NZ533594A - A method for determining the biological activity of defibrotide - Google Patents
A method for determining the biological activity of defibrotideInfo
- Publication number
- NZ533594A NZ533594A NZ533594A NZ53359402A NZ533594A NZ 533594 A NZ533594 A NZ 533594A NZ 533594 A NZ533594 A NZ 533594A NZ 53359402 A NZ53359402 A NZ 53359402A NZ 533594 A NZ533594 A NZ 533594A
- Authority
- NZ
- New Zealand
- Prior art keywords
- plasmin
- defibrotide
- determining
- biological activity
- substrate
- Prior art date
Links
- JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004120 defibrotide Drugs 0.000 title abstract 3
- 230000004071 biological effect Effects 0.000 title abstract 2
- 229940012957 plasmin Drugs 0.000 abstract 5
- 239000000758 substrate Substances 0.000 abstract 3
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01830770A EP1325962A1 (en) | 2001-12-17 | 2001-12-17 | A method for determining the biological activity of defibrotide |
| PCT/EP2002/013371 WO2003052130A2 (en) | 2001-12-17 | 2002-11-27 | A method for determining the biological activity of defibrotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ533594A true NZ533594A (en) | 2006-03-31 |
Family
ID=8184814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ533594A NZ533594A (en) | 2001-12-17 | 2002-11-27 | A method for determining the biological activity of defibrotide |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7338777B2 (enExample) |
| EP (2) | EP1325962A1 (enExample) |
| JP (1) | JP4348192B2 (enExample) |
| KR (1) | KR100912424B1 (enExample) |
| CN (1) | CN100408690C (enExample) |
| AR (1) | AR037870A1 (enExample) |
| AT (1) | ATE480637T1 (enExample) |
| AU (1) | AU2002360945B2 (enExample) |
| CA (1) | CA2468877C (enExample) |
| DE (1) | DE60237639D1 (enExample) |
| DK (1) | DK1456404T3 (enExample) |
| ES (1) | ES2349509T3 (enExample) |
| HR (1) | HRP20040548A2 (enExample) |
| HU (1) | HUP0402231A3 (enExample) |
| IL (2) | IL162511A0 (enExample) |
| IS (1) | IS7312A (enExample) |
| MX (1) | MXPA04005958A (enExample) |
| NO (1) | NO20042972L (enExample) |
| NZ (1) | NZ533594A (enExample) |
| PL (1) | PL373243A1 (enExample) |
| PT (1) | PT1456404E (enExample) |
| RS (1) | RS63104A (enExample) |
| RU (1) | RU2323979C2 (enExample) |
| UA (1) | UA80104C2 (enExample) |
| WO (1) | WO2003052130A2 (enExample) |
| ZA (1) | ZA200404656B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| JP6069209B2 (ja) | 2010-11-12 | 2017-02-01 | ジェンティウム ソシエタ ア レスポンサビリタ リミタータ | 移植片対宿主病（ｇｖｈｄ）の予防および／または治療に使用するためのデフィブロタイド |
| DK2864496T4 (da) * | 2012-06-22 | 2021-01-04 | Gentium S R L | Euglobulin-baseret fremgangsmåde til bestemmelse af den biologiske aktivitet af defibrotid |
| US9655761B2 (en) | 2012-11-12 | 2017-05-23 | Djo, Llc | Orthopedic back brace |
| TWI615473B (zh) * | 2013-11-26 | 2018-02-21 | 金提恩責任有限公司 | 用於測定去纖維蛋白多核苷酸的生物活性之基於優球蛋白的方法 |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| RU2766143C2 (ru) * | 2017-07-26 | 2022-02-08 | Джентиум С.Р.Л. | Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни |
| KR20200121780A (ko) | 2017-08-03 | 2020-10-26 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 높은 농도에서 핵산을 포함하는 제제 |
| WO2019200251A1 (en) | 2018-04-12 | 2019-10-17 | Jazz Pharmaceuticals, Inc. | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
| WO2020118165A1 (en) | 2018-12-07 | 2020-06-11 | Jazz Pharmaceuticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| EP4110287A1 (en) | 2020-02-28 | 2023-01-04 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| WO2022234101A1 (en) | 2021-05-06 | 2022-11-10 | Jazz Pharmaceuticals Ireland Limited | Defibrotide for the treatment and prevention of acute respiratory distress syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154279A1 (de) * | 1970-11-03 | 1972-05-25 | Crinos Industria Farmaco | Medikamente für das fibrinolytische System |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| IT1170215B (it) * | 1983-09-12 | 1987-06-03 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta |
| IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
| IT1252174B (it) * | 1991-12-09 | 1995-06-05 | Crinos Industria Farmaco | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
| US5321006A (en) * | 1992-12-09 | 1994-06-14 | International Flavors & Fragrances Inc. | Flavor and fragrance compositions produced using process for quantitatively and qualitatively substantially continuously analyzing the aroma emitted from a living fruit |
| CN1187201A (zh) * | 1995-05-05 | 1998-07-08 | 生物药物研究与发展有限公司 | 血纤维蛋白交联和/或转谷氨酰胺酶的抑制剂 |
| GB9719161D0 (en) * | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | New therapeutic method |
| EP1325962A1 (en) | 2001-12-17 | 2003-07-09 | Gentium S.p.A. | A method for determining the biological activity of defibrotide |
-
2001
- 2001-12-17 EP EP01830770A patent/EP1325962A1/en not_active Withdrawn
-
2002
- 2002-11-27 AU AU2002360945A patent/AU2002360945B2/en not_active Expired
- 2002-11-27 AT AT02795074T patent/ATE480637T1/de active
- 2002-11-27 KR KR1020047009476A patent/KR100912424B1/ko not_active Expired - Lifetime
- 2002-11-27 HU HU0402231A patent/HUP0402231A3/hu unknown
- 2002-11-27 RS YU63104A patent/RS63104A/sr unknown
- 2002-11-27 MX MXPA04005958A patent/MXPA04005958A/es unknown
- 2002-11-27 CN CNB028269799A patent/CN100408690C/zh not_active Expired - Lifetime
- 2002-11-27 HR HR20040548A patent/HRP20040548A2/hr not_active Application Discontinuation
- 2002-11-27 EP EP02795074A patent/EP1456404B1/en not_active Expired - Lifetime
- 2002-11-27 UA UA20040705856A patent/UA80104C2/uk unknown
- 2002-11-27 JP JP2003552997A patent/JP4348192B2/ja not_active Expired - Lifetime
- 2002-11-27 WO PCT/EP2002/013371 patent/WO2003052130A2/en not_active Ceased
- 2002-11-27 IL IL16251102A patent/IL162511A0/xx unknown
- 2002-11-27 PL PL02373243A patent/PL373243A1/xx not_active Application Discontinuation
- 2002-11-27 RU RU2004121962/13A patent/RU2323979C2/ru not_active IP Right Cessation
- 2002-11-27 NZ NZ533594A patent/NZ533594A/xx unknown
- 2002-11-27 PT PT02795074T patent/PT1456404E/pt unknown
- 2002-11-27 CA CA2468877A patent/CA2468877C/en not_active Expired - Lifetime
- 2002-11-27 ES ES02795074T patent/ES2349509T3/es not_active Expired - Lifetime
- 2002-11-27 DE DE60237639T patent/DE60237639D1/de not_active Expired - Lifetime
- 2002-11-27 DK DK02795074.0T patent/DK1456404T3/da active
- 2002-12-17 AR ARP020104901A patent/AR037870A1/es not_active Application Discontinuation
-
2004
- 2004-06-11 ZA ZA200404656A patent/ZA200404656B/en unknown
- 2004-06-14 IL IL162511A patent/IL162511A/en active IP Right Grant
- 2004-06-14 IS IS7312A patent/IS7312A/is unknown
- 2004-06-17 US US10/868,798 patent/US7338777B2/en not_active Expired - Lifetime
- 2004-07-14 NO NO20042972A patent/NO20042972L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |