NZ531503A - Prostaglandin analogs as chloride channel opener - Google Patents
Prostaglandin analogs as chloride channel openerInfo
- Publication number
- NZ531503A NZ531503A NZ531503A NZ53150302A NZ531503A NZ 531503 A NZ531503 A NZ 531503A NZ 531503 A NZ531503 A NZ 531503A NZ 53150302 A NZ53150302 A NZ 53150302A NZ 531503 A NZ531503 A NZ 531503A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- compound
- hydroxy
- halogen
- hydrogen
- Prior art date
Links
- 102000011045 Chloride Channels Human genes 0.000 title claims description 21
- 108010062745 Chloride Channels Proteins 0.000 title claims description 21
- 150000003180 prostaglandins Chemical class 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 127
- 125000000217 alkyl group Chemical group 0.000 claims description 106
- -1 prostaglandin compound Chemical class 0.000 claims description 87
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 71
- 125000003545 alkoxy group Chemical group 0.000 claims description 55
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 54
- 239000001257 hydrogen Substances 0.000 claims description 47
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- 229920006395 saturated elastomer Polymers 0.000 claims description 47
- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 229940125904 compound 1 Drugs 0.000 claims description 44
- 125000003118 aryl group Chemical group 0.000 claims description 42
- 150000002367 halogens Chemical class 0.000 claims description 41
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 29
- 108091006146 Channels Proteins 0.000 claims description 28
- 125000004104 aryloxy group Chemical group 0.000 claims description 24
- 238000012360 testing method Methods 0.000 claims description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
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- 125000001931 aliphatic group Chemical group 0.000 claims description 17
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
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- 229910052717 sulfur Chemical group 0.000 claims description 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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Landscapes
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Applications Claiming Priority (3)
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| US31591701P | 2001-08-31 | 2001-08-31 | |
| US37210402P | 2002-04-15 | 2002-04-15 | |
| PCT/JP2002/008705 WO2003030912A1 (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
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| NZ531503A true NZ531503A (en) | 2006-01-27 |
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| TW (1) | TWI298256B (enExample) |
| WO (1) | WO2003030912A1 (enExample) |
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| TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| ES2379652T3 (es) * | 2002-10-23 | 2012-04-30 | Sucampo Ag | Compuestos de prostaglandina para el tratamiento de obesidad |
| NZ541110A (en) * | 2002-12-27 | 2008-11-28 | Sucampo Ag | Derivatives of prostaglandins for treating abdominal discomfort |
| WO2005002588A1 (en) * | 2003-07-03 | 2005-01-13 | Sucampo Ag | Enteric coated composition comprising prostaglandin analogs as chloride channel opener |
| TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
| TWI387454B (zh) | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| JP5241484B2 (ja) * | 2005-03-07 | 2013-07-17 | ザ ユニヴァーシティー オヴ シカゴ | 内皮細胞増殖及び内皮細胞遊走を減弱するためのオピオイドアンタゴニストの使用 |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| JP5711442B2 (ja) * | 2005-04-12 | 2015-04-30 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 胃腸障害の処置のためのプロスタグランジン化合物およびプロトンポンプ阻害剤の併用 |
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| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
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| ES2451790T3 (es) * | 2009-08-07 | 2014-03-28 | Scipharm Sàrl | Composición para el tratamiento de la fibrosis quística |
| MX342548B (es) * | 2009-09-18 | 2016-10-04 | Merck Sharp & Dohme Corp * | Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal. |
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| IT1098350B (it) * | 1977-07-28 | 1985-09-07 | Upjohn Co | Derivati prostaglandinici |
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2002
- 2002-08-29 MX MXPA04002006A patent/MXPA04002006A/es active IP Right Grant
- 2002-08-29 BR BR0212233-2A patent/BR0212233A/pt not_active Application Discontinuation
- 2002-08-29 WO PCT/JP2002/008705 patent/WO2003030912A1/en not_active Ceased
- 2002-08-29 CA CA2458471A patent/CA2458471C/en not_active Expired - Lifetime
- 2002-08-29 EP EP02767866.3A patent/EP1420794B1/en not_active Expired - Lifetime
- 2002-08-29 NZ NZ531503A patent/NZ531503A/en not_active IP Right Cessation
- 2002-08-29 JP JP2003533944A patent/JP4786866B2/ja not_active Expired - Lifetime
- 2002-08-29 AU AU2002330747A patent/AU2002330747B2/en not_active Expired
- 2002-08-30 US US10/231,341 patent/US7064148B2/en not_active Expired - Lifetime
- 2002-08-30 TW TW091119830A patent/TWI298256B/zh not_active IP Right Cessation
- 2002-08-30 AR ARP020103284A patent/AR036391A1/es active IP Right Grant
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- 2006-01-18 US US11/333,511 patent/US7253295B2/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2003030912A1 (en) | 2003-04-17 |
| US7064148B2 (en) | 2006-06-20 |
| BR0212233A (pt) | 2004-10-05 |
| US7253295B2 (en) | 2007-08-07 |
| JP4786866B2 (ja) | 2011-10-05 |
| AR036391A1 (es) | 2004-09-08 |
| TWI298256B (en) | 2008-07-01 |
| CA2458471A1 (en) | 2003-04-17 |
| EP1420794A1 (en) | 2004-05-26 |
| EP1420794B1 (en) | 2017-12-27 |
| CA2458471C (en) | 2012-07-31 |
| JP2011102313A (ja) | 2011-05-26 |
| AU2002330747B2 (en) | 2007-07-19 |
| MXPA04002006A (es) | 2004-06-07 |
| JP2005504836A (ja) | 2005-02-17 |
| US20030130352A1 (en) | 2003-07-10 |
| US20060122411A1 (en) | 2006-06-08 |
| JP5568021B2 (ja) | 2014-08-06 |
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