KR100912424B1 - 디파이브로타이드의 생물학적 활성 측정 방법 - Google Patents

디파이브로타이드의 생물학적 활성 측정 방법 Download PDF

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Publication number
KR100912424B1
KR100912424B1 KR1020047009476A KR20047009476A KR100912424B1 KR 100912424 B1 KR100912424 B1 KR 100912424B1 KR 1020047009476 A KR1020047009476 A KR 1020047009476A KR 20047009476 A KR20047009476 A KR 20047009476A KR 100912424 B1 KR100912424 B1 KR 100912424B1
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South Korea
Prior art keywords
plasmin
biological activity
difibrotide
concentration
measuring
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KR1020047009476A
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Korean (ko)
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KR20040090959A (ko
Inventor
로베르또 포르타
프랭코 카타니오
로라 페로
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젠티엄 에스피에이
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020047009476A 2001-12-17 2002-11-27 디파이브로타이드의 생물학적 활성 측정 방법 Expired - Lifetime KR100912424B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01830770A EP1325962A1 (en) 2001-12-17 2001-12-17 A method for determining the biological activity of defibrotide
EP01830770.2 2001-12-17
PCT/EP2002/013371 WO2003052130A2 (en) 2001-12-17 2002-11-27 A method for determining the biological activity of defibrotide

Publications (2)

Publication Number Publication Date
KR20040090959A KR20040090959A (ko) 2004-10-27
KR100912424B1 true KR100912424B1 (ko) 2009-08-14

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ID=8184814

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KR1020047009476A Expired - Lifetime KR100912424B1 (ko) 2001-12-17 2002-11-27 디파이브로타이드의 생물학적 활성 측정 방법

Country Status (26)

Country Link
US (1) US7338777B2 (enExample)
EP (2) EP1325962A1 (enExample)
JP (1) JP4348192B2 (enExample)
KR (1) KR100912424B1 (enExample)
CN (1) CN100408690C (enExample)
AR (1) AR037870A1 (enExample)
AT (1) ATE480637T1 (enExample)
AU (1) AU2002360945B2 (enExample)
CA (1) CA2468877C (enExample)
DE (1) DE60237639D1 (enExample)
DK (1) DK1456404T3 (enExample)
ES (1) ES2349509T3 (enExample)
HR (1) HRP20040548A2 (enExample)
HU (1) HUP0402231A3 (enExample)
IL (2) IL162511A0 (enExample)
IS (1) IS7312A (enExample)
MX (1) MXPA04005958A (enExample)
NO (1) NO20042972L (enExample)
NZ (1) NZ533594A (enExample)
PL (1) PL373243A1 (enExample)
PT (1) PT1456404E (enExample)
RS (1) RS63104A (enExample)
RU (1) RU2323979C2 (enExample)
UA (1) UA80104C2 (enExample)
WO (1) WO2003052130A2 (enExample)
ZA (1) ZA200404656B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107109458A (zh) * 2014-11-27 2017-08-29 真蒂奥姆责任有限公司 基于细胞的去纤维蛋白多核苷酸效力测定方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1325962A1 (en) 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
EP1872787A1 (en) * 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
JP6069209B2 (ja) 2010-11-12 2017-02-01 ジェンティウム ソシエタ ア レスポンサビリタ リミタータ 移植片対宿主病（ｇｖｈｄ）の予防および／または治療に使用するためのデフィブロタイド
DK2864496T4 (da) * 2012-06-22 2021-01-04 Gentium S R L Euglobulin-baseret fremgangsmåde til bestemmelse af den biologiske aktivitet af defibrotid
US9655761B2 (en) 2012-11-12 2017-05-23 Djo, Llc Orthopedic back brace
TWI615473B (zh) * 2013-11-26 2018-02-21 金提恩責任有限公司 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法
RU2766143C2 (ru) * 2017-07-26 2022-02-08 Джентиум С.Р.Л. Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни
KR20200121780A (ko) 2017-08-03 2020-10-26 재즈 파마슈티칼즈 아일랜드 리미티드 높은 농도에서 핵산을 포함하는 제제
WO2019200251A1 (en) 2018-04-12 2019-10-17 Jazz Pharmaceuticals, Inc. Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion
WO2020118165A1 (en) 2018-12-07 2020-06-11 Jazz Pharmaceuticals Ireland Limited Subcutaneous delivery of high concentration formulations
EP4110287A1 (en) 2020-02-28 2023-01-04 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649134A (en) * 1983-09-12 1987-03-10 Crinos Industria Farmacobiologica Spa Pharmaceutical composition containing defibrotide for the treatment of states of acute renal insufficiency
WO1999012935A1 (en) * 1997-09-09 1999-03-18 Glaxo Group Limited Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
IT1252174B (it) * 1991-12-09 1995-06-05 Crinos Industria Farmaco Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
US5321006A (en) * 1992-12-09 1994-06-14 International Flavors & Fragrances Inc. Flavor and fragrance compositions produced using process for quantitatively and qualitatively substantially continuously analyzing the aroma emitted from a living fruit
CN1187201A (zh) * 1995-05-05 1998-07-08 生物药物研究与发展有限公司 血纤维蛋白交联和/或转谷氨酰胺酶的抑制剂
EP1325962A1 (en) 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649134A (en) * 1983-09-12 1987-03-10 Crinos Industria Farmacobiologica Spa Pharmaceutical composition containing defibrotide for the treatment of states of acute renal insufficiency
WO1999012935A1 (en) * 1997-09-09 1999-03-18 Glaxo Group Limited Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107109458A (zh) * 2014-11-27 2017-08-29 真蒂奥姆责任有限公司 基于细胞的去纤维蛋白多核苷酸效力测定方法
CN107109458B (zh) * 2014-11-27 2021-10-26 真蒂奥姆责任有限公司 基于细胞的去纤维蛋白多核苷酸效力测定方法

Also Published As

Publication number Publication date
WO2003052130A2 (en) 2003-06-26
UA80104C2 (en) 2007-08-27
CN100408690C (zh) 2008-08-06
KR20040090959A (ko) 2004-10-27
RU2004121962A (ru) 2005-05-10
CA2468877C (en) 2012-03-20
HK1077332A1 (zh) 2006-02-10
EP1456404B1 (en) 2010-09-08
IS7312A (is) 2004-06-14
EP1456404A2 (en) 2004-09-15
IL162511A0 (en) 2005-11-20
ZA200404656B (en) 2005-06-13
HUP0402231A2 (hu) 2005-01-28
MXPA04005958A (es) 2004-11-01
PL373243A1 (en) 2005-08-22
PT1456404E (pt) 2010-12-03
ES2349509T3 (es) 2011-01-04
EP1325962A1 (en) 2003-07-09
HUP0402231A3 (en) 2010-01-28
JP4348192B2 (ja) 2009-10-21
NZ533594A (en) 2006-03-31
HRP20040548A2 (en) 2004-10-31
ATE480637T1 (de) 2010-09-15
US7338777B2 (en) 2008-03-04
DE60237639D1 (de) 2010-10-21
WO2003052130A3 (en) 2004-01-15
CN1612938A (zh) 2005-05-04
AU2002360945B2 (en) 2007-11-08
RS63104A (sr) 2006-10-27
AU2002360945A1 (en) 2003-06-30
IL162511A (en) 2010-02-17
DK1456404T3 (da) 2010-11-01
AR037870A1 (es) 2004-12-09
RU2323979C2 (ru) 2008-05-10
JP2005512547A (ja) 2005-05-12
US20050009131A1 (en) 2005-01-13
NO20042972L (no) 2004-07-14
CA2468877A1 (en) 2003-06-26

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