BRPI0815674A2 - Aril-éter de pirrolidina como antagonista de receptor de nk3 - Google Patents
Aril-éter de pirrolidina como antagonista de receptor de nk3Info
- Publication number
- BRPI0815674A2 BRPI0815674A2 BRPI0815674-3A2A BRPI0815674A BRPI0815674A2 BR PI0815674 A2 BRPI0815674 A2 BR PI0815674A2 BR PI0815674 A BRPI0815674 A BR PI0815674A BR PI0815674 A2 BRPI0815674 A2 BR PI0815674A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrolidine
- receptor antagonist
- aryl ether
- aryl
- ether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114790 | 2007-08-22 | ||
| PCT/EP2008/060566 WO2009024502A1 (en) | 2007-08-22 | 2008-08-12 | Pyrrolidine aryl-ether as nk3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0815674A2 true BRPI0815674A2 (pt) | 2015-02-18 |
Family
ID=39870345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0815674-3A2A BRPI0815674A2 (pt) | 2007-08-22 | 2008-08-12 | Aril-éter de pirrolidina como antagonista de receptor de nk3 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7812021B2 (pt) |
| EP (1) | EP2190815B1 (pt) |
| JP (1) | JP2010536818A (pt) |
| KR (1) | KR101194467B1 (pt) |
| CN (1) | CN101861302A (pt) |
| AR (1) | AR067991A1 (pt) |
| AT (1) | ATE519738T1 (pt) |
| AU (1) | AU2008290634B2 (pt) |
| BR (1) | BRPI0815674A2 (pt) |
| CA (1) | CA2697325A1 (pt) |
| CL (1) | CL2008002450A1 (pt) |
| ES (1) | ES2369955T3 (pt) |
| MX (1) | MX2010001774A (pt) |
| PE (1) | PE20090621A1 (pt) |
| RU (1) | RU2010108687A (pt) |
| TW (1) | TW200916462A (pt) |
| WO (1) | WO2009024502A1 (pt) |
| ZA (1) | ZA201001125B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8063075B2 (en) * | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
| CA2738870A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Pyrrolidine n-benzyl derivatives |
| KR101372743B1 (ko) | 2009-01-30 | 2014-03-14 | 에프. 호프만-라 로슈 아게 | Ｎｋ3 수용체 길항제로서 피페리딘 유도체 |
| US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
| SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
| US8394834B2 (en) | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| US20110144081A1 (en) | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
| US20110152233A1 (en) * | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
| JP5827683B2 (ja) | 2010-07-06 | 2015-12-02 | アストラゼネカ アクチボラグ | 療法薬９７６ |
| US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
| AU2018221148B2 (en) | 2017-02-17 | 2022-05-05 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| WO2018152286A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148482B (pt) | 1977-06-03 | 1981-03-07 | Pfizer | |
| GB9321557D0 (en) | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| EP0714891A1 (en) * | 1994-11-22 | 1996-06-05 | Eli Lilly And Company | Heterocyclic tachykinin receptor antagonists |
| KR100514263B1 (ko) * | 1996-12-19 | 2005-09-15 | 아벤티스 파마슈티칼스 인크. | 신규한 헤테로시클릭 치환된 피롤리딘 아미드 유도체 |
| CA2540061A1 (en) * | 2003-09-30 | 2005-04-14 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| EP1817285A4 (en) * | 2004-11-22 | 2009-01-21 | Merck & Co Inc | Cycloalkyl KETO PIPERIDINE tachykinin receptor Antagonist |
| EP1817302A4 (en) * | 2004-11-22 | 2009-07-01 | Merck & Co Inc | PIPERIDINYLPIPERIDIN-tachykinin receptor Antagonist |
| ATE517100T1 (de) * | 2007-08-07 | 2011-08-15 | Hoffmann La Roche | Pyrrolidinarylether als nk3-rezeptorantagonisten |
-
2008
- 2008-08-12 JP JP2010521396A patent/JP2010536818A/ja active Pending
- 2008-08-12 WO PCT/EP2008/060566 patent/WO2009024502A1/en active Application Filing
- 2008-08-12 KR KR1020107006058A patent/KR101194467B1/ko not_active IP Right Cessation
- 2008-08-12 AU AU2008290634A patent/AU2008290634B2/en not_active Expired - Fee Related
- 2008-08-12 EP EP08787130A patent/EP2190815B1/en not_active Not-in-force
- 2008-08-12 ES ES08787130T patent/ES2369955T3/es active Active
- 2008-08-12 BR BRPI0815674-3A2A patent/BRPI0815674A2/pt not_active IP Right Cessation
- 2008-08-12 CA CA2697325A patent/CA2697325A1/en not_active Abandoned
- 2008-08-12 AT AT08787130T patent/ATE519738T1/de active
- 2008-08-12 CN CN200880103704A patent/CN101861302A/zh active Pending
- 2008-08-12 MX MX2010001774A patent/MX2010001774A/es active IP Right Grant
- 2008-08-12 RU RU2010108687/04A patent/RU2010108687A/ru not_active Application Discontinuation
- 2008-08-20 CL CL2008002450A patent/CL2008002450A1/es unknown
- 2008-08-21 TW TW097131984A patent/TW200916462A/zh unknown
- 2008-08-21 AR ARP080103635A patent/AR067991A1/es unknown
- 2008-08-21 PE PE2008001420A patent/PE20090621A1/es not_active Application Discontinuation
- 2008-08-21 US US12/195,545 patent/US7812021B2/en not_active Expired - Fee Related
-
2010
- 2010-02-16 ZA ZA201001125A patent/ZA201001125B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008290634B2 (en) | 2012-12-06 |
| JP2010536818A (ja) | 2010-12-02 |
| EP2190815B1 (en) | 2011-08-10 |
| ES2369955T3 (es) | 2011-12-09 |
| MX2010001774A (es) | 2010-03-10 |
| EP2190815A1 (en) | 2010-06-02 |
| WO2009024502A1 (en) | 2009-02-26 |
| CA2697325A1 (en) | 2009-02-26 |
| AR067991A1 (es) | 2009-10-28 |
| ZA201001125B (en) | 2010-10-27 |
| CL2008002450A1 (es) | 2009-07-31 |
| KR20100043105A (ko) | 2010-04-27 |
| AU2008290634A1 (en) | 2009-02-26 |
| KR101194467B1 (ko) | 2012-10-24 |
| CN101861302A (zh) | 2010-10-13 |
| US20090054644A1 (en) | 2009-02-26 |
| US7812021B2 (en) | 2010-10-12 |
| TW200916462A (en) | 2009-04-16 |
| RU2010108687A (ru) | 2011-09-27 |
| ATE519738T1 (de) | 2011-08-15 |
| PE20090621A1 (es) | 2009-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0815674A2 (pt) | Aril-éter de pirrolidina como antagonista de receptor de nk3 | |
| BRPI0815658A2 (pt) | Aril-éter pirrolidina como antagonistas do receptor nk3 | |
| BRPI1016189A2 (pt) | compostos de 4-azetidinil-1-fenil-ciclohexano antagonistas de ccr2 | |
| BRPI0911542A2 (pt) | compostos de quinuclina como ligantes de receptor de receptor de acetilcolina alfa-7-nicotínica | |
| BRPI0821141A2 (pt) | Derivados de heteroarila como antagonistas do receptor de orexina | |
| BRPI0909157A2 (pt) | compostos heterocíclicos como antagonistas de receptores de adenosina | |
| BRPI0913930A2 (pt) | antagonistas de receptores de prostaglandinas d2 | |
| BRPI0810462A2 (pt) | Derivados de quinolina-carboxamida como antagonistas de p2y12 | |
| CR10926A (es) | Nuevas 2-aminooxazolinas como ligandos taar1 | |
| BRPI1013614A2 (pt) | compostos substituídos de espiro-amida | |
| BRPI0919844A2 (pt) | compostos de azaindazol como antagonistas do receptor ccr1 | |
| CR20130271A (es) | Antagonistas de mdm2 de espiro-oxindol | |
| BRPI1013821A2 (pt) | piridinas substituídas como antagonistas de ccr3. | |
| BRPI0717937A2 (pt) | Compostos de pirazona como antagonistas do receptor mineralocorticóide | |
| DK2821407T3 (da) | Piperidinoncarboxamidazaindan-cgrp receptorantagonister | |
| BR112012005616A2 (pt) | compostos antivirais heterocíclicos | |
| BRPI1005525A2 (pt) | compostos de azaazuleno | |
| BRPI0717023A2 (pt) | Tiazol pirazolopirimidina como antagonistas do receptor de crf1 | |
| BRPI0810926A2 (pt) | Antagonista de crig | |
| BRPI0814806A2 (pt) | Pirazinas substituídas como antagonistas de cb1 | |
| BRPI1010852A2 (pt) | compostos antivirais heterocíclicos | |
| BRPI1009398A2 (pt) | compostos de pirimidina fundida substituída | |
| BRPI1016266A2 (pt) | compostos antivirais heterocíclicos | |
| BRPI0814767A2 (pt) | Derivados de monoamida como antagonistas do receptor de orexina | |
| BRPI0923237A2 (pt) | compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |