JP2005512547A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005512547A5 JP2005512547A5 JP2003552997A JP2003552997A JP2005512547A5 JP 2005512547 A5 JP2005512547 A5 JP 2005512547A5 JP 2003552997 A JP2003552997 A JP 2003552997A JP 2003552997 A JP2003552997 A JP 2003552997A JP 2005512547 A5 JP2005512547 A5 JP 2005512547A5
- Authority
- JP
- Japan
- Prior art keywords
- plasmin
- substrate
- concentration
- defibrotide
- nitroaniline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940012957 plasmin Drugs 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 26
- 239000000758 substrate Substances 0.000 claims description 17
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 claims description 12
- 229960004120 defibrotide Drugs 0.000 claims description 12
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 5
- 230000004071 biological effect Effects 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000006911 enzymatic reaction Methods 0.000 claims description 2
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical group NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000012429 reaction media Substances 0.000 claims 2
- JBIJLHTVPXGSAM-UHFFFAOYSA-N 2-naphthylamine Chemical group C1=CC=CC2=CC(N)=CC=C21 JBIJLHTVPXGSAM-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000002798 spectrophotometry method Methods 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000007981 phosphate-citrate buffer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01830770A EP1325962A1 (en) | 2001-12-17 | 2001-12-17 | A method for determining the biological activity of defibrotide |
| PCT/EP2002/013371 WO2003052130A2 (en) | 2001-12-17 | 2002-11-27 | A method for determining the biological activity of defibrotide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005512547A JP2005512547A (ja) | 2005-05-12 |
| JP2005512547A5 true JP2005512547A5 (enExample) | 2006-01-12 |
| JP4348192B2 JP4348192B2 (ja) | 2009-10-21 |
Family
ID=8184814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552997A Expired - Lifetime JP4348192B2 (ja) | 2001-12-17 | 2002-11-27 | デフィブロチドの生物学的活性を決定する方法 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7338777B2 (enExample) |
| EP (2) | EP1325962A1 (enExample) |
| JP (1) | JP4348192B2 (enExample) |
| KR (1) | KR100912424B1 (enExample) |
| CN (1) | CN100408690C (enExample) |
| AR (1) | AR037870A1 (enExample) |
| AT (1) | ATE480637T1 (enExample) |
| AU (1) | AU2002360945B2 (enExample) |
| CA (1) | CA2468877C (enExample) |
| DE (1) | DE60237639D1 (enExample) |
| DK (1) | DK1456404T3 (enExample) |
| ES (1) | ES2349509T3 (enExample) |
| HR (1) | HRP20040548A2 (enExample) |
| HU (1) | HUP0402231A3 (enExample) |
| IL (2) | IL162511A0 (enExample) |
| IS (1) | IS7312A (enExample) |
| MX (1) | MXPA04005958A (enExample) |
| NO (1) | NO20042972L (enExample) |
| NZ (1) | NZ533594A (enExample) |
| PL (1) | PL373243A1 (enExample) |
| PT (1) | PT1456404E (enExample) |
| RS (1) | RS63104A (enExample) |
| RU (1) | RU2323979C2 (enExample) |
| UA (1) | UA80104C2 (enExample) |
| WO (1) | WO2003052130A2 (enExample) |
| ZA (1) | ZA200404656B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| DK2637672T3 (en) | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
| CN110079580B (zh) | 2012-06-22 | 2022-12-06 | 真蒂奥姆责任有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
| US9655761B2 (en) | 2012-11-12 | 2017-05-23 | Djo, Llc | Orthopedic back brace |
| TWI615473B (zh) * | 2013-11-26 | 2018-02-21 | 金提恩責任有限公司 | 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| RU2766143C2 (ru) * | 2017-07-26 | 2022-02-08 | Джентиум С.Р.Л. | Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни |
| SG11202000952PA (en) | 2017-08-03 | 2020-02-27 | Jazz Pharmaceuticals Ireland Ltd | Formulations comprising a nucleic acid in a high concentration |
| MX2020010689A (es) | 2018-04-12 | 2021-01-20 | Jazz Pharmaceuticals Inc | Defibrotida para la prevencion y tratamiento del sindrome de liberacion de citocinas y la neurotoxicidad asociada con la inmunodeplecion. |
| US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| US20230190783A1 (en) | 2020-02-28 | 2023-06-22 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| TW202308659A (zh) | 2021-05-06 | 2023-03-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
| IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
| IT1252174B (it) * | 1991-12-09 | 1995-06-05 | Crinos Industria Farmaco | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
| US5321006A (en) * | 1992-12-09 | 1994-06-14 | International Flavors & Fragrances Inc. | Flavor and fragrance compositions produced using process for quantitatively and qualitatively substantially continuously analyzing the aroma emitted from a living fruit |
| CN1187201A (zh) * | 1995-05-05 | 1998-07-08 | 生物药物研究与发展有限公司 | 血纤维蛋白交联和/或转谷氨酰胺酶的抑制剂 |
| GB9719161D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
-
2001
- 2001-12-17 EP EP01830770A patent/EP1325962A1/en not_active Withdrawn
-
2002
- 2002-11-27 ES ES02795074T patent/ES2349509T3/es not_active Expired - Lifetime
- 2002-11-27 HR HR20040548A patent/HRP20040548A2/hr not_active Application Discontinuation
- 2002-11-27 WO PCT/EP2002/013371 patent/WO2003052130A2/en not_active Ceased
- 2002-11-27 AT AT02795074T patent/ATE480637T1/de active
- 2002-11-27 HU HU0402231A patent/HUP0402231A3/hu unknown
- 2002-11-27 RS YU63104A patent/RS63104A/sr unknown
- 2002-11-27 DE DE60237639T patent/DE60237639D1/de not_active Expired - Lifetime
- 2002-11-27 CA CA2468877A patent/CA2468877C/en not_active Expired - Lifetime
- 2002-11-27 IL IL16251102A patent/IL162511A0/xx unknown
- 2002-11-27 AU AU2002360945A patent/AU2002360945B2/en not_active Expired
- 2002-11-27 KR KR1020047009476A patent/KR100912424B1/ko not_active Expired - Lifetime
- 2002-11-27 PT PT02795074T patent/PT1456404E/pt unknown
- 2002-11-27 EP EP02795074A patent/EP1456404B1/en not_active Expired - Lifetime
- 2002-11-27 JP JP2003552997A patent/JP4348192B2/ja not_active Expired - Lifetime
- 2002-11-27 MX MXPA04005958A patent/MXPA04005958A/es unknown
- 2002-11-27 RU RU2004121962/13A patent/RU2323979C2/ru not_active IP Right Cessation
- 2002-11-27 UA UA20040705856A patent/UA80104C2/uk unknown
- 2002-11-27 NZ NZ533594A patent/NZ533594A/xx unknown
- 2002-11-27 CN CNB028269799A patent/CN100408690C/zh not_active Expired - Lifetime
- 2002-11-27 PL PL02373243A patent/PL373243A1/xx not_active Application Discontinuation
- 2002-11-27 DK DK02795074.0T patent/DK1456404T3/da active
- 2002-12-17 AR ARP020104901A patent/AR037870A1/es not_active Application Discontinuation
-
2004
- 2004-06-11 ZA ZA200404656A patent/ZA200404656B/en unknown
- 2004-06-14 IS IS7312A patent/IS7312A/is unknown
- 2004-06-14 IL IL162511A patent/IL162511A/en active IP Right Grant
- 2004-06-17 US US10/868,798 patent/US7338777B2/en not_active Expired - Lifetime
- 2004-07-14 NO NO20042972A patent/NO20042972L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005512547A5 (enExample) | ||
| WO2002066671A3 (en) | Improved method for detection of atp | |
| JP4942872B2 (ja) | トロンビン阻害剤の濃度を測定する方法 | |
| WO2004085650A8 (en) | A high-troughput diagnostic assay for the human virus causing severe acute respiratory syndrome (sars) | |
| WO2003035896A3 (en) | Chromogenic enzyme substrates and method for detecting beta-d-ribofuranosidase activity | |
| RU2004121962A (ru) | Способ определения биологической активности дефибротида | |
| JPH0417640B2 (enExample) | ||
| JPH0346119B2 (enExample) | ||
| Wellner et al. | Oxidation of L-proline and L-3, 4-dehydroproline by D-amino acid oxidase | |
| CN111304298B (zh) | 半胱天冬酶生物传感器及应用、半胱天冬酶活性的检测方法 | |
| EP0264815B1 (en) | Methods for selective measurement of amino acids | |
| JPH01128797A (ja) | 酵素活性の定量法 | |
| JPH07155196A (ja) | 生体成分の測定法 | |
| FR2731711A1 (fr) | Procede de detection qualitative et quantitative de lesions de l'adn | |
| Dietrich et al. | Investigation of the pH dependencies of coenzyme binding to liver alcohol dehydrogenase lacking zinc ion at the active sites | |
| Jacobson et al. | Distance relationships between the catalytic site labeled with 4-(iodoacetamido) salicylic acid and regulatory sites of glutamate dehydrogenase | |
| JP6033084B2 (ja) | 血漿に基づく参照材料を用いた第ｘｉｉｉ因子の測定方法 | |
| HU181684B (en) | Process and reagent for the determination of creatine kynase mb | |
| YAMAMOTO et al. | Differential effects of anti-inflammatory agents on lysosomal cysteine proteinases cathepsins B and H from rat spleen | |
| Avery et al. | Is γ-chymotrypsin an autolytic product in the activation scheme of chymotrypsinogen A? | |
| CA2756908A1 (en) | Methods for the detection and treatment of aberrant prion disease | |
| Reeves et al. | Induction of D-6-hydroxynicotine oxidase in resting cells of Arthrobacter oxidans | |
| JPH0229319B2 (enExample) | ||
| JP2701044B2 (ja) | 新規なフローインジェクション分析法 | |
| AU5858499A (en) | Oligo nucleotides, method and kit for detecting (listeria monocytogenes) by amplifying and/or hybridizing nucleic acids |