JP2005508289A5 - - Google Patents
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- Publication number
- JP2005508289A5 JP2005508289A5 JP2002591455A JP2002591455A JP2005508289A5 JP 2005508289 A5 JP2005508289 A5 JP 2005508289A5 JP 2002591455 A JP2002591455 A JP 2002591455A JP 2002591455 A JP2002591455 A JP 2002591455A JP 2005508289 A5 JP2005508289 A5 JP 2005508289A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- diethylcarbamoyl
- benzamide
- piperidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
- -1 CF 3 Chemical group 0.000 claims 2
- 230000002152 alkylating effect Effects 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- HUGSBYQOVYWCAP-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1,3-thiazol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2SC=CN=2)CC1 HUGSBYQOVYWCAP-UHFFFAOYSA-N 0.000 claims 1
- HSZIVHLCQPNQOE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=CN=2)CC1 HSZIVHLCQPNQOE-UHFFFAOYSA-N 0.000 claims 1
- YUWAIKLSVXKDQM-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-5-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=NC=2)CC1 YUWAIKLSVXKDQM-UHFFFAOYSA-N 0.000 claims 1
- VDUAGEPXEARSAO-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-pyrrol-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2NC=CC=2)CC1 VDUAGEPXEARSAO-UHFFFAOYSA-N 0.000 claims 1
- SKZXILXJTUIGSZ-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2OC=CC=2)CC1 SKZXILXJTUIGSZ-UHFFFAOYSA-N 0.000 claims 1
- JIXCNNYRTPMFJN-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC2=COC=C2)CC1 JIXCNNYRTPMFJN-UHFFFAOYSA-N 0.000 claims 1
- GRGQARAXZATPBE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2N=CC=CC=2)CC1 GRGQARAXZATPBE-UHFFFAOYSA-N 0.000 claims 1
- JZJSPCADPUUUEJ-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=NC=CC=2)CC1 JZJSPCADPUUUEJ-UHFFFAOYSA-N 0.000 claims 1
- GZJALTYZCKYWTC-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-4-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CN=CC=2)CC1 GZJALTYZCKYWTC-UHFFFAOYSA-N 0.000 claims 1
- XSTIMPUSVYWHJR-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-2-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2SC=CC=2)CC1 XSTIMPUSVYWHJR-UHFFFAOYSA-N 0.000 claims 1
- HUSCFKNTULOKOT-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-3-ylmethyl)piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC2=CSC=C2)CC1 HUSCFKNTULOKOT-UHFFFAOYSA-N 0.000 claims 1
- SJBURJKJEJSVCV-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(1-methylimidazol-2-yl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2N(C=CN=2)C)CC1 SJBURJKJEJSVCV-UHFFFAOYSA-N 0.000 claims 1
- KDIDFELALMETAT-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(F)=CC=2)CC1 KDIDFELALMETAT-UHFFFAOYSA-N 0.000 claims 1
- QFSXVMVWFGFILE-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(OC)=CC=2)CC1 QFSXVMVWFGFILE-UHFFFAOYSA-N 0.000 claims 1
- JTJXQWZJBAJVGH-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-[(4-methylphenyl)methyl]piperidin-4-yl]anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(C)=CC=2)CC1 JTJXQWZJBAJVGH-UHFFFAOYSA-N 0.000 claims 1
- YCKPFIZUVGRVLD-UHFFFAOYSA-N 3-[n-(1-benzylpiperidin-4-yl)-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC=CC=2)CC1 YCKPFIZUVGRVLD-UHFFFAOYSA-N 0.000 claims 1
- ASVFDTYOAIGRTG-UHFFFAOYSA-N 3-[n-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C(=CC(Cl)=CC=2)Cl)CC1 ASVFDTYOAIGRTG-UHFFFAOYSA-N 0.000 claims 1
- VQRODKIKEPXZGG-UHFFFAOYSA-N 3-[n-[1-[(4-bromophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(Br)=CC=2)CC1 VQRODKIKEPXZGG-UHFFFAOYSA-N 0.000 claims 1
- RTYGKHNAXMRHOM-UHFFFAOYSA-N 3-[n-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C=C(C=CC=1)C(N)=O)C1CCN(CC=2C=CC(Cl)=CC=2)CC1 RTYGKHNAXMRHOM-UHFFFAOYSA-N 0.000 claims 1
- STXAVEHFKAXGOX-UHFFFAOYSA-N 3-bromobenzonitrile Chemical compound BrC1=CC=CC(C#N)=C1 STXAVEHFKAXGOX-UHFFFAOYSA-N 0.000 claims 1
- LDUPVXSXLZOQAF-UHFFFAOYSA-N 4-bromo-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=C(Br)C=C1 LDUPVXSXLZOQAF-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101769A SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| PCT/SE2002/000944 WO2002094782A1 (en) | 2001-05-18 | 2002-05-16 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derativatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508289A JP2005508289A (ja) | 2005-03-31 |
| JP2005508289A5 true JP2005508289A5 (enExample) | 2005-12-22 |
Family
ID=20284172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591455A Pending JP2005508289A (ja) | 2001-05-18 | 2002-05-16 | ４−（フェニル−（ピペリジン−４−イル）−アミノ）−ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7226933B2 (enExample) |
| EP (1) | EP1395555B1 (enExample) |
| JP (1) | JP2005508289A (enExample) |
| KR (1) | KR20030094425A (enExample) |
| CN (1) | CN1639123A (enExample) |
| AR (1) | AR033758A1 (enExample) |
| AT (1) | ATE313528T1 (enExample) |
| BG (1) | BG108330A (enExample) |
| BR (1) | BR0209670A (enExample) |
| CA (1) | CA2446311A1 (enExample) |
| CO (1) | CO5540317A2 (enExample) |
| CZ (1) | CZ20033089A3 (enExample) |
| DE (1) | DE60208192T2 (enExample) |
| EE (1) | EE200300554A (enExample) |
| HU (1) | HUP0401328A2 (enExample) |
| IL (1) | IL158628A0 (enExample) |
| IS (1) | IS7028A (enExample) |
| MX (1) | MXPA03010440A (enExample) |
| NO (1) | NO20035113D0 (enExample) |
| NZ (1) | NZ529398A (enExample) |
| PL (1) | PL366387A1 (enExample) |
| RU (1) | RU2003131966A (enExample) |
| SE (1) | SE0101769D0 (enExample) |
| SK (1) | SK13912003A3 (enExample) |
| WO (1) | WO2002094782A1 (enExample) |
| ZA (1) | ZA200308631B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2476583C (en) * | 2002-03-13 | 2011-07-05 | Kristof Van Emelen | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| KR20140015122A (ko) | 2003-10-01 | 2014-02-06 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| WO2008033299A2 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| SI3233825T1 (sl) * | 2014-12-19 | 2020-10-30 | Pharmnovo Ab | Derivati diarilmetiliden-piperidina in njihova uporaba kot agonisti delta opioidnega receptorja |
| US20250084091A1 (en) * | 2021-05-04 | 2025-03-13 | The Texas A&M University System | Inhibitors of sars-cov-2 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) * | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| US4252812A (en) * | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) * | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) * | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| SE9604786D0 (sv) * | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| CA2316341A1 (en) | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| JP4498602B2 (ja) | 1998-03-10 | 2010-07-07 | リサーチ・トライアングル・インスティチュート | 新規なオピエート化合物、その調製法及び使用法 |
| SE9904675D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| US6552036B2 (en) * | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| JPWO2009028275A1 (ja) * | 2007-08-28 | 2010-11-25 | コニカミノルタエムジー株式会社 | シンチレータパネル |
-
2001
- 2001-05-18 SE SE0101769A patent/SE0101769D0/xx unknown
-
2002
- 2002-05-16 AR ARP020101814A patent/AR033758A1/es unknown
- 2002-05-16 HU HU0401328A patent/HUP0401328A2/hu unknown
- 2002-05-16 DE DE60208192T patent/DE60208192T2/de not_active Expired - Fee Related
- 2002-05-16 SK SK1391-2003A patent/SK13912003A3/sk unknown
- 2002-05-16 IL IL15862802A patent/IL158628A0/xx unknown
- 2002-05-16 CA CA002446311A patent/CA2446311A1/en not_active Abandoned
- 2002-05-16 EP EP02733702A patent/EP1395555B1/en not_active Expired - Lifetime
- 2002-05-16 MX MXPA03010440A patent/MXPA03010440A/es unknown
- 2002-05-16 CN CNA028141601A patent/CN1639123A/zh active Pending
- 2002-05-16 BR BR0209670-6A patent/BR0209670A/pt not_active IP Right Cessation
- 2002-05-16 KR KR10-2003-7014946A patent/KR20030094425A/ko not_active Withdrawn
- 2002-05-16 NZ NZ529398A patent/NZ529398A/en unknown
- 2002-05-16 CZ CZ20033089A patent/CZ20033089A3/cs unknown
- 2002-05-16 JP JP2002591455A patent/JP2005508289A/ja active Pending
- 2002-05-16 PL PL02366387A patent/PL366387A1/xx not_active Application Discontinuation
- 2002-05-16 RU RU2003131966/04A patent/RU2003131966A/ru not_active Application Discontinuation
- 2002-05-16 EE EEP200300554A patent/EE200300554A/xx unknown
- 2002-05-16 WO PCT/SE2002/000944 patent/WO2002094782A1/en not_active Ceased
- 2002-05-16 US US10/477,852 patent/US7226933B2/en not_active Expired - Fee Related
- 2002-05-16 AT AT02733702T patent/ATE313528T1/de not_active IP Right Cessation
-
2003
- 2003-11-05 ZA ZA200308631A patent/ZA200308631B/xx unknown
- 2003-11-07 BG BG108330A patent/BG108330A/bg unknown
- 2003-11-12 CO CO03100165A patent/CO5540317A2/es not_active Application Discontinuation
- 2003-11-12 IS IS7028A patent/IS7028A/is unknown
- 2003-11-17 NO NO20035113A patent/NO20035113D0/no not_active Application Discontinuation
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