JP2005506324A - 抗炎症剤としてのアミノピロール化合物 - Google Patents
抗炎症剤としてのアミノピロール化合物 Download PDFInfo
- Publication number
- JP2005506324A JP2005506324A JP2003524985A JP2003524985A JP2005506324A JP 2005506324 A JP2005506324 A JP 2005506324A JP 2003524985 A JP2003524985 A JP 2003524985A JP 2003524985 A JP2003524985 A JP 2003524985A JP 2005506324 A JP2005506324 A JP 2005506324A
- Authority
- JP
- Japan
- Prior art keywords
- disease
- formula
- compound
- phenyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CI[n]1c(-c2cccnc2)cc(C([Al])=O)c1* Chemical compound CI[n]1c(-c2cccnc2)cc(C([Al])=O)c1* 0.000 description 1
- CJKHFNPTLXXSGS-QMMMGPOBSA-N C[C@@H](C(c1c(N)[n](C)c(-c2cnccc2)c1)=O)I Chemical compound C[C@@H](C(c1c(N)[n](C)c(-c2cnccc2)c1)=O)I CJKHFNPTLXXSGS-QMMMGPOBSA-N 0.000 description 1
- FLXCHAMIFYQQEL-UHFFFAOYSA-N C[n](c(-c1cnccc1)c1)c(N)c1C([AlH2])=O Chemical compound C[n](c(-c1cnccc1)c1)c(N)c1C([AlH2])=O FLXCHAMIFYQQEL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31616901P | 2001-08-30 | 2001-08-30 | |
| PCT/EP2002/009505 WO2003020715A1 (en) | 2001-08-30 | 2002-08-26 | Aminopyrrole compounds as antiinflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506324A true JP2005506324A (ja) | 2005-03-03 |
| JP2005506324A5 JP2005506324A5 (https=) | 2005-11-17 |
Family
ID=23227809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524985A Pending JP2005506324A (ja) | 2001-08-30 | 2002-08-26 | 抗炎症剤としてのアミノピロール化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6696471B2 (https=) |
| EP (1) | EP1423378B1 (https=) |
| JP (1) | JP2005506324A (https=) |
| KR (1) | KR20040029075A (https=) |
| CN (1) | CN1281603C (https=) |
| AR (1) | AR037140A1 (https=) |
| AT (1) | ATE309239T1 (https=) |
| AU (1) | AU2002331179B2 (https=) |
| BR (1) | BR0212077A (https=) |
| CA (1) | CA2458808A1 (https=) |
| DE (1) | DE60207273T2 (https=) |
| ES (1) | ES2252509T3 (https=) |
| MX (1) | MXPA04001810A (https=) |
| PL (1) | PL373115A1 (https=) |
| RU (1) | RU2315045C2 (https=) |
| WO (1) | WO2003020715A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US20080113016A1 (en) * | 2004-07-26 | 2008-05-15 | Gary Steven Firestein | Method for Prevention or Treatment of Inflammatory Disease |
| CA2681420A1 (en) * | 2007-03-20 | 2008-09-25 | Cadila Pharmaceuticals Limited | P38 inhibitors |
| WO2017075274A1 (en) | 2015-10-27 | 2017-05-04 | Children's Hospital Medical Center | Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068234A (en) * | 1990-02-26 | 1991-11-26 | Sterling Drug Inc. | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
| BR9710352A (pt) | 1996-07-11 | 1999-08-17 | Pfizer | Compostos piridilpirrole |
| WO1998007425A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
| CA2329065A1 (en) | 1998-05-05 | 1999-11-11 | Francisco Xavier Talamas | Pyrazole derivatives as p-38 map kinase inhibitors |
| WO1999058523A1 (en) * | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
-
2002
- 2002-08-26 JP JP2003524985A patent/JP2005506324A/ja active Pending
- 2002-08-26 WO PCT/EP2002/009505 patent/WO2003020715A1/en not_active Ceased
- 2002-08-26 ES ES02767427T patent/ES2252509T3/es not_active Expired - Lifetime
- 2002-08-26 AU AU2002331179A patent/AU2002331179B2/en not_active Ceased
- 2002-08-26 PL PL02373115A patent/PL373115A1/xx not_active Application Discontinuation
- 2002-08-26 BR BR0212077-1A patent/BR0212077A/pt not_active IP Right Cessation
- 2002-08-26 AT AT02767427T patent/ATE309239T1/de not_active IP Right Cessation
- 2002-08-26 RU RU2004109817/04A patent/RU2315045C2/ru not_active IP Right Cessation
- 2002-08-26 CA CA002458808A patent/CA2458808A1/en not_active Abandoned
- 2002-08-26 CN CNB028166310A patent/CN1281603C/zh not_active Expired - Fee Related
- 2002-08-26 KR KR10-2004-7002895A patent/KR20040029075A/ko not_active Abandoned
- 2002-08-26 EP EP02767427A patent/EP1423378B1/en not_active Expired - Lifetime
- 2002-08-26 DE DE60207273T patent/DE60207273T2/de not_active Expired - Fee Related
- 2002-08-26 MX MXPA04001810A patent/MXPA04001810A/es active IP Right Grant
- 2002-08-28 AR ARP020103226A patent/AR037140A1/es unknown
- 2002-08-29 US US10/231,792 patent/US6696471B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1547578A (zh) | 2004-11-17 |
| MXPA04001810A (es) | 2004-07-08 |
| PL373115A1 (en) | 2005-08-08 |
| US6696471B2 (en) | 2004-02-24 |
| ES2252509T3 (es) | 2006-05-16 |
| KR20040029075A (ko) | 2004-04-03 |
| DE60207273D1 (de) | 2005-12-15 |
| EP1423378A1 (en) | 2004-06-02 |
| DE60207273T2 (de) | 2006-07-20 |
| AR037140A1 (es) | 2004-10-27 |
| AU2002331179B2 (en) | 2008-04-17 |
| CA2458808A1 (en) | 2003-03-13 |
| EP1423378B1 (en) | 2005-11-09 |
| US20030130319A1 (en) | 2003-07-10 |
| BR0212077A (pt) | 2004-09-28 |
| WO2003020715A1 (en) | 2003-03-13 |
| RU2315045C2 (ru) | 2008-01-20 |
| ATE309239T1 (de) | 2005-11-15 |
| CN1281603C (zh) | 2006-10-25 |
| RU2004109817A (ru) | 2005-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI88504B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-benzyl-1-(2h)-ftalazinonderivat | |
| KR900006853B1 (ko) | 약리학적으로 활성인 피라졸로/4,3-c/피리딘의 제조방법 | |
| JPH02270874A (ja) | アザビシクロ化合物及びそれらの塩、それらの製造方法、それらを含有する製薬組成物並びにそれらの薬剤としての使用 | |
| JPH0647589B2 (ja) | キヌクリジン誘導体及びその組成物 | |
| HUT74090A (en) | Indole derivatives, process for producing them and pharmaceutical compositions containing them | |
| KR20110057157A (ko) | 비만세포 트립타제의 억제제로서 ［４－（５－아미노메틸－２－플루오로-페닐）－피페리딘－１－일］－［7－플루오로－1－(２－메톡시－에틸)－４－트리플루오로메톡시－１ｈ－인돌－３－일］－메타논 | |
| JP4740116B2 (ja) | 精神疾患および神経障害の処置のための５−ｈｔ受容体アンタゴニスト | |
| JPS58219161A (ja) | １，３−ジヒドロ−４−（１−ヒドロキシ−２−アミノエチル）−２ｈ−インド−ル−２−オンの新誘導体、それらの塩類、それらの製造法、薬剤としての使用及びこれらを含有する組成物 | |
| JP3057095B2 (ja) | イサチン誘導体、その製造方法及びその使用方法 | |
| JP2005506324A (ja) | 抗炎症剤としてのアミノピロール化合物 | |
| JPH05140108A (ja) | ピリジニルピペラジン誘導体 | |
| JPS5824581A (ja) | ２―オキソピリド―３―イル又はピペリジン―３―イルインドールの新誘導体及びそれらの塩、これらの製造法並びにそれらを含有する薬剤組成物 | |
| JPH02178263A (ja) | アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤 | |
| JP2588977B2 (ja) | ベンゼン誘導体、その調製およびこれを含有する薬学的組成物 | |
| JP3171261B2 (ja) | 神経弛緩薬等としてのｎ−置換された３−アザビシクロ［３．２．０］ヘプタン誘導体 | |
| AU2002331179A1 (en) | Aminopyrrole compounds as antiinflammatory agents | |
| JP2726999B2 (ja) | イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤 | |
| JP3694774B2 (ja) | フェニルカルボン酸誘導体 | |
| JPH03163042A (ja) | カルコン誘導体 | |
| HU198296B (en) | Process for producing new 2-pyridyl acetic acid derivatives and pharmaceutical compositions comprising same | |
| EP0058009A1 (en) | Novel benzanilide derivatives and pharmaceutical compositions containing them | |
| JPS625423B2 (https=) | ||
| JPH0688999B2 (ja) | ピロロ〔３，２―ｅ〕ピラゾロ〔１，５―ａ〕ピリミジン誘導体およびこれを含有する医薬 | |
| JP3709203B2 (ja) | ５−ｈｔ１ａレセプターに対して親和性をもつ三環式化合物 | |
| JP2009519279A (ja) | 三員環ラクタム誘導体、それらの製造方法、及び医薬剤としての使用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050805 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20090204 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090210 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090630 |