JP2005504836A5 - - Google Patents

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Publication number
JP2005504836A5
JP2005504836A5 JP2003533944A JP2003533944A JP2005504836A5 JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5 JP 2003533944 A JP2003533944 A JP 2003533944A JP 2003533944 A JP2003533944 A JP 2003533944A JP 2005504836 A5 JP2005504836 A5 JP 2005504836A5
Authority
JP
Japan
Prior art keywords
compound
prostaglandin
dihydro
alkyl
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003533944A
Other languages
English (en)
Japanese (ja)
Other versions
JP4786866B2 (ja
JP2005504836A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2002/008705 external-priority patent/WO2003030912A1/en
Publication of JP2005504836A publication Critical patent/JP2005504836A/ja
Publication of JP2005504836A5 publication Critical patent/JP2005504836A5/ja
Application granted granted Critical
Publication of JP4786866B2 publication Critical patent/JP4786866B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003533944A 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ Expired - Lifetime JP4786866B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31591701P 2001-08-31 2001-08-31
US60/315,917 2001-08-31
US37210402P 2002-04-15 2002-04-15
US60/372,104 2002-04-15
PCT/JP2002/008705 WO2003030912A1 (en) 2001-08-31 2002-08-29 Prostaglandin analogs as chloride channel opener

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011001763A Division JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Publications (3)

Publication Number Publication Date
JP2005504836A JP2005504836A (ja) 2005-02-17
JP2005504836A5 true JP2005504836A5 (enExample) 2006-01-05
JP4786866B2 JP4786866B2 (ja) 2011-10-05

Family

ID=26980134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003533944A Expired - Lifetime JP4786866B2 (ja) 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Country Status (11)

Country Link
US (2) US7064148B2 (enExample)
EP (1) EP1420794B1 (enExample)
JP (2) JP4786866B2 (enExample)
AR (1) AR036391A1 (enExample)
AU (1) AU2002330747B2 (enExample)
BR (1) BR0212233A (enExample)
CA (1) CA2458471C (enExample)
MX (1) MXPA04002006A (enExample)
NZ (1) NZ531503A (enExample)
TW (1) TWI298256B (enExample)
WO (1) WO2003030912A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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BR0209863A (pt) * 2001-05-18 2004-06-08 Sucampo Ag Composição catártica
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
ES2379652T3 (es) * 2002-10-23 2012-04-30 Sucampo Ag Compuestos de prostaglandina para el tratamiento de obesidad
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
DE602004030245D1 (de) * 2003-07-03 2011-01-05 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI348386B (en) 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
MX2007010833A (es) * 2005-03-07 2009-02-17 Univ Chicago Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales.
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
KR101466980B1 (ko) * 2005-04-12 2014-12-01 수캄포 아게 위장 장애 치료를 위한 프로스타글란딘 화합물과 양성자펌프 억제제의 병용
JP5377970B2 (ja) * 2006-02-28 2013-12-25 スキャンポ・アーゲー 慢性閉塞性肺疾患を処置するための方法および組成物
US7868045B2 (en) * 2006-09-06 2011-01-11 Sucampo Ag Method for promoting gastrointestinal bicarbonate secretion
WO2008108322A2 (en) * 2007-02-27 2008-09-12 Sucampo Ag Composition and method for protecting mitochondria
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
US20090030072A1 (en) 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
WO2009049159A1 (en) 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
AU2010280684B2 (en) * 2009-08-07 2016-07-28 Scipharm Sarl Composition for the treatment of cystic fibrosis
US20110071163A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders
RS55624B1 (sr) * 2011-02-07 2017-06-30 Scipharm Sàrl Nova kompozicija za lečenje cistične fibroze
EP2717855A4 (en) 2011-06-07 2014-11-12 Parion Sciences Inc Methods of Treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US10724986B2 (en) 2012-11-29 2020-07-28 Indiana University Research & Technology Corporation Dielectric electrolyte measurement device
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US20150057351A1 (en) * 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
EP3053575B1 (en) * 2013-10-04 2020-09-02 Tohoku University Agent for preventing or ameliorating renal dysfunction
US11534404B2 (en) 2016-10-06 2022-12-27 Sucampo Ag Multilayer beads for pharmaceutical use
CN110267670B (zh) 2016-10-20 2023-08-15 表飞鸣制药株式会社 对肠道的离子跨细胞转运体的作用剂、氯离子通道活化剂、肾脏疾病的预防或治疗剂或者排便促进剂
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
IE43462B1 (en) * 1975-06-23 1981-03-11 Pfizer Substituted tetranorprostaglandins
US4091207A (en) * 1976-04-22 1978-05-23 Pfizer Inc. Prostaglandin intermediate including oxathio heterocyclic ring
IT1098350B (it) * 1977-07-28 1985-09-07 Upjohn Co Derivati prostaglandinici
JPS6033429B2 (ja) * 1980-04-28 1985-08-02 小野薬品工業株式会社 プロスタグランジン類似化合物
CA1322749C (en) 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5166174A (en) 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
JPH0681728B2 (ja) * 1987-10-02 1994-10-19 株式会社上野製薬応用研究所 下 剤
EP0310305B1 (en) * 1987-10-02 1992-07-22 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Cathartics
JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
JPH0791192B2 (ja) * 1989-11-22 1995-10-04 株式会社上野製薬応用研究所 ガス交換機能不全処置剤
CA2030344C (en) 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
TW249226B (enExample) 1990-04-04 1995-06-11 Aderk Ueno Kk
DE69130586T2 (de) * 1990-05-01 1999-06-17 R-Tech Ueno, Ltd., Osaka Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
CA2150287C (en) * 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
US6015828A (en) * 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
KR19990036322A (ko) 1996-06-10 1999-05-25 류지 우에노 엔도텔린길항제
WO1999018968A1 (en) * 1997-10-13 1999-04-22 R-Tech Ueno, Ltd. Portal hypertension inhibitor
DK0978284T3 (da) 1997-11-28 2008-10-27 Sucampo Ag Anvendelse af 15-keto-prostaglandin-E-forbindelser som endothelinantagonister
CA2333038C (en) * 1998-05-25 2008-12-02 Taisho Pharmaceutical Co., Ltd. Sleep-inducing preparation
TWI284535B (en) 2000-03-24 2007-08-01 Sucampo Ag Apoptosis inhibitor
ATE433754T1 (de) 2000-04-06 2009-07-15 Sucampo Ag Gallensäurefördernde zusammensetzung für lebertransplantation welche ein 15-keto prostaglandin enthält
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
FR2829293B1 (fr) * 2001-08-31 2003-11-14 Centre Nat Rech Scient Memoire moleculaire et son procede de fabrication

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