BR0209670A - Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade - Google Patents

Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade

Info

Publication number
BR0209670A
BR0209670A BR0209670-6A BR0209670A BR0209670A BR 0209670 A BR0209670 A BR 0209670A BR 0209670 A BR0209670 A BR 0209670A BR 0209670 A BR0209670 A BR 0209670A
Authority
BR
Brazil
Prior art keywords
anxiety
preparing
compound
pharmaceutical composition
methods
Prior art date
Application number
BR0209670-6A
Other languages
English (en)
Inventor
William Brown
Andrew Griffin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0209670A publication Critical patent/BR0209670A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR E USO DO MESMO, COMPOSIçãO FARMACêUTICA, E, MéTODOS PARA O TRATAMENTO DA DOR, DE DISTúRBIOS GASTRINTESTINAIS FUNCIONAIS E DA ANSIEDADE". Os compostos da fórmula geral I: R^ 1^ é selecionado de qualquer um dentre fenila, piridinila, pirrolila, tienila, furanila, imidazolila., triazolila, e N-óxido de piridina; em que cada anel fenila R^ 1^ e anel heteroaromático R^ 1^ pode opcional e independentemente ser ainda substituido por 1, 2 ou 3 substituintes selecionados de alquila C~ 1~-C~ 6~ reto ou ramificado, NO~ 2~,CF~ 3~, alcóxi C~ 1-6~, cloro, flúor, bromo e iodo. As substituições no anel fenila e no anel heteroaromático podem ter lugar em qualquer posição nos referidos sistemas de anel; são apresentados e reivindicados no presente pedido, assim como seus sais farmaceuticamente aceitáveis e composições farmacêuticas compreendendo os novos compostos, e seu uso em terapia, em particular no controle da dor, da ansiedade e de distúrbios gastrintestinais funcionais.
BR0209670-6A 2001-05-18 2002-05-16 Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade BR0209670A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101769A SE0101769D0 (sv) 2001-05-18 2001-05-18 Novel compounds
PCT/SE2002/000944 WO2002094782A1 (en) 2001-05-18 2002-05-16 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derativatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

Publications (1)

Publication Number Publication Date
BR0209670A true BR0209670A (pt) 2004-04-20

Family

ID=20284172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209670-6A BR0209670A (pt) 2001-05-18 2002-05-16 Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade

Country Status (26)

Country Link
US (1) US7226933B2 (pt)
EP (1) EP1395555B1 (pt)
JP (1) JP2005508289A (pt)
KR (1) KR20030094425A (pt)
CN (1) CN1639123A (pt)
AR (1) AR033758A1 (pt)
AT (1) ATE313528T1 (pt)
BG (1) BG108330A (pt)
BR (1) BR0209670A (pt)
CA (1) CA2446311A1 (pt)
CO (1) CO5540317A2 (pt)
CZ (1) CZ20033089A3 (pt)
DE (1) DE60208192T2 (pt)
EE (1) EE200300554A (pt)
HU (1) HUP0401328A2 (pt)
IL (1) IL158628A0 (pt)
IS (1) IS7028A (pt)
MX (1) MXPA03010440A (pt)
NO (1) NO20035113D0 (pt)
NZ (1) NZ529398A (pt)
PL (1) PL366387A1 (pt)
RU (1) RU2003131966A (pt)
SE (1) SE0101769D0 (pt)
SK (1) SK13912003A3 (pt)
WO (1) WO2002094782A1 (pt)
ZA (1) ZA200308631B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4725944B2 (ja) * 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの阻害剤
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2008033299A2 (en) * 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091096A (en) 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
US4252812A (en) 1977-05-23 1981-02-24 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
SE441448B (sv) 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
EP0181793B1 (fr) 1984-10-16 1988-07-27 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique
KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
ZA9811842B (en) 1997-12-24 2000-06-23 Ortho Mcneil Pharm Inc 4-[aryl(piperidin-4-yl)]aminobenzamides.
CA2683097A1 (en) 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
IL151550A0 (en) * 2000-03-03 2003-04-10 Ortho Mcneil Pharm Inc 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
WO2009028275A1 (ja) * 2007-08-28 2009-03-05 Konica Minolta Medical & Graphic, Inc. シンチレータパネル

Also Published As

Publication number Publication date
ATE313528T1 (de) 2006-01-15
EP1395555B1 (en) 2005-12-21
DE60208192D1 (de) 2006-01-26
IL158628A0 (en) 2004-05-12
KR20030094425A (ko) 2003-12-11
RU2003131966A (ru) 2005-05-10
EP1395555A1 (en) 2004-03-10
CO5540317A2 (es) 2005-07-29
WO2002094782A1 (en) 2002-11-28
ZA200308631B (en) 2005-02-07
AR033758A1 (es) 2004-01-07
PL366387A1 (en) 2005-01-24
US7226933B2 (en) 2007-06-05
CN1639123A (zh) 2005-07-13
CZ20033089A3 (en) 2004-06-16
MXPA03010440A (es) 2004-03-09
CA2446311A1 (en) 2002-11-28
HUP0401328A2 (hu) 2004-12-28
DE60208192T2 (de) 2006-07-13
NO20035113D0 (no) 2003-11-17
IS7028A (is) 2003-11-12
NZ529398A (en) 2005-08-26
BG108330A (bg) 2004-12-30
SE0101769D0 (sv) 2001-05-18
US20040235897A1 (en) 2004-11-25
JP2005508289A (ja) 2005-03-31
SK13912003A3 (sk) 2004-04-06
EE200300554A (et) 2004-02-16

Similar Documents

Publication Publication Date Title
BR0209678A (pt) Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais
BR0109816A (pt) Composto, processo para prepará-lo, uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, papa o tratamento de distúrbios gastrointestinais, e para o tratamento de lesões espinhais
BR0209676A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade.
BR0212959A (pt) Composto, uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrointestinais e de lesões espinhais
BRPI0412291A (pt) antagonistas duplos de nka/nk3 para o tratamento de esquizofrenia
BRPI0515860B8 (pt) derivados de tetralin e indano, seus usos, e composição farmacêutica
BR0209677A (pt) Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade
BR0212477A (pt) 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças
BR0201437A (pt) Processo para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-substituìdos"
BRPI0409110A (pt) derivados de 4-(4-heterociclilalcoxi)fenil-1-(heterociclil-carboni l)piridina e compostos relacionados como antagonistas de histamina h3 para o tratamento de doenças neurológicas tais como alzheimer
BR0210538A (pt) Derivados de 5-halotriptamina usados como ligantes dos receptores de serotonina 5-ht6 e/ou 5-ht7
BR0212101A (pt) 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças
BR0209668A (pt) Composto, uso do mesmo, composição farmacêutica, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade, e, processo para preparar um composto
BR0109817A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, para o tratamento de distúrbios gastrointestinais, e para o tratamento de lesões espinhais
BR0016578A (pt) Composto, uso do mesmo, composição farmacêutica, e, métodos para o tratamento de dor, para o tratamento de distúrbios gastrointestinais e para o tratamento de danos na coluna vertebral.
BR0109818A (pt) Composto, processo para a preparação e uso do mesmo, composição farmacêutica, e, métodos para o tratamento de dor, de distúrbios gastrointestinais e de lesões espinhais
BR0016594A (pt) Composto, uso de um composto, composição farmacêutica, métodos para o tratamento da dor, para o tratamento de distúrbios gastrointestinais e para o tratamento de danos na coluna vertebral
BR0103210A (pt) Derivados de azabicicloalcano e suas utilizações terapêuticas
BR0209667A (pt) Composto, processo para preparar o mesmo, composição farmacêutica, e, métodos para o tratamento de dor, de distúrbios gastrointestinais funcionais, e de ansiedade
BR0016591A (pt) Composto, uso de um composto, composição farmacêutica, e métodos para o tratamento da dor, de distúrbios gastrointestinais, e de danos na coluna vertebral
BR0209670A (pt) Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e da ansiedade
BR0209675A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade
BR0209669A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais e de lesões espinhais
BR0209665A (pt) Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade
NO20055997L (no) Diarylmetylidenpiperidinderivater og deres anvendelse som opiodreseptoragonister

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.