KR100718378B1 - Ｂ2:ｂ1 아베르멕틴의 비를 제어하는 스트렙토마이세스아베르미틸리스 유전자 - Google Patents

Ｂ2:ｂ1 아베르멕틴의 비를 제어하는 스트렙토마이세스아베르미틸리스 유전자 Download PDF

Info

Publication number
KR100718378B1
KR100718378B1 KR1020047012437A KR20047012437A KR100718378B1 KR 100718378 B1 KR100718378 B1 KR 100718378B1 KR 1020047012437 A KR1020047012437 A KR 1020047012437A KR 20047012437 A KR20047012437 A KR 20047012437A KR 100718378 B1 KR100718378 B1 KR 100718378B1
Authority
KR
South Korea
Prior art keywords
amino acid
cyclohexyl
avermectin
avec
streptomyces avermitilis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020047012437A
Other languages
English (en)
Korean (ko)
Other versions
KR20040081199A (ko
Inventor
스투츠만-엥월킴조넬
구스타프쏜클라에스에릭다니엘
크레버안케
레일라드선아이
민슐제레미스티븐
킴세란
첸얀
Original Assignee
화이자 프로덕츠 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 프로덕츠 인코포레이티드 filed Critical 화이자 프로덕츠 인코포레이티드
Publication of KR20040081199A publication Critical patent/KR20040081199A/ko
Application granted granted Critical
Publication of KR100718378B1 publication Critical patent/KR100718378B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
KR1020047012437A 2002-02-12 2003-01-31 Ｂ2:ｂ1 아베르멕틴의 비를 제어하는 스트렙토마이세스아베르미틸리스 유전자 Expired - Lifetime KR100718378B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35622202P 2002-02-12 2002-02-12
US60/356,222 2002-02-12
PCT/IB2003/000348 WO2003068955A2 (en) 2002-02-12 2003-01-31 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
KR20040081199A KR20040081199A (ko) 2004-09-20
KR100718378B1 true KR100718378B1 (ko) 2007-05-14

Family

ID=27734621

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047012437A Expired - Lifetime KR100718378B1 (ko) 2002-02-12 2003-01-31 Ｂ2:ｂ1 아베르멕틴의 비를 제어하는 스트렙토마이세스아베르미틸리스 유전자

Country Status (25)

Country Link
US (2) US7388085B2 (enExample)
EP (2) EP2050815B1 (enExample)
JP (1) JP2005517406A (enExample)
KR (1) KR100718378B1 (enExample)
CN (2) CN1630712B (enExample)
AR (1) AR038405A1 (enExample)
AT (2) ATE530645T1 (enExample)
AU (1) AU2003245052B2 (enExample)
BR (1) BRPI0307620B8 (enExample)
CA (1) CA2475214C (enExample)
CY (2) CY1110454T1 (enExample)
DE (1) DE60326824D1 (enExample)
DK (2) DK1476539T3 (enExample)
ES (2) ES2373629T3 (enExample)
IL (3) IL162866A0 (enExample)
ME (1) ME00472B (enExample)
MX (1) MXPA04007777A (enExample)
PL (1) PL211693B1 (enExample)
PT (2) PT1476539E (enExample)
RS (1) RS50813B (enExample)
RU (1) RU2293117C2 (enExample)
SI (2) SI1476539T1 (enExample)
TW (1) TWI341330B (enExample)
WO (1) WO2003068955A2 (enExample)
ZA (1) ZA200405345B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine
CN102241750B (zh) * 2010-05-14 2014-05-28 中国科学院微生物研究所 一种生产阿维菌素的基因工程方法及其专用菌株
CN102093997B (zh) * 2010-12-01 2013-03-13 中国科学院上海有机化学研究所 一种改造除虫链霉菌产生多拉菌素的方法
CN109576196B (zh) * 2019-01-25 2022-01-04 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及多拉菌素的生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (enExample) 1987-01-23 1991-01-19 Pfizer
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
AU680039B2 (en) * 1993-10-05 1997-07-17 Pfizer Inc. Process and antiparasitic intermediates for doramectin
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
JP2002503473A (ja) * 1998-02-13 2002-02-05 ファイザー・プロダクツ・インク Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
RU2156301C2 (ru) * 1998-06-09 2000-09-20 Мосин Владимир Александрович Штамм актиномицета streptomyces avermitilis ссм 4697 - продуцент авермектинов
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
PT1200606E (pt) * 1999-08-12 2006-12-29 Pfizer Prod Inc Gene de streptomyces avermitilis que regula a proporção de avermectinas b2:b1
AR032130A1 (es) 1999-08-13 2003-10-29 Vertex Pharma Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuesto
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine

Also Published As

Publication number Publication date
ME00472B (me) 2011-10-10
DE60326824D1 (de) 2009-05-07
WO2003068955A3 (en) 2003-11-13
TWI341330B (en) 2011-05-01
PT1476539E (pt) 2009-04-09
AR038405A1 (es) 2005-01-12
PL211693B1 (pl) 2012-06-29
ATE530645T1 (de) 2011-11-15
EP1476539B1 (en) 2009-03-25
EP1476539A2 (en) 2004-11-17
CA2475214A1 (en) 2003-08-21
US7388085B2 (en) 2008-06-17
CY1112491T1 (el) 2015-12-09
BRPI0307620B1 (pt) 2015-08-11
BR0307620A (pt) 2004-12-07
CN102392028B (zh) 2013-08-14
IL162866A0 (en) 2005-11-20
DK1476539T3 (da) 2009-05-11
JP2005517406A (ja) 2005-06-16
ES2373629T3 (es) 2012-02-07
PT2050815E (pt) 2012-01-02
AU2003245052A1 (en) 2003-09-04
CN102392028A (zh) 2012-03-28
IL192371A (en) 2010-11-30
BRPI0307620B8 (pt) 2016-09-13
KR20040081199A (ko) 2004-09-20
HK1074644A1 (en) 2005-11-18
WO2003068955A2 (en) 2003-08-21
PL371320A1 (en) 2005-06-13
CA2475214C (en) 2012-07-31
MXPA04007777A (es) 2004-10-15
SI1476539T1 (sl) 2009-06-30
IL162866A (en) 2009-11-18
CN1630712A (zh) 2005-06-22
RS50813B (sr) 2010-08-31
SI2050815T1 (sl) 2012-01-31
RU2293117C2 (ru) 2007-02-10
ZA200405345B (en) 2005-06-14
RU2004124521A (ru) 2005-04-10
EP2050815A1 (en) 2009-04-22
CN1630712B (zh) 2011-09-28
AU2003245052B2 (en) 2008-07-31
ATE426659T1 (de) 2009-04-15
DK2050815T3 (da) 2011-12-12
IL192371A0 (en) 2008-12-29
ES2321827T3 (es) 2009-06-12
TW200303918A (en) 2003-09-16
US8008078B2 (en) 2011-08-30
US20090017508A1 (en) 2009-01-15
HK1168383A1 (en) 2012-12-28
US20030166165A1 (en) 2003-09-04
CY1110454T1 (el) 2015-04-29
EP2050815B1 (en) 2011-10-26
RS70004A (sr) 2006-10-27

Similar Documents

Publication Publication Date Title
US8008078B2 (en) Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
JP3688640B2 (ja) Ｂ２：Ｂ１アベルメクチン比率を支配するＳｔｒｅｐｔｏｍｙｃｅｓａｖｅｒｍｉｔｉｌｉｓ遺伝子
KR100489856B1 (ko) Ｂ2:ｂ1 아베르멕틴의 비율을 제어하는 스트렙토마이세스아베르미틸리스 유전자
NZ518657A (en) Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins
HK1168383B (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
HK1074644B (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Legal Events

Date Code Title Description
A201 Request for examination
PA0105 International application

Patent event date: 20040811

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20040811

Comment text: Request for Examination of Application

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20060331

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20061107

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20060331

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

Patent event date: 20061208

Comment text: Request for Trial against Decision on Refusal

Patent event code: PJ02012R01D

Patent event date: 20061107

Comment text: Decision to Refuse Application

Patent event code: PJ02011S01I

Appeal kind category: Appeal against decision to decline refusal

Decision date: 20070221

Appeal identifier: 2006101010774

Request date: 20061208

AMND Amendment
PB0901 Examination by re-examination before a trial

Comment text: Amendment to Specification, etc.

Patent event date: 20070108

Patent event code: PB09011R02I

Comment text: Request for Trial against Decision on Refusal

Patent event date: 20061208

Patent event code: PB09011R01I

Comment text: Amendment to Specification, etc.

Patent event date: 20060630

Patent event code: PB09011R02I

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

Patent event date: 20070221

Comment text: Decision to Grant Registration

Patent event code: PB07012S01D

Patent event date: 20070124

Comment text: Transfer of Trial File for Re-examination before a Trial

Patent event code: PB07011S01I

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20070508

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20070508

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20100429

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20110428

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20120427

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20130429

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20130429

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20140430

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20140430

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20160330

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20160330

Start annual number: 10

End annual number: 10

FPAY Annual fee payment

Payment date: 20170330

Year of fee payment: 11

PR1001 Payment of annual fee

Payment date: 20170330

Start annual number: 11

End annual number: 11

FPAY Annual fee payment

Payment date: 20180329

Year of fee payment: 12

PR1001 Payment of annual fee

Payment date: 20180329

Start annual number: 12

End annual number: 12

FPAY Annual fee payment

Payment date: 20190327

Year of fee payment: 13

PR1001 Payment of annual fee

Payment date: 20190327

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20200324

Start annual number: 14

End annual number: 14

PR1001 Payment of annual fee

Payment date: 20210329

Start annual number: 15

End annual number: 15

PC1801 Expiration of term

Termination date: 20230731

Termination category: Expiration of duration