JP2005517900A - デジタルアッセイ - Google Patents
デジタルアッセイ Download PDFInfo
- Publication number
- JP2005517900A JP2005517900A JP2003546815A JP2003546815A JP2005517900A JP 2005517900 A JP2005517900 A JP 2005517900A JP 2003546815 A JP2003546815 A JP 2003546815A JP 2003546815 A JP2003546815 A JP 2003546815A JP 2005517900 A JP2005517900 A JP 2005517900A
- Authority
- JP
- Japan
- Prior art keywords
- target
- specific
- beads
- probe
- certain embodiments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IMMMOXWIMYISFY-UHFFFAOYSA-N CCCCC1=CC(C2)CC2C1 Chemical compound CCCCC1=CC(C2)CC2C1 IMMMOXWIMYISFY-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33251901P | 2001-11-21 | 2001-11-21 | |
US38473102P | 2002-05-31 | 2002-05-31 | |
PCT/US2002/037499 WO2003045310A2 (en) | 2001-11-21 | 2002-11-21 | Digital assay |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009124765A Division JP2009229468A (ja) | 2001-11-21 | 2009-05-22 | デジタルアッセイ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005517900A true JP2005517900A (ja) | 2005-06-16 |
JP2005517900A5 JP2005517900A5 (de) | 2005-12-22 |
Family
ID=26988251
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003546815A Pending JP2005517900A (ja) | 2001-11-21 | 2002-11-21 | デジタルアッセイ |
JP2009124765A Pending JP2009229468A (ja) | 2001-11-21 | 2009-05-22 | デジタルアッセイ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009124765A Pending JP2009229468A (ja) | 2001-11-21 | 2009-05-22 | デジタルアッセイ |
Country Status (7)
Country | Link |
---|---|
US (3) | US20030165935A1 (de) |
EP (2) | EP1448800A4 (de) |
JP (2) | JP2005517900A (de) |
CN (1) | CN100360722C (de) |
AU (1) | AU2002362013B2 (de) |
CA (1) | CA2466821A1 (de) |
WO (1) | WO2003045310A2 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015508995A (ja) * | 2011-12-30 | 2015-03-26 | アボツト・モレキユラー・インコーポレイテツド | 核酸ハイブリダイゼーションプローブ |
JP2016517275A (ja) * | 2013-03-15 | 2016-06-16 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | 多重核酸検出のためのコード化ナノポアセンサー |
JP2019528675A (ja) * | 2016-06-14 | 2019-10-17 | ベース4 イノベーション リミテッド | ポリヌクレオチド分離法 |
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US20030165935A1 (en) * | 2001-11-21 | 2003-09-04 | Vann Charles S. | Digital assay |
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US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
JP2007525151A (ja) | 2003-01-29 | 2007-09-06 | 454 コーポレーション | 一本鎖dnaライブラリーの調製方法 |
JP2007518107A (ja) * | 2004-01-13 | 2007-07-05 | ユー.エス. ジェノミクス, インコーポレイテッド | ポリマーを使用する溶液中の分析物の検出および定量化 |
US7517978B1 (en) | 2004-04-14 | 2009-04-14 | Applied Biosystems, Llc | Modified oligonucleotides and applications thereof |
US7408051B2 (en) * | 2004-04-14 | 2008-08-05 | Applera Corporation | Modified oligonucleotides and applications thereof |
US20070015176A1 (en) * | 2005-02-18 | 2007-01-18 | Applera Corporation | Small nucleic acid detection probes and uses thereof |
JP2008535518A (ja) * | 2005-04-14 | 2008-09-04 | アプレラ コーポレイション | プソイドイソシトシン核酸塩基誘導体を含む3’改変オリゴヌクレオチド、およびプライマーまたはプローブとしてのその適用 |
US8628918B2 (en) * | 2005-05-09 | 2014-01-14 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
US8632970B2 (en) | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
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KR20080011308A (ko) * | 2005-06-01 | 2008-02-01 | 올림푸스 가부시키가이샤 | 핵산의 검출 방법 |
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CN104673905B (zh) * | 2005-06-20 | 2016-09-07 | 领先细胞医疗诊断有限公司 | 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法 |
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CN104755938B (zh) * | 2012-08-31 | 2017-02-22 | 环球生物研究株式会社 | 变形元件内置分注管、变形元件内置分注装置及变形元件内置分注处理方法 |
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CN107208158B (zh) | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | 空间上可寻址的分子条形编码 |
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DK3362462T3 (da) | 2015-10-12 | 2021-10-11 | Advanced Cell Diagnostics Inc | In situ-detektion af nukleotidvarianter i prøver med højt støjniveau, og sammensætninger og fremgangsmåder relateret dertil |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
JP7091348B2 (ja) | 2016-09-26 | 2022-06-27 | ベクトン・ディキンソン・アンド・カンパニー | バーコード付きオリゴヌクレオチド配列を有する試薬を用いたタンパク質発現の測定 |
KR101862198B1 (ko) * | 2016-09-30 | 2018-05-30 | (주)스파크바이오파마 | 2차원 겔 전기영동에서의 열 안정성 변화-기반 형광 차이를 이용한 표적 단백질의 규명 방법 |
EP3577232A1 (de) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selektive amplifikation unter verwendung von blockierenden oligonukleotiden |
EP3635135A1 (de) | 2017-06-05 | 2020-04-15 | Becton, Dickinson and Company | Probenindizierung für einzelzellen |
US10781480B1 (en) * | 2017-07-01 | 2020-09-22 | Acgt Corporation | Method of detecting nucleic acids with amplified signal using nanoparticles |
ES2945191T3 (es) | 2018-05-03 | 2023-06-29 | Becton Dickinson Co | Análisis de muestras multiómicas de alto rendimiento |
WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
EP3861134A1 (de) | 2018-10-01 | 2021-08-11 | Becton, Dickinson and Company | Bestimmung von 5'-transkriptsequenzen |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
ES2945227T3 (es) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
US11684926B2 (en) * | 2019-07-14 | 2023-06-27 | Zhuhai Sanmed Biotech Ltd. | System and processes for isolation and enrichment by magnetic separation |
CN114051534A (zh) | 2019-07-22 | 2022-02-15 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
JP2023500679A (ja) | 2019-11-08 | 2023-01-10 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
CN115244184A (zh) | 2020-01-13 | 2022-10-25 | 贝克顿迪金森公司 | 用于定量蛋白和rna的方法和组合物 |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
EP4247967A1 (de) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profilierung von stark exprimierten und schwach exprimierten proteinen |
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AU2002362013B2 (en) | 2008-04-24 |
US20050118589A1 (en) | 2005-06-02 |
WO2003045310A8 (en) | 2004-05-27 |
WO2003045310A9 (en) | 2004-07-22 |
EP2196544A1 (de) | 2010-06-16 |
US20100167293A1 (en) | 2010-07-01 |
CA2466821A1 (en) | 2003-06-05 |
CN1608139A (zh) | 2005-04-20 |
EP1448800A4 (de) | 2007-05-16 |
AU2002362013A1 (en) | 2003-06-10 |
WO2003045310A3 (en) | 2003-11-13 |
US20030165935A1 (en) | 2003-09-04 |
JP2009229468A (ja) | 2009-10-08 |
CN100360722C (zh) | 2008-01-09 |
EP1448800A2 (de) | 2004-08-25 |
WO2003045310A2 (en) | 2003-06-05 |
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