JP2005516043A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005516043A5 JP2005516043A5 JP2003563319A JP2003563319A JP2005516043A5 JP 2005516043 A5 JP2005516043 A5 JP 2005516043A5 JP 2003563319 A JP2003563319 A JP 2003563319A JP 2003563319 A JP2003563319 A JP 2003563319A JP 2005516043 A5 JP2005516043 A5 JP 2005516043A5
- Authority
- JP
- Japan
- Prior art keywords
- subunit
- polypeptide fragment
- conglycinin
- soybean
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108700037728 Glycine max beta-conglycinin Proteins 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical group [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 230000009144 enzymatic modification Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052759 nickel Chemical group 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000147A ITMI20020147A1 (it) | 2002-01-29 | 2002-01-29 | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
| ITMI2002A000147 | 2002-01-29 | ||
| PCT/EP2003/000798 WO2003063608A1 (en) | 2002-01-29 | 2003-01-27 | A process for the extraction, purification and enzymatic modification of soy 7s globulin alpha' subunit for use as hypocholesterolemizing agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516043A JP2005516043A (ja) | 2005-06-02 |
| JP2005516043A5 true JP2005516043A5 (https=) | 2006-03-09 |
| JP4522706B2 JP4522706B2 (ja) | 2010-08-11 |
Family
ID=11449014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003563319A Expired - Fee Related JP4522706B2 (ja) | 2002-01-29 | 2003-01-27 | 血中コレステロール低下剤として使用するための大豆β−コングリシニンα’サブユニットの選択的抽出、精製及び酵素的改変方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7465467B2 (https=) |
| EP (1) | EP1469741B1 (https=) |
| JP (1) | JP4522706B2 (https=) |
| KR (1) | KR100991641B1 (https=) |
| CN (1) | CN100558243C (https=) |
| AT (1) | ATE341943T1 (https=) |
| AU (1) | AU2003208346B8 (https=) |
| CA (1) | CA2474106C (https=) |
| CY (1) | CY1107514T1 (https=) |
| DE (1) | DE60308994T2 (https=) |
| DK (1) | DK1469741T3 (https=) |
| ES (1) | ES2274208T3 (https=) |
| IL (1) | IL163225A (https=) |
| IT (1) | ITMI20020147A1 (https=) |
| NO (1) | NO327156B1 (https=) |
| PL (1) | PL209342B1 (https=) |
| PT (1) | PT1469741E (https=) |
| RU (1) | RU2300898C2 (https=) |
| SG (1) | SG152048A1 (https=) |
| WO (1) | WO2003063608A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| DE60316833T2 (de) * | 2002-11-12 | 2008-07-17 | Fuji Oil Co., Ltd. | Fraktioniertes sojabohnenprotein und herstellungsverfahren dafür |
| WO2005055735A1 (ja) * | 2003-12-11 | 2005-06-23 | Fuji Oil Company, Limited | 改良大豆７ｓたん白及びその製造法 |
| JP5382840B2 (ja) * | 2005-08-23 | 2014-01-08 | 特定非営利活動法人プライメイト・アゴラ | サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤 |
| RU2011132127A (ru) * | 2008-12-31 | 2013-02-10 | СОЛАЕ, ЭлЭлСи | Композиции белкового гидролизата |
| EP2264054A1 (en) * | 2009-06-17 | 2010-12-22 | Indena S.p.A. | Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis |
| DK2264055T3 (da) * | 2009-06-17 | 2014-04-07 | Indena Spa | Kloning, gærekspression, oprensning og biologisk aktivitet af forlængelsesregionen af sojabønne-7S-globulin-alfa'-underenheden involveret i Hep-G2-cellekolesterolhomøostase |
| CN101904406B (zh) * | 2010-07-02 | 2012-07-25 | 山西大学 | 一种葵花籽多肽的制备方法和用途 |
| CN104163767B (zh) * | 2014-07-25 | 2017-01-18 | 湖北泓肽生物科技有限公司 | 一种氨基酸和多肽水溶性物质的纯化方法 |
| CN114874301A (zh) * | 2022-05-10 | 2022-08-09 | 吉林农业大学 | 不同亚基组成β-伴大豆球蛋白的制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409248A (en) * | 1981-08-10 | 1983-10-11 | A. E. Staley Manufacturing Company | Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates |
| JPH06197788A (ja) * | 1993-01-06 | 1994-07-19 | Fuji Oil Co Ltd | 蛋白質の製造法 |
| EP0797928B1 (en) * | 1996-03-28 | 1999-11-10 | Fuji Oil Co., Ltd. | Process for producing a soy protein hydrolysate |
| WO1997047731A2 (en) * | 1996-06-14 | 1997-12-18 | E.I. Du Pont De Nemours And Company | Suppression of specific classes of soybean seed protein genes |
| US6171640B1 (en) * | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
| US6365802B2 (en) * | 1998-08-14 | 2002-04-02 | Calgene Llc | Methods for increasing stearate content in soybean oil |
| FR2784029B1 (fr) * | 1998-10-05 | 2001-01-05 | Pharmascience Lab | Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie |
| MXPA01010488A (es) * | 1999-04-15 | 2003-07-21 | Calgene Llc | Secuencias de acidos nucleicos para proteinas que intervienen en sintesis isoprenoide. |
| CA2274414A1 (en) | 1999-06-11 | 2000-12-11 | Universite Laval | Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals |
| AUPQ877300A0 (en) | 2000-07-13 | 2000-08-03 | Johnson & Johnson Pacific Pty Limited | Topical treatment of skin |
| BRPI0309421B8 (pt) * | 2002-04-18 | 2021-05-25 | Monsanto Technology Llc | método de preparar um gênero alimentício e composição para tratar ou prevenir hipercolesterolemia |
| ATE446969T1 (de) * | 2003-08-20 | 2009-11-15 | Seikagaku Kogyo Co Ltd | Stabilisierungsmittel für enzyme |
| MX2007008496A (es) * | 2005-01-14 | 2007-09-14 | Solae Llc | Proteina de soya para formula infantil. |
-
2002
- 2002-01-29 IT IT2002MI000147A patent/ITMI20020147A1/it unknown
-
2003
- 2003-01-27 CN CNB038028050A patent/CN100558243C/zh not_active Expired - Fee Related
- 2003-01-27 WO PCT/EP2003/000798 patent/WO2003063608A1/en not_active Ceased
- 2003-01-27 JP JP2003563319A patent/JP4522706B2/ja not_active Expired - Fee Related
- 2003-01-27 KR KR1020047011441A patent/KR100991641B1/ko not_active Expired - Fee Related
- 2003-01-27 PT PT03706387T patent/PT1469741E/pt unknown
- 2003-01-27 PL PL370294A patent/PL209342B1/pl unknown
- 2003-01-27 US US10/502,582 patent/US7465467B2/en not_active Expired - Fee Related
- 2003-01-27 CA CA2474106A patent/CA2474106C/en not_active Expired - Fee Related
- 2003-01-27 RU RU2004123201/13A patent/RU2300898C2/ru not_active IP Right Cessation
- 2003-01-27 DE DE60308994T patent/DE60308994T2/de not_active Expired - Lifetime
- 2003-01-27 AU AU2003208346A patent/AU2003208346B8/en not_active Ceased
- 2003-01-27 SG SG200506973-7A patent/SG152048A1/en unknown
- 2003-01-27 ES ES03706387T patent/ES2274208T3/es not_active Expired - Lifetime
- 2003-01-27 EP EP03706387A patent/EP1469741B1/en not_active Expired - Lifetime
- 2003-01-27 AT AT03706387T patent/ATE341943T1/de active
- 2003-01-27 DK DK03706387T patent/DK1469741T3/da active
-
2004
- 2004-07-27 IL IL163225A patent/IL163225A/en not_active IP Right Cessation
- 2004-07-27 NO NO20043186A patent/NO327156B1/no not_active IP Right Cessation
-
2006
- 2006-11-28 CY CY20061101709T patent/CY1107514T1/el unknown
-
2008
- 2008-04-17 US US12/104,473 patent/US7901718B2/en not_active Expired - Fee Related
-
2011
- 2011-01-26 US US13/013,966 patent/US8257758B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7116823B2 (ja) | 新規なトリプシンアイソフォームおよびそれらの使用 | |
| EP0088398B1 (en) | Low-molecular weight peptide mixture and method of producing same | |
| JP2005516043A5 (https=) | ||
| EP2343370B1 (en) | A throbin-like enzyme of agkistrodon acutus | |
| CN103923177B (zh) | 一种海洋微藻来源的血管紧张素转化酶抑制肽 | |
| RU2004123201A (ru) | СПОСОБ ЭКСТРАГИРОВАНИЯ, ОЧИСТКИ И ФЕРМЕНТАТИВНОЙ МОДИФИКАЦИИ α'-СУБЪЕДИНИЦЫ 7S-ГЛОБУЛИНА СОИ ДЛЯ ИСПОЛЬЗОВАНИЯ В КАЧЕСТВЕ ГИПОХОЛЕСТЕРИНЕМИЧЕСКОГО АГЕНТА | |
| JP2012244930A (ja) | かつおの中骨を原料とするコラーゲンペプチドの製造方法 | |
| CN116535496A (zh) | 一种改善焦虑和短期记忆力的核桃肽及其制备方法和应用 | |
| CN106107423A (zh) | 一种脱除大米蛋白中苯丙氨酸的方法 | |
| JP2009284798A (ja) | ジペプチジルペプチダーゼｉｖ阻害剤の製造方法 | |
| CN120366416A (zh) | 一种地龙蛋白肽及其制备方法和应用 | |
| CN106834399A (zh) | 一种来源于厚壳贻贝闭壳肌的降压肽 | |
| CN101773522B (zh) | 一种动物肠黏膜提取物及其制备方法与应用 | |
| CN104497135A (zh) | 一种病毒灭活去除纯化乌司他丁的方法及含有乌司他丁的药物组合物 | |
| CN117264019A (zh) | 一种苦荞蛋白源dpp-iv抑制肽及其分离纯化方法 | |
| CN104892723B (zh) | 带鱼肝脏抗菌肽的制备方法 | |
| JP2004508384A5 (https=) | ||
| CN102268422B (zh) | 一种可抑制hiv-1反转录酶的蝉花蛋白酶及制备方法 | |
| Woodley et al. | The presence of pancreatic proteases in particulate preparations of rat intestinal mucosa | |
| Meienhofer et al. | Preparation of an insulin A chain derivative with an intact intra-chain disulphide bond | |
| KR101823045B1 (ko) | 크릴 단백질 가수분해물을 포함하는 고혈압 치료 및 예방용 조성물, 이를 포함하는 건강기능성 식품 및 그 제조방법 | |
| WO2004046199A3 (fr) | Procede d'obtention d'acide chondroitine sulfurique et ses utilisations | |
| CN103103239A (zh) | 一种酶合成胸腺五肽的方法 | |
| CN100542602C (zh) | 一种肝水解肽注射液的制备方法 | |
| JPS60260518A (ja) | 人尿トリプシンインヒビタ−および人尿カリクレインの濃縮分離方法 |