PE20030821A1 - Derivados del benzotiazol como ligandos del receptor de adenosina - Google Patents
Derivados del benzotiazol como ligandos del receptor de adenosinaInfo
- Publication number
- PE20030821A1 PE20030821A1 PE2002001131A PE2002001131A PE20030821A1 PE 20030821 A1 PE20030821 A1 PE 20030821A1 PE 2002001131 A PE2002001131 A PE 2002001131A PE 2002001131 A PE2002001131 A PE 2002001131A PE 20030821 A1 PE20030821 A1 PE 20030821A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkyl
- benzothiazol
- morpholin
- benzamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE BENZOTIAZOL DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES ALQUILO, (CH2)n-O-ALQUILO, CICLOALQUILO, (CH2)n-NR'2; R' ES H, ALQUILO, (CH2)n-O-ALQUILO O JUNTO A N FORMAN PIRROLIDINA; n ES 1-3; SON COMPUESTOS PREFERIDOS 4-[(2-METOXI-ACETILAMINO)-METIL]-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)BENZAMIDA; 4-[(METOXIACETIL-METIL-AMINO)-METIL]-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)BENZAMIDA; 4-[(CICLOPROPANOCARBONIL-AMINO)-METIL]-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)BENZAMIDA; 4-[(DIMETILAMINOACETIL-METIL-AMINO)METIL]-N-(4-METOXI-7-MORFOLIN-4-IL-BENZOTIAZOL-2-IL)BENZAMIDA, ENTRE OTROS; TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON LIGANDOS DEL RECEPTOR DE ADENOSINA A2A Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDAD DE ALZHEIMER, PARKINSON, HUNTINGTON, NEUROPROTECCION, ESQUIZOFRENIA, ANSIEDAD, DOLOR, DEFICITS DE RESPIRACION, DEPRESION, ADICCION A DROGAS COMO ANFETAMINA, COCAINA, OPIOIDE, ETANOL, NICOTINA, CANNABINOIDES, ASMA, RESPUESTAS ALERGICAS, HIPOXIA, ISQUEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01128338 | 2001-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030821A1 true PE20030821A1 (es) | 2003-10-04 |
Family
ID=8179392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001131A PE20030821A1 (es) | 2001-11-29 | 2002-11-25 | Derivados del benzotiazol como ligandos del receptor de adenosina |
Country Status (20)
Country | Link |
---|---|
US (1) | US6624163B2 (es) |
EP (1) | EP1450797B1 (es) |
JP (1) | JP4146799B2 (es) |
KR (1) | KR100581704B1 (es) |
CN (1) | CN1304383C (es) |
AR (1) | AR037457A1 (es) |
AT (1) | ATE330603T1 (es) |
AU (1) | AU2002365506B2 (es) |
BR (1) | BR0214488A (es) |
CA (1) | CA2468311C (es) |
DE (1) | DE60212694T2 (es) |
ES (1) | ES2266608T3 (es) |
MX (1) | MXPA04005077A (es) |
PA (1) | PA8558701A1 (es) |
PE (1) | PE20030821A1 (es) |
PL (1) | PL373947A1 (es) |
RU (1) | RU2301232C2 (es) |
TW (1) | TW200408395A (es) |
UY (1) | UY27559A1 (es) |
WO (1) | WO2003045386A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100809201B1 (ko) * | 2003-06-20 | 2008-02-29 | 에프. 호프만-라 로슈 아게 | 카나바노이드 수용체 1 역작용제로서 2-아미노벤조티아졸 |
KR20060058132A (ko) | 2003-09-19 | 2006-05-29 | 에프. 호프만-라 로슈 아게 | 아데노신 수용체 리간드로서의 싸이아졸로피리딘 유도체 |
TW200524887A (en) * | 2003-10-27 | 2005-08-01 | Lundbeck & Co As H | N-thiazol-2-yl-benzamide derivatives |
US7714009B2 (en) | 2003-10-31 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing fused heterocyclic compounds |
US7834010B2 (en) * | 2003-12-23 | 2010-11-16 | Serodus As | Modulators of peripheral 5-HT receptors |
BRPI0513510A (pt) * | 2004-07-22 | 2008-05-06 | Hoffmann La Roche | benzotiazóis substituìdos |
ATE457986T1 (de) * | 2004-07-22 | 2010-03-15 | Hoffmann La Roche | Benzothiazolderivate |
US7910613B2 (en) | 2004-09-22 | 2011-03-22 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
US7674912B2 (en) | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
CN111205244B (zh) * | 2018-11-22 | 2023-08-18 | 上海科技大学 | 噻唑并环类化合物、其制备方法、中间体和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3374550D1 (en) | 1982-12-21 | 1987-12-23 | Johnsen Jorgensen Plastics Ltd | Dispensing container |
FI91859C (fi) | 1987-06-17 | 1994-08-25 | Eisai Co Ltd | Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi |
IL90337A0 (en) | 1988-05-24 | 1989-12-15 | Pfizer | Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents |
DE69327572T2 (de) * | 1992-05-21 | 2000-06-21 | Otsuka Pharmaceutical Factory, Inc. | Phosphonsäurediester-derivat |
IL153278A0 (en) | 2000-06-21 | 2003-07-06 | Hoffmann La Roche | Benzothiazole derivatives |
-
2002
- 2002-11-15 US US10/295,500 patent/US6624163B2/en not_active Expired - Fee Related
- 2002-11-21 WO PCT/EP2002/013046 patent/WO2003045386A1/en active IP Right Grant
- 2002-11-21 PL PL02373947A patent/PL373947A1/xx not_active Application Discontinuation
- 2002-11-21 AT AT02790418T patent/ATE330603T1/de active
- 2002-11-21 RU RU2004119985/04A patent/RU2301232C2/ru not_active IP Right Cessation
- 2002-11-21 ES ES02790418T patent/ES2266608T3/es not_active Expired - Lifetime
- 2002-11-21 DE DE60212694T patent/DE60212694T2/de not_active Expired - Lifetime
- 2002-11-21 MX MXPA04005077A patent/MXPA04005077A/es active IP Right Grant
- 2002-11-21 KR KR1020047007915A patent/KR100581704B1/ko not_active IP Right Cessation
- 2002-11-21 BR BR0214488-3A patent/BR0214488A/pt not_active Application Discontinuation
- 2002-11-21 JP JP2003546888A patent/JP4146799B2/ja not_active Expired - Fee Related
- 2002-11-21 CN CNB028236939A patent/CN1304383C/zh not_active Expired - Fee Related
- 2002-11-21 EP EP02790418A patent/EP1450797B1/en not_active Expired - Lifetime
- 2002-11-21 CA CA2468311A patent/CA2468311C/en not_active Expired - Fee Related
- 2002-11-21 AU AU2002365506A patent/AU2002365506B2/en not_active Ceased
- 2002-11-25 TW TW091134237A patent/TW200408395A/zh unknown
- 2002-11-25 PE PE2002001131A patent/PE20030821A1/es not_active Application Discontinuation
- 2002-11-26 PA PA20028558701A patent/PA8558701A1/es unknown
- 2002-11-28 UY UY27559A patent/UY27559A1/es not_active Application Discontinuation
- 2002-11-28 AR ARP020104580A patent/AR037457A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA04005077A (es) | 2004-08-19 |
AU2002365506B2 (en) | 2006-08-10 |
ATE330603T1 (de) | 2006-07-15 |
JP2005518363A (ja) | 2005-06-23 |
CA2468311A1 (en) | 2003-06-05 |
WO2003045386A1 (en) | 2003-06-05 |
CN1596112A (zh) | 2005-03-16 |
RU2004119985A (ru) | 2006-01-10 |
JP4146799B2 (ja) | 2008-09-10 |
CA2468311C (en) | 2011-03-15 |
US20030134855A1 (en) | 2003-07-17 |
AR037457A1 (es) | 2004-11-10 |
PA8558701A1 (es) | 2003-09-05 |
UY27559A1 (es) | 2003-05-30 |
TW200408395A (en) | 2004-06-01 |
KR20040062967A (ko) | 2004-07-09 |
PL373947A1 (en) | 2005-09-19 |
DE60212694D1 (de) | 2006-08-03 |
EP1450797B1 (en) | 2006-06-21 |
EP1450797A1 (en) | 2004-09-01 |
DE60212694T2 (de) | 2007-06-28 |
ES2266608T3 (es) | 2007-03-01 |
BR0214488A (pt) | 2004-10-19 |
RU2301232C2 (ru) | 2007-06-20 |
CN1304383C (zh) | 2007-03-14 |
US6624163B2 (en) | 2003-09-23 |
AU2002365506A1 (en) | 2003-06-10 |
KR100581704B1 (ko) | 2006-05-22 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |