JP2005513023A5 - - Google Patents
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- Publication number
- JP2005513023A5 JP2005513023A5 JP2003545294A JP2003545294A JP2005513023A5 JP 2005513023 A5 JP2005513023 A5 JP 2005513023A5 JP 2003545294 A JP2003545294 A JP 2003545294A JP 2003545294 A JP2003545294 A JP 2003545294A JP 2005513023 A5 JP2005513023 A5 JP 2005513023A5
- Authority
- JP
- Japan
- Prior art keywords
- octadeca
- acyl
- active ingredient
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 13
- 239000004480 active ingredient Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002252 acyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- -1 β-D-glucopyranosyl Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 230000004968 inflammatory condition Effects 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 125000003563 glycoside group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- QUZHZFAQJATMCA-VLTMIGNISA-N 1,2-Di-(9Z,12Z,15Z-octadecatrienoyl)-3-O-beta-D-galactosyl-sn-glycerol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O QUZHZFAQJATMCA-VLTMIGNISA-N 0.000 claims 1
- 206010003267 Arthritis reactive Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010057178 Osteoarthropathies Diseases 0.000 claims 1
- QUZHZFAQJATMCA-ALNPWPOFSA-N [2-[(9z,12z,15z)-octadeca-9,12,15-trienoyl]oxy-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] (9z,12z,15z)-octadeca-9,12,15-trienoate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/C\C=C/C\C=C/CC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QUZHZFAQJATMCA-ALNPWPOFSA-N 0.000 claims 1
- 125000003550 alpha-D-galactosyl group Chemical class C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 1
- 125000001488 beta-D-galactosyl group Chemical class C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 1
- 230000035605 chemotaxis Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33208401P | 2001-11-21 | 2001-11-21 | |
| US60/332,084 | 2001-11-21 | ||
| US34160901P | 2001-12-18 | 2001-12-18 | |
| US60/341,609 | 2001-12-18 | ||
| US35839102P | 2002-02-22 | 2002-02-22 | |
| US60/358,391 | 2002-02-22 | ||
| PCT/DK2002/000783 WO2003043613A2 (en) | 2001-11-21 | 2002-11-21 | Use of glycosides of mono- and diacylglycerol as anti-inflammatory agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010142945A Division JP2010215660A (ja) | 2001-11-21 | 2010-06-23 | 抗炎症剤としてのモノ−およびジアシルグリセロールのグリコシドの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005513023A JP2005513023A (ja) | 2005-05-12 |
| JP2005513023A5 true JP2005513023A5 (https=) | 2006-03-02 |
| JP4716655B2 JP4716655B2 (ja) | 2011-07-06 |
Family
ID=27406836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545294A Expired - Lifetime JP4716655B2 (ja) | 2001-11-21 | 2002-11-21 | 抗炎症剤としてのモノ−およびジアシルグリセロールのグリコシドの使用 |
| JP2010142945A Pending JP2010215660A (ja) | 2001-11-21 | 2010-06-23 | 抗炎症剤としてのモノ−およびジアシルグリセロールのグリコシドの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010142945A Pending JP2010215660A (ja) | 2001-11-21 | 2010-06-23 | 抗炎症剤としてのモノ−およびジアシルグリセロールのグリコシドの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7084122B2 (https=) |
| EP (1) | EP1453844B1 (https=) |
| JP (2) | JP4716655B2 (https=) |
| CN (1) | CN100469784C (https=) |
| AU (1) | AU2002366210A1 (https=) |
| DK (1) | DK1453844T3 (https=) |
| NO (1) | NO334587B1 (https=) |
| PL (2) | PL213644B1 (https=) |
| WO (1) | WO2003043613A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004151D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004152D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| AR035700A1 (es) * | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| SE0102640D0 (sv) * | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| SE0203304D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Coumpounds |
| JP3914519B2 (ja) * | 2003-06-06 | 2007-05-16 | 株式会社スピルリナ研究所 | グリセロ糖脂質化合物を含有してなるリパーゼ活性阻害剤 |
| US7758903B2 (en) | 2003-09-12 | 2010-07-20 | Access Business Group International Llc | Cytokine modulators and related methods of use |
| CN1882354B (zh) * | 2003-09-12 | 2012-07-04 | 捷通国际有限公司 | 细胞因子调节剂及相关用法 |
| US7758902B2 (en) * | 2003-09-12 | 2010-07-20 | Access Business Group International Llc | Cytokine modulators and related methods of use |
| US20070269540A1 (en) * | 2006-05-16 | 2007-11-22 | Morishita Jintan Co., Ltd. | Fat metabolism improving agent |
| JP3790767B2 (ja) * | 2004-06-30 | 2006-06-28 | 森下仁丹株式会社 | 脂肪代謝改善組成物 |
| JP4866067B2 (ja) * | 2005-11-22 | 2012-02-01 | 株式会社ファンケル | メラニン産生抑制剤 |
| US8435588B2 (en) | 2005-11-23 | 2013-05-07 | The Coca-Cola Company | High-potency sweetener composition with an anti-inflammatory agent and compositions sweetened therewith |
| ATE524483T1 (de) * | 2006-07-03 | 2011-09-15 | Hyben Vital Licens Aps | Verfahren zur herstellung eines glykosids eines mono- oder diacylglyzerinprodukts aus einem pflanzlichen material |
| US7547455B2 (en) | 2006-09-20 | 2009-06-16 | Academia Sinica | Cancer and inflammatory disorder treatment |
| KR100772078B1 (ko) | 2006-11-07 | 2007-10-31 | 한국기초과학지원연구원 | 갈조류 지충이로부터 분리된 신규모노갈락토실디아실글리세롤 화합물 |
| WO2008108001A1 (ja) * | 2007-03-02 | 2008-09-12 | Toyo Shinyaku Co., Ltd. | ガラクト脂質 |
| DK2224939T3 (da) * | 2007-12-21 | 2015-06-22 | Finzelberg Gmbh & Co Kg | Præparater med hybenekstrakt, og fremgangsmåde til fremstilling af hybenekstrakt |
| NZ567712A (en) * | 2008-04-24 | 2010-11-26 | Fonterra Cooperative Group Ltd | Compositions and methods for maintaining bone health or reducing bone loss |
| EP2288361B1 (de) | 2008-05-06 | 2013-08-21 | Finzelberg GmbH & Co. KG | Zistrosenextrakt mit angereicherten sekundären pflanzeninhaltsstoffen |
| EP2349281A1 (en) * | 2008-10-30 | 2011-08-03 | Hyben Vital Licens ApS | Composition comprising a glycoside of a mono- or diacyiglycerol compound and an oil rich in n-3 polyunsaturated fatty acids, a method of producing the composition and use of the composition |
| DK177605B1 (en) | 2010-03-16 | 2013-11-18 | Hyben Vital Licens Aps | Compositions of rose hips enriched with seeds of rose hips and their use as anti-inflammatory natural medicine for alleviating/reducing symptoms associated with inflammation and joint diseases such as arthritis and/or osteo-arthritis |
| EP2389816A1 (en) | 2010-05-25 | 2011-11-30 | Nestec S.A. | Synergistic antioxidant composition |
| WO2011161655A1 (en) * | 2010-06-25 | 2011-12-29 | Horphag Research (Ip) Pre Ltd | Composition for improving sexual wellness |
| TWI558403B (zh) * | 2013-06-04 | 2016-11-21 | 中央研究院 | 富含半乳糖脂之植物萃取物及其用途 |
| JP6339426B2 (ja) * | 2014-06-30 | 2018-06-06 | 株式会社ファンケル | グリセロ糖脂質を含有する組成物の製造方法及びグリセロ糖脂質含有組成物 |
| SG11201811595SA (en) * | 2016-06-27 | 2019-01-30 | Ohio State Innovation Foundation | Liponucleotide-based therapy for ards |
| CN106983763B (zh) * | 2017-04-25 | 2021-04-20 | 中国海洋大学 | 单半乳糖基二酰基甘油酯及其制备方法与用途 |
| CN110201026B (zh) * | 2019-07-15 | 2021-09-24 | 青岛农业大学 | 一种非抗生素型结肠炎修复制剂 |
| KR102780726B1 (ko) * | 2022-12-30 | 2025-03-13 | 주식회사 미래생명자원 | 테트라셀미스 츄이로부터 분리한 신규 화합물 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05271270A (ja) | 1992-03-27 | 1993-10-19 | Nippon Paper Ind Co Ltd | 糖ーグリセロール誘導体とその合成法 |
| JP3298723B2 (ja) | 1993-03-30 | 2002-07-08 | 武田食品工業株式会社 | 発癌プロモーション抑制組成物 |
| AU6821294A (en) * | 1993-04-30 | 1994-11-21 | Rodner R. Winget | Anti-inflammatory compositions containing eicosapentaenoic acid bearing monogalactosyldiacylglycerol and methods relating thereto |
| JPH07149786A (ja) * | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | グリセロ糖脂質及び発癌プロモーター阻害剤 |
| US5663151A (en) * | 1994-03-04 | 1997-09-02 | Bristol-Myers Squibb Company | Sulfated α-glycolipid derivatives as cell adhesion inhibitors |
| CA2142153A1 (en) | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
| US5486536A (en) * | 1994-08-15 | 1996-01-23 | The Regents Of The University Of Michigan | Sulfatides as anti-inflammatory compounds |
| DE19634021A1 (de) | 1996-08-23 | 1998-02-26 | Beiersdorf Ag | Antiadhäsive Glycoglycerolipide |
| DE19634019A1 (de) * | 1996-08-23 | 1998-02-26 | Beiersdorf Ag | Gegen Mikroogranismen, Viren, Parasiten und Protozoen wirksame Glycoglycerolipide |
| DE19700774A1 (de) | 1997-01-13 | 1998-07-16 | Hoechst Ag | Antiadhäsive Sulfatid-Mimetika |
| US6024960A (en) * | 1998-04-17 | 2000-02-15 | Otto Torbjorn Hansen And Marianne Hansen | Rose-hip formulations as anti-inflammatory natural medicine for alleviating/reducing symptoms associated with inflammation and arthritis |
-
2002
- 2002-11-21 AU AU2002366210A patent/AU2002366210A1/en not_active Abandoned
- 2002-11-21 PL PL370888A patent/PL213644B1/pl not_active IP Right Cessation
- 2002-11-21 DK DK02803339.7T patent/DK1453844T3/da active
- 2002-11-21 JP JP2003545294A patent/JP4716655B2/ja not_active Expired - Lifetime
- 2002-11-21 EP EP02803339.7A patent/EP1453844B1/en not_active Expired - Lifetime
- 2002-11-21 US US10/300,831 patent/US7084122B2/en not_active Expired - Lifetime
- 2002-11-21 CN CNB028258169A patent/CN100469784C/zh not_active Expired - Lifetime
- 2002-11-21 PL PL393941A patent/PL393941A1/pl not_active Application Discontinuation
- 2002-11-21 WO PCT/DK2002/000783 patent/WO2003043613A2/en not_active Ceased
-
2004
- 2004-05-21 NO NO20042112A patent/NO334587B1/no not_active IP Right Cessation
- 2004-10-13 US US10/962,664 patent/US20050049205A1/en not_active Abandoned
-
2010
- 2010-06-23 JP JP2010142945A patent/JP2010215660A/ja active Pending
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