AR067991A1 - Pirrolidina-aril-eteres como antagonistas de receptores de nk3 - Google Patents
Pirrolidina-aril-eteres como antagonistas de receptores de nk3Info
- Publication number
- AR067991A1 AR067991A1 ARP080103635A ARP080103635A AR067991A1 AR 067991 A1 AR067991 A1 AR 067991A1 AR P080103635 A ARP080103635 A AR P080103635A AR P080103635 A ARP080103635 A AR P080103635A AR 067991 A1 AR067991 A1 AR 067991A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- hydrogen
- halogen
- alkyl
- case
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se refiere aun compuesto de la formula general 1 en la que Ar es arilo o un heteroarilo de cinco o seis eslabones; la formula 2 es un resto mono- o bi-heterocíclico de seis a nueve eslabones, en el que X puede ser un átomo de carbono, SO2 u otro heteroátomo elegido entre el grupo formado por N y O; si X es un átomo de carbono, O, SO1 o N sin sustituir, entonces R1 es hidrogeno, hidroxi, ciano, -(CH2)q-OH, -(CH2)q-NRR', -(CH2)q-CN, alquilo inferior, -S(O)2-alquilo inferior. -NR-S(O)2-alquilo inferior, -C(O)-alquilo inferior, -NR-C(O)-alquilo inferior, fenilo o es un resto heterocíclico elegido entre piperidinil-2-ona; si X es un átomo de N sustituido por R1, entonces R1 es hidrogeno, -(CH2)q-OH, -(CH2)q-NRR', -(CH2)q-CN, alquilo inferior, -S(O)2-alquilo inferior, arilo o un heteroarilo de cinco o seis eslabones o -C(O)-alquilo inferior, con la condicion de que q sea 2 o 3; R/R' con independencia entre sí son hidrogeno o alquilo inferior; R2 es hidrogeno, halogeno, alquilo inferior, ciano, alcoxi inferior sustituido por halogeno, alquilo inferior sustituido por halogeno o es un heteroarilo de cinco o seis eslabones; R3 es hidrogeno o halogeno; R4 es hidrogeno o alquilo inferior; n es el numero 1 o 2 en caso de que n sea 2, R1 puede ser el mismo o diferente; o es el numero 1 o 2; en caso de que o sea 2, R2 puede ser el mismo o diferente; p es el numero 1 o 2 en caso de que p sea 2, R3 puede ser el mismo o diferente; q es el numero 1, 2 o 3; s es el numero 0, 1, 2, 3 o 4; o una sal farmacéuticamente activa del mismo, incluyendo todas ias formas estereoisoméricas, los diastereoisomeros y enantiomeros individuales del compuesto de la formula (1) así como a las mezclas racémicas y no racémicas del mismo. Se ha encontrado que los compuestos presentes tienen un gran potencial como antagonistas del receptor de NK-3 para el tratamiento de la depresion, el dolor, la psicosis, la enfermedad de Parkinson, la esquizofrenia, la ansiedad o el trastorno de hiperactividad con déficit de atencion (ADHD). Proceso medicamento, composicion farmacéutica y uso para fabricar medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07114790 | 2007-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067991A1 true AR067991A1 (es) | 2009-10-28 |
Family
ID=39870345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103635A AR067991A1 (es) | 2007-08-22 | 2008-08-21 | Pirrolidina-aril-eteres como antagonistas de receptores de nk3 |
Country Status (18)
Country | Link |
---|---|
US (1) | US7812021B2 (es) |
EP (1) | EP2190815B1 (es) |
JP (1) | JP2010536818A (es) |
KR (1) | KR101194467B1 (es) |
CN (1) | CN101861302A (es) |
AR (1) | AR067991A1 (es) |
AT (1) | ATE519738T1 (es) |
AU (1) | AU2008290634B2 (es) |
BR (1) | BRPI0815674A2 (es) |
CA (1) | CA2697325A1 (es) |
CL (1) | CL2008002450A1 (es) |
ES (1) | ES2369955T3 (es) |
MX (1) | MX2010001774A (es) |
PE (1) | PE20090621A1 (es) |
RU (1) | RU2010108687A (es) |
TW (1) | TW200916462A (es) |
WO (1) | WO2009024502A1 (es) |
ZA (1) | ZA201001125B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8063075B2 (en) * | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
WO2010040663A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Pyrrolidine n-benzyl derivatives |
BRPI1008349A2 (pt) | 2009-01-30 | 2016-02-23 | Hoffmann La Roche | derivados de piperidina tal como antagonistas de receptor de nk3 |
US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
US20110144081A1 (en) * | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
US20110152233A1 (en) * | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
CN103209979B (zh) | 2010-07-06 | 2016-02-10 | 阿斯利康(瑞典)有限公司 | 治疗剂976 |
US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
CA3052480A1 (en) * | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN148482B (es) | 1977-06-03 | 1981-03-07 | Pfizer | |
GB9321557D0 (en) | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
CA2162786A1 (en) * | 1994-11-22 | 1996-05-23 | Philip Arthur Hipskind | Heterocyclic tachykinin receptor antagonists |
ATE214063T1 (de) * | 1996-12-19 | 2002-03-15 | Aventis Pharma Inc | Heterocyclische substituierte pyrrolidinamid- derivate |
CN1859914A (zh) * | 2003-09-30 | 2006-11-08 | 默克公司 | 苯基吡咯烷醚速激肽受体拮抗剂 |
US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
US20080146588A1 (en) * | 2004-11-22 | 2008-06-19 | Devita Robert J | Piperidinyl Piperidine Tachykinin Receptor Antagonists |
EP1817285A4 (en) * | 2004-11-22 | 2009-01-21 | Merck & Co Inc | Cycloalkyl KETO PIPERIDINE tachykinin receptor Antagonist |
MX2010001080A (es) * | 2007-08-07 | 2010-03-01 | Hoffmann La Roche | Pirrolidin-aril-eteres como antagonistas de receptor de nk3. |
-
2008
- 2008-08-12 WO PCT/EP2008/060566 patent/WO2009024502A1/en active Application Filing
- 2008-08-12 KR KR1020107006058A patent/KR101194467B1/ko not_active IP Right Cessation
- 2008-08-12 AT AT08787130T patent/ATE519738T1/de active
- 2008-08-12 MX MX2010001774A patent/MX2010001774A/es active IP Right Grant
- 2008-08-12 AU AU2008290634A patent/AU2008290634B2/en not_active Expired - Fee Related
- 2008-08-12 JP JP2010521396A patent/JP2010536818A/ja active Pending
- 2008-08-12 CA CA2697325A patent/CA2697325A1/en not_active Abandoned
- 2008-08-12 RU RU2010108687/04A patent/RU2010108687A/ru not_active Application Discontinuation
- 2008-08-12 ES ES08787130T patent/ES2369955T3/es active Active
- 2008-08-12 EP EP08787130A patent/EP2190815B1/en not_active Not-in-force
- 2008-08-12 BR BRPI0815674-3A2A patent/BRPI0815674A2/pt not_active IP Right Cessation
- 2008-08-12 CN CN200880103704A patent/CN101861302A/zh active Pending
- 2008-08-20 CL CL2008002450A patent/CL2008002450A1/es unknown
- 2008-08-21 US US12/195,545 patent/US7812021B2/en not_active Expired - Fee Related
- 2008-08-21 PE PE2008001420A patent/PE20090621A1/es not_active Application Discontinuation
- 2008-08-21 TW TW097131984A patent/TW200916462A/zh unknown
- 2008-08-21 AR ARP080103635A patent/AR067991A1/es unknown
-
2010
- 2010-02-16 ZA ZA201001125A patent/ZA201001125B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2697325A1 (en) | 2009-02-26 |
ES2369955T3 (es) | 2011-12-09 |
BRPI0815674A2 (pt) | 2015-02-18 |
AU2008290634A1 (en) | 2009-02-26 |
US20090054644A1 (en) | 2009-02-26 |
EP2190815A1 (en) | 2010-06-02 |
ATE519738T1 (de) | 2011-08-15 |
EP2190815B1 (en) | 2011-08-10 |
TW200916462A (en) | 2009-04-16 |
ZA201001125B (en) | 2010-10-27 |
RU2010108687A (ru) | 2011-09-27 |
KR20100043105A (ko) | 2010-04-27 |
US7812021B2 (en) | 2010-10-12 |
AU2008290634B2 (en) | 2012-12-06 |
PE20090621A1 (es) | 2009-05-16 |
KR101194467B1 (ko) | 2012-10-24 |
CN101861302A (zh) | 2010-10-13 |
WO2009024502A1 (en) | 2009-02-26 |
CL2008002450A1 (es) | 2009-07-31 |
JP2010536818A (ja) | 2010-12-02 |
MX2010001774A (es) | 2010-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR067991A1 (es) | Pirrolidina-aril-eteres como antagonistas de receptores de nk3 | |
AR067808A1 (es) | Pirrolidina -aril-eteres como antagonistas de receptor de nk3 | |
AR049263A1 (es) | Heterociclos biciclicos inhibidores de quinasa utiles como agentes anticancer | |
CY1118723T1 (el) | Ενωσεις βενζοθειαζολιου και αζαβενζοθειαζολιου χρησιμες ως αναστολεiς κινασης | |
DE602006006850D1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
PE20071152A1 (es) | Compuestos derivados de azabiciclo[3.1.0]hex como moduladores de receptores de dopamina d3 | |
PE20020510A1 (es) | DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT) | |
PE20081454A1 (es) | Derivados de pirazol como moduladores del receptor 5-ht2a de serotonina utiles para el tratamiento de los transtornos relacionados con dicho receptor | |
MX2015015893A (es) | 2-fenilimidazo[1,2-a]pirimidinas como agentes formadores de imagen. | |
PE20061144A1 (es) | DERIVADOS DE PIRROLIDINA Y PIPERIDINA ACETILENO COMO ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO METABOTROPICO (mGluRs) | |
AR054024A1 (es) | Derivados de piridina -3- carboxamida como agonistas inversos de cb1 | |
AR055878A1 (es) | Derivados de ciclopropanocarboxamida | |
CY1114702T1 (el) | Νεοι εναnτιομερως καθαροι βητα αγωνιστες, μεθοδος για την παραγωγη τους και χρηση αυτων ως φαρμακων | |
AR067772A1 (es) | Derivados piperazinicos de nicotinamida, medicamentos que los contienen, proceso para prepararlos y usos de los mismos para el tratamiento de trastornos asociados al sistema nervioso, cardiovascular y/o trastornos metabolicos. | |
AR078756A1 (es) | Moduladores alostericos positivos (map) | |
DE602006011725D1 (de) | 3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3-rezeptors | |
PE20100718A1 (es) | Derivados triciclicos de 1, 4-dihidropiridina [b, e]-condensados como inhibidores de aurora quinasas | |
AR047958A1 (es) | Derivados de 1-bencil-5-piperazin-1-il-3,4 dihidro-1h-quinazolin-2-ona y sus derivados 1h-benzo(1,2,6)tiadiazina-2,2-dioxidos y 1,4-dihidro-benzo(d)(1,3)oxazinas-2-ona,como moduladores del receptor 5-ht,para el tratamiento de enfermedades del sistema nervioso central. | |
AR064136A1 (es) | Derivados de espiro-piperidina, metodos para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades relacionadas con la accion antagonista del receptor v1a. | |
PE20030718A1 (es) | Lactamas como antagonistas de taquiquininas | |
CO6260069A2 (es) | Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de la leucotrieno a4 hidrolasa | |
AR065863A1 (es) | Derivados de imidazolidinona | |
PE20140968A1 (es) | Derivados de benzamida sustituida | |
AR071925A1 (es) | Malonamidas como antagonistas de orexina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |