JP2014509298A5 - - Google Patents

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Publication number
JP2014509298A5
JP2014509298A5 JP2013539024A JP2013539024A JP2014509298A5 JP 2014509298 A5 JP2014509298 A5 JP 2014509298A5 JP 2013539024 A JP2013539024 A JP 2013539024A JP 2013539024 A JP2013539024 A JP 2013539024A JP 2014509298 A5 JP2014509298 A5 JP 2014509298A5
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JP
Japan
Prior art keywords
optionally substituted
methyl
substituted
pyrazino
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013539024A
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English (en)
Japanese (ja)
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JP2014509298A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/JP2012/055489 external-priority patent/WO2012115286A1/en
Publication of JP2014509298A publication Critical patent/JP2014509298A/ja
Publication of JP2014509298A5 publication Critical patent/JP2014509298A5/ja
Pending legal-status Critical Current

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JP2013539024A 2011-02-25 2012-02-27 アルファへリックスミメティック及びその関連の方法 Pending JP2014509298A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446801P 2011-02-25 2011-02-25
US61/446,801 2011-02-25
PCT/JP2012/055489 WO2012115286A1 (en) 2011-02-25 2012-02-27 Alpha helix mimetics and methods relating thereto

Publications (2)

Publication Number Publication Date
JP2014509298A JP2014509298A (ja) 2014-04-17
JP2014509298A5 true JP2014509298A5 (enExample) 2015-05-07

Family

ID=45878996

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013539024A Pending JP2014509298A (ja) 2011-02-25 2012-02-27 アルファへリックスミメティック及びその関連の方法

Country Status (5)

Country Link
US (1) US20140051706A1 (enExample)
EP (1) EP2678341A1 (enExample)
JP (1) JP2014509298A (enExample)
CN (1) CN103517904A (enExample)
WO (1) WO2012115286A1 (enExample)

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KR102168006B1 (ko) * 2010-10-07 2020-10-20 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제
AU2011329854B2 (en) * 2010-11-16 2017-03-30 University Of Southern California CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
CA2851187A1 (en) * 2011-10-07 2013-04-11 University Of Southern California Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
CN104902902A (zh) * 2012-10-19 2015-09-09 株式会社棱镜制药 使用cbp/连环蛋白的抑制剂治疗硬皮病
CA2889010A1 (en) * 2012-10-19 2014-04-24 Prism Pharma Co., Ltd. Treatment of hyperproliferative and pre-cancerous skin diseases using an inhibitor of cbp/catenin
WO2014092154A1 (ja) 2012-12-12 2014-06-19 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 肝線維症の予防または治療剤
EP3057590B1 (en) * 2013-10-18 2019-11-27 PRISM BioLab Co., Ltd. Treatment of hepatic fibrosis using an inhibitor of cbp/catenin
US9174998B2 (en) * 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
KR102559211B1 (ko) 2015-06-23 2023-07-25 에자이 알앤드디 매니지먼트 가부시키가이샤 (6S,9aS)-N-벤질-8-({6-[3-(4-에틸피페라진-1-일)아제티딘-1-일]피리딘-2-일}메틸)-6-(2-플루오로-4-하이드록시벤질)-4,7-디옥소-2-(프로프-2-엔-1-일)헥사하이드로-2H-피라지노[2,1-c][1,2,4]트리아진-1(6H)-카복사마이드의 결정
CN105061315B (zh) * 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
JP6785487B2 (ja) * 2015-09-18 2020-11-18 国立大学法人鳥取大学 低分子化合物による癌と線維化の抑制と再生促進の効果
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
BR112019023064A2 (pt) 2017-05-16 2020-06-09 Eisai R&D Man Co Ltd tratamento de carcinoma hepatocelular
US20220409724A1 (en) 2019-10-29 2022-12-29 Eisai R&D Management Co., Ltd. Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer
CA3175150A1 (en) 2020-03-12 2021-09-16 3+2 Pharma LLC Cbp/catenin signaling pathway inhibitors and uses thereof
WO2021183791A1 (en) * 2020-03-12 2021-09-16 City Of Hope Wnt/cbp/catenin signaling pathway inhibitors and uses thereof
JP7689761B2 (ja) * 2020-07-16 2025-06-09 株式会社 PRISM BioLab 新規ヘテロ環化合物
CN116925081A (zh) * 2022-04-11 2023-10-24 中国科学院上海药物研究所 一种环肽类化合物及其应用
WO2023215378A1 (en) * 2022-05-04 2023-11-09 Athira Pharma, Inc. Methods of treating fibrosis

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WO2010128685A1 (en) 2009-05-07 2010-11-11 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto

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