JP2005504836A5 - - Google Patents

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Publication number
JP2005504836A5
JP2005504836A5 JP2003533944A JP2003533944A JP2005504836A5 JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5 JP 2003533944 A JP2003533944 A JP 2003533944A JP 2003533944 A JP2003533944 A JP 2003533944A JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5
Authority
JP
Japan
Prior art keywords
compound
prostaglandin
dihydro
alkyl
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003533944A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005504836A (ja
JP4786866B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2002/008705 external-priority patent/WO2003030912A1/en
Publication of JP2005504836A publication Critical patent/JP2005504836A/ja
Publication of JP2005504836A5 publication Critical patent/JP2005504836A5/ja
Application granted granted Critical
Publication of JP4786866B2 publication Critical patent/JP4786866B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003533944A 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ Expired - Lifetime JP4786866B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31591701P 2001-08-31 2001-08-31
US60/315,917 2001-08-31
US37210402P 2002-04-15 2002-04-15
US60/372,104 2002-04-15
PCT/JP2002/008705 WO2003030912A1 (en) 2001-08-31 2002-08-29 Prostaglandin analogs as chloride channel opener

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011001763A Division JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Publications (3)

Publication Number Publication Date
JP2005504836A JP2005504836A (ja) 2005-02-17
JP2005504836A5 true JP2005504836A5 (enExample) 2006-01-05
JP4786866B2 JP4786866B2 (ja) 2011-10-05

Family

ID=26980134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003533944A Expired - Lifetime JP4786866B2 (ja) 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Country Status (11)

Country Link
US (2) US7064148B2 (enExample)
EP (1) EP1420794B1 (enExample)
JP (2) JP4786866B2 (enExample)
AR (1) AR036391A1 (enExample)
AU (1) AU2002330747B2 (enExample)
BR (1) BR0212233A (enExample)
CA (1) CA2458471C (enExample)
MX (1) MXPA04002006A (enExample)
NZ (1) NZ531503A (enExample)
TW (1) TWI298256B (enExample)
WO (1) WO2003030912A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035242A1 (es) * 2001-05-18 2004-05-05 Sucampo Ag Uso de un lipido bioactivo halogenadopara preparar una composicion catartica y compuesto lipido bioactivo halogenado
TWI331920B (en) 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
EP1562604B1 (en) * 2002-10-23 2012-01-04 Sucampo AG Prostaglandin compounds for the treatment of obesity
AU2003292556B2 (en) * 2002-12-27 2009-09-10 Sucampo Ag Derivatives of prostaglandins for treating abdominal discomfort
US8337891B2 (en) * 2003-07-03 2012-12-25 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI495471B (zh) 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) * 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
EP1871380B1 (en) * 2005-04-12 2011-10-19 Sucampo AG Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
AU2007223469B2 (en) * 2006-02-28 2012-06-07 Sucampo Ag Method and composition for treating chronic obstructive pulmonary disease
US7868045B2 (en) * 2006-09-06 2011-01-11 Sucampo Ag Method for promoting gastrointestinal bicarbonate secretion
JP2010519177A (ja) * 2007-02-27 2010-06-03 スキャンポ・アーゲー ミトコンドリアを保護するための組成物および方法
US20090030072A1 (en) 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
EP2211956A4 (en) 2007-10-10 2014-07-09 Parion Sciences Inc DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
US20120184622A1 (en) * 2009-08-07 2012-07-19 Scipharm Sarl Composition for the treatment of cystic fibrosis
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
SI2672957T1 (sl) 2011-02-07 2017-03-31 Scipharm Sarl Nova sestava za zdravljenje cistične fibroze
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
WO2014085655A1 (en) * 2012-11-29 2014-06-05 Indiana University Research And Technology Corporation Dielectric electrolyte measurement device
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US20150057351A1 (en) * 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
US20160228403A1 (en) 2013-10-04 2016-08-11 Tohoku University Agent for preventing or ameliorating renal dysfunction
JP6957610B2 (ja) 2016-10-06 2021-11-02 スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ 医薬品用途のための多層ビーズ
CN110267670B (zh) 2016-10-20 2023-08-15 表飞鸣制药株式会社 对肠道的离子跨细胞转运体的作用剂、氯离子通道活化剂、肾脏疾病的预防或治疗剂或者排便促进剂
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
IE43462B1 (en) * 1975-06-23 1981-03-11 Pfizer Substituted tetranorprostaglandins
US4091207A (en) * 1976-04-22 1978-05-23 Pfizer Inc. Prostaglandin intermediate including oxathio heterocyclic ring
IT1098350B (it) * 1977-07-28 1985-09-07 Upjohn Co Derivati prostaglandinici
JPS6033429B2 (ja) * 1980-04-28 1985-08-02 小野薬品工業株式会社 プロスタグランジン類似化合物
CA1322749C (en) 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5166174A (en) 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
ATE78465T1 (de) 1987-10-02 1992-08-15 Ueno Seiyaku Oyo Kenkyujo Kk Kathartica.
JPH0681728B2 (ja) * 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
CA2030344C (en) 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
JPH0791192B2 (ja) * 1989-11-22 1995-10-04 株式会社上野製薬応用研究所 ガス交換機能不全処置剤
TW224942B (enExample) 1990-04-04 1994-06-11 Adka Ueno Kk
EP0455448B1 (en) * 1990-05-01 1998-12-09 R-Tech Ueno Ltd. Treatment of pancreatic disease with 15-keto-prostaglandin E compounds
CA2150287C (en) 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
US6015828A (en) * 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
US6242485B1 (en) 1996-06-10 2001-06-05 R-Tech Ueno Endothelin antagonist
US6291521B1 (en) * 1997-10-13 2001-09-18 R-Tech Ueno, Ltd. Anti-portal hypertensive agent
EP0978284B1 (en) * 1997-11-28 2008-07-23 Sucampo AG Use of 15-keto-prostaglandin-e compounds as endothelin antagonists
DE69912277T2 (de) * 1998-05-25 2004-07-15 Taisho Pharmaceutical Co., Ltd. Prostaglandinderivate
CA2403086C (en) 2000-03-24 2010-08-17 Sucampo Ag Apoptosis inhibiting composition comprising a 15-keto-prostaglandin or derivative thereof
JP4183943B2 (ja) 2000-04-06 2008-11-19 スキャンポ・アーゲー １５−ケトプロスタグランジンを含む胆汁分泌促進剤組成物
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
FR2829293B1 (fr) * 2001-08-31 2003-11-14 Centre Nat Rech Scient Memoire moleculaire et son procede de fabrication

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