JP2005517406A5 - - Google Patents
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- Publication number
- JP2005517406A5 JP2005517406A5 JP2003568070A JP2003568070A JP2005517406A5 JP 2005517406 A5 JP2005517406 A5 JP 2005517406A5 JP 2003568070 A JP2003568070 A JP 2003568070A JP 2003568070 A JP2003568070 A JP 2003568070A JP 2005517406 A5 JP2005517406 A5 JP 2005517406A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexyl
- avermectin
- combination
- avermitilis
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 17
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims 15
- 239000005660 Abamectin Substances 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 241001468227 Streptomyces avermitilis Species 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 108700028369 Alleles Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000001963 growth medium Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102220512658 Olfactory receptor 51A7_V196A_mutation Human genes 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 102200015997 rs12718465 Human genes 0.000 claims 3
- 102200004729 rs13213314 Human genes 0.000 claims 3
- 102200005898 rs137852378 Human genes 0.000 claims 3
- 102220291113 rs1555898522 Human genes 0.000 claims 3
- 102200004256 rs199473394 Human genes 0.000 claims 3
- 102220302463 rs35434411 Human genes 0.000 claims 3
- 102220044659 rs587781460 Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 102200108007 rs199473557 Human genes 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35622202P | 2002-02-12 | 2002-02-12 | |
| PCT/IB2003/000348 WO2003068955A2 (en) | 2002-02-12 | 2003-01-31 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005517406A JP2005517406A (ja) | 2005-06-16 |
| JP2005517406A5 true JP2005517406A5 (enExample) | 2006-03-09 |
Family
ID=27734621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003568070A Pending JP2005517406A (ja) | 2002-02-12 | 2003-01-31 | Ｂ２：Ｂ１アベルメクチン比を支配するＳｔｒｅｐｔｏｍｙｃｅｓａｖｅｒｍｉｔｉｌｉｓ遺伝子 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7388085B2 (enExample) |
| EP (2) | EP1476539B1 (enExample) |
| JP (1) | JP2005517406A (enExample) |
| KR (1) | KR100718378B1 (enExample) |
| CN (2) | CN102392028B (enExample) |
| AR (1) | AR038405A1 (enExample) |
| AT (2) | ATE530645T1 (enExample) |
| AU (1) | AU2003245052B2 (enExample) |
| BR (1) | BRPI0307620B8 (enExample) |
| CA (1) | CA2475214C (enExample) |
| CY (2) | CY1110454T1 (enExample) |
| DE (1) | DE60326824D1 (enExample) |
| DK (2) | DK1476539T3 (enExample) |
| ES (2) | ES2321827T3 (enExample) |
| IL (3) | IL162866A0 (enExample) |
| ME (1) | ME00472B (enExample) |
| MX (1) | MXPA04007777A (enExample) |
| PL (1) | PL211693B1 (enExample) |
| PT (2) | PT2050815E (enExample) |
| RS (1) | RS50813B (enExample) |
| RU (1) | RU2293117C2 (enExample) |
| SI (2) | SI1476539T1 (enExample) |
| TW (1) | TWI341330B (enExample) |
| WO (1) | WO2003068955A2 (enExample) |
| ZA (1) | ZA200405345B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003245052B2 (en) * | 2002-02-12 | 2008-07-31 | Zoetis Services Llc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| CN102241750B (zh) * | 2010-05-14 | 2014-05-28 | 中国科学院微生物研究所 | 一种生产阿维菌素的基因工程方法及其专用菌株 |
| CN102093997B (zh) * | 2010-12-01 | 2013-03-13 | 中国科学院上海有机化学研究所 | 一种改造除虫链霉菌产生多拉菌素的方法 |
| CN109576196B (zh) * | 2019-01-25 | 2022-01-04 | 北大方正集团有限公司 | 一种生产多拉菌素的发酵培养基及多拉菌素的生产方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (enExample) | 1987-01-23 | 1991-01-19 | Pfizer | |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| EP0722453B1 (en) * | 1993-10-05 | 1999-10-13 | Pfizer Inc. | Process and antiparasitic intermediates for doramectin |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6248579B1 (en) | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| KR20040053390A (ko) * | 1998-02-13 | 2004-06-23 | 화이자 프로덕츠 인코포레이티드 | 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자 |
| RU2156301C2 (ru) * | 1998-06-09 | 2000-09-20 | Мосин Владимир Александрович | Штамм актиномицета streptomyces avermitilis ссм 4697 - продуцент авермектинов |
| US6197591B1 (en) | 1998-09-14 | 2001-03-06 | Pfizer Inc. | Streptomyces avermitilis regulatory genes for increased avermectin production |
| EP1200606B1 (en) * | 1999-08-12 | 2006-10-04 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| CZ2002534A3 (cs) | 1999-08-13 | 2002-07-17 | Vertex Pharmaceuticals Incorporated | Inhibitory protein-kináz, farmaceutické prostředky, které je obsahují, a jejich pouľití |
| AU2003245052B2 (en) * | 2002-02-12 | 2008-07-31 | Zoetis Services Llc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
-
2003
- 2003-01-31 AU AU2003245052A patent/AU2003245052B2/en not_active Expired
- 2003-01-31 CN CN2011102082591A patent/CN102392028B/zh not_active Expired - Lifetime
- 2003-01-31 AT AT09150098T patent/ATE530645T1/de active
- 2003-01-31 IL IL16286603A patent/IL162866A0/xx unknown
- 2003-01-31 PT PT09150098T patent/PT2050815E/pt unknown
- 2003-01-31 PT PT03739390T patent/PT1476539E/pt unknown
- 2003-01-31 MX MXPA04007777A patent/MXPA04007777A/es active IP Right Grant
- 2003-01-31 RU RU2004124521/13A patent/RU2293117C2/ru active
- 2003-01-31 PL PL371320A patent/PL211693B1/pl unknown
- 2003-01-31 WO PCT/IB2003/000348 patent/WO2003068955A2/en not_active Ceased
- 2003-01-31 AT AT03739390T patent/ATE426659T1/de active
- 2003-01-31 ES ES03739390T patent/ES2321827T3/es not_active Expired - Lifetime
- 2003-01-31 ES ES09150098T patent/ES2373629T3/es not_active Expired - Lifetime
- 2003-01-31 KR KR1020047012437A patent/KR100718378B1/ko not_active Expired - Lifetime
- 2003-01-31 CA CA2475214A patent/CA2475214C/en not_active Expired - Lifetime
- 2003-01-31 EP EP03739390A patent/EP1476539B1/en not_active Expired - Lifetime
- 2003-01-31 ME MEP-2008-730A patent/ME00472B/me unknown
- 2003-01-31 SI SI200331553T patent/SI1476539T1/sl unknown
- 2003-01-31 EP EP09150098A patent/EP2050815B1/en not_active Expired - Lifetime
- 2003-01-31 CN CN038037416A patent/CN1630712B/zh not_active Expired - Lifetime
- 2003-01-31 BR BRPI0307620A patent/BRPI0307620B8/pt active IP Right Grant
- 2003-01-31 SI SI200332087T patent/SI2050815T1/sl unknown
- 2003-01-31 JP JP2003568070A patent/JP2005517406A/ja active Pending
- 2003-01-31 RS YUP-700/04A patent/RS50813B/sr unknown
- 2003-01-31 DK DK03739390T patent/DK1476539T3/da active
- 2003-01-31 DE DE60326824T patent/DE60326824D1/de not_active Expired - Lifetime
- 2003-01-31 DK DK09150098.3T patent/DK2050815T3/da active
- 2003-02-10 TW TW092102676A patent/TWI341330B/zh not_active IP Right Cessation
- 2003-02-10 US US10/361,376 patent/US7388085B2/en not_active Expired - Lifetime
- 2003-02-10 AR ARP030100408A patent/AR038405A1/es active IP Right Grant
-
2004
- 2004-07-05 IL IL162866A patent/IL162866A/en active IP Right Grant
- 2004-07-05 ZA ZA200405345A patent/ZA200405345B/xx unknown
-
2008
- 2008-04-23 US US12/107,949 patent/US8008078B2/en not_active Expired - Fee Related
- 2008-06-22 IL IL192371A patent/IL192371A/en active IP Right Grant
-
2009
- 2009-04-27 CY CY20091100467T patent/CY1110454T1/el unknown
-
2011
- 2011-12-02 CY CY20111101193T patent/CY1112491T1/el unknown
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