2011-01-19 | 弗·哈夫曼-拉罗切有限公司 | 取代的苯并噻唑 |
| DE602005019408D1 (de) * | 2004-07-22 | 2010-04-01 | Hoffmann La Roche | Benzothiazolderivate |
| AU2005287729A1 (en) | 2004-09-22 | 2006-03-30 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| WO2020103930A1 (zh) * | 2018-11-22 | 2020-05-28 | 上海科技大学 | 噻唑并环类化合物、其制备方法、中间体和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113219B1 (en) | 1982-12-21 | 1987-11-19 | Johnsen & Jorgensen (Plastics) Limited | Dispensing container |
| FI91859C (fi) | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
| GB8717068D0 (en) * | 1987-07-20 | 1987-08-26 | Fujisawa Pharmaceutical Co | Nitric ester derivative |
| IL90337A0 (en) * | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
| PT604657E (pt) * | 1992-05-21 | 2000-04-28 | Otsuka Pharma Co Ltd | Derivado de diester fosfonico |
| CZ2003182A3 (cs) | 2000-06-21 | 2003-06-18 | F. Hoffmann-La Roche Ag | Deriváty benzothiazolu |
-
2002
- 2002-11-15 US US10/295,500 patent/US6624163B2/en not_active Expired - Fee Related
- 2002-11-21 DE DE60212694T patent/DE60212694T2/de not_active Expired - Lifetime
- 2002-11-21 ES ES02790418T patent/ES2266608T3/es not_active Expired - Lifetime
- 2002-11-21 RU RU2004119985/04A patent/RU2301232C2/ru not_active IP Right Cessation
- 2002-11-21 CA CA2468311A patent/CA2468311C/en not_active Expired - Fee Related
- 2002-11-21 PL PL02373947A patent/PL373947A1/xx not_active Application Discontinuation
- 2002-11-21 WO PCT/EP2002/013046 patent/WO2003045386A1/en not_active Ceased
- 2002-11-21 AT AT02790418T patent/ATE330603T1/de active
- 2002-11-21 BR BR0214488-3A patent/BR0214488A/pt not_active Application Discontinuation
- 2002-11-21 CN CNB028236939A patent/CN1304383C/zh not_active Expired - Fee Related
- 2002-11-21 KR KR1020047007915A patent/KR100581704B1/ko not_active Expired - Fee Related
- 2002-11-21 MX MXPA04005077A patent/MXPA04005077A/es active IP Right Grant
- 2002-11-21 JP JP2003546888A patent/JP4146799B2/ja not_active Expired - Fee Related
- 2002-11-21 EP EP02790418A patent/EP1450797B1/en not_active Expired - Lifetime
- 2002-11-21 AU AU2002365506A patent/AU2002365506B2/en not_active Ceased
- 2002-11-25 TW TW091134237A patent/TW200408395A/zh unknown
- 2002-11-25 PE PE2002001131A patent/PE20030821A1/es not_active Application Discontinuation
- 2002-11-26 PA PA20028558701A patent/PA8558701A1/es unknown
- 2002-11-28 AR ARP020104580A patent/AR037457A1/es unknown
- 2002-11-28 UY UY27559A patent/UY27559A1/es not_active Application Discontinuation
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