CN1639123A - 4－(苯基－(哌啶－4－基)－氨基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠道疾病中的应用 - Google Patents
4－(苯基－(哌啶－4－基)－氨基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠道疾病中的应用 Download PDFInfo
- Publication number
- CN1639123A CN1639123A CNA028141601A CN02814160A CN1639123A CN 1639123 A CN1639123 A CN 1639123A CN A028141601 A CNA028141601 A CN A028141601A CN 02814160 A CN02814160 A CN 02814160A CN 1639123 A CN1639123 A CN 1639123A
- Authority
- CN
- China
- Prior art keywords
- phenyl
- compound
- piperidin
- benzamide
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101769A SE0101769D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| SE01017698 | 2001-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1639123A true CN1639123A (zh) | 2005-07-13 |
Family
ID=20284172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028141601A Pending CN1639123A (zh) | 2001-05-18 | 2002-05-16 | 4－(苯基－(哌啶－4－基)－氨基)－苯甲酰胺衍生物及其在治疗疼痛、焦虑症或胃肠道疾病中的应用 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7226933B2 (enExample) |
| EP (1) | EP1395555B1 (enExample) |
| JP (1) | JP2005508289A (enExample) |
| KR (1) | KR20030094425A (enExample) |
| CN (1) | CN1639123A (enExample) |
| AR (1) | AR033758A1 (enExample) |
| AT (1) | ATE313528T1 (enExample) |
| BG (1) | BG108330A (enExample) |
| BR (1) | BR0209670A (enExample) |
| CA (1) | CA2446311A1 (enExample) |
| CO (1) | CO5540317A2 (enExample) |
| CZ (1) | CZ20033089A3 (enExample) |
| DE (1) | DE60208192T2 (enExample) |
| EE (1) | EE200300554A (enExample) |
| HU (1) | HUP0401328A2 (enExample) |
| IL (1) | IL158628A0 (enExample) |
| IS (1) | IS7028A (enExample) |
| MX (1) | MXPA03010440A (enExample) |
| NO (1) | NO20035113D0 (enExample) |
| NZ (1) | NZ529398A (enExample) |
| PL (1) | PL366387A1 (enExample) |
| RU (1) | RU2003131966A (enExample) |
| SE (1) | SE0101769D0 (enExample) |
| SK (1) | SK13912003A3 (enExample) |
| WO (1) | WO2002094782A1 (enExample) |
| ZA (1) | ZA200308631B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501417B2 (en) * | 2002-03-13 | 2009-03-10 | Janssen Pharmaceutica, N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| SE0300987D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| AU2004278414B2 (en) | 2003-10-01 | 2012-05-24 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7598261B2 (en) * | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) * | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CA2662115A1 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Methods for enhancing cognitive function |
| HUE050241T2 (hu) * | 2014-12-19 | 2020-11-30 | Pharmnovo Ab | Diarilmetilidén-piperidin származékok és alkalmazásuk delta opioid receptor agonistaként |
| EP4333821A4 (en) * | 2021-05-04 | 2025-07-09 | Texas A & M Univ Sys | SARS-COV-2 INHIBITORS |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| US4252812A (en) | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3563964D1 (en) | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| WO1999033806A1 (en) | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| AU756983B2 (en) | 1998-03-10 | 2003-01-30 | Research Triangle Institute | Novel opiate compounds, methods of making and methods of use |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| IL151550A0 (en) * | 2000-03-03 | 2003-04-10 | Ortho Mcneil Pharm Inc | 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| JPWO2009028275A1 (ja) * | 2007-08-28 | 2010-11-25 | コニカミノルタエムジー株式会社 | シンチレータパネル |
-
2001
- 2001-05-18 SE SE0101769A patent/SE0101769D0/xx unknown
-
2002
- 2002-05-16 KR KR10-2003-7014946A patent/KR20030094425A/ko not_active Withdrawn
- 2002-05-16 RU RU2003131966/04A patent/RU2003131966A/ru not_active Application Discontinuation
- 2002-05-16 AT AT02733702T patent/ATE313528T1/de not_active IP Right Cessation
- 2002-05-16 HU HU0401328A patent/HUP0401328A2/hu unknown
- 2002-05-16 MX MXPA03010440A patent/MXPA03010440A/es unknown
- 2002-05-16 JP JP2002591455A patent/JP2005508289A/ja active Pending
- 2002-05-16 EP EP02733702A patent/EP1395555B1/en not_active Expired - Lifetime
- 2002-05-16 EE EEP200300554A patent/EE200300554A/xx unknown
- 2002-05-16 BR BR0209670-6A patent/BR0209670A/pt not_active IP Right Cessation
- 2002-05-16 US US10/477,852 patent/US7226933B2/en not_active Expired - Fee Related
- 2002-05-16 CN CNA028141601A patent/CN1639123A/zh active Pending
- 2002-05-16 PL PL02366387A patent/PL366387A1/xx not_active Application Discontinuation
- 2002-05-16 CZ CZ20033089A patent/CZ20033089A3/cs unknown
- 2002-05-16 WO PCT/SE2002/000944 patent/WO2002094782A1/en not_active Ceased
- 2002-05-16 CA CA002446311A patent/CA2446311A1/en not_active Abandoned
- 2002-05-16 AR ARP020101814A patent/AR033758A1/es unknown
- 2002-05-16 SK SK1391-2003A patent/SK13912003A3/sk unknown
- 2002-05-16 DE DE60208192T patent/DE60208192T2/de not_active Expired - Fee Related
- 2002-05-16 IL IL15862802A patent/IL158628A0/xx unknown
- 2002-05-16 NZ NZ529398A patent/NZ529398A/en unknown
-
2003
- 2003-11-05 ZA ZA200308631A patent/ZA200308631B/xx unknown
- 2003-11-07 BG BG108330A patent/BG108330A/bg unknown
- 2003-11-12 IS IS7028A patent/IS7028A/is unknown
- 2003-11-12 CO CO03100165A patent/CO5540317A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035113A patent/NO20035113D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60208192T2 (de) | 2006-07-13 |
| EE200300554A (et) | 2004-02-16 |
| SK13912003A3 (sk) | 2004-04-06 |
| EP1395555A1 (en) | 2004-03-10 |
| RU2003131966A (ru) | 2005-05-10 |
| IS7028A (is) | 2003-11-12 |
| US20040235897A1 (en) | 2004-11-25 |
| KR20030094425A (ko) | 2003-12-11 |
| IL158628A0 (en) | 2004-05-12 |
| BG108330A (bg) | 2004-12-30 |
| US7226933B2 (en) | 2007-06-05 |
| CA2446311A1 (en) | 2002-11-28 |
| ZA200308631B (en) | 2005-02-07 |
| BR0209670A (pt) | 2004-04-20 |
| DE60208192D1 (de) | 2006-01-26 |
| CO5540317A2 (es) | 2005-07-29 |
| WO2002094782A1 (en) | 2002-11-28 |
| NO20035113D0 (no) | 2003-11-17 |
| ATE313528T1 (de) | 2006-01-15 |
| JP2005508289A (ja) | 2005-03-31 |
| PL366387A1 (en) | 2005-01-24 |
| HUP0401328A2 (hu) | 2004-12-28 |
| CZ20033089A3 (en) | 2004-06-16 |
| AR033758A1 (es) | 2004-01-07 |
| EP1395555B1 (en) | 2005-12-21 |
| NZ529398A (en) | 2005-08-26 |
| MXPA03010440A (es) | 2004-03-09 |
| SE0101769D0 (sv) | 2001-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |