CN1630712B - 指导b2:b1除虫菌素比例的除虫链霉菌基因 - Google Patents

指导b2:b1除虫菌素比例的除虫链霉菌基因 Download PDF

Info

Publication number
CN1630712B
CN1630712B CN038037416A CN03803741A CN1630712B CN 1630712 B CN1630712 B CN 1630712B CN 038037416 A CN038037416 A CN 038037416A CN 03803741 A CN03803741 A CN 03803741A CN 1630712 B CN1630712 B CN 1630712B
Authority
CN
China
Prior art keywords
amino acid
avec
cyclohexyl
avermitilis
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN038037416A
Other languages
English (en)
Chinese (zh)
Other versions
CN1630712A (zh
Inventor
金·J·施图茨曼-恩格沃尔
克莱斯·E·D·古斯塔夫森
安克·克雷伯
森·A·雷拉德
杰里米·S·明舒尔
塞兰·金
陈燕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Services LLC
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1630712A publication Critical patent/CN1630712A/zh
Application granted granted Critical
Publication of CN1630712B publication Critical patent/CN1630712B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
CN038037416A 2002-02-12 2003-01-31 指导b2:b1除虫菌素比例的除虫链霉菌基因 Expired - Lifetime CN1630712B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35622202P 2002-02-12 2002-02-12
US60/356,222 2002-02-12
PCT/IB2003/000348 WO2003068955A2 (en) 2002-02-12 2003-01-31 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2011102082591A Division CN102392028B (zh) 2002-02-12 2003-01-31 指导b2:b1除虫菌素比例的除虫链霉菌基因

Publications (2)

Publication Number Publication Date
CN1630712A CN1630712A (zh) 2005-06-22
CN1630712B true CN1630712B (zh) 2011-09-28

Family

ID=27734621

Family Applications (2)

Application Number Title Priority Date Filing Date
CN038037416A Expired - Lifetime CN1630712B (zh) 2002-02-12 2003-01-31 指导b2:b1除虫菌素比例的除虫链霉菌基因
CN2011102082591A Expired - Lifetime CN102392028B (zh) 2002-02-12 2003-01-31 指导b2:b1除虫菌素比例的除虫链霉菌基因

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011102082591A Expired - Lifetime CN102392028B (zh) 2002-02-12 2003-01-31 指导b2:b1除虫菌素比例的除虫链霉菌基因

Country Status (25)

Country Link
US (2) US7388085B2 (enExample)
EP (2) EP2050815B1 (enExample)
JP (1) JP2005517406A (enExample)
KR (1) KR100718378B1 (enExample)
CN (2) CN1630712B (enExample)
AR (1) AR038405A1 (enExample)
AT (2) ATE530645T1 (enExample)
AU (1) AU2003245052B2 (enExample)
BR (1) BRPI0307620B8 (enExample)
CA (1) CA2475214C (enExample)
CY (2) CY1110454T1 (enExample)
DE (1) DE60326824D1 (enExample)
DK (2) DK1476539T3 (enExample)
ES (2) ES2373629T3 (enExample)
IL (3) IL162866A0 (enExample)
ME (1) ME00472B (enExample)
MX (1) MXPA04007777A (enExample)
PL (1) PL211693B1 (enExample)
PT (2) PT1476539E (enExample)
RS (1) RS50813B (enExample)
RU (1) RU2293117C2 (enExample)
SI (2) SI1476539T1 (enExample)
TW (1) TWI341330B (enExample)
WO (1) WO2003068955A2 (enExample)
ZA (1) ZA200405345B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine
CN102241750B (zh) * 2010-05-14 2014-05-28 中国科学院微生物研究所 一种生产阿维菌素的基因工程方法及其专用菌株
CN102093997B (zh) * 2010-12-01 2013-03-13 中国科学院上海有机化学研究所 一种改造除虫链霉菌产生多拉菌素的方法
CN109576196B (zh) * 2019-01-25 2022-01-04 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及多拉菌素的生产方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009863A1 (en) * 1993-10-05 1995-04-13 Pfizer Inc. Process and antiparasitic intermediates for doramectin
WO1999041389A1 (en) * 1998-02-13 1999-08-19 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (enExample) 1987-01-23 1991-01-19 Pfizer
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
RU2156301C2 (ru) * 1998-06-09 2000-09-20 Мосин Владимир Александрович Штамм актиномицета streptomyces avermitilis ссм 4697 - продуцент авермектинов
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
AR032130A1 (es) 1999-08-13 2003-10-29 Vertex Pharma Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuesto
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009863A1 (en) * 1993-10-05 1995-04-13 Pfizer Inc. Process and antiparasitic intermediates for doramectin
WO1999041389A1 (en) * 1998-02-13 1999-08-19 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
WO2001012821A1 (en) * 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Also Published As

Publication number Publication date
ME00472B (me) 2011-10-10
DE60326824D1 (de) 2009-05-07
WO2003068955A3 (en) 2003-11-13
KR100718378B1 (ko) 2007-05-14
TWI341330B (en) 2011-05-01
PT1476539E (pt) 2009-04-09
AR038405A1 (es) 2005-01-12
PL211693B1 (pl) 2012-06-29
ATE530645T1 (de) 2011-11-15
EP1476539B1 (en) 2009-03-25
EP1476539A2 (en) 2004-11-17
CA2475214A1 (en) 2003-08-21
US7388085B2 (en) 2008-06-17
CY1112491T1 (el) 2015-12-09
BRPI0307620B1 (pt) 2015-08-11
BR0307620A (pt) 2004-12-07
CN102392028B (zh) 2013-08-14
IL162866A0 (en) 2005-11-20
DK1476539T3 (da) 2009-05-11
JP2005517406A (ja) 2005-06-16
ES2373629T3 (es) 2012-02-07
PT2050815E (pt) 2012-01-02
AU2003245052A1 (en) 2003-09-04
CN102392028A (zh) 2012-03-28
IL192371A (en) 2010-11-30
BRPI0307620B8 (pt) 2016-09-13
KR20040081199A (ko) 2004-09-20
HK1074644A1 (en) 2005-11-18
WO2003068955A2 (en) 2003-08-21
PL371320A1 (en) 2005-06-13
CA2475214C (en) 2012-07-31
MXPA04007777A (es) 2004-10-15
SI1476539T1 (sl) 2009-06-30
IL162866A (en) 2009-11-18
CN1630712A (zh) 2005-06-22
RS50813B (sr) 2010-08-31
SI2050815T1 (sl) 2012-01-31
RU2293117C2 (ru) 2007-02-10
ZA200405345B (en) 2005-06-14
RU2004124521A (ru) 2005-04-10
EP2050815A1 (en) 2009-04-22
AU2003245052B2 (en) 2008-07-31
ATE426659T1 (de) 2009-04-15
DK2050815T3 (da) 2011-12-12
IL192371A0 (en) 2008-12-29
ES2321827T3 (es) 2009-06-12
TW200303918A (en) 2003-09-16
US8008078B2 (en) 2011-08-30
US20090017508A1 (en) 2009-01-15
HK1168383A1 (en) 2012-12-28
US20030166165A1 (en) 2003-09-04
CY1110454T1 (el) 2015-04-29
EP2050815B1 (en) 2011-10-26
RS70004A (sr) 2006-10-27

Similar Documents

Publication Publication Date Title
US8008078B2 (en) Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
US7029887B2 (en) Methods related to Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
AU752343C (en) Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
EP1200606B1 (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
HK1074644B (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
HK1168383B (en) Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1074644

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1074644

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: PAH AMERICA 15 CO., LTD.

Free format text: FORMER OWNER: PFIZER PRODUCTS INC.

Effective date: 20130508

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: ZOETIS P LLC

Free format text: FORMER NAME: PAH AMERICA 15 CO., LTD.

CP03 Change of name, title or address

Address after: New jersey, USA

Patentee after: Zotis P LLC

Address before: American New York

Patentee before: PAH USA 15 LLC

TR01 Transfer of patent right

Effective date of registration: 20130508

Address after: American New York

Patentee after: PAH USA 15 LLC

Address before: American Connecticut

Patentee before: Pfizer Products Inc.

ASS Succession or assignment of patent right

Owner name: SHUOTENG SERVICE LLC

Free format text: FORMER OWNER: ZOETIS P LLC

Effective date: 20150826

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20150826

Address after: New jersey, USA

Patentee after: Zoetis Services LLC

Address before: New jersey, USA

Patentee before: Zotis P LLC

CX01 Expiry of patent term

Granted publication date: 20110928

CX01 Expiry of patent term