CA2458471C - Prostaglandin analogs as chloride channel opener - Google Patents
Prostaglandin analogs as chloride channel opener Download PDFInfo
- Publication number
- CA2458471C CA2458471C CA2458471A CA2458471A CA2458471C CA 2458471 C CA2458471 C CA 2458471C CA 2458471 A CA2458471 A CA 2458471A CA 2458471 A CA2458471 A CA 2458471A CA 2458471 C CA2458471 C CA 2458471C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- prostaglandin
- alkyl
- dihydro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000011045 Chloride Channels Human genes 0.000 title abstract description 22
- 108010062745 Chloride Channels Proteins 0.000 title abstract description 22
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- -1 prostaglandin compound Chemical class 0.000 claims abstract description 86
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- 150000001875 compounds Chemical class 0.000 claims description 126
- 239000000203 mixture Substances 0.000 claims description 79
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 52
- 229920006395 saturated elastomer Polymers 0.000 claims description 39
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
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- 239000001257 hydrogen Substances 0.000 claims description 27
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 22
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- 125000005843 halogen group Chemical group 0.000 claims description 15
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Classifications
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Landscapes
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| US60/372,104 | 2002-04-15 | ||
| PCT/JP2002/008705 WO2003030912A1 (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
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| TWI263505B (en) * | 2001-11-19 | 2006-10-11 | Sucampo Ag | Pharmaceutical composition comprising a C1C-2 channel opener |
| ES2379652T3 (es) * | 2002-10-23 | 2012-04-30 | Sucampo Ag | Compuestos de prostaglandina para el tratamiento de obesidad |
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| TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
| TWI387454B (zh) | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| JP5241484B2 (ja) * | 2005-03-07 | 2013-07-17 | ザ ユニヴァーシティー オヴ シカゴ | 内皮細胞増殖及び内皮細胞遊走を減弱するためのオピオイドアンタゴニストの使用 |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| JP5711442B2 (ja) * | 2005-04-12 | 2015-04-30 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 胃腸障害の処置のためのプロスタグランジン化合物およびプロトンポンプ阻害剤の併用 |
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| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
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| MX342548B (es) * | 2009-09-18 | 2016-10-04 | Merck Sharp & Dohme Corp * | Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal. |
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| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | PROCESSING METHODS |
| US10724986B2 (en) | 2012-11-29 | 2020-07-28 | Indiana University Research & Technology Corporation | Dielectric electrolyte measurement device |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
| EP3053575B1 (en) | 2013-10-04 | 2020-09-02 | Tohoku University | Agent for preventing or ameliorating renal dysfunction |
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| US10457623B1 (en) * | 2018-07-13 | 2019-10-29 | Chirogate International Inc. | Process for the preparation of Lubiprostone and intermediates thereof |
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| IE43462B1 (en) * | 1975-06-23 | 1981-03-11 | Pfizer | Substituted tetranorprostaglandins |
| US4091207A (en) * | 1976-04-22 | 1978-05-23 | Pfizer Inc. | Prostaglandin intermediate including oxathio heterocyclic ring |
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-
2002
- 2002-08-29 MX MXPA04002006A patent/MXPA04002006A/es active IP Right Grant
- 2002-08-29 BR BR0212233-2A patent/BR0212233A/pt not_active Application Discontinuation
- 2002-08-29 WO PCT/JP2002/008705 patent/WO2003030912A1/en not_active Ceased
- 2002-08-29 CA CA2458471A patent/CA2458471C/en not_active Expired - Lifetime
- 2002-08-29 EP EP02767866.3A patent/EP1420794B1/en not_active Expired - Lifetime
- 2002-08-29 NZ NZ531503A patent/NZ531503A/en not_active IP Right Cessation
- 2002-08-29 JP JP2003533944A patent/JP4786866B2/ja not_active Expired - Lifetime
- 2002-08-29 AU AU2002330747A patent/AU2002330747B2/en not_active Expired
- 2002-08-30 US US10/231,341 patent/US7064148B2/en not_active Expired - Lifetime
- 2002-08-30 TW TW091119830A patent/TWI298256B/zh not_active IP Right Cessation
- 2002-08-30 AR ARP020103284A patent/AR036391A1/es active IP Right Grant
-
2006
- 2006-01-18 US US11/333,511 patent/US7253295B2/en not_active Expired - Lifetime
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2011
- 2011-01-07 JP JP2011001763A patent/JP5568021B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003030912A1 (en) | 2003-04-17 |
| US7064148B2 (en) | 2006-06-20 |
| BR0212233A (pt) | 2004-10-05 |
| US7253295B2 (en) | 2007-08-07 |
| JP4786866B2 (ja) | 2011-10-05 |
| AR036391A1 (es) | 2004-09-08 |
| TWI298256B (en) | 2008-07-01 |
| CA2458471A1 (en) | 2003-04-17 |
| NZ531503A (en) | 2006-01-27 |
| EP1420794A1 (en) | 2004-05-26 |
| EP1420794B1 (en) | 2017-12-27 |
| JP2011102313A (ja) | 2011-05-26 |
| AU2002330747B2 (en) | 2007-07-19 |
| MXPA04002006A (es) | 2004-06-07 |
| JP2005504836A (ja) | 2005-02-17 |
| US20030130352A1 (en) | 2003-07-10 |
| US20060122411A1 (en) | 2006-06-08 |
| JP5568021B2 (ja) | 2014-08-06 |
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