PE20020510A1 - DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT) - Google Patents

DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT)

Info

Publication number
PE20020510A1
PE20020510A1 PE2001000944A PE2001000944A PE20020510A1 PE 20020510 A1 PE20020510 A1 PE 20020510A1 PE 2001000944 A PE2001000944 A PE 2001000944A PE 2001000944 A PE2001000944 A PE 2001000944A PE 20020510 A1 PE20020510 A1 PE 20020510A1
Authority
PE
Peru
Prior art keywords
alkyl
azepyl
serotonin
receptors
derivatives
Prior art date
Application number
PE2001000944A
Other languages
English (en)
Inventor
Kristine M Frank
Jian-Min Fu
Brad A Acker
Jed F Fisher
Mcwhorter
Rogier
Jeanette K Morris
Eric Jon Jacobsen
Michael D Ennis
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020510A1 publication Critical patent/PE20020510A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS DE FORMULA I DONDE R1 ES H, ALQUILO C1-C8, ENTRE OTROS; R2 ES ALQUILO C1-C8, OH; R3 ES H, ALQUILO C1-C8, Ar, HET, R7C(=O), ENTRE OTROS; R4 ES Ar, ALQUILO C1-C8, ArO-, ALCOXI C1-C8, ENTRE OTROS; R5 Y R6 SON H, ALQUILO C1-C8, ALQUENILO C2-C8, ALQUINILO C2-C8, HALOALQUILO, ENTRE OTROS; R7 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, ALQUINILO C2-C8, ENTRE OTROS; p ES 0-4; q ES 0-10. SON COMPUESTOS PREFERIDOS (5aS*,10bS*)-10-(2-ETOXIFENIL)-1,2,3,4,5,5a,6,10b-OCTAHIDROAZEPINO[4,5-b]INDOL, (5aS,10bS)-10-(2-ETOXIFENIL)-1,2,3,4,5,5a,6,10b-OCTAHIDROAZEPINO[4,5-b]INDOL, (5aS,10bS)-10-(2-ETOXIFENIL)-1,2,3,4,5,5a,6,10b-OCTAHIDROAZEPINO[4,5-b]INDOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT) Y SON UTILES PARA EL TRATAMIENTO DE ANSIEDAD, DEPRESION, ESQUIZOFRENIA, EPILEPSIA
PE2001000944A 2000-09-20 2001-09-20 DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT) PE20020510A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23437600P 2000-09-20 2000-09-20
US26604701P 2001-02-01 2001-02-01
US30196401P 2001-06-29 2001-06-29

Publications (1)

Publication Number Publication Date
PE20020510A1 true PE20020510A1 (es) 2002-06-12

Family

ID=27398561

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2001000944A PE20020510A1 (es) 2000-09-20 2001-09-20 DERIVADOS DE AZEPILO [4,5b] INDOLINA SUSTITUIDOS COMO LIGANDOS DE LOS RECEPTORES DE SEROTONINA (5-HT)
PE2001000945A PE20020443A1 (es) 2000-09-20 2001-09-20 DERIVADOS AZEPINO [4,5-b] INDOL SUSTITUIDOS COMO LIGANDOS DEL RECEPTOR DE SEROTONINA 5HT

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2001000945A PE20020443A1 (es) 2000-09-20 2001-09-20 DERIVADOS AZEPINO [4,5-b] INDOL SUSTITUIDOS COMO LIGANDOS DEL RECEPTOR DE SEROTONINA 5HT

Country Status (7)

Country Link
US (4) US6583135B2 (es)
EP (2) EP1319004A2 (es)
JP (2) JP2004509894A (es)
AR (2) AR034264A1 (es)
AU (2) AU2001294606A1 (es)
PE (2) PE20020510A1 (es)
WO (2) WO2002024700A2 (es)

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Also Published As

Publication number Publication date
EP1319005A2 (en) 2003-06-18
US6903090B2 (en) 2005-06-07
US6828314B2 (en) 2004-12-07
US20030220321A1 (en) 2003-11-27
AU2001292898A1 (en) 2002-04-02
WO2002024701A3 (en) 2002-06-13
AR035493A1 (es) 2004-06-02
WO2002024701A2 (en) 2002-03-28
AR034264A1 (es) 2004-02-18
US6583135B2 (en) 2003-06-24
US6586421B2 (en) 2003-07-01
PE20020443A1 (es) 2002-05-16
JP2004509893A (ja) 2004-04-02
WO2002024700A3 (en) 2002-06-13
AU2001294606A1 (en) 2002-04-02
EP1319004A2 (en) 2003-06-18
US20020107278A1 (en) 2002-08-08
JP2004509894A (ja) 2004-04-02
US20030225058A1 (en) 2003-12-04
WO2002024700A2 (en) 2002-03-28
US20020077318A1 (en) 2002-06-20

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