JP2005516043A5 - - Google Patents
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- Publication number
- JP2005516043A5 JP2005516043A5 JP2003563319A JP2003563319A JP2005516043A5 JP 2005516043 A5 JP2005516043 A5 JP 2005516043A5 JP 2003563319 A JP2003563319 A JP 2003563319A JP 2003563319 A JP2003563319 A JP 2003563319A JP 2005516043 A5 JP2005516043 A5 JP 2005516043A5
- Authority
- JP
- Japan
- Prior art keywords
- subunit
- polypeptide fragment
- conglycinin
- soybean
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108700037728 Glycine max beta-conglycinin Proteins 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical group [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 230000009144 enzymatic modification Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052759 nickel Chemical group 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000147A ITMI20020147A1 (it) | 2002-01-29 | 2002-01-29 | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
| ITMI2002A000147 | 2002-01-29 | ||
| PCT/EP2003/000798 WO2003063608A1 (en) | 2002-01-29 | 2003-01-27 | A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516043A JP2005516043A (ja) | 2005-06-02 |
| JP2005516043A5 true JP2005516043A5 (https=) | 2006-03-09 |
| JP4522706B2 JP4522706B2 (ja) | 2010-08-11 |
Family
ID=11449014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003563319A Expired - Fee Related JP4522706B2 (ja) | 2002-01-29 | 2003-01-27 | 血中コレステロール低下剤として使用するための大豆β−コングリシニンα’サブユニットの選択的抽出、精製及び酵素的改変方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7465467B2 (https=) |
| EP (1) | EP1469741B1 (https=) |
| JP (1) | JP4522706B2 (https=) |
| KR (1) | KR100991641B1 (https=) |
| CN (1) | CN100558243C (https=) |
| AT (1) | ATE341943T1 (https=) |
| AU (1) | AU2003208346B8 (https=) |
| CA (1) | CA2474106C (https=) |
| CY (1) | CY1107514T1 (https=) |
| DE (1) | DE60308994T2 (https=) |
| DK (1) | DK1469741T3 (https=) |
| ES (1) | ES2274208T3 (https=) |
| IL (1) | IL163225A (https=) |
| IT (1) | ITMI20020147A1 (https=) |
| NO (1) | NO327156B1 (https=) |
| PL (1) | PL209342B1 (https=) |
| PT (1) | PT1469741E (https=) |
| RU (1) | RU2300898C2 (https=) |
| SG (1) | SG152048A1 (https=) |
| WO (1) | WO2003063608A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| AU2003275628B2 (en) * | 2002-11-12 | 2008-04-03 | Fuji Oil Company, Limited | Fractionated soybean protein and process for producing the same |
| WO2005055735A1 (ja) * | 2003-12-11 | 2005-06-23 | Fuji Oil Company, Limited | 改良大豆７ｓたん白及びその製造法 |
| JP5382840B2 (ja) * | 2005-08-23 | 2014-01-08 | 特定非営利活動法人プライメイト・アゴラ | サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤 |
| MX2011007107A (es) * | 2008-12-31 | 2011-08-03 | Novozymes As | Composiciones de hidrolizado de proteina. |
| PT2264055E (pt) * | 2009-06-17 | 2014-05-07 | Indena Spa | Clonagem, expressão em levedura, purificação e atividade biológica da região de extensão da subunidade alfa' da globulina 7s da soja implicada na homeostase do colesterol em células hep g2 |
| EP2264054A1 (en) * | 2009-06-17 | 2010-12-22 | Indena S.p.A. | Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis |
| CN101904406B (zh) * | 2010-07-02 | 2012-07-25 | 山西大学 | 一种葵花籽多肽的制备方法和用途 |
| CN104163767B (zh) * | 2014-07-25 | 2017-01-18 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽水溶性物质的纯化方法 |
| CN114874301A (zh) * | 2022-05-10 | 2022-08-09 | 吉林农业大学 | 不同亚基组成β-伴大豆球蛋白的制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409248A (en) * | 1981-08-10 | 1983-10-11 | A. E. Staley Manufacturing Company | Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates |
| JPH06197788A (ja) | 1993-01-06 | 1994-07-19 | Fuji Oil Co Ltd | 蛋白質の製造法 |
| CN1082345C (zh) | 1996-03-28 | 2002-04-10 | 不二制油株式会社 | 蛋白水解产物的制备方法 |
| BR9709697A (pt) * | 1996-06-14 | 1999-10-05 | Du Pont | Método para reduzir a quantidade de proteìna de armazenamento em semente de soja, método para reduzir simultaneamente a expressão de dois genes de soja, planta de soja transgênica e sementes transgênicas. |
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| US6365802B2 (en) * | 1998-08-14 | 2002-04-02 | Calgene Llc | Methods for increasing stearate content in soybean oil |
| FR2784029B1 (fr) | 1998-10-05 | 2001-01-05 | Pharmascience Lab | Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie |
| JP2003527077A (ja) * | 1999-04-15 | 2003-09-16 | カルジーン エルエルシー | トコフェロール合成に関与するタンパク質の核酸配列 |
| CA2274414A1 (en) | 1999-06-11 | 2000-12-11 | Universite Laval | Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals |
| AUPQ877300A0 (en) * | 2000-07-13 | 2000-08-03 | Johnson & Johnson Pacific Pty Limited | Topical treatment of skin |
| BRPI0309421B8 (pt) * | 2002-04-18 | 2021-05-25 | Monsanto Technology Llc | método de preparar um gênero alimentício e composição para tratar ou prevenir hipercolesterolemia |
| ATE446969T1 (de) * | 2003-08-20 | 2009-11-15 | Seikagaku Kogyo Co Ltd | Stabilisierungsmittel für enzyme |
| WO2006076425A1 (en) * | 2005-01-14 | 2006-07-20 | Solae, Llc | Soy protein for infant formula |
-
2002
- 2002-01-29 IT IT2002MI000147A patent/ITMI20020147A1/it unknown
-
2003
- 2003-01-27 PT PT03706387T patent/PT1469741E/pt unknown
- 2003-01-27 US US10/502,582 patent/US7465467B2/en not_active Expired - Fee Related
- 2003-01-27 DK DK03706387T patent/DK1469741T3/da active
- 2003-01-27 JP JP2003563319A patent/JP4522706B2/ja not_active Expired - Fee Related
- 2003-01-27 AU AU2003208346A patent/AU2003208346B8/en not_active Ceased
- 2003-01-27 AT AT03706387T patent/ATE341943T1/de active
- 2003-01-27 WO PCT/EP2003/000798 patent/WO2003063608A1/en not_active Ceased
- 2003-01-27 PL PL370294A patent/PL209342B1/pl unknown
- 2003-01-27 KR KR1020047011441A patent/KR100991641B1/ko not_active Expired - Fee Related
- 2003-01-27 DE DE60308994T patent/DE60308994T2/de not_active Expired - Lifetime
- 2003-01-27 SG SG200506973-7A patent/SG152048A1/en unknown
- 2003-01-27 EP EP03706387A patent/EP1469741B1/en not_active Expired - Lifetime
- 2003-01-27 RU RU2004123201/13A patent/RU2300898C2/ru not_active IP Right Cessation
- 2003-01-27 CN CNB038028050A patent/CN100558243C/zh not_active Expired - Fee Related
- 2003-01-27 ES ES03706387T patent/ES2274208T3/es not_active Expired - Lifetime
- 2003-01-27 CA CA2474106A patent/CA2474106C/en not_active Expired - Fee Related
-
2004
- 2004-07-27 NO NO20043186A patent/NO327156B1/no not_active IP Right Cessation
- 2004-07-27 IL IL163225A patent/IL163225A/en not_active IP Right Cessation
-
2006
- 2006-11-28 CY CY20061101709T patent/CY1107514T1/el unknown
-
2008
- 2008-04-17 US US12/104,473 patent/US7901718B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/013,966 patent/US8257758B2/en not_active Expired - Fee Related
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