NZ531503A - Prostaglandin analogs as chloride channel opener - Google Patents
Prostaglandin analogs as chloride channel openerInfo
- Publication number
- NZ531503A NZ531503A NZ531503A NZ53150302A NZ531503A NZ 531503 A NZ531503 A NZ 531503A NZ 531503 A NZ531503 A NZ 531503A NZ 53150302 A NZ53150302 A NZ 53150302A NZ 531503 A NZ531503 A NZ 531503A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- compound
- hydroxy
- halogen
- hydrogen
- Prior art date
Links
- 102000011045 Chloride Channels Human genes 0.000 title claims description 21
- 108010062745 Chloride Channels Proteins 0.000 title claims description 21
- 150000003180 prostaglandins Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 127
- 125000000217 alkyl group Chemical group 0.000 claims description 106
- -1 prostaglandin compound Chemical class 0.000 claims description 87
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 71
- 125000003545 alkoxy group Chemical group 0.000 claims description 55
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 54
- 239000001257 hydrogen Substances 0.000 claims description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- 229920006395 saturated elastomer Polymers 0.000 claims description 47
- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 229940125904 compound 1 Drugs 0.000 claims description 44
- 125000003118 aryl group Chemical group 0.000 claims description 42
- 150000002367 halogens Chemical class 0.000 claims description 41
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 29
- 108091006146 Channels Proteins 0.000 claims description 28
- 125000004104 aryloxy group Chemical group 0.000 claims description 24
- 238000012360 testing method Methods 0.000 claims description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
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- 125000001931 aliphatic group Chemical group 0.000 claims description 17
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
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- 229910052717 sulfur Chemical group 0.000 claims description 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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Landscapes
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Applications Claiming Priority (3)
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| US31591701P | 2001-08-31 | 2001-08-31 | |
| US37210402P | 2002-04-15 | 2002-04-15 | |
| PCT/JP2002/008705 WO2003030912A1 (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
Publications (1)
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| NZ531503A true NZ531503A (en) | 2006-01-27 |
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| NZ531503A NZ531503A (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
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| WO (1) | WO2003030912A1 (enExample) |
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| TWI331920B (en) | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| EP1562604B1 (en) * | 2002-10-23 | 2012-01-04 | Sucampo AG | Prostaglandin compounds for the treatment of obesity |
| AU2003292556B2 (en) * | 2002-12-27 | 2009-09-10 | Sucampo Ag | Derivatives of prostaglandins for treating abdominal discomfort |
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| TWI495471B (zh) | 2003-08-12 | 2015-08-11 | R Tech Ueno Ltd | 促進毛髮生長之組成物及方法 |
| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| CN101171010B (zh) * | 2005-03-07 | 2014-09-17 | 芝加哥大学 | 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途 |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
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| JP2010519177A (ja) * | 2007-02-27 | 2010-06-03 | スキャンポ・アーゲー | ミトコンドリアを保護するための組成物および方法 |
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| EP2211956A4 (en) | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
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| US20120184622A1 (en) * | 2009-08-07 | 2012-07-19 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
| JP5797655B2 (ja) * | 2009-09-18 | 2015-10-21 | アドラー・コーポレーション | 消化管障害のためのオピオイド受容体アンタゴニストの使用 |
| SI2672957T1 (sl) | 2011-02-07 | 2017-03-31 | Scipharm Sarl | Nova sestava za zdravljenje cistične fibroze |
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| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
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2002
- 2002-08-29 AU AU2002330747A patent/AU2002330747B2/en not_active Expired
- 2002-08-29 NZ NZ531503A patent/NZ531503A/en not_active IP Right Cessation
- 2002-08-29 WO PCT/JP2002/008705 patent/WO2003030912A1/en not_active Ceased
- 2002-08-29 MX MXPA04002006A patent/MXPA04002006A/es active IP Right Grant
- 2002-08-29 EP EP02767866.3A patent/EP1420794B1/en not_active Expired - Lifetime
- 2002-08-29 BR BR0212233-2A patent/BR0212233A/pt not_active Application Discontinuation
- 2002-08-29 JP JP2003533944A patent/JP4786866B2/ja not_active Expired - Lifetime
- 2002-08-29 CA CA2458471A patent/CA2458471C/en not_active Expired - Lifetime
- 2002-08-30 US US10/231,341 patent/US7064148B2/en not_active Expired - Lifetime
- 2002-08-30 TW TW091119830A patent/TWI298256B/zh not_active IP Right Cessation
- 2002-08-30 AR ARP020103284A patent/AR036391A1/es active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| US20030130352A1 (en) | 2003-07-10 |
| BR0212233A (pt) | 2004-10-05 |
| EP1420794B1 (en) | 2017-12-27 |
| EP1420794A1 (en) | 2004-05-26 |
| AR036391A1 (es) | 2004-09-08 |
| CA2458471C (en) | 2012-07-31 |
| TWI298256B (en) | 2008-07-01 |
| CA2458471A1 (en) | 2003-04-17 |
| MXPA04002006A (es) | 2004-06-07 |
| JP2005504836A (ja) | 2005-02-17 |
| JP4786866B2 (ja) | 2011-10-05 |
| US7253295B2 (en) | 2007-08-07 |
| JP5568021B2 (ja) | 2014-08-06 |
| AU2002330747B2 (en) | 2007-07-19 |
| US20060122411A1 (en) | 2006-06-08 |
| WO2003030912A1 (en) | 2003-04-17 |
| US7064148B2 (en) | 2006-06-20 |
| JP2011102313A (ja) | 2011-05-26 |
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