CA2458471C - Prostaglandin analogs as chloride channel opener - Google Patents
Prostaglandin analogs as chloride channel opener Download PDFInfo
- Publication number
- CA2458471C CA2458471C CA2458471A CA2458471A CA2458471C CA 2458471 C CA2458471 C CA 2458471C CA 2458471 A CA2458471 A CA 2458471A CA 2458471 A CA2458471 A CA 2458471A CA 2458471 C CA2458471 C CA 2458471C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- prostaglandin
- alkyl
- dihydro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000011045 Chloride Channels Human genes 0.000 title abstract description 22
- 108010062745 Chloride Channels Proteins 0.000 title abstract description 22
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- -1 prostaglandin compound Chemical class 0.000 claims abstract description 86
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- 150000001875 compounds Chemical class 0.000 claims description 126
- 239000000203 mixture Substances 0.000 claims description 79
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 52
- 229920006395 saturated elastomer Polymers 0.000 claims description 39
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
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- 239000001257 hydrogen Substances 0.000 claims description 27
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 22
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- 125000005843 halogen group Chemical group 0.000 claims description 15
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Landscapes
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| PCT/JP2002/008705 WO2003030912A1 (en) | 2001-08-31 | 2002-08-29 | Prostaglandin analogs as chloride channel opener |
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| US7732487B2 (en) * | 2001-11-19 | 2010-06-08 | Sucampo Ag | Method for treating a disease or condition responsive to opening of C1C-2 channel |
| ES2379652T3 (es) * | 2002-10-23 | 2012-04-30 | Sucampo Ag | Compuestos de prostaglandina para el tratamiento de obesidad |
| JP4889219B2 (ja) | 2002-12-27 | 2012-03-07 | スキャンポ・アーゲー | 腹部不快感の処置のためのプロスタグランジン誘導体 |
| DE602004030245D1 (de) * | 2003-07-03 | 2011-01-05 | Sucampo Ag | Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner |
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| TWI387454B (zh) * | 2004-09-02 | 2013-03-01 | 蘇坎波公司 | 治療胃腸道疾病之方法及組成物 |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| MX2007010833A (es) * | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| KR101466980B1 (ko) * | 2005-04-12 | 2014-12-01 | 수캄포 아게 | 위장 장애 치료를 위한 프로스타글란딘 화합물과 양성자펌프 억제제의 병용 |
| JP5377970B2 (ja) * | 2006-02-28 | 2013-12-25 | スキャンポ・アーゲー | 慢性閉塞性肺疾患を処置するための方法および組成物 |
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| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| CN101318948B (zh) * | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
| US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
| AU2010280684B2 (en) * | 2009-08-07 | 2016-07-28 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
| US20110071163A1 (en) * | 2009-09-18 | 2011-03-24 | Adolor Corporation | Use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders |
| RS55624B1 (sr) * | 2011-02-07 | 2017-06-30 | Scipharm Sàrl | Nova kompozicija za lečenje cistične fibroze |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Methods of Treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| US10724986B2 (en) | 2012-11-29 | 2020-07-28 | Indiana University Research & Technology Corporation | Dielectric electrolyte measurement device |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
| EP3053575B1 (en) * | 2013-10-04 | 2020-09-02 | Tohoku University | Agent for preventing or ameliorating renal dysfunction |
| US11534404B2 (en) | 2016-10-06 | 2022-12-27 | Sucampo Ag | Multilayer beads for pharmaceutical use |
| CN110267670B (zh) | 2016-10-20 | 2023-08-15 | 表飞鸣制药株式会社 | 对肠道的离子跨细胞转运体的作用剂、氯离子通道活化剂、肾脏疾病的预防或治疗剂或者排便促进剂 |
| US10457623B1 (en) * | 2018-07-13 | 2019-10-29 | Chirogate International Inc. | Process for the preparation of Lubiprostone and intermediates thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE43462B1 (en) * | 1975-06-23 | 1981-03-11 | Pfizer | Substituted tetranorprostaglandins |
| US4091207A (en) * | 1976-04-22 | 1978-05-23 | Pfizer Inc. | Prostaglandin intermediate including oxathio heterocyclic ring |
| IT1098350B (it) * | 1977-07-28 | 1985-09-07 | Upjohn Co | Derivati prostaglandinici |
| JPS6033429B2 (ja) * | 1980-04-28 | 1985-08-02 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| US5221763A (en) | 1987-04-30 | 1993-06-22 | R-Tech Ueno, Ltd. | Prostaglandins of the F series |
| JPH0681728B2 (ja) * | 1987-10-02 | 1994-10-19 | 株式会社上野製薬応用研究所 | 下 剤 |
| EP0310305B1 (en) * | 1987-10-02 | 1992-07-22 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Cathartics |
| JP2579193B2 (ja) | 1988-07-19 | 1997-02-05 | 小野薬品工業株式会社 | １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体 |
| JPH0791192B2 (ja) * | 1989-11-22 | 1995-10-04 | 株式会社上野製薬応用研究所 | ガス交換機能不全処置剤 |
| CA2030344C (en) | 1989-11-22 | 2000-04-18 | Ryuji Ueno | Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds |
| TW249226B (enExample) | 1990-04-04 | 1995-06-11 | Aderk Ueno Kk | |
| DE69130586T2 (de) * | 1990-05-01 | 1999-06-17 | R-Tech Ueno, Ltd., Osaka | Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten |
| CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| US6015828A (en) * | 1996-05-31 | 2000-01-18 | Cuppoletti; John | Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases |
| KR19990036322A (ko) | 1996-06-10 | 1999-05-25 | 류지 우에노 | 엔도텔린길항제 |
| WO1999018968A1 (en) * | 1997-10-13 | 1999-04-22 | R-Tech Ueno, Ltd. | Portal hypertension inhibitor |
| DK0978284T3 (da) | 1997-11-28 | 2008-10-27 | Sucampo Ag | Anvendelse af 15-keto-prostaglandin-E-forbindelser som endothelinantagonister |
| CA2333038C (en) * | 1998-05-25 | 2008-12-02 | Taisho Pharmaceutical Co., Ltd. | Sleep-inducing preparation |
| TWI284535B (en) | 2000-03-24 | 2007-08-01 | Sucampo Ag | Apoptosis inhibitor |
| ATE433754T1 (de) | 2000-04-06 | 2009-07-15 | Sucampo Ag | Gallensäurefördernde zusammensetzung für lebertransplantation welche ein 15-keto prostaglandin enthält |
| TWI302100B (en) | 2001-05-02 | 2008-10-21 | Sucampo Ag | Composition for treating drug-induced constipation |
| FR2829293B1 (fr) * | 2001-08-31 | 2003-11-14 | Centre Nat Rech Scient | Memoire moleculaire et son procede de fabrication |
-
2002
- 2002-08-29 JP JP2003533944A patent/JP4786866B2/ja not_active Expired - Lifetime
- 2002-08-29 BR BR0212233-2A patent/BR0212233A/pt not_active Application Discontinuation
- 2002-08-29 MX MXPA04002006A patent/MXPA04002006A/es active IP Right Grant
- 2002-08-29 NZ NZ531503A patent/NZ531503A/en not_active IP Right Cessation
- 2002-08-29 WO PCT/JP2002/008705 patent/WO2003030912A1/en not_active Ceased
- 2002-08-29 AU AU2002330747A patent/AU2002330747B2/en not_active Expired
- 2002-08-29 EP EP02767866.3A patent/EP1420794B1/en not_active Expired - Lifetime
- 2002-08-29 CA CA2458471A patent/CA2458471C/en not_active Expired - Lifetime
- 2002-08-30 US US10/231,341 patent/US7064148B2/en not_active Expired - Lifetime
- 2002-08-30 TW TW091119830A patent/TWI298256B/zh not_active IP Right Cessation
- 2002-08-30 AR ARP020103284A patent/AR036391A1/es active IP Right Grant
-
2006
- 2006-01-18 US US11/333,511 patent/US7253295B2/en not_active Expired - Lifetime
-
2011
- 2011-01-07 JP JP2011001763A patent/JP5568021B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030130352A1 (en) | 2003-07-10 |
| US7064148B2 (en) | 2006-06-20 |
| AR036391A1 (es) | 2004-09-08 |
| JP2011102313A (ja) | 2011-05-26 |
| CA2458471A1 (en) | 2003-04-17 |
| JP4786866B2 (ja) | 2011-10-05 |
| AU2002330747B2 (en) | 2007-07-19 |
| JP2005504836A (ja) | 2005-02-17 |
| BR0212233A (pt) | 2004-10-05 |
| US20060122411A1 (en) | 2006-06-08 |
| NZ531503A (en) | 2006-01-27 |
| TWI298256B (en) | 2008-07-01 |
| MXPA04002006A (es) | 2004-06-07 |
| US7253295B2 (en) | 2007-08-07 |
| JP5568021B2 (ja) | 2014-08-06 |
| EP1420794B1 (en) | 2017-12-27 |
| EP1420794A1 (en) | 2004-05-26 |
| WO2003030912A1 (en) | 2003-04-17 |
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