JP2005510456A5 - - Google Patents
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- Publication number
- JP2005510456A5 JP2005510456A5 JP2002591456A JP2002591456A JP2005510456A5 JP 2005510456 A5 JP2005510456 A5 JP 2005510456A5 JP 2002591456 A JP2002591456 A JP 2002591456A JP 2002591456 A JP2002591456 A JP 2002591456A JP 2005510456 A5 JP2005510456 A5 JP 2005510456A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- fluoro
- benzamide
- piperidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- -1 CF 3 Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- DIZYCOPDBIXYLR-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1,3-thiazol-2-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2SC=CN=2)CC1 DIZYCOPDBIXYLR-UHFFFAOYSA-N 0.000 claims 1
- HIGBZBZZYNBWMA-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-2-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2NC=CN=2)CC1 HIGBZBZZYNBWMA-UHFFFAOYSA-N 0.000 claims 1
- YSAQUXQVMSWIFD-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(1h-imidazol-5-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2NC=NC=2)CC1 YSAQUXQVMSWIFD-UHFFFAOYSA-N 0.000 claims 1
- QUPGZHABBRSEBW-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-2-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2OC=CC=2)CC1 QUPGZHABBRSEBW-UHFFFAOYSA-N 0.000 claims 1
- XMLNYTYEDYXAET-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(furan-3-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC2=COC=C2)CC1 XMLNYTYEDYXAET-UHFFFAOYSA-N 0.000 claims 1
- QBQDPJAFFUHBFG-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-2-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2N=CC=CC=2)CC1 QBQDPJAFFUHBFG-UHFFFAOYSA-N 0.000 claims 1
- RGWVUGXRNJHPRZ-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-3-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2C=NC=CC=2)CC1 RGWVUGXRNJHPRZ-UHFFFAOYSA-N 0.000 claims 1
- VFTSYXNZPNAGNC-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(pyridin-4-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2C=CN=CC=2)CC1 VFTSYXNZPNAGNC-UHFFFAOYSA-N 0.000 claims 1
- XDKROVGILIZACM-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-2-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2SC=CC=2)CC1 XDKROVGILIZACM-UHFFFAOYSA-N 0.000 claims 1
- YRPAAJXIBBYUOY-UHFFFAOYSA-N 3-[4-(diethylcarbamoyl)-n-[1-(thiophen-3-ylmethyl)piperidin-4-yl]anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC2=CSC=C2)CC1 YRPAAJXIBBYUOY-UHFFFAOYSA-N 0.000 claims 1
- YNODUHNHOKSGKL-UHFFFAOYSA-N 3-[n-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2C(=CC(Cl)=CC=2)Cl)CC1 YNODUHNHOKSGKL-UHFFFAOYSA-N 0.000 claims 1
- IIEFPDHYFQDGFF-UHFFFAOYSA-N 3-[n-[1-[(4-bromophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2C=CC(Br)=CC=2)CC1 IIEFPDHYFQDGFF-UHFFFAOYSA-N 0.000 claims 1
- IEJQZXHLXXFXHM-UHFFFAOYSA-N 3-[n-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-4-(diethylcarbamoyl)anilino]-2-fluorobenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1N(C=1C(=C(C(N)=O)C=CC=1)F)C1CCN(CC=2C=CC(Cl)=CC=2)CC1 IEJQZXHLXXFXHM-UHFFFAOYSA-N 0.000 claims 1
- LDUPVXSXLZOQAF-UHFFFAOYSA-N 4-bromo-n,n-diethylbenzamide Chemical compound CCN(CC)C(=O)C1=CC=C(Br)C=C1 LDUPVXSXLZOQAF-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- 208000020339 Spinal injury Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101770A SE0101770D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| PCT/SE2002/000945 WO2002094783A1 (en) | 2001-05-18 | 2002-05-16 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005510456A JP2005510456A (ja) | 2005-04-21 |
| JP2005510456A5 true JP2005510456A5 (enExample) | 2005-12-22 |
Family
ID=20284173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591456A Pending JP2005510456A (ja) | 2001-05-18 | 2002-05-16 | ４−（フェニル−（ピペリジン−４−イル）−アミノ）−ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7064137B2 (enExample) |
| EP (1) | EP1395558B1 (enExample) |
| JP (1) | JP2005510456A (enExample) |
| KR (1) | KR20040000469A (enExample) |
| CN (1) | CN1620435A (enExample) |
| AR (1) | AR033759A1 (enExample) |
| AT (1) | ATE313529T1 (enExample) |
| BG (1) | BG108331A (enExample) |
| BR (1) | BR0209669A (enExample) |
| CA (1) | CA2446313A1 (enExample) |
| CO (1) | CO5540319A2 (enExample) |
| CZ (1) | CZ20033090A3 (enExample) |
| DE (1) | DE60208193T2 (enExample) |
| EE (1) | EE200300534A (enExample) |
| HU (1) | HUP0401608A2 (enExample) |
| IL (1) | IL158629A0 (enExample) |
| IS (1) | IS7031A (enExample) |
| MX (1) | MXPA03010441A (enExample) |
| NO (1) | NO20035112D0 (enExample) |
| PL (1) | PL366390A1 (enExample) |
| RU (1) | RU2003131967A (enExample) |
| SE (1) | SE0101770D0 (enExample) |
| SK (1) | SK13922003A3 (enExample) |
| WO (1) | WO2002094783A1 (enExample) |
| ZA (1) | ZA200308637B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| US7338962B2 (en) | 2003-10-01 | 2008-03-04 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| WO2016099394A1 (en) * | 2014-12-19 | 2016-06-23 | Pharmnovo Ab | Novel selective delta-opioid receptor agonists useful for the treatment of pain, anxiety and depression. |
| WO2022235813A1 (en) * | 2021-05-04 | 2022-11-10 | The Texas A&M University System | Inhibitors of sars-cov-2 |
| CN116554100B (zh) * | 2023-02-22 | 2025-08-15 | 江苏师范大学 | 一种钯催化合成菲啶酮类化合物的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| US4252812A (en) | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| EP0181793B1 (fr) | 1984-10-16 | 1988-07-27 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
| ATE522503T1 (de) | 1998-03-10 | 2011-09-15 | Res Triangle Inst | Neue opiate, herstellungsverfahren und verwendungen |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| AU2001241676A1 (en) * | 2000-03-03 | 2001-09-17 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives |
| US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101770A patent/SE0101770D0/xx unknown
-
2002
- 2002-05-16 JP JP2002591456A patent/JP2005510456A/ja active Pending
- 2002-05-16 MX MXPA03010441A patent/MXPA03010441A/es unknown
- 2002-05-16 HU HU0401608A patent/HUP0401608A2/hu unknown
- 2002-05-16 DE DE60208193T patent/DE60208193T2/de not_active Expired - Fee Related
- 2002-05-16 EP EP02736338A patent/EP1395558B1/en not_active Expired - Lifetime
- 2002-05-16 EE EEP200300534A patent/EE200300534A/xx unknown
- 2002-05-16 AT AT02736338T patent/ATE313529T1/de not_active IP Right Cessation
- 2002-05-16 US US10/477,853 patent/US7064137B2/en not_active Expired - Fee Related
- 2002-05-16 CN CNA028141709A patent/CN1620435A/zh active Pending
- 2002-05-16 KR KR10-2003-7014948A patent/KR20040000469A/ko not_active Withdrawn
- 2002-05-16 BR BR0209669-2A patent/BR0209669A/pt not_active Application Discontinuation
- 2002-05-16 CZ CZ20033090A patent/CZ20033090A3/cs unknown
- 2002-05-16 SK SK1392-2003A patent/SK13922003A3/sk unknown
- 2002-05-16 PL PL02366390A patent/PL366390A1/xx not_active Application Discontinuation
- 2002-05-16 WO PCT/SE2002/000945 patent/WO2002094783A1/en not_active Ceased
- 2002-05-16 CA CA002446313A patent/CA2446313A1/en not_active Abandoned
- 2002-05-16 IL IL15862902A patent/IL158629A0/xx unknown
- 2002-05-16 RU RU2003131967/04A patent/RU2003131967A/ru not_active Application Discontinuation
- 2002-05-16 AR ARP020101815A patent/AR033759A1/es unknown
-
2003
- 2003-11-05 ZA ZA200308637A patent/ZA200308637B/en unknown
- 2003-11-07 BG BG108331A patent/BG108331A/bg unknown
- 2003-11-12 CO CO03100167A patent/CO5540319A2/es not_active Application Discontinuation
- 2003-11-13 IS IS7031A patent/IS7031A/is unknown
- 2003-11-17 NO NO20035112A patent/NO20035112D0/no not_active Application Discontinuation
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