JP2005514482A5 - - Google Patents
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- Publication number
- JP2005514482A5 JP2005514482A5 JP2003558067A JP2003558067A JP2005514482A5 JP 2005514482 A5 JP2005514482 A5 JP 2005514482A5 JP 2003558067 A JP2003558067 A JP 2003558067A JP 2003558067 A JP2003558067 A JP 2003558067A JP 2005514482 A5 JP2005514482 A5 JP 2005514482A5
- Authority
- JP
- Japan
- Prior art keywords
- lactide
- bioabsorbable polyester
- polyester
- bioabsorbable
- copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 30
- 229920000728 polyester Polymers 0.000 claims description 28
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000000178 monomer Substances 0.000 claims description 7
- 239000011541 reaction mixture Substances 0.000 claims description 7
- 238000012662 bulk polymerization Methods 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 238000006116 polymerization reaction Methods 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 5
- -1 polypropylene Polymers 0.000 claims description 5
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 4
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 4
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 229920002313 fluoropolymer Polymers 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 230000002745 absorbent Effects 0.000 description 9
- 239000002250 absorbent Substances 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229920003232 aliphatic polyester Polymers 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10200738.1 | 2002-01-11 | ||
| DE10200738A DE10200738A1 (de) | 2002-01-11 | 2002-01-11 | Verfahren zur Herstellung von resorbierbaren Polyestern durch Massepolymerisation |
| PCT/EP2003/000096 WO2003057756A1 (de) | 2002-01-11 | 2003-01-08 | Verfahren zur herstellung von resorbierbaren polyestern durch massepolymerisation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514482A JP2005514482A (ja) | 2005-05-19 |
| JP2005514482A5 true JP2005514482A5 (https=) | 2012-03-08 |
| JP4975953B2 JP4975953B2 (ja) | 2012-07-11 |
Family
ID=7711853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558067A Expired - Lifetime JP4975953B2 (ja) | 2002-01-11 | 2003-01-08 | 塊状重合による再吸収性ポリエステルの製造方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1468035B1 (https=) |
| JP (1) | JP4975953B2 (https=) |
| AR (1) | AR038286A1 (https=) |
| AT (1) | ATE299156T1 (https=) |
| AU (1) | AU2003206699A1 (https=) |
| CA (1) | CA2472648C (https=) |
| DE (2) | DE10200738A1 (https=) |
| ES (1) | ES2244919T3 (https=) |
| PE (1) | PE20030842A1 (https=) |
| TW (1) | TW200302838A (https=) |
| UY (1) | UY27611A1 (https=) |
| WO (1) | WO2003057756A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842261B2 (en) | 2005-04-21 | 2010-11-30 | Purac Biochem Bv | Process for preparing resorbable polyesters by bulk polymerization |
| DE102007036101A1 (de) | 2007-08-01 | 2009-02-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue glycolidreiche Copolymere |
| EP2030679A1 (de) * | 2007-09-03 | 2009-03-04 | Uhde Inventa-Fischer GmbH | Polymerisationsreaktor, Polymerisationsvorrichtung, Verfahren zur Herstellung von bioabbaubarem Polyester sowie Verwendungen |
| WO2014108191A1 (en) | 2013-01-10 | 2014-07-17 | Evonik Industries Ag | Electronic device unit comprising a polymer coating |
| WO2015028060A1 (en) | 2013-08-29 | 2015-03-05 | Evonik Industries Ag | Process for preparing a bio-resorbable polyester in the form of a powder |
| ES2710603T3 (es) | 2014-11-14 | 2019-04-26 | Evonik Roehm Gmbh | Procedimiento para preparar un poliéster bio-reabsorbible en forma de partículas |
| WO2016198351A1 (en) | 2015-06-10 | 2016-12-15 | Evonik Röhm Gmbh | Process for preparing a powder comprising a human coagulation factor protein and a lactic acid polymer |
| MX2020011724A (es) | 2018-05-08 | 2021-01-08 | Evonik Operations Gmbh | Nanoparticula que comprende un poliester biorresorbible, un polimero hidrofilo y un peptido acilado derivado de lactoferrina humana. |
| CA3120479C (en) | 2018-11-27 | 2025-05-06 | Evonik Operations Gmbh | METHOD FOR PREPARING A RESORBABLE POLYESTER IN THE FORM OF GRANULES OR POWDER BY BULK POLYMERIZATION |
| CN117337168A (zh) | 2021-04-01 | 2024-01-02 | 渤健马萨诸塞州股份有限公司 | 向中枢神经系统的核酸递送 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379138A (en) * | 1981-12-28 | 1983-04-05 | Research Triangle Institute | Biodegradable polymers of lactones |
| US4643734A (en) * | 1983-05-05 | 1987-02-17 | Hexcel Corporation | Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom |
| EP0661325B1 (en) * | 1993-12-28 | 2001-10-10 | Dainippon Ink And Chemicals, Inc. | Continuously production process for lactide copolymer |
| JPH10316745A (ja) * | 1997-05-19 | 1998-12-02 | Tokuyama Corp | ポリ（ｐ−ジオキサノン）の製造方法 |
| KR100891603B1 (ko) * | 2001-07-10 | 2009-04-08 | 가부시끼가이샤 구레하 | 폴리에스테르 제조방법 및 반응 장치 |
-
2002
- 2002-01-11 DE DE10200738A patent/DE10200738A1/de not_active Ceased
-
2003
- 2003-01-07 UY UY27611A patent/UY27611A1/es not_active Application Discontinuation
- 2003-01-08 CA CA2472648A patent/CA2472648C/en not_active Expired - Lifetime
- 2003-01-08 DE DE50300729T patent/DE50300729D1/de not_active Expired - Lifetime
- 2003-01-08 AT AT03704361T patent/ATE299156T1/de active
- 2003-01-08 WO PCT/EP2003/000096 patent/WO2003057756A1/de not_active Ceased
- 2003-01-08 AU AU2003206699A patent/AU2003206699A1/en not_active Abandoned
- 2003-01-08 JP JP2003558067A patent/JP4975953B2/ja not_active Expired - Lifetime
- 2003-01-08 EP EP03704361A patent/EP1468035B1/de not_active Expired - Lifetime
- 2003-01-08 ES ES03704361T patent/ES2244919T3/es not_active Expired - Lifetime
- 2003-01-09 PE PE2003000034A patent/PE20030842A1/es not_active Application Discontinuation
- 2003-01-09 TW TW092100409A patent/TW200302838A/zh unknown
- 2003-01-10 AR ARP030100057A patent/AR038286A1/es not_active Application Discontinuation
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